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PLACENTA
BY
SUMIT RAWAT
2
PLACENTA
• This is a fetomaternal organ.
• It has two components:
– Fetal part – develops from the chorionic sac ( chorion
frondosum )
– Maternal part – derived from the endometrium ( functional
layer – decidua basalis )
• The placenta and the umbilical cord are a transport system for
substances between the mother and the fetus.( vessels in umbilical
cord )
• Function Of The Placenta:
1. Protection
2. Nutrition
3. Respiration
4. Excretion
5. Hormone production
Further Development of Chorionic
Villi
Early in the 3rd
week,
mesenchyme growth into the
primary villi forming a core of
mesenchymal tissue. Thus the
Secondary Chorionic Villi are
formed over the entire surface of
the chorionic sac.
Some mesenchymal cells in the
secondary villi differentiate into
capillaries and blood cells
forming the Tertiary Chorionic
Villi.
The capillaries in the villi fuse to
form arteriocapillary networks.
The previous formed
arteriocapillary networks
become connected with the
embryonic heart through
vessels which are formed in the
mesenchyme of the chorion and
connecting stalk.
By the end of the 3rd
week,
embryonic blood begins to flow
through the capillaries in the
chorionic villi.
Oxygen & nutrients in the
maternal blood in the intervillous
space diffuse through the walls
of the villi and enter the
embryo’s blood.
Carbon dioxide & waste
products diffuse from blood in
the fetal capillaries through the
wall of the chorionic villi into the
6
DECIDUA
• This is the endometrium
of the gravid (pregnant)
uterus.
• It has four parts:
– Decidua basalis: it
forms the maternal
part of the placenta
– Decidua capsularis:
it covers the
conceptus
– Decidua parietalis:
the rest of the
endometrium
– Decidua reflexa:
– Junction between
capsularis &
parietalis.
7
DEVELOPMENT OF PLACENTA
• Until the beginning of the 8th
week, the entire chorionic
sac is covered with villi.
• After that, as the sac grows,
only the part that is
associated with Decidua
basalis retain its villi.
• Villi of Decidua capsularis
compressed by the
developing sac.
• Thus, two types of chorion
are formed:
– Chorion frondosum
(villous chorion)
– Chorion laeve – bare
(smooth) chorion
– About 18 weeks old, it
covers 15-30% of the
decidua and weights
about 1 6 of fetus
8
DEVELOPMENT OF
PLACENTA
• The villous
chorion ( increase
in number, enlarge
and branch ) will
form the fetal part
of the placenta.
• The decidua
basalis will form
the maternal part
of the placenta.
• The placenta will
grow rapidly.
• By the end of the
4th
month, the
decidua basalis is
almost entirely
replaced by the
fetal part of the
placenta.
9
FULL-TERM
PLACENTA
• Cotyledons –about 15 to 20
slightly bulging villous areas.
Their surface is covered by
shreds of decidua basalis
from the uterine wall.
• After birth, the placenta is
always inspeced for missing
cotyledons. Cotyledons
remaining attached to the
uterine wall after birth may
cause severe bleeding.
• Grooves – formerly occupied
by placental septa
• The fetal part of placenta;
fetal membranes called
developmental adnexa
• Placenta;fetal membranes
which are expelled are called
afterbirth or secundina
Maternal side
10
FULL-TERM PLACENTA
( Discoid shape -500- 600 gm- Diameter 15-20 cm
– Thickness of 2-3 cm)
• Fetal surface:
• This side is smooth
and shiny. It is
covered by amnion.
• The umbilical cord is
attached close to the
center of the placenta.
• The umbilical vessels
radiate from the
umbilical cord.
• They branch on the
fetal surface to form
chorionic vessels.
• They enter the
chorionic villi to form
arteriocapillary-
venous system.
Fetal side
11
PLACENTAL CIRCULATION 80 to 100
each cotyledon - inflow
12
STRUCTURE OF STEM CHORIONIC VILLUS
13
PLACENTAL MEMBRANE
knot –syncytiotrophoblast
–Toward end of pregnancy –
phagocytic cells
• This is a composite structure
that consists of the extrafetal
tissues separating the fetal
blood from the maternal
blood.
• It has four layers:
– Syncytiotrophoblast
– Cytotrophoblast
– Connective tissue of
villus
– Endothelium of fetal
capillaries
• After the 20th
week, the
cytotrophoblastic cells
disappear and the placental
membrane consists only of
three layers.
14
TRANSFER
ACROSS THE
PLACENTAL
MEMBRANE
Viruses:
measles;poliomyeliti
s Microorganism:
treponema pallidum
of syphilis ; T.g
which produce
destructive change
in the eye; brain .
IgG( gamma
globulin) , IgS;IgM (
immunoglobulin
S;M )
Placental endocrine synthesis
• The syncytiotrophoblast synthesizes protein
&steroid hormones
• The protein homones
• 1- human chorionic gonadotropin
• 2- h.c. somatomammotropin
• 3-h.c. thyrotropin
• 4-h.c. corticotropin
• The steroid hormones
• Progesterone & Estrogens
16
Third trimester
bleeding is the common
sign of these anomalies
17
Biscoid
placenta
Bipartita
Horseshoe
When villi persist on the entire
surface of the chorionic sac ,a
thin layer of placenta attaches to
a large area of the uterus …… it
is a membranous placenta.
19
20
21
FULL-TERM
UMBILICAL CORD
• Usually it is attached
near the center of the
fetal surface of
placenta.
• Length: about 40 cm
• Diameter: 1-2 cm
• Contains two arteries
and one vein,
surrounded by
mucoid connective
tissue (Wharton jelly)
• The vessels are
longer than the cord
and may have loops
(false knots).
THE END

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Description of placenta

  • 2. 2 PLACENTA • This is a fetomaternal organ. • It has two components: – Fetal part – develops from the chorionic sac ( chorion frondosum ) – Maternal part – derived from the endometrium ( functional layer – decidua basalis ) • The placenta and the umbilical cord are a transport system for substances between the mother and the fetus.( vessels in umbilical cord ) • Function Of The Placenta: 1. Protection 2. Nutrition 3. Respiration 4. Excretion 5. Hormone production
  • 3. Further Development of Chorionic Villi Early in the 3rd week, mesenchyme growth into the primary villi forming a core of mesenchymal tissue. Thus the Secondary Chorionic Villi are formed over the entire surface of the chorionic sac. Some mesenchymal cells in the secondary villi differentiate into capillaries and blood cells forming the Tertiary Chorionic Villi. The capillaries in the villi fuse to form arteriocapillary networks.
  • 4. The previous formed arteriocapillary networks become connected with the embryonic heart through vessels which are formed in the mesenchyme of the chorion and connecting stalk. By the end of the 3rd week, embryonic blood begins to flow through the capillaries in the chorionic villi. Oxygen & nutrients in the maternal blood in the intervillous space diffuse through the walls of the villi and enter the embryo’s blood. Carbon dioxide & waste products diffuse from blood in the fetal capillaries through the wall of the chorionic villi into the
  • 5.
  • 6. 6 DECIDUA • This is the endometrium of the gravid (pregnant) uterus. • It has four parts: – Decidua basalis: it forms the maternal part of the placenta – Decidua capsularis: it covers the conceptus – Decidua parietalis: the rest of the endometrium – Decidua reflexa: – Junction between capsularis & parietalis.
  • 7. 7 DEVELOPMENT OF PLACENTA • Until the beginning of the 8th week, the entire chorionic sac is covered with villi. • After that, as the sac grows, only the part that is associated with Decidua basalis retain its villi. • Villi of Decidua capsularis compressed by the developing sac. • Thus, two types of chorion are formed: – Chorion frondosum (villous chorion) – Chorion laeve – bare (smooth) chorion – About 18 weeks old, it covers 15-30% of the decidua and weights about 1 6 of fetus
  • 8. 8 DEVELOPMENT OF PLACENTA • The villous chorion ( increase in number, enlarge and branch ) will form the fetal part of the placenta. • The decidua basalis will form the maternal part of the placenta. • The placenta will grow rapidly. • By the end of the 4th month, the decidua basalis is almost entirely replaced by the fetal part of the placenta.
  • 9. 9 FULL-TERM PLACENTA • Cotyledons –about 15 to 20 slightly bulging villous areas. Their surface is covered by shreds of decidua basalis from the uterine wall. • After birth, the placenta is always inspeced for missing cotyledons. Cotyledons remaining attached to the uterine wall after birth may cause severe bleeding. • Grooves – formerly occupied by placental septa • The fetal part of placenta; fetal membranes called developmental adnexa • Placenta;fetal membranes which are expelled are called afterbirth or secundina Maternal side
  • 10. 10 FULL-TERM PLACENTA ( Discoid shape -500- 600 gm- Diameter 15-20 cm – Thickness of 2-3 cm) • Fetal surface: • This side is smooth and shiny. It is covered by amnion. • The umbilical cord is attached close to the center of the placenta. • The umbilical vessels radiate from the umbilical cord. • They branch on the fetal surface to form chorionic vessels. • They enter the chorionic villi to form arteriocapillary- venous system. Fetal side
  • 11. 11 PLACENTAL CIRCULATION 80 to 100 each cotyledon - inflow
  • 12. 12 STRUCTURE OF STEM CHORIONIC VILLUS
  • 13. 13 PLACENTAL MEMBRANE knot –syncytiotrophoblast –Toward end of pregnancy – phagocytic cells • This is a composite structure that consists of the extrafetal tissues separating the fetal blood from the maternal blood. • It has four layers: – Syncytiotrophoblast – Cytotrophoblast – Connective tissue of villus – Endothelium of fetal capillaries • After the 20th week, the cytotrophoblastic cells disappear and the placental membrane consists only of three layers.
  • 14. 14 TRANSFER ACROSS THE PLACENTAL MEMBRANE Viruses: measles;poliomyeliti s Microorganism: treponema pallidum of syphilis ; T.g which produce destructive change in the eye; brain . IgG( gamma globulin) , IgS;IgM ( immunoglobulin S;M )
  • 15. Placental endocrine synthesis • The syncytiotrophoblast synthesizes protein &steroid hormones • The protein homones • 1- human chorionic gonadotropin • 2- h.c. somatomammotropin • 3-h.c. thyrotropin • 4-h.c. corticotropin • The steroid hormones • Progesterone & Estrogens
  • 16. 16 Third trimester bleeding is the common sign of these anomalies
  • 18. When villi persist on the entire surface of the chorionic sac ,a thin layer of placenta attaches to a large area of the uterus …… it is a membranous placenta.
  • 19. 19
  • 20. 20
  • 21. 21 FULL-TERM UMBILICAL CORD • Usually it is attached near the center of the fetal surface of placenta. • Length: about 40 cm • Diameter: 1-2 cm • Contains two arteries and one vein, surrounded by mucoid connective tissue (Wharton jelly) • The vessels are longer than the cord and may have loops (false knots).