Edward Perello, CBO of Desktop Genetics, joins us at the Science: Disrupt London Session on Disruptor Stories to talk machine learning, CRSIPR, pivoting and his startup story.

1. @EdwardPerello | @DesktopGenetics© Desktop Genetics Ltd. 2016 An Illumina-backed company
PERSONALISING CRISPR
GENOME EDITING
August 2016
Edward Perello| CBO & Founder

2. @EdwardPerello | @DesktopGenetics
DESKTOP GENETICS
HELPING YOU MANIPULATE GENOMES
LONDON
EST. 2012
BIOINFORMATICS
TOOLS
GENE EDITING
SERVICES
BACKED BY LARGEST
SEQUENCING PROVIDER

3. @EdwardPerello | @DesktopGenetics
TWO PATHS TO DESKTOP GENETICS
PRODUCTS & SERVICES  DATA

4. @EdwardPerello | @DesktopGenetics
4
TEACH AI TO PERFORM GENETIC SURGERY
MACHINE INTELLIGENCE IS THE ONLY WAY TO EDIT THE GENOME
SAFELY

5. @EdwardPerello | @DesktopGenetics
AGENDA
1. Brief intro to CRISPR
1. Our story so far
1. Taking CRISPR to the clinic

6. @EdwardPerello | @DesktopGenetics© Desktop Genetics Ltd. 2016 An Illumina-backed company
Editing the Genome with
CRISPR

7. @EdwardPerello | @DesktopGenetics
GENE THERAPY TACKLES DISEASES
CRISPR is used to modify the genome of a patient’s cells

8. @EdwardPerello | @DesktopGenetics
CRISPR OVERVIEW
Programmable two-component system
CAS9
NUCLEASE
RNA
COMPONENT

9. @EdwardPerello | @DesktopGenetics
CRISPR OVERVIEW
Programmable two-component system
CAS9
NUCLEASE
RNA
COMPONENT
VARIABLE
20 BP GUIDE RNA
CONSTANT
REGION

10. @EdwardPerello | @DesktopGenetics
CRISPR OVERVIEW
Programmable two-component system
CAS9
NUCLEASE
RNA
COMPONENT
ACTIVE
RNA-GUIDED CAS9
COMPLEX

11. @EdwardPerello | @DesktopGenetics
CRISPR OVERVIEW
Molecular find and replace for DNA
Source: McGovern Brain Institute Youtube Channel

12. @EdwardPerello | @DesktopGenetics
WHY EDIT GENOMES?
Research & development → Clinical interventions
- Degenerative blindness
- Custom disease models
- Humanization of heart valves
- Swine fever resistance
- HIV eradicated in vitro
- Immuno-oncology
- Clinical trials cured cancer
- Clinical trials cured HIV

13. @EdwardPerello | @DesktopGenetics
WHY START A BUSINESS IN THIS
SPACE?Huge biotechnology, life science and clinical prospects
75M PATIENTS
3M RESEARCH
EXPERIMENTS

14. @EdwardPerello | @DesktopGenetics© Desktop Genetics Ltd. 2016 An Illumina-backed company
Our Story

15. @EdwardPerello | @DesktopGenetics
2011 – MEETING AT CAMBRIDGE
MPHIL BIOSCIENCE ENTERPRISE DEGREE

16. @EdwardPerello | @DesktopGenetics
2012 – SYNTHBOT, CUTEC, SEED
THE BIOTECH NESPRESSO

17. @EdwardPerello | @DesktopGenetics
2013 – AUTOCLONE, TSB , RAISE
HARDWARE OUT, SOFTWARE IN

18. @EdwardPerello | @DesktopGenetics
2014 – HORIZON CRISPR TOOL & TSB
INTERNAL CRISPR R&D TOOL

19. @EdwardPerello | @DesktopGenetics
2014 - GUIDEBOOK
CO-BRANDED CRISPR DESIGN & SALES PORTAL

20. @EdwardPerello | @DesktopGenetics
2015 – DESKGEN, CLASS, PARTNERS
UNITING & OPTIMISING OUR TOOLSET

21. @EdwardPerello | @DesktopGenetics
CRISPR EXPERIMENTS MODE, RICHER UI
2015 – DESKGEN, CLASS, PARTNERS

22. @EdwardPerello | @DesktopGenetics
2015 – DESKGEN, CLASS, PARTNERS
PARTNERSHIPS MAKE LITERAL DESKTOP GENETICS
POSSIBLE

23. @EdwardPerello | @DesktopGenetics© Desktop Genetics Ltd. 2016 An Illumina-backed company
Taking CRISPR into the clinic

24. @EdwardPerello | @DesktopGenetics
INTERNATIONAL ENDEAVOUR
CRISPR is a global phenomenon

25. @EdwardPerello | @DesktopGenetics
2016 – GUIDE PICKER, NGS, BEYOND
MULTIDIMENSIONAL GUIDE SELECTION

26. @EdwardPerello | @DesktopGenetics
2016 – GUIDE PICKER, NGS, BEYOND
USING BIOLOGICAL DATA TO TAKE OUR AI FURTHER

27. @EdwardPerello | @DesktopGenetics
HUMANS VS. MACHINES
MACHINES OUT-PERFORM MANUAL DESIGN
CRISPRSuccessRate

28. @EdwardPerello | @DesktopGenetics
2
8
PERFORM GENETIC SURGERY WITH AI
Design CRISPR for every lab, teach our algorithms, go to the clinic

29. @EdwardPerello | @DesktopGenetics
LIFE AT DESKTOP GENETICS
Recognition in tech, biology, and everything in between

30. @EdwardPerello | @DesktopGenetics
WE’RE HIRING
Join us in Shoreditch; tell your friends!

31. @EdwardPerello | @DesktopGenetics© Desktop Genetics Ltd. 2015© Desktop Genetics Ltd. 2
www.deskgen.com
edwardp@desktopgenetics.com
@edwardperello