A healthy 25 year old man is undergoing a brief surgical procedure requiring general anaesthesia. He underwent an unremarkable intubation and induction of anaesthesia using I V succinyl choline and inhaled halothane. During the surgery the patient developes muscle rigidity and tachycardia and his temperature rapidly rises.

2. A healthy 25 year old man is undergoing a
brief surgical procedure requiring general
anaesthesia. He underwent an unremarkable
intubation and induction of anaesthesia using
I V succinyl choline and inhaled halothane.
During the surgery the patient developes
muscle rigidity and tachycardia and his
temperature rapidly rises.

3. 1.What is the mechanism of action of
succinylcholine?
2.What reaction is occurring in the patient?
3.What drug should immediately be given to
the patient and what is its mechanism of
action?
Questions

4. Summary
 A 25-year-old man develops muscle rigidity,
tachycardia, and high fever during surgery
after giving succinylcholine

5. Mechanism of action of
succinylcholine
Nicotinic receptor agonist at the motor end plate
of neuro muscular junction which causes
persistent stimulation and depolarization of
muscle cells

6. Reaction that is occurring
 Malignant Hyperthermia

7. Drugs given for treatment of
malignant hyperthermia and its moa
Dantrolene is drug of choice. It acts by
interfering with calcium release from the
sarcoplasmic reticulum.