Filtrum - NEW GENERATION ENTEROSORBENT

1. FILTRUM
(0,45 g LIGNIN, TABS)
NEW GENERATION ENTEROSORBENT
Life free of toxins

2. FILTRUM
Lignin fibres of plant origin to neutralize wide range
of endo- and exogenous toxins and pathogenic
microorganisms in GI tract
INDICATIONS:
 Intoxication by poor food, alcohol, drugs.
Intoxication by detrimental substances accumulating at hepatic
and renal insufficiency.
 Acute intestinal diseases (dysentery, salmonellosis, rota-virus
infections etc.)
 Diarrhea syndrom of unspecified origin
Filtrum does not affect any tissues of the gastro-intestinal tract, is does
not accumulate in any organs and is entirely eliminated from the
intestines.

3. FILTRUM
COMPOSITION
• Lignin is formed by removal of
water from sugars to create
aromatic structures.
• These reactions are non reversible. There are
many possible monomers of lignin, and the
types and proportions depend on the source
in nature. Some typical monomers are shown
in the sketch :
• The OH groups (either the alcoholic OH's on
the chains or the phenolic OH's on the aromatic
rings) can react with each other or with the
aldehyde or ketone groups. When an OH reacts
with another, an ether linkage is formed. As we
see, an OH reacts with an aldehyde to form a
hemiacetal. The reactions of OH groups with
ketones forms ketals. An early stage in the
condensation of various monomers to form
lignin is shown in the next sketch :

4. FILTRUM / LIGNIN
There are several groups shown in red
that can react further. Some will simply
extend the polymer while others would
establish cross linking. The monomer that
is shaded in orange has three of its
functional groups linked to other
monomers, so it is starting a branch or
cross link. The large lignin molecules fill
three dimensions and are heavily cross
linked. Sometimes lignin is isolated as a
brown powder, but more often it is a
gummy mixture of lignins with a wide
range of molecular weights.
Lignin resists attack by most
microorganisms, and anaerobic processes tend
not to attack the aromatic rings at all. Aerobic
breakdown of lignin is slow and may take
many days. Lignin is nature's cement along
with hemicellulose to exploit the strength of
cellulose while conferring flexibility.
COMPOSITION

5. FILTRUM / LIGNIN
• 1943 / Germany – original enterosorbent product Porlisan (on the basis of lignin)
appeared as anti-diarrhea product for curing diarrhea syndrome of infection and non-
infection nature
• 1970 / Russia – improved form of lignin was elaborated (lignin powder with higher
absorbtion properties)
• 1997 / Russia – tableted formulation of medical lignin (Filtrum) was patented
There are many pores on the surface of Filtrum-sorbent:
micro-, mezo- and macropores, which results in broad
spectrum of absorbtion activity – from heavy metal ions
to microbic cells and organic metabolits. Prevalence of
mezopores enables Filtrum to neutralize middle- and
long-chained molecules including endo- and exotoxins.
HISTORY AND BACKGROUND

6. FILTRUM vs Activated Charcoal
FILTRUM®
Broad absorbtion spectrum
Neutralizes bacteria and its toxins
Binds gistamine and food allergens
Reparative effect of lignin
on intestinal mucous surface
Activated Charcoal
Narrow absorbtion spectrum
Low absorbtion of bacteria and its toxins
Binds low spectrum of allergens
Negative influence on intestinal
mucous surface

7. FILTRUM
Universal means of decreasing intoxication in case of intoxication of different
etiology (poor food, acute intestinal diseases, alchogol overdosage etc.)
Neutrolizes pathogenic microflora and its toxins thus blocking the pathogenic
mechanism (vs. loperamide)
No negative effect on normal microflora (vs. intestinal antiobiotics)
Does not form resistant stamps in pathogenic microflora.
High safety profile.
Can be used to prevent an assumed intoxication.
Advantages in intoxication and acute intestinal
diseases segment

8. FILTRUM
Frequency of acute toxic infections symptoms in people
77
60
48
32
25
14
2
0 10 20 30 40 50 60 70 80 90 100
Abdominal pain
Diarrhea
Nausea, vomitting
Meteorism, swelling
Anorexia
Fever
Other
%

9. FILTRUM
According to marketing research 60% of
people at least once a year suffered from
the following symptoms:
1. Gastro-intestinal disorders caused by
“food poisoning”
2. Alimentary toxic infection
3. Intestinal infection
4. Gastro-intestinal disorder of unspecified
toxic origin
60%
Intoxication and acute intestinal diseases

10. FILTRUM
0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
days
,
Fig.1 Duration of main clinical symptoms in patients with acute
dysentery
Russian State Medical University (Moscow, 2001)
CLINICAL EVIDENCE
Treatment of acute intestinal infections accompanied by
diarrhea syndrome
Control group (basic therapy):
antimicrobials Furazolidon
(nitrofurans) and ciprofloxacin
(fluoroquinolones), and pathogenetic
therapy – parenteral detoxification
solutions (colloid and salt solutions),
astringents, reparative drugs and
adrenomimetics.
Filtrum group = standard therapy
+Filtrum

11. Fig.2 Duration of main clinical symptoms in patients with
gastrointestinal form of salmonellosis
0
0.5
1
1.5
2
2.5
3
3.5
4
days
FILTRUM
Russian State Medical University (Moscow 2001)
Standard therapy (control group):
parenteral and oral rehydration by salt
solutions and adrenomimetics
Filtrum group: standard therapy
+ Filtrum

12. Fig.3 Duration of main clinical symptoms in patients
with alimentary toxic infections
0
0.5
1
1.5
2
2.5
3
3.5
4
days
FILTRUM
Russian State Medical University, 2001
Standard therapy (control group):
parenteral and oral rehydration by
salt solutions and adrenomimetics
Filtrum group: standard therapy +
Filtrum

13. FILTRUM
DOSAGES:
Children under 6 months - 1/4
tablet 3-4 times a day
6 months - 1 year - 1/3 tablet 3-
4 times a day
1-3 years - 1/2 - 1 tablet 3 times
a day
4-7 years - 1 - 1,5 tablets 3 times
a day
over 7 years - 2 tablets 3-4 times
a day
1-1,5 hours before or 1-1,5 hours
after meal
Conclusion 1:
Filtrum is highly effective for treatment of
acute intestinal infections accompanied by
diarrhea syndrome, e.g. acute dysentery,
gastrointestinal form of salmonellosis and,
particularly, gastroenteritic form of
alimentary toxic infection. Filtrum therapy
results in shortening of the major clinical
signs statistical decrease (in days) over
30%.
Conclusion 2:
Filtrum can be recommended as a drug of
choice for patients with mild alimentary
toxic infections and salmonellosis as well
as a component of combined therapy of
moderate and severe dysentery,
salmonellosis and alimentary toxic
infections
Сlinical evidence

14. FILTRUM
Patients characteristics
Characteristic Filtrum
(n=61)
Control
(n=58)
Age (years) 3.420.44 4.220.79
Disease
duration (days)
3.340.36 2.450.2
Etiology: Klebsiella,
Salmonella,
Campilobacter,
Rotaviruses, Thoroviruses,
Norwalk viruses,
Unspecified
Filtrum addition to basic therapy of acute intestinal
infections in children had beneficial effect on general
toxicity and resulted in alleviation of fever,
intoxication, nausea and vomiting and in
improvement of appetite
Research Institute of Pediatric Infections (St.Petersburg, 2003)
Efficacy in combined treatment of acute intestinal infections
in children

15. Fig.1 Duration of general infection symptoms in study
and control patient groups
Days
0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
Filtrum Control
Fever
Vomiting
Fatigue
Poor appetite
FILTRUM
Research Institute of Pediatric Infections (St. Petersburg, 2003)
(rehydration, diet)

16. Fig.2 Duration of local infection symptoms
0 0.5 1 1.5 2 2.5 3 3.5 4 4.5
Filtrum
Control
Undigested food remnants in feces Mucus in feces
Loose stool Tenderness
Abdominal pain
FILTRUM
Research Institute of Pediatric Infections (St.Petersburg, 2003)
Days

17. FILTRUM
Clinical evidence conclusion:
addition of intestinal sorbent Filtrum to standard therapy of
acute intestinal infections significantly enhances treatment
efficacy and results in a quicker clinical recovery. Good
tolerability and significant therapeutic effect on the course
of acute intestinal infections in children, including infants,
allows giving Filtrum a positive opinion and
recommendation towards a wider promotion of the drug
into clinical practice
Research Institute of Pediatric Infections (St.Petersburg, 2003)

18. First aid natural means for protecting organism from
alimentary intoxication
Multipurpose non-drug means for decreasing acute intoxication
of different nature (food, intestinal infections, alcohol)
Universal anti-”Travellers diarrhea” protector
Convenient first aid supplement – always at hand in case of
unexpected acute intoxication
Strengthens effect of the standard therapy in case of acute
intestinal disorders
Accelerates rehabilitation after food intoxication
FILTRUM
Positioning: key messages aspects