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Mister g-Fus 
New Kid on the Fibroid Block
• InSightec ExAblate™ system. 
• “Most Advanced MRgFUS system in India” 
• One of the few centers in the world to offer both MRgFUS and 
Uterine Fibroid Embolization 
• Since 2004, over 9000 women have been treated with 
ExAblate for their uterine fibroids.
How does MRgFUS work ? 
• ExAblate uses a combination of high-intensity ultrasound 
waves and MRI to non-invasively image the fibroid and 
surrounding organs in 3D, treat the fibroid, obtain real-time 
feedback about the treated area, and observe what has been 
treated. 
• The high intensity focused ultrasound energy heats the fibroid 
only at the target area, producing safe and controlled 
coagulative necrosis without damaging the surrounding 
tissue. 
• The treatment procedure lasts about 3 hours, and patients 
return to regular activities within a few days.
Beam path visualization 
2 for controlled treatment 
4 3 
1 
Multi-planar imaging 
for precise tumor 
targeting 
CLOSED 
LOOP 
THERAPY 
5 
MR thermometry 
temperature feedback Thermal dose accumulation 
Post treatment 
contrast imaging for 
precise treatment 
validation 
Real Time MRI Guidance and Monitoring
Who can be treated by MRgFUS ? 
• Fibroids greater than 2cm and smaller than 20cm are 
particularly amenable to treatment with the most noticeable 
symptomatic relief from bleeding and pressure symptoms. 
• A screening MRI is done that gives us information about the 
size, location, number, T2 Hyperintensity and Post contrast 
enhancement characteristics. 
• These help us choose the best modality to treat your patient’s 
fibroid.
Contraindications for MRgFus : 
• MR incompatible implantable medical devices such as pacemakers 
and cochlear implants. 
• Severe claustrophobia. 
• Known intolerance to MR contrast agents. 
• Vertical abdominal or high horizontal scars through the mid-line 
which would prevent access to the fibroid (low horizontal scars such 
as normal Caesarean section scars or scars to either side of the mid-line 
such as appendectomy scars are not a contra-indication). 
• Such patients can be treated by Uterine Fibroid Embolization.
MRgFUS & Pregnancy ? 
Total number of pregnancies 
Mean age 
Average months to conception 
Total deliveries 
- Of them vaginal 
Elective pregnancy termination 
Spontaneous abortions 
Ongoing pregnancies 
Unknown 
Average baby weight at term 
delivery 
117 
36 
9 
64 (55%) 
59% 
10 (9%) 
22 (19%) 
9 (8%) 
12 (10%) 
3.27 kg
Pre 
Procedur 
e T2 
Coronal 
Post 
Procedure 
80 % NPV 
Patients treated at Nanavati Supersepciality 
Hospital 
Patient 1 : 34 yr old female 
Symptoms: Heavy menstrual bleeding, pelvic 
pain and urinary frequency 
T2 Hypointense heterogeneous fibroid. 
Treatment time: 3 hours, 30 mins 
Results: 90% NPV with no adverse events 
Non Perfused Volume denotes the volume of 
fibroid that is no longer viable.
Patients treated at Nanavati Supersepciality 
Hospital 
Patient 2 : 33 yr old female 
Symptoms: Heavy menstrual bleeding, pelvic 
pain and constipation 
T2 Hypointense heterogeneous fibroid. 
Treatment time: 3 hours, 40 mins 
Results: 90% NPV with no adverse events 
Non Perfused Volume denotes the volume of 
fibroid that is no longer viable. 
Pre 
Procedure 
T2 Sagittal 
Post 
Procedure 
80 % NPV
More Information ? 
• www.veincenter.in 
• SMS : Vein Fibroid to 56677 ( India Only )

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MRI Guided Focused Ultrasound Mumbai

  • 1. Mister g-Fus New Kid on the Fibroid Block
  • 2. • InSightec ExAblate™ system. • “Most Advanced MRgFUS system in India” • One of the few centers in the world to offer both MRgFUS and Uterine Fibroid Embolization • Since 2004, over 9000 women have been treated with ExAblate for their uterine fibroids.
  • 3. How does MRgFUS work ? • ExAblate uses a combination of high-intensity ultrasound waves and MRI to non-invasively image the fibroid and surrounding organs in 3D, treat the fibroid, obtain real-time feedback about the treated area, and observe what has been treated. • The high intensity focused ultrasound energy heats the fibroid only at the target area, producing safe and controlled coagulative necrosis without damaging the surrounding tissue. • The treatment procedure lasts about 3 hours, and patients return to regular activities within a few days.
  • 4. Beam path visualization 2 for controlled treatment 4 3 1 Multi-planar imaging for precise tumor targeting CLOSED LOOP THERAPY 5 MR thermometry temperature feedback Thermal dose accumulation Post treatment contrast imaging for precise treatment validation Real Time MRI Guidance and Monitoring
  • 5. Who can be treated by MRgFUS ? • Fibroids greater than 2cm and smaller than 20cm are particularly amenable to treatment with the most noticeable symptomatic relief from bleeding and pressure symptoms. • A screening MRI is done that gives us information about the size, location, number, T2 Hyperintensity and Post contrast enhancement characteristics. • These help us choose the best modality to treat your patient’s fibroid.
  • 6. Contraindications for MRgFus : • MR incompatible implantable medical devices such as pacemakers and cochlear implants. • Severe claustrophobia. • Known intolerance to MR contrast agents. • Vertical abdominal or high horizontal scars through the mid-line which would prevent access to the fibroid (low horizontal scars such as normal Caesarean section scars or scars to either side of the mid-line such as appendectomy scars are not a contra-indication). • Such patients can be treated by Uterine Fibroid Embolization.
  • 7. MRgFUS & Pregnancy ? Total number of pregnancies Mean age Average months to conception Total deliveries - Of them vaginal Elective pregnancy termination Spontaneous abortions Ongoing pregnancies Unknown Average baby weight at term delivery 117 36 9 64 (55%) 59% 10 (9%) 22 (19%) 9 (8%) 12 (10%) 3.27 kg
  • 8. Pre Procedur e T2 Coronal Post Procedure 80 % NPV Patients treated at Nanavati Supersepciality Hospital Patient 1 : 34 yr old female Symptoms: Heavy menstrual bleeding, pelvic pain and urinary frequency T2 Hypointense heterogeneous fibroid. Treatment time: 3 hours, 30 mins Results: 90% NPV with no adverse events Non Perfused Volume denotes the volume of fibroid that is no longer viable.
  • 9. Patients treated at Nanavati Supersepciality Hospital Patient 2 : 33 yr old female Symptoms: Heavy menstrual bleeding, pelvic pain and constipation T2 Hypointense heterogeneous fibroid. Treatment time: 3 hours, 40 mins Results: 90% NPV with no adverse events Non Perfused Volume denotes the volume of fibroid that is no longer viable. Pre Procedure T2 Sagittal Post Procedure 80 % NPV
  • 10. More Information ? • www.veincenter.in • SMS : Vein Fibroid to 56677 ( India Only )