The Application of Non-Combinatorial Chemistry to Lead Discovery

The Application of Non-Combinatorial Chemistry to Lead Discovery Dr Graham F. Smith Library Design and Production Group Pfizer Global R & D Sandwich, UK See Drug Discovery Today, 2001, volume 6, No. 15, p779-785

Parallel synthesis is a powerful technique The application of automation, parallelisation and miniaturization of Organic Chemistry has radically changed Chemistry Departments in Pharmaceutical companies. Combinatorial Chemistry is only one possible use of parallel synthesis

Our Groups Initial Goals ,[object Object],[object Object],[object Object],[object Object],[object Object]

Non Combinatorial Chemistry ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Diversity ,[object Object],[object Object],[object Object],[object Object],[object Object]

Large clusters high similarity Cluster algorithm from Mike Miller - PGRD Groton USA Small clusters low similarity Spotfire Shenghua Shi

IT for Non Combinatorial Chemistry - LiCRA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

LDP - Technology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Technology in use (2) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Unforeseen advantages of Non Combinatorial Chemistry and HPLC library purification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Summary ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Acknowledgements ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

The Application of Non-Combinatorial Chemistry to Lead Discovery

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The Application of Non-Combinatorial Chemistry to Lead Discovery