brain cns neuroscience acetylcholinesterase inhibitors treatment cholinergic hypothesis neurofibrillary tangles plaque formation beta-amyloid plaques pathology of ad alzheimer’s disease progresses through distinct st the progress of alzheimer disease prevalence and impact of ad memory memory impairment cognitive functions symptoms progressive disorder alzheimer's disease ammonia toxicity ammonia metabolisms of ammonia in the cns. energy metabolism in the cns. brain metabolism brain energy central nervous system release and inactivation nicotinic acetylcholine receptors muscarinic acetylcholine receptors nicotinic receptors acetylcholine storage ach neurotransmitter acetylcholine receptors acetylcholine synthesis acetylcholine neurotransmission acetylcholine
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