From Strength in Diversity to Smart Nanoscale Technologies - David Smith
1. Prof. David K. Smith
University of York
UNIT 2017, Berlin, Germany
May 2017@professor_dave
From Strength in Diversity…
To Smart Nanoscale Technologies
3. Prof. David K. Smith
University of York My Educational Environment
@professor_dave
4. Prof. David K. Smith
University of York My Educational Environment
@professor_dave
5. Prof. David K. Smith
University of York Science in Schools
@professor_dave
‘David says it would have
helped him to have a teacher
who was a point of contact
for students with LGBT
issues.
While he had many teachers
who made a huge difference
in his scientific development,
this was not related to
finding his LGBT identity’
Joseph Unsay
7. Prof. David K. Smith
University of York Chemistry World Article
@professor_dave
8. ‘You are mistaking us for people who give a ****.
Your sexuality is NOT important vis-a-vis your job’.
‘So your fellow scientists don't give
a shite about your sexuality,
just your research credentials
and publication records?
Isn't that equality?’
Meritocracy or ‘Don’t Ask Don’t Tell’?
Prof. David K. Smith
University of York Is Science Diverse and Equal?
@professor_dave
9. ‘I had violated an unspoken convention of STEM:
the invisibility of its LGBT members’ Manil Suri
Prof. David K. Smith
University of York Straight Science?
@professor_dave
https://www.nytimes.com/2015/09/05/opinion/manil-suri-why-is-science-so-straight.html
Why is Science so Straight?
10. Publication
Prof. David K. Smith
University of York Young LGBT Scientists
@professor_dave
‘Except for rumour we have zero LGBT staff or students here.
It is quite isolating’
Anonymous Chemistry Student in Major UK Metropolitan University
11. Prof. David K. Smith
University of York Young Scientists?
@professor_dave
12. ‘I am thinking about coming out to my fellow lab mates and
maybe also to my supervisor (when it comes up in a chat
naturally), but I am still not quite sure about it.’
Prof. David K. Smith
University of York Young Scientists
@professor_dave
‘A lot of people worry that there will be unconscious bias against them in
the job hunting process. This should be something we are happy to
discuss as scientists. It should just be a part of life.’
Female Researcher (Anon):
13. A junior researcher’s supervisor can have a lot
of influence on their prospects, many
researchers think it is necessary to avoid
personal details.
‘If you can’t even have a conversation with a
colleague about who you spent the weekend
with it’s not a nice working environment’
Prof. David K. Smith
University of York Being 100% Yourself
@professor_dave
Matthew Mears, University of Sheffield
14. ‘Throughout my academic life in Chemistry,
I've found it normally has a
very conservative, macho culture.
Any sexuality related issues
are met with embarrassment
or sometimes hostility,
more so than other academic areas.
It doesn't help on an emotional level,
leading to feelings of isolation
perhaps leading to giving up
on a science career.’
Academic (Anon)
Prof. David K. Smith
University of York STEM Cultural Problems
@professor_dave
15. Prof. David K. Smith
University of York
LGBT STEM Survey
http://www.queerstem.org@professor_dave
How ‘Out’ Are You?
Is Your Workplace?
J. Homosexuality, DOI 10.1080/00918369.2015.1078632
18. Prof. David K. Smith
University of York My Research Motivation
@professor_dave
19. S.J. Shieh, J.P. Vacanti, Surgery 2005, 137, 1-7
Prof. David K. Smith
University of York
Tissue Engineering
New Organs
A smart ‘matrix’ could
encourage cell differentiation
@professor_dave
Matrix = Gel
A.R. Hirst, D.K. Smith, et al, Angew. Chem. Int. Ed. 2008, 47, 8002
23. Prof. David K. Smith
University of York Nanoscience
@professor_dave
24. Inspiration from History
Prof. David K. Smith
University of York
M. J. Meunier,
Ann. Chim. Phys. 1891, 22, 412
@professor_dave
B.O. Okesola, V.M.P. Vieira, D.J. Cornwell, N.K. Whitelaw, D.K. Smith
Soft Matter 2015, 11, 4768-4787
E. L. Roehl,
US Patent 4,346,079, 1982
T. Ando and Y. Yamazaki,
US Patent, 3846363, 1974
25. DBS – Butterfly Surfactant
Prof. David K. Smith
University of York
B.O. Okesola, V.M.P. Vieira, D.J. Cornwell, N.K. Whitelaw, D.K. Smith
Soft Matter 2015, 11, 4768-4787
@professor_dave
27. Innovative DBS Hydrogels
Prof. David K. Smith
University of York
B.O. Okesola, D.K. Smith, Chem. Commun. 2013, 49, 11164
D.J. Cornwell, B.O. Okesola, D.K. Smith, Soft Matter 2013, 9, 8730
@professor_dave
Modified Wings Two New Hydrogelators
28. Embedded Hybrid
NanostructuresTissue Growth
Prof. David K. Smith
University of York
@professor_dave
3T3 Cells – mouse embryonic fibroblasts
Cell growth on DBS-CONHNH2 transwells
With Nano-FM Groningen, NL
V. M. P. Vieira, M de Jong, D.K. Smith, unpublished results
29. Prof. David K. Smith
University of York Problems
@professor_dave
Complexity
Many cell types
Structural organisation
Cellular communication
High-level function
Use a Complex Self-Organised Gel to Program Cellular Function
From Multi-Component Chemistry to Multi-Component Biology
30. Prof. David K. Smith
University of York
Harnessing Chemical Diversity
To Achieve Biological Function@professor_dave
Diverse Inputs
31. Envirogel
B.O. Okesola, D.K. Smith,
Chem. Commun. 2013, 49, 11164
Embedded Hybrid
Nanostructures
Innovative Technology 1
Interactive Gels
Prof. David K. Smith
University of York
@professor_dave
32. Embedded Hybrid
Nanostructures
Controlled Release from
Interactive Gels
Prof. David K. Smith
University of York
@professor_dave
E.J. Howe, B.O. Okesola, D.K. Smith, Chem. Commun. 2015, 51, 7451
Painkillers
Drugs bound at low pH (stomach), released at pH 8 (intestine)
pH=4
pH=8
pH=7100
80
60
40
20
20 40
% Release
Hours
33. Embedded Hybrid
Nanostructures
Innovative Technology 2
Hybrid Hydrogels
Prof. David K. Smith
University of York
@professor_dave
D.J. Cornwell, D.K. Smith
Mater. Horiz. 2015, 2, 278
Self-Assembled
Gel
Polymer GelHybrid Gel
Responsive RobustAND
34. Photoinitiator
UV, 10 min
pH
Embedded Hybrid
Nanostructures
Hybrid Hydrogels
In Action
Prof. David K. Smith
University of York
@professor_dave
D.J. Cornwell, B.O. Okesola, D.K. Smith,
Angew. Chem. Int. Ed. 2014, 53, 12461
Can Polymerise
Can Assemble
Robust Robust
And
Responsive
35. Multi-domain gels
– Masking during UV stimulation enables regions of
hybrid gel and non-hybrid gel to form with
spatial control in a bulk sample:
Solution of LMWG and PG (+ PI and GdL)Apply mask......cure under UV lightPG network forms...... followed by LMWG network over time
Embedded Hybrid
Nanostructures
Innovative Technology 3
Spatially Resolved Gels
Prof. David K. Smith
University of York
@professor_dave
D.J. Cornwell, B.O. Okesola, D.K. Smith,
Angew. Chem. Int. Ed. 2014, 53, 12461
36. Regions with different material strength:
Multi-
domain gel
Weak LMWG
domain
Robust PG+LMWG
domain
Embedded Hybrid
NanostructuresMulti-Domain Gels
Prof. David K. Smith
University of York
@professor_dave
D.J. Cornwell, B.O. Okesola, D.K. Smith,
Angew. Chem. Int. Ed. 2014, 53, 12461
Spatially resolved rheological performance
Stem cells differentiate on different domains
38. Clean water obtained
Maximum gold loading =1915 mg/g
Thermally and pH stable nanoparticle-gel
Au3+
Embedded Hybrid
Nanostructures
Innovative Technology 4
Conductive Gels
Prof. David K. Smith
University of York
@professor_dave
B.O. Okesola, S.K. Survaram, A. Parkin, D.K. Smith
Angew. Chem. Int. Ed. 2016, 55, 183-187
39. Embedded Hybrid
Nanostructures
Hybrid Conducting Gels
Prof. David K. Smith
University of York
@professor_dave
0
50
100
150
200
250
300
Basic-Gel Nano-Gel Gel + SWNT
Conductivity/mScm-1
Solvated Gel
Gel - 30% of Water Removed
B.O. Okesola, S.K. Survaram, A. Parkin, D.K. Smith
Angew. Chem. Int. Ed. 2016, 55, 183-187
Interactive hydrogel Polymer hydrogel
Organises Gold/Silver Robust Material
40. Complexity in Tissue Growth
Simple Self-Assembly
of Diverse Components
Commercial Hybrid Interactive ConductingPatterned
From Multi-Component Chemistry to Multi-Component Biology
From New Technologies
Into the Future
Prof. David K. Smith
University of York
@professor_dave
46. Publication
Prof. David K. Smith
University of York
York
Changing the Ethos@professor_dave
Tim Bradbury
‘There is gossip in the department about Dave Smith
It is homophobic in nature, and is making some of us very uncomfortable’
2005
47. Publication
Prof. David K. Smith
University of York
Year 1
Introduction to Organic Chemistry@professor_dave
51. ‘It's important for LGBT students like me to see that there are people
like us who make it higher up and do great things with their lives
in our field of study - we see that we too can have a future like that.’
Publication
Prof. David K. Smith
University of York
LGBT Chemistry
Student Survey@professor_dave
‘It made me feel a lot better, having come from a school where
LGBTQ welfare was swept under the carpet and there were next to
no “out” students or teachers. It helped my coming out process.’
54. Publication
Prof. David K. Smith
University of York LGBT Games
@professor_dave
Chris Unsworth
Chemistry, Yr 2 PhD
Laurence Bastidas
Chemistry, Yr 1
“The University of York
is very progressive,
particularly with respect to
diversity and inclusion,”
he told Attitude.
http://attitude.co.uk/york-university-sending-swim-team-to-stockholm-eurogames/
56. Publication
Prof. David K. Smith
University of York Turning Point?
@professor_dave
Interview on LGBT
representation
in science
Nature
2016, 531, 265
57. ‘Diverse scientists will have
diverse ideas and approaches –
essential for cutting-edge research
Happy and fulfilled scientists will
perform better.
If we only care about the science,
and not the people who do it,
we won’t achieve the best results’
Publication
Prof. David K. Smith
University of York Scientists are Individuals
@professor_dave
Chemistry World, April 2014