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Prof. David K. Smith
University of York
UNIT 2017, Berlin, Germany
May 2017@professor_dave
From Strength in Diversity…
To Smart Nanoscale Technologies
Prof. David K. Smith
University of York
@professor_dave
Prof. David K. Smith
University of York My Educational Environment
@professor_dave
Prof. David K. Smith
University of York My Educational Environment
@professor_dave
Prof. David K. Smith
University of York Science in Schools
@professor_dave
‘David says it would have
helped him to have a teacher
who was a point of contact
for students with LGBT
issues.
While he had many teachers
who made a huge difference
in his scientific development,
this was not related to
finding his LGBT identity’
Joseph Unsay
http://www.youtube.com/professordaveatyork
Prof. David K. Smith
University of York YouTube
@professor_dave
Prof. David K. Smith
University of York Chemistry World Article
@professor_dave
‘You are mistaking us for people who give a ****.
Your sexuality is NOT important vis-a-vis your job’.
‘So your fellow scientists don't give
a shite about your sexuality,
just your research credentials
and publication records?
Isn't that equality?’
Meritocracy or ‘Don’t Ask Don’t Tell’?
Prof. David K. Smith
University of York Is Science Diverse and Equal?
@professor_dave
‘I had violated an unspoken convention of STEM:
the invisibility of its LGBT members’ Manil Suri
Prof. David K. Smith
University of York Straight Science?
@professor_dave
https://www.nytimes.com/2015/09/05/opinion/manil-suri-why-is-science-so-straight.html
Why is Science so Straight?
Publication
Prof. David K. Smith
University of York Young LGBT Scientists
@professor_dave
‘Except for rumour we have zero LGBT staff or students here.
It is quite isolating’
Anonymous Chemistry Student in Major UK Metropolitan University
Prof. David K. Smith
University of York Young Scientists?
@professor_dave
‘I am thinking about coming out to my fellow lab mates and
maybe also to my supervisor (when it comes up in a chat
naturally), but I am still not quite sure about it.’
Prof. David K. Smith
University of York Young Scientists
@professor_dave
‘A lot of people worry that there will be unconscious bias against them in
the job hunting process. This should be something we are happy to
discuss as scientists. It should just be a part of life.’
Female Researcher (Anon):
A junior researcher’s supervisor can have a lot
of influence on their prospects, many
researchers think it is necessary to avoid
personal details.
‘If you can’t even have a conversation with a
colleague about who you spent the weekend
with it’s not a nice working environment’
Prof. David K. Smith
University of York Being 100% Yourself
@professor_dave
Matthew Mears, University of Sheffield
‘Throughout my academic life in Chemistry,
I've found it normally has a
very conservative, macho culture.
Any sexuality related issues
are met with embarrassment
or sometimes hostility,
more so than other academic areas.
It doesn't help on an emotional level,
leading to feelings of isolation
perhaps leading to giving up
on a science career.’
Academic (Anon)
Prof. David K. Smith
University of York STEM Cultural Problems
@professor_dave
Prof. David K. Smith
University of York
LGBT STEM Survey
http://www.queerstem.org@professor_dave
How ‘Out’ Are You?
Is Your Workplace?
J. Homosexuality, DOI 10.1080/00918369.2015.1078632
Research Fortnight Magazine
http://tinyurl.com/researchfortnight
Prof. David K. Smith
University of York Don’t Ask, Don’t Tell
@professor_dave
Prof. David K. Smith
University of York My Research Motivation
@professor_dave
S.J. Shieh, J.P. Vacanti, Surgery 2005, 137, 1-7
Prof. David K. Smith
University of York
Tissue Engineering
New Organs
A smart ‘matrix’ could
encourage cell differentiation
@professor_dave
Matrix = Gel
A.R. Hirst, D.K. Smith, et al, Angew. Chem. Int. Ed. 2008, 47, 8002
Polymer Gels
Prof. David K. Smith
University of York
@professor_dave
We Can Do This!
Prof. David K. Smith
University of York
@professor_dave
Self-Assembly
Prof. David K. Smith
University of York
@professor_dave
Prof. David K. Smith
University of York Nanoscience
@professor_dave
Inspiration from History
Prof. David K. Smith
University of York
M. J. Meunier,
Ann. Chim. Phys. 1891, 22, 412
@professor_dave
B.O. Okesola, V.M.P. Vieira, D.J. Cornwell, N.K. Whitelaw, D.K. Smith
Soft Matter 2015, 11, 4768-4787
E. L. Roehl,
US Patent 4,346,079, 1982
T. Ando and Y. Yamazaki,
US Patent, 3846363, 1974
DBS – Butterfly Surfactant
Prof. David K. Smith
University of York
B.O. Okesola, V.M.P. Vieira, D.J. Cornwell, N.K. Whitelaw, D.K. Smith
Soft Matter 2015, 11, 4768-4787
@professor_dave
Embedded Hybrid
Nanostructures
Biology is Aqueous
@professor_dave
Prof. David K. Smith
University of York
Innovative DBS Hydrogels
Prof. David K. Smith
University of York
B.O. Okesola, D.K. Smith, Chem. Commun. 2013, 49, 11164
D.J. Cornwell, B.O. Okesola, D.K. Smith, Soft Matter 2013, 9, 8730
@professor_dave
Modified Wings Two New Hydrogelators
Embedded Hybrid
NanostructuresTissue Growth
Prof. David K. Smith
University of York
@professor_dave
3T3 Cells – mouse embryonic fibroblasts
Cell growth on DBS-CONHNH2 transwells
With Nano-FM Groningen, NL
V. M. P. Vieira, M de Jong, D.K. Smith, unpublished results
Prof. David K. Smith
University of York Problems
@professor_dave
Complexity
Many cell types
Structural organisation
Cellular communication
High-level function
Use a Complex Self-Organised Gel to Program Cellular Function
From Multi-Component Chemistry to Multi-Component Biology
Prof. David K. Smith
University of York
Harnessing Chemical Diversity
To Achieve Biological Function@professor_dave
Diverse Inputs
Envirogel
B.O. Okesola, D.K. Smith,
Chem. Commun. 2013, 49, 11164
Embedded Hybrid
Nanostructures
Innovative Technology 1
Interactive Gels
Prof. David K. Smith
University of York
@professor_dave
Embedded Hybrid
Nanostructures
Controlled Release from
Interactive Gels
Prof. David K. Smith
University of York
@professor_dave
E.J. Howe, B.O. Okesola, D.K. Smith, Chem. Commun. 2015, 51, 7451
Painkillers
Drugs bound at low pH (stomach), released at pH 8 (intestine)
pH=4
pH=8
pH=7100
80
60
40
20
20 40
% Release
Hours
Embedded Hybrid
Nanostructures
Innovative Technology 2
Hybrid Hydrogels
Prof. David K. Smith
University of York
@professor_dave
D.J. Cornwell, D.K. Smith
Mater. Horiz. 2015, 2, 278
Self-Assembled
Gel
Polymer GelHybrid Gel
Responsive RobustAND
Photoinitiator
UV, 10 min
pH
Embedded Hybrid
Nanostructures
Hybrid Hydrogels
In Action
Prof. David K. Smith
University of York
@professor_dave
D.J. Cornwell, B.O. Okesola, D.K. Smith,
Angew. Chem. Int. Ed. 2014, 53, 12461
Can Polymerise
Can Assemble
Robust Robust
And
Responsive
Multi-domain gels
– Masking during UV stimulation enables regions of
hybrid gel and non-hybrid gel to form with
spatial control in a bulk sample:
Solution of LMWG and PG (+ PI and GdL)Apply mask......cure under UV lightPG network forms...... followed by LMWG network over time
Embedded Hybrid
Nanostructures
Innovative Technology 3
Spatially Resolved Gels
Prof. David K. Smith
University of York
@professor_dave
D.J. Cornwell, B.O. Okesola, D.K. Smith,
Angew. Chem. Int. Ed. 2014, 53, 12461
Regions with different material strength:
Multi-
domain gel
Weak LMWG
domain
Robust PG+LMWG
domain
Embedded Hybrid
NanostructuresMulti-Domain Gels
Prof. David K. Smith
University of York
@professor_dave
D.J. Cornwell, B.O. Okesola, D.K. Smith,
Angew. Chem. Int. Ed. 2014, 53, 12461
Spatially resolved rheological performance
Stem cells differentiate on different domains
Embedded Hybrid
Nanostructures
Combining Technologies
Prof. David K. Smith
University of York
@professor_dave
P.R.A. Chivers, D.K. Smith, Manuscript submitted
UV
30 min
pH 3 pH 7
Directional Release
 Clean water obtained
 Maximum gold loading =1915 mg/g
 Thermally and pH stable nanoparticle-gel
Au3+
Embedded Hybrid
Nanostructures
Innovative Technology 4
Conductive Gels
Prof. David K. Smith
University of York
@professor_dave
B.O. Okesola, S.K. Survaram, A. Parkin, D.K. Smith
Angew. Chem. Int. Ed. 2016, 55, 183-187
Embedded Hybrid
Nanostructures
Hybrid Conducting Gels
Prof. David K. Smith
University of York
@professor_dave
0
50
100
150
200
250
300
Basic-Gel Nano-Gel Gel + SWNT
Conductivity/mScm-1
Solvated Gel
Gel - 30% of Water Removed
B.O. Okesola, S.K. Survaram, A. Parkin, D.K. Smith
Angew. Chem. Int. Ed. 2016, 55, 183-187
Interactive hydrogel Polymer hydrogel
Organises Gold/Silver Robust Material
Complexity in Tissue Growth
Simple Self-Assembly
of Diverse Components
Commercial Hybrid Interactive ConductingPatterned
From Multi-Component Chemistry to Multi-Component Biology
From New Technologies
Into the Future
Prof. David K. Smith
University of York
@professor_dave
Publication
Prof. David K. Smith
University of York Science
@professor_dave
Publication
Prof. David K. Smith
University of York YouTube Outreach
@professor_dave
Publication
Prof. David K. Smith
University of York My Working Environment
@professor_dave
Publication
Prof. David K. Smith
University of York Chemistry at York
@professor_dave
Publication
Prof. David K. Smith
University of York
York
Changing the Ethos@professor_dave
Tim Bradbury
‘There is gossip in the department about Dave Smith
It is homophobic in nature, and is making some of us very uncomfortable’
2005
Publication
Prof. David K. Smith
University of York
Year 1
Introduction to Organic Chemistry@professor_dave
Publication
Prof. David K. Smith
University of York Individual Steps
@professor_dave
@professor_dave
Publication
Prof. David K. Smith
University of York Twitter
@professor_dave
Publication
Prof. David K. Smith
University of York Sharing
@professor_dave
#adoption
‘It's important for LGBT students like me to see that there are people
like us who make it higher up and do great things with their lives
in our field of study - we see that we too can have a future like that.’
Publication
Prof. David K. Smith
University of York
LGBT Chemistry
Student Survey@professor_dave
‘It made me feel a lot better, having come from a school where
LGBTQ welfare was swept under the carpet and there were next to
no “out” students or teachers. It helped my coming out process.’
Publication
Prof. David K. Smith
University of York Wider Student Media
@professor_dave
Publication
Prof. David K. Smith
University of York
Embedding within
Departmental Ethos@professor_dave
Publication
Prof. David K. Smith
University of York LGBT Games
@professor_dave
Chris Unsworth
Chemistry, Yr 2 PhD
Laurence Bastidas
Chemistry, Yr 1
“The University of York
is very progressive,
particularly with respect to
diversity and inclusion,”
he told Attitude.
http://attitude.co.uk/york-university-sending-swim-team-to-stockholm-eurogames/
Publication
Prof. David K. Smith
University of York Talk
@professor_dave
Publication
Prof. David K. Smith
University of York Turning Point?
@professor_dave
Interview on LGBT
representation
in science
Nature
2016, 531, 265
‘Diverse scientists will have
diverse ideas and approaches –
essential for cutting-edge research
Happy and fulfilled scientists will
perform better.
If we only care about the science,
and not the people who do it,
we won’t achieve the best results’
Publication
Prof. David K. Smith
University of York Scientists are Individuals
@professor_dave
Chemistry World, April 2014

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From Strength in Diversity to Smart Nanoscale Technologies - David Smith

  • 1. Prof. David K. Smith University of York UNIT 2017, Berlin, Germany May 2017@professor_dave From Strength in Diversity… To Smart Nanoscale Technologies
  • 2. Prof. David K. Smith University of York @professor_dave
  • 3. Prof. David K. Smith University of York My Educational Environment @professor_dave
  • 4. Prof. David K. Smith University of York My Educational Environment @professor_dave
  • 5. Prof. David K. Smith University of York Science in Schools @professor_dave ‘David says it would have helped him to have a teacher who was a point of contact for students with LGBT issues. While he had many teachers who made a huge difference in his scientific development, this was not related to finding his LGBT identity’ Joseph Unsay
  • 6. http://www.youtube.com/professordaveatyork Prof. David K. Smith University of York YouTube @professor_dave
  • 7. Prof. David K. Smith University of York Chemistry World Article @professor_dave
  • 8. ‘You are mistaking us for people who give a ****. Your sexuality is NOT important vis-a-vis your job’. ‘So your fellow scientists don't give a shite about your sexuality, just your research credentials and publication records? Isn't that equality?’ Meritocracy or ‘Don’t Ask Don’t Tell’? Prof. David K. Smith University of York Is Science Diverse and Equal? @professor_dave
  • 9. ‘I had violated an unspoken convention of STEM: the invisibility of its LGBT members’ Manil Suri Prof. David K. Smith University of York Straight Science? @professor_dave https://www.nytimes.com/2015/09/05/opinion/manil-suri-why-is-science-so-straight.html Why is Science so Straight?
  • 10. Publication Prof. David K. Smith University of York Young LGBT Scientists @professor_dave ‘Except for rumour we have zero LGBT staff or students here. It is quite isolating’ Anonymous Chemistry Student in Major UK Metropolitan University
  • 11. Prof. David K. Smith University of York Young Scientists? @professor_dave
  • 12. ‘I am thinking about coming out to my fellow lab mates and maybe also to my supervisor (when it comes up in a chat naturally), but I am still not quite sure about it.’ Prof. David K. Smith University of York Young Scientists @professor_dave ‘A lot of people worry that there will be unconscious bias against them in the job hunting process. This should be something we are happy to discuss as scientists. It should just be a part of life.’ Female Researcher (Anon):
  • 13. A junior researcher’s supervisor can have a lot of influence on their prospects, many researchers think it is necessary to avoid personal details. ‘If you can’t even have a conversation with a colleague about who you spent the weekend with it’s not a nice working environment’ Prof. David K. Smith University of York Being 100% Yourself @professor_dave Matthew Mears, University of Sheffield
  • 14. ‘Throughout my academic life in Chemistry, I've found it normally has a very conservative, macho culture. Any sexuality related issues are met with embarrassment or sometimes hostility, more so than other academic areas. It doesn't help on an emotional level, leading to feelings of isolation perhaps leading to giving up on a science career.’ Academic (Anon) Prof. David K. Smith University of York STEM Cultural Problems @professor_dave
  • 15. Prof. David K. Smith University of York LGBT STEM Survey http://www.queerstem.org@professor_dave How ‘Out’ Are You? Is Your Workplace? J. Homosexuality, DOI 10.1080/00918369.2015.1078632
  • 16. Research Fortnight Magazine http://tinyurl.com/researchfortnight Prof. David K. Smith University of York Don’t Ask, Don’t Tell @professor_dave
  • 17.
  • 18. Prof. David K. Smith University of York My Research Motivation @professor_dave
  • 19. S.J. Shieh, J.P. Vacanti, Surgery 2005, 137, 1-7 Prof. David K. Smith University of York Tissue Engineering New Organs A smart ‘matrix’ could encourage cell differentiation @professor_dave Matrix = Gel A.R. Hirst, D.K. Smith, et al, Angew. Chem. Int. Ed. 2008, 47, 8002
  • 20. Polymer Gels Prof. David K. Smith University of York @professor_dave
  • 21. We Can Do This! Prof. David K. Smith University of York @professor_dave
  • 22. Self-Assembly Prof. David K. Smith University of York @professor_dave
  • 23. Prof. David K. Smith University of York Nanoscience @professor_dave
  • 24. Inspiration from History Prof. David K. Smith University of York M. J. Meunier, Ann. Chim. Phys. 1891, 22, 412 @professor_dave B.O. Okesola, V.M.P. Vieira, D.J. Cornwell, N.K. Whitelaw, D.K. Smith Soft Matter 2015, 11, 4768-4787 E. L. Roehl, US Patent 4,346,079, 1982 T. Ando and Y. Yamazaki, US Patent, 3846363, 1974
  • 25. DBS – Butterfly Surfactant Prof. David K. Smith University of York B.O. Okesola, V.M.P. Vieira, D.J. Cornwell, N.K. Whitelaw, D.K. Smith Soft Matter 2015, 11, 4768-4787 @professor_dave
  • 26. Embedded Hybrid Nanostructures Biology is Aqueous @professor_dave Prof. David K. Smith University of York
  • 27. Innovative DBS Hydrogels Prof. David K. Smith University of York B.O. Okesola, D.K. Smith, Chem. Commun. 2013, 49, 11164 D.J. Cornwell, B.O. Okesola, D.K. Smith, Soft Matter 2013, 9, 8730 @professor_dave Modified Wings Two New Hydrogelators
  • 28. Embedded Hybrid NanostructuresTissue Growth Prof. David K. Smith University of York @professor_dave 3T3 Cells – mouse embryonic fibroblasts Cell growth on DBS-CONHNH2 transwells With Nano-FM Groningen, NL V. M. P. Vieira, M de Jong, D.K. Smith, unpublished results
  • 29. Prof. David K. Smith University of York Problems @professor_dave Complexity Many cell types Structural organisation Cellular communication High-level function Use a Complex Self-Organised Gel to Program Cellular Function From Multi-Component Chemistry to Multi-Component Biology
  • 30. Prof. David K. Smith University of York Harnessing Chemical Diversity To Achieve Biological Function@professor_dave Diverse Inputs
  • 31. Envirogel B.O. Okesola, D.K. Smith, Chem. Commun. 2013, 49, 11164 Embedded Hybrid Nanostructures Innovative Technology 1 Interactive Gels Prof. David K. Smith University of York @professor_dave
  • 32. Embedded Hybrid Nanostructures Controlled Release from Interactive Gels Prof. David K. Smith University of York @professor_dave E.J. Howe, B.O. Okesola, D.K. Smith, Chem. Commun. 2015, 51, 7451 Painkillers Drugs bound at low pH (stomach), released at pH 8 (intestine) pH=4 pH=8 pH=7100 80 60 40 20 20 40 % Release Hours
  • 33. Embedded Hybrid Nanostructures Innovative Technology 2 Hybrid Hydrogels Prof. David K. Smith University of York @professor_dave D.J. Cornwell, D.K. Smith Mater. Horiz. 2015, 2, 278 Self-Assembled Gel Polymer GelHybrid Gel Responsive RobustAND
  • 34. Photoinitiator UV, 10 min pH Embedded Hybrid Nanostructures Hybrid Hydrogels In Action Prof. David K. Smith University of York @professor_dave D.J. Cornwell, B.O. Okesola, D.K. Smith, Angew. Chem. Int. Ed. 2014, 53, 12461 Can Polymerise Can Assemble Robust Robust And Responsive
  • 35. Multi-domain gels – Masking during UV stimulation enables regions of hybrid gel and non-hybrid gel to form with spatial control in a bulk sample: Solution of LMWG and PG (+ PI and GdL)Apply mask......cure under UV lightPG network forms...... followed by LMWG network over time Embedded Hybrid Nanostructures Innovative Technology 3 Spatially Resolved Gels Prof. David K. Smith University of York @professor_dave D.J. Cornwell, B.O. Okesola, D.K. Smith, Angew. Chem. Int. Ed. 2014, 53, 12461
  • 36. Regions with different material strength: Multi- domain gel Weak LMWG domain Robust PG+LMWG domain Embedded Hybrid NanostructuresMulti-Domain Gels Prof. David K. Smith University of York @professor_dave D.J. Cornwell, B.O. Okesola, D.K. Smith, Angew. Chem. Int. Ed. 2014, 53, 12461 Spatially resolved rheological performance Stem cells differentiate on different domains
  • 37. Embedded Hybrid Nanostructures Combining Technologies Prof. David K. Smith University of York @professor_dave P.R.A. Chivers, D.K. Smith, Manuscript submitted UV 30 min pH 3 pH 7 Directional Release
  • 38.  Clean water obtained  Maximum gold loading =1915 mg/g  Thermally and pH stable nanoparticle-gel Au3+ Embedded Hybrid Nanostructures Innovative Technology 4 Conductive Gels Prof. David K. Smith University of York @professor_dave B.O. Okesola, S.K. Survaram, A. Parkin, D.K. Smith Angew. Chem. Int. Ed. 2016, 55, 183-187
  • 39. Embedded Hybrid Nanostructures Hybrid Conducting Gels Prof. David K. Smith University of York @professor_dave 0 50 100 150 200 250 300 Basic-Gel Nano-Gel Gel + SWNT Conductivity/mScm-1 Solvated Gel Gel - 30% of Water Removed B.O. Okesola, S.K. Survaram, A. Parkin, D.K. Smith Angew. Chem. Int. Ed. 2016, 55, 183-187 Interactive hydrogel Polymer hydrogel Organises Gold/Silver Robust Material
  • 40. Complexity in Tissue Growth Simple Self-Assembly of Diverse Components Commercial Hybrid Interactive ConductingPatterned From Multi-Component Chemistry to Multi-Component Biology From New Technologies Into the Future Prof. David K. Smith University of York @professor_dave
  • 41.
  • 42. Publication Prof. David K. Smith University of York Science @professor_dave
  • 43. Publication Prof. David K. Smith University of York YouTube Outreach @professor_dave
  • 44. Publication Prof. David K. Smith University of York My Working Environment @professor_dave
  • 45. Publication Prof. David K. Smith University of York Chemistry at York @professor_dave
  • 46. Publication Prof. David K. Smith University of York York Changing the Ethos@professor_dave Tim Bradbury ‘There is gossip in the department about Dave Smith It is homophobic in nature, and is making some of us very uncomfortable’ 2005
  • 47. Publication Prof. David K. Smith University of York Year 1 Introduction to Organic Chemistry@professor_dave
  • 48. Publication Prof. David K. Smith University of York Individual Steps @professor_dave
  • 49. @professor_dave Publication Prof. David K. Smith University of York Twitter @professor_dave
  • 50. Publication Prof. David K. Smith University of York Sharing @professor_dave #adoption
  • 51. ‘It's important for LGBT students like me to see that there are people like us who make it higher up and do great things with their lives in our field of study - we see that we too can have a future like that.’ Publication Prof. David K. Smith University of York LGBT Chemistry Student Survey@professor_dave ‘It made me feel a lot better, having come from a school where LGBTQ welfare was swept under the carpet and there were next to no “out” students or teachers. It helped my coming out process.’
  • 52. Publication Prof. David K. Smith University of York Wider Student Media @professor_dave
  • 53. Publication Prof. David K. Smith University of York Embedding within Departmental Ethos@professor_dave
  • 54. Publication Prof. David K. Smith University of York LGBT Games @professor_dave Chris Unsworth Chemistry, Yr 2 PhD Laurence Bastidas Chemistry, Yr 1 “The University of York is very progressive, particularly with respect to diversity and inclusion,” he told Attitude. http://attitude.co.uk/york-university-sending-swim-team-to-stockholm-eurogames/
  • 55. Publication Prof. David K. Smith University of York Talk @professor_dave
  • 56. Publication Prof. David K. Smith University of York Turning Point? @professor_dave Interview on LGBT representation in science Nature 2016, 531, 265
  • 57. ‘Diverse scientists will have diverse ideas and approaches – essential for cutting-edge research Happy and fulfilled scientists will perform better. If we only care about the science, and not the people who do it, we won’t achieve the best results’ Publication Prof. David K. Smith University of York Scientists are Individuals @professor_dave Chemistry World, April 2014