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•To evaluate effectiveness and
safety of ketofol for procedural
sedation and analgesia in ED.
•To assess recovery time, staff
and patient satisfaction.
Aims & Objectives
•Forty patients were
administered ketofol for painful
procedures in ED.
•Median dose of Ketofol
administered was 0.6 mg/kg
(range 0.4 to 1.00 mg/kg; IQR
0.5 to 0.71 mg/kg).
•Of the 40 procedures
performed, 40 (100%) were
completed successfully.
•None of patient had
hypotension or evidence of poor
perfusion.
•Median recovery time was 10
minutes (range 5 to 25 minutes;
IQR 6.25 to 15 minutes).
•In 20 minutes 92.5% of patients
recovered.
Methods
Conclusion
Ketofol is easy to use,
effective and safe for painful
procedures in ED. Recovery
time was rapid, staff and
patients were very satisfied.
Few adverse events
occurred and responded to
minimal intervention.
A PROSPECTIVE EVALUATION OF “KETOFOL”
(KETAMINE/PROPOFOL COMBINATION)
FOR PROCEDURAL SEDATION & ANALGESIA IN ED
Dr.Kesavardhan Reddy Narsing*; Dr. Srihari Cattamanchi; Dr. T,V, Ramakrishnan.
Sri Ramchandra Medical College & Research Institute, Porur, Chennai – 600116. Tamil Nadu. India.
Results
Dr. Kesavardhan Reddy Narsing,
Address: ; Mobile: ; Email id:;
Design: A Prospective,
interventional analytical study.
Setting: Accident &
Emergency Department, of Sri
Ramachandra Medical
College & Research Institute,
a tertiary care, level I trauma
centre in Chennai, India.
Duration: 1st May to 31st
December 2009.
Inclusion: All trauma patients
above 18 years administered
ketofol for procedural sedation
and analgesia, and Visual
Analog Scale (VAS) pain
score of > 6/10 were included.
Methodology: Ketofol was
prepared as 1:1 mixture of
Ketamine and Propofol 10
mg/mL each in 10-mL syringe
and 1 - 3 mL administered.
Recovery Time Calculated.
Instrument: Likert's Scale
used to record satisfaction
ratings.
Statistical Analysis: done
using SPSS software Ver. 17.
Doctor's Likert Scale
2 5.0 5.0 5.0
38 95.0 95.0 100.0
40 100.0 100.0
Satisfied
Very Satisfied
Total
Valid
Frequency Percent Valid Percent
Cumulative
Percent
Patient’s Likert Scale
10 25.0 25.0 25.0
30 75.0 75.0 100.0
40 100.0 100.0
Satisfied
Very Satisfied
Total
Valid
Frequency Percent Valid Percent
Cumulative
Percent
Drug Descriptive
Statistics
Estimated
Value
Ketamine Mean +/- S.D. 0.61 +/- 0.14
Median (Range) 0.61 (0.60)
Minimum 0.40
Maximum 1.00
Inter-quaretile
Range
0.50 to 0.71
Propofol Mean +/- S.D. 0.61 +/- 0.14
Median (Range) 0.61 (0.60)
Minimum 0.40
Maximum 1.00
Inter-quaretile
Range
0.50 to 0.71