HEME SYNTHESIS

1. Succinyl CoA Glycine
δ- Aminolevulinate
2 δ- Aminolevulinate
Porphobilinogen
4-Porphobilinogen
Uroporphyrinogen III
Coproporphyrinogen III
Protoporphyrinogen III
Protoporphyrin IX
Heme
δ- Aminolevulinate
Synthase
δ- Aminolevulinate
dehydratase
Uroporphyrinogen I
Synthase &
uroporphyrinogen
III cosynthase
Uroporphyrinogen
decarboxylase
Coprophyrinogen
oxidase
Protophyrinogen
oxidase
Ferrochelatase
Fe2+
4H+
4CO2
4CO2
4NH3
4H2O
CoASH
Synthesis of heme