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DISEASE & DENGUE
BY SURAJ DHARA
4TH YEAR MBBS
MIDNAPORE MEDICAL COLLEGE & HOSPITAL,
WEST BENGAL, INDIA
ANNOUNCEMENT
 This presentation was made for class 11 & 12 students & was
explained in detail during the seminar (SCIEN-CON’ 19).
 This approach was taken by the medical students of
MIDNAPORE MEDICAL COLLEGE, WEST BENGAL, INDIA
for creating awareness about the health & hygiene and self
assessment, knowledge & basic management of the most
prevalent disease “Dengue”.
 This was guided by the our beloved principal sir Dr.
Panchanan Kundu & professors of other depts.
 The school students (300) were divided in 6 grps & each
were subdivided into 5 subgroups before grand lecture &
were shown & demonstrated 6 major depts under guidance
of medical students.
 Seminar was attended by respective schools’ teachers. 2
HEALTH ??
 Free from disease
 It is a state of complete –
 Physical
 Mental
 Social wellbeing
 Not merely an absence of
 Disease
 Infirmity
 Ability to lead a productive life
 Socially
 Economically 3
GOOD HEALTH ??
 Free from sickness and disease.
 Free from unnecessary anxiety.
 Free from social & psychological tensions.
 Self – confidence.
 Feeling joy in living.
 Ability to work efficiently and up to its best.
Your life is nothing but how you are seeing it.
4
LIFE CYCLE OF A HEALTHY INDIVIDUAL
5
 Newborn
 Infant
 Childhood
 Adolescent
 Adult
 Old age
 Death
DISEASE (DEVOID OF EASE)
6
ONSET OF DISEASE
 The normal chain of growth & development of an
individual is broken.
 Usual life-span becomes shorter ( life expectancy).
 Post disease stages of life will come earlier & affect
the functioning of the person.
 Disease is nothing but the heading of story.
7
 Every disease has left some scar (visible or invisible)
in the body
 The later the diagnosis , more grave is the prognosis.
8
A
B
C D. . . . . . . . . . . . . . . .
AFTER TREATMENT
 Cure
 Morbidity (preval. Of disease)
 Mortality (death)
9
ICEBERG OF DISEASE
10
TYPES OF DISEASES
Disease
Congenital
Gene mutation
Chromosomal
mutation
Acquired
Communicable NCD
11
Down S
Klienfelter S
Hemophilia
Color Blindness
12
COMMUNICABLE
 Can be spread from p to p/a/o.
 Sudden onset.
 Mostly single cause.
 Short natural history (course).
 Short treatment schedule.
 Cure is achieved mostly.
 Short follow up .
 Examples
 COMMON COLD
 VIRAL CONJUCTIVITIS
 HEPATITIS B
 HIV / AIDS
 TB
 MALARIA
 DENGUE
NON-COMMUNICABLE
 Can’t be spread from p to p.
 Gradual onset.
 Multifactorial.
 Long natural history.
 Prolonged treatment schedule.
 Care predominates.
 Prolonged follow up.
 Examples
 HTN
 DM
 ASTHMA
 ARTHRITIS
 HEART DISEASES
BASIC IDEAS
 Pathogen (agent) : disease causative organism.
 Vector : an organism that does not cause disease
itself but spreads infection by conveying pathogens
from one host to another.
 Host : harbours the agent & affected due to this.
Plasmodium Anopheles mosquito Malaria in man
13
VECTOR BORNE DISEASES
 Mosquito borne
 Flies borne
 Lice borne
 Fleas borne
 Tick borne
14
MOSQUITO BORNE DISEASES
 Dengue
 Malaria
 Chikungunya
 Yellow fever
 Filariasis.
15
DENGUE !!!
 Agent : dengue virus.
 DENV – 1,2,3,4 Serotypes
 Vector : Aedes aegypti & Aedes albopictus (tiger
mosquito)
 Host :
 Primary : human
 Secondary : non human primates.
16
17
Bites more than one
host to complete one
blood meal & gonotropic
cycle.
Complete blood meal in
one host & 2nd feed is
not required to complete
gonotropic cycle.
18
TRANSMISSION
 By vector ……
 They bite primarily during the day time.
 Female mosquito takes blood meal from infected
person & carry the dengue virus within its gut.
 About 8 – 10 days later, virus spreads to the other
tissues like salivary glands of the mosquito.
 Released in saliva.
19
NOW IT WILL BITE U
 Now this mosquito carrying dengue virus bites another
person.
 Virus + mosquito’s saliva enters through skin.
 Virus binds to the WBCs in blood & reproduces inside
it (in primary host).
 In severe infection, the virus production inside the
body is greatly increased & involves more organs
(liver, bone marrow).
 Fluid from blood stream leaks through the wall of
small blood vessels into body cavity…low BP….less
blood supply.
 Dysfunction of b/m …dec. platelet count…bleeding…
20
21
FATE
 Asymptomatic / mild symptoms – uncomplicated fever
(80%)
 More severe illness (5%)
 It becomes life threatening also.
 Incubation period : 3 – 14 days. (4 – 7 d)
22
Incubation period
HOW U WILL FEEL
 Sudden onset of fever.
 Retro orbital pain.
 Muscle & joint pain (break
bone fever).
 Skin rash.
 Dengue hemorrhagic fever.
 Bleeding (+ tourniquet test)
 Platelet count < 1 lakh/mm3
 Plasma leakage..... Low BP...
 Dengue shock syndrome.
 Tachycardia
 Cool extremities
 Feeble pulse
 Lethargy or restlessness.
23
WARNING SIGNS
 Abdominal pain
 Ongoing vomiting
 Hepatomegaly
 Mucosal bleeding
 High hematocrit & low platelets
 Lethargy
24
COURSE OF INFECTION
 Febrile phase
 Critical phase
 Recovery phase
25
FEBRILE
 High fever, often over 40⁰ C.
 Generalized pain.
 Headache (lasts 2 to 7 days)
 Rash (1st to 2nd day)
 Tourniquet test > 10 spots.
26
CRITICAL
 Follows the resolution of the high fever and lasts for
1 to 2 days.
 Fluid accumulation in chest & abdominal cavity.
 Dec. blood supply to vital organs…. Organ dysfunction
 Severe bleeding (GIT mainly)
 Oliguria
 DHF & DSS < 5% cases
 Inc. risk of secondary infection by other serotypes.
27
RECOVERY
 Resorption of the leaked plasma fluid back into the
blood stream…(fluid overload … reduced
consciousness)
 Lasts for 2 to 3 days.
 Severe itching & slow HR.
28
MANAGEMENT
 ORS , fruit juice
 Paracetamol
 IV fluids
 Hospitalization
 Blood transfusion ( platelet )
29
30
PREVENTION
vaccination
Mosquito
control
31
MOSQUITO CONTROL
 Protect youself from the bite of mosquitos.
 Reduce collection of stagnant water.
 Wearing clothing that fully covers
the skin (long sleeved shirts..)
 Mosquito nets during resting
 Apply mosquito repellent.
 As they bite during day time …special precautions
should be taken during early morning hours & late
afternoon.
3232
 Dengue patients are to be kept under mosquito nets.
 Eliminate habitats of aedes.
 Removing unused plastics, old tires, buckets
 Cleaning clogged gutters.
 Insectisides
 Biological agents
 Advise people showing symptoms of dengue
immediately go for check-ups, and get treatment.
33
34
VACCINATION
 Developed by Sanofi Pasteur, in Dec, 2015.
 CYD-TDF (brand name Dengvaxia)
 Tetravalent
 Between 9 to 45 yrs of age (3 inj : 0,6,12 month).
35
36
If they breed,
You will bleed.
37
NOW YOUR TIME !!!
1. Identify the mosquito seen
38
2. Dengue is a disease caused by
A. Aedes aegypti
B. DENV
C. Plasmodium falciparum
D. Culex quinquefasciatus
39
3. Most commonly dengue is
A. Having fever
B. Pain behind the eye
C. Asymptomatic
D. Break bone fever
40
4. Health is
A. Economically productive life
B. Physical, social & mental well-being.
C. Absence of deformity.
D. All the above
41
5. Part below the water level
indicates
A. Fever
B. Chest pain
C. Headache
D. None of the above
42
43

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DISEASE AND DENGUE

  • 1. DISEASE & DENGUE BY SURAJ DHARA 4TH YEAR MBBS MIDNAPORE MEDICAL COLLEGE & HOSPITAL, WEST BENGAL, INDIA
  • 2. ANNOUNCEMENT  This presentation was made for class 11 & 12 students & was explained in detail during the seminar (SCIEN-CON’ 19).  This approach was taken by the medical students of MIDNAPORE MEDICAL COLLEGE, WEST BENGAL, INDIA for creating awareness about the health & hygiene and self assessment, knowledge & basic management of the most prevalent disease “Dengue”.  This was guided by the our beloved principal sir Dr. Panchanan Kundu & professors of other depts.  The school students (300) were divided in 6 grps & each were subdivided into 5 subgroups before grand lecture & were shown & demonstrated 6 major depts under guidance of medical students.  Seminar was attended by respective schools’ teachers. 2
  • 3. HEALTH ??  Free from disease  It is a state of complete –  Physical  Mental  Social wellbeing  Not merely an absence of  Disease  Infirmity  Ability to lead a productive life  Socially  Economically 3
  • 4. GOOD HEALTH ??  Free from sickness and disease.  Free from unnecessary anxiety.  Free from social & psychological tensions.  Self – confidence.  Feeling joy in living.  Ability to work efficiently and up to its best. Your life is nothing but how you are seeing it. 4
  • 5. LIFE CYCLE OF A HEALTHY INDIVIDUAL 5  Newborn  Infant  Childhood  Adolescent  Adult  Old age  Death
  • 7. ONSET OF DISEASE  The normal chain of growth & development of an individual is broken.  Usual life-span becomes shorter ( life expectancy).  Post disease stages of life will come earlier & affect the functioning of the person.  Disease is nothing but the heading of story. 7
  • 8.  Every disease has left some scar (visible or invisible) in the body  The later the diagnosis , more grave is the prognosis. 8 A B C D. . . . . . . . . . . . . . . .
  • 9. AFTER TREATMENT  Cure  Morbidity (preval. Of disease)  Mortality (death) 9
  • 11. TYPES OF DISEASES Disease Congenital Gene mutation Chromosomal mutation Acquired Communicable NCD 11 Down S Klienfelter S Hemophilia Color Blindness
  • 12. 12 COMMUNICABLE  Can be spread from p to p/a/o.  Sudden onset.  Mostly single cause.  Short natural history (course).  Short treatment schedule.  Cure is achieved mostly.  Short follow up .  Examples  COMMON COLD  VIRAL CONJUCTIVITIS  HEPATITIS B  HIV / AIDS  TB  MALARIA  DENGUE NON-COMMUNICABLE  Can’t be spread from p to p.  Gradual onset.  Multifactorial.  Long natural history.  Prolonged treatment schedule.  Care predominates.  Prolonged follow up.  Examples  HTN  DM  ASTHMA  ARTHRITIS  HEART DISEASES
  • 13. BASIC IDEAS  Pathogen (agent) : disease causative organism.  Vector : an organism that does not cause disease itself but spreads infection by conveying pathogens from one host to another.  Host : harbours the agent & affected due to this. Plasmodium Anopheles mosquito Malaria in man 13
  • 14. VECTOR BORNE DISEASES  Mosquito borne  Flies borne  Lice borne  Fleas borne  Tick borne 14
  • 15. MOSQUITO BORNE DISEASES  Dengue  Malaria  Chikungunya  Yellow fever  Filariasis. 15
  • 16. DENGUE !!!  Agent : dengue virus.  DENV – 1,2,3,4 Serotypes  Vector : Aedes aegypti & Aedes albopictus (tiger mosquito)  Host :  Primary : human  Secondary : non human primates. 16
  • 17. 17 Bites more than one host to complete one blood meal & gonotropic cycle. Complete blood meal in one host & 2nd feed is not required to complete gonotropic cycle.
  • 18. 18
  • 19. TRANSMISSION  By vector ……  They bite primarily during the day time.  Female mosquito takes blood meal from infected person & carry the dengue virus within its gut.  About 8 – 10 days later, virus spreads to the other tissues like salivary glands of the mosquito.  Released in saliva. 19
  • 20. NOW IT WILL BITE U  Now this mosquito carrying dengue virus bites another person.  Virus + mosquito’s saliva enters through skin.  Virus binds to the WBCs in blood & reproduces inside it (in primary host).  In severe infection, the virus production inside the body is greatly increased & involves more organs (liver, bone marrow).  Fluid from blood stream leaks through the wall of small blood vessels into body cavity…low BP….less blood supply.  Dysfunction of b/m …dec. platelet count…bleeding… 20
  • 21. 21
  • 22. FATE  Asymptomatic / mild symptoms – uncomplicated fever (80%)  More severe illness (5%)  It becomes life threatening also.  Incubation period : 3 – 14 days. (4 – 7 d) 22 Incubation period
  • 23. HOW U WILL FEEL  Sudden onset of fever.  Retro orbital pain.  Muscle & joint pain (break bone fever).  Skin rash.  Dengue hemorrhagic fever.  Bleeding (+ tourniquet test)  Platelet count < 1 lakh/mm3  Plasma leakage..... Low BP...  Dengue shock syndrome.  Tachycardia  Cool extremities  Feeble pulse  Lethargy or restlessness. 23
  • 24. WARNING SIGNS  Abdominal pain  Ongoing vomiting  Hepatomegaly  Mucosal bleeding  High hematocrit & low platelets  Lethargy 24
  • 25. COURSE OF INFECTION  Febrile phase  Critical phase  Recovery phase 25
  • 26. FEBRILE  High fever, often over 40⁰ C.  Generalized pain.  Headache (lasts 2 to 7 days)  Rash (1st to 2nd day)  Tourniquet test > 10 spots. 26
  • 27. CRITICAL  Follows the resolution of the high fever and lasts for 1 to 2 days.  Fluid accumulation in chest & abdominal cavity.  Dec. blood supply to vital organs…. Organ dysfunction  Severe bleeding (GIT mainly)  Oliguria  DHF & DSS < 5% cases  Inc. risk of secondary infection by other serotypes. 27
  • 28. RECOVERY  Resorption of the leaked plasma fluid back into the blood stream…(fluid overload … reduced consciousness)  Lasts for 2 to 3 days.  Severe itching & slow HR. 28
  • 29. MANAGEMENT  ORS , fruit juice  Paracetamol  IV fluids  Hospitalization  Blood transfusion ( platelet ) 29
  • 30. 30
  • 32. MOSQUITO CONTROL  Protect youself from the bite of mosquitos.  Reduce collection of stagnant water.  Wearing clothing that fully covers the skin (long sleeved shirts..)  Mosquito nets during resting  Apply mosquito repellent.  As they bite during day time …special precautions should be taken during early morning hours & late afternoon. 3232
  • 33.  Dengue patients are to be kept under mosquito nets.  Eliminate habitats of aedes.  Removing unused plastics, old tires, buckets  Cleaning clogged gutters.  Insectisides  Biological agents  Advise people showing symptoms of dengue immediately go for check-ups, and get treatment. 33
  • 34. 34
  • 35. VACCINATION  Developed by Sanofi Pasteur, in Dec, 2015.  CYD-TDF (brand name Dengvaxia)  Tetravalent  Between 9 to 45 yrs of age (3 inj : 0,6,12 month). 35
  • 36. 36 If they breed, You will bleed.
  • 37. 37
  • 38. NOW YOUR TIME !!! 1. Identify the mosquito seen 38
  • 39. 2. Dengue is a disease caused by A. Aedes aegypti B. DENV C. Plasmodium falciparum D. Culex quinquefasciatus 39
  • 40. 3. Most commonly dengue is A. Having fever B. Pain behind the eye C. Asymptomatic D. Break bone fever 40
  • 41. 4. Health is A. Economically productive life B. Physical, social & mental well-being. C. Absence of deformity. D. All the above 41
  • 42. 5. Part below the water level indicates A. Fever B. Chest pain C. Headache D. None of the above 42
  • 43. 43