Scientists have identified two proteins that could aid in diagnosis and treatment of diseases: TDP-43 is linked to Alzheimer's disease and may help diagnose it through brain scans, while FGF1 regulates blood sugar in diabetics and shows promise as a new treatment by making cells more sensitive to insulin. Researchers also discovered that abnormal TDP-43 deposits relate to other neurodegenerative diseases. Further research on these and other proteins could lead to answers for diseases that have been difficult to diagnose and treat.
1. “Scientists tie new protein to
Alzheimer's disease; may aid
diagnosis, research on treatments and
researchers discover protein
regulating diabetic’s blood sugar.”
MOLECULAR BIOLOGY
VALENTINA SERNA LOAIZA.
Medicine student
3rd semester
4. INTRODUCTION
Proteins like a key in diagnosis and treatment :
TDP-43 in Alzheimer disease.
FGF1 in type 2
Diabetes.
5. “Scientists tie new protein to Alzheimer's disease;
may aid diagnosis, research on treatments”
BY Marilynn Marchione, The star phoenix.
6. “Scientists tie new protein to Alzheimer's disease;
may aid diagnosis, research on treatments”
TDP-43 has more
connection with
the symptoms of
Alzheimer's disease
than amyloid
plaques and tau
protein. Although amyloid
plaques and tau
protein are in the
brain is not 100% sure
that the person
suffers the symptoms
of this disease, even
if they have the
disease.
HIGH
SECURITY
TDP-43 AS A
MARKER OF
ALZHEIMER.
7. “Scientists tie new protein to Alzheimer's disease;
may aid diagnosis, research on treatments”
Although we know the proteins that
are Involved in Alzheimer's, has been
very difficult to make a diagnosis
through them Because it could only be
observed in the brain after death.
However, the first time images were
obtained by brain scans of tau tangles and
amyloid plaques in living people.
8. “Scientists tie new protein to Alzheimer's disease;
may aid diagnosis, research on treatments”
The abnormal form of TDP-43 that is found as deposits
in certain areas of the cortex of Alzheimer's patients
also relates to Amyotrophic lateral sclerosis (ALS) and
frontotemporal dementia.
11. “Researchers Discover Protein Regulating
Diabetics' Blood Sugar”
The potential of FGF1 protein was
discovered in mice with type 2
diabetes induced by the
investigators.
Investigators injecting
this growth factor.
Levels of blood glucose were
positioned in very stable
values for more than two days.
12. “Researchers Discover Protein
Regulating Diabetics' Blood Sugar”
“FGF1 appears to resensitize
the body to insulin, which
transports glucose into the
cells, normalizing blood
sugar levels.”
This is a big difference with existing
treatments that its action is produce
more insulin, these types of treatments
have many adverse effects.
13. “Researchers Discover Protein Regulating
Diabetics' Blood Sugar”
Ron Evans, says:
“So, as a result, the combination of FGF1 and the
body’s insulin rebalances the equation and
allows glucose to be controlled as if it was
normal. ”
14. Student observation
To ensure good progress and great expectations for
patients suffering from different diseases is essential
to continue research into molecules that can be
linked to the disease.
Investigate the application of molecules that
apparently not have any important function in
some diseases because it could be the answer to
questions that take decades trying to answer.
16. Medical utility
Diagnosis of Alzheimer's through the future
development of new brain scanning techniques to
find the defective TDP-43.
If you come to an early diagnosis, it can be done
timely treatment, more effective without many
complications.
17. Medical utility
FGF1 in glycemic control, as sensitizing the cell to insulin in
type 2 diabetes.
Thanks to the development of
a new treatment can prevent
or reduce many of the
symptoms experienced by
diabetic patients.
18. Medical utility
The power of knowing the proteins that are
affected in certain diseases. for use as
markers and to research on how to reverse
the damage.
The power of knowing functions of proteins
to use them in treat for health problems.
19. BIBLIOGRAPHY
Barchione, M. (2014). Scientists tie new protein to alzheimer's
disease; may aid diagnosis, research on treatments.
www.thestarphoenix.com retrieve august 17,2014 from
http://www.thestarphoenix.com/health/scientists+protein+alzheime
rs+disease+diagnosis+research/10033107/story.html
• Berman, J. (2014). Researchers discover protein regulating
diabetics' blood sugar, www.voanews.comretrieve august 17,2014
from http://www.voanews.com/content/researchers-discover-protein-
that-regulates-diabetics-blood-sugar/1959155.html.
