Drugs Of Abuse

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Mesolimbic Dopamine Pathway and the Psychopharmacology of Reward[R einforcement] ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Drug induced high Natural High

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Stimulants: Cocaine and Amphetamine

Cocaine ,[object Object],[object Object],[object Object],[object Object],[object Object],Local anesthetic Freud and tongue Ca

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Nicotine-Cigarette smoking is a nicotine delivery system ,[object Object],[object Object],[object Object]

Reinforcing actions of nicotine similar cocaine and Amphetamine-But SUBTLE Nicotine shuts down receptor shortly after binding to it Neither it nor Ach can stimulate for a while [longer and much more intense euphoria with cocaine ] Pleasure of nicotine is a desirable but small boost in the sensation of pleasure ("minirush"), -> decline until the smoker takes the next puff or smokes the next cigarette. Somewhat self-regulating – Behavioral effects less severe thancocaine

Over time, up-regulation Of receptors

Nicotine and DA release No Nicotine and No DA release CRAVING

Cigarette smoking is a pulsatile nicotine delivery system withdrawal from nicotine is characterized by craving and agitation,

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Opiate drugs act on a variety of receptors, “ Brain's own morphine-like molecules."

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Alcohol Decreases the actions of the excitatory NMDA receptor complex — that is, it diminishes excitation. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Benzodiazepine Modulators of GABA-A ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Drugs Of Abuse

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Drugs Of Abuse