Malaria & Case Study

2.  Malaria is an infectious disease, which is
caused by protozoan parasites of genus
plasmodium.
Causative Organism :
 Plasmodium falciparum
 Plasmodium vivax
 Plasmodium ovale
 Plasmodium malariae

4. The Symptoms of Malaria
Severe malaria
• Seizures
• Respiratory distress
• Anemia
• Organ failure
• Coma
• Death

5.  Microscopic examination of blood
 Antigen detection test
 Patients history & clinical observation

6.  4-Aminoquinolines—
Chloroquine, Amodiaquine
 Aryl-amino alcohols—
Quinine, Mefloquine, Halofantrine
 8-Aminoquinolines—Primaquine
 Antifolate—
Sulfadoxine, Proguanil, Pyrimethamine
 Antibiotics—Tetracycline
 Qinghaosu—Artemisinin (derived from
leeches)
 New drugs—
Atovaquona, Pyronaridine, Benflumetol

7.  Mosquito nets
 Keep your surroundings clean
 Mosquito repellants
 Vaccines for malaria are underdevelopment

8. Case Study

9.  Name – Mr. X
 Age – 26 yrs
 Gender – Male
 Date of admission – 06/10/12
 Date of discharge – 10/10/12

10. Chief complaints
C/O fever, vomiting, back pain, fatigue, head
ache X 3days.
History of present illness
H/O back pain ,headache.
Past Medical History
N/K/C/O DM, HTN, BA,
Personal History
Non-alcoholic, Non-smoker.

11. Physical Examination
 Patient is conscious oriented
 Temp- 104 F Pulse- 90/min
 Bp- 130/90 mm/Hg RR- 20beats/min
Systemic examination
CVS- S1S2+ CNS- NFND
RS- NVBS P/A- Soft

12. Data's Observed Value Normal Value
Hb 12.6 gm/dl(↓) 14-18
RBC 4.4million/cubic
mm(↓)
4.2-5.6
ESR(1 Hour) 25mm/hr(↑) 15-20
Platelet 110cubic mm (↓) 140-450
Pot 3.1meq/l (↓) 3.5-5.5
Bili (T) 1.8 mg/dl(↑) 0.2-1.4
Bili (D) 1.5mg/dl (↑) 0.0-0.4
Bili (ID) 0.3mm/dl Total-Direct

13. OTHER TEST’S
 Dengue test – Negative
 Polymerase chain reaction – Positive
 MP QBC – Positive (P.vivax)
Diagnosis
Malaria

14. Drugs Dose R.O.A Frequency Duration
IV Fluids 2 Days
Cap.
Doxycycline
100mg P/O BD X 5 Days
Tab. Dolo 650mg P/O TDS X 1 Day
Tab. Larigo 600mg P/O OD X 5 Days
Inj. Emeset 4 mg I.V STAT X 2 Days

15. Doxycycline decrease the effect of
amoxicilline by pharmacodynamic
antagonism- Use alternatively
Discharge Advice:
Tab. Larigo (600mg) OD for 14 days
Tab. Dolo (650mg) STAT
Cap. Doxycycline (100mg) BD for 7 Days
Review after 14 Days

16.  Take adequate rest
 Drink plenty of clean water.
 MB QBC Test recommended after 14 days