Deck for Integriculture Inc. - commercialization of clean meat and cellular agriculture products, starting from cosmetics and supplements, ingredients then to food

1. Integriculture Inc.
Cell-Ag Initiative

2. Cell culture cost
1/10000
Cell-
based
meat
PCT/JP2016/067599
JP-Pat.6111510

3. Cell-based meat
3
Muscle cells Bioreactor
Culture medium
Processing
Cell-based chicken liver paste

4. Seafood
$200B
$2 Trillion
(2020)*
Beef
$800B
10x
resource
intensive > soy
70%
of
deforestation
18%
of GHG
emissions
Footprints
Animal Agriculture (And Its Environmental Cost) Is Growing
4*Zion Market Research

5. The mounting food security crisis
5
*Reuters (2017)
**Nikkei (2017)
“Alternative protein sources are necessary.
Consider algae and insect as options.”
Signed to invest $300M to Israeli alternative
protein startups.
Trading companies priced out to other countries
importing beef.

6. Land use -98%, Water use -95%?
Near zero
food miles
Algal production
of culture media
Meat cell
culture
Tuomisto (2011)

7. Cellular Agriculture
Production of agricultural products by cell culture

8. The technological problem
€250,000
Clean meat burger, 200g

9. ～2016
Conventional
$2
Growth
factors
Consumables
CapEx
Serum-free
2017
Lab scale
2026 large
scale plant
”Culnet System” : General purpose large-scale cell culture
Cells
[A]
Cells
[B]
Dialysis,oxygenationetc.
Musclecells
PCT/JP2016/067599
Japan Pat.6111510
Cell culture cost
1/10000
$600K/kg
$2K

10. No externally added
FBS & growth factors
*
*
“Culnet System” grows variety of cells without added growth factors
Liver cells Muscle stem cell Placental cells
Conventional“CulnetSystem”
”Culnet System"
Cellcount(ratio)
□Liver cells
■Pancreas cells
■Ovary cells
*p<0.01, **p<0.05

11. Amnion Liver Oviduct
(adult chicken)
Intestine Brain Gallbladder
Pancreas
Muscle
Versatility: tested cell types

12. “Culnet System” at a glacne
“General-purpose large-scale
cell culture system”
The technology to inexpensively
produce wide range of cells
Currently at > 1/100,
> 1/100,000 within sight
by economy of scale

13. ✅Not limited to muscle
✅No added growth factors
✅Scalable(Flow-based)
“Culnet System” proof of concept
Cell-based chicken liver paste
Proof of
Concept
No.1 & 2

14. Enzymes
Nucleic acids
Sugars
Lipids
Extracellular matrix
Organ cells
Cellular proteins
Cellular metabolites
Products of the “Culnet System”
Culture
medium
Cell
mass
Acellular products
Cellular products

15. “Cell-ag infrastructure”
Sugar &
amino acid
“Culnet System”
infrastructure
Cells
ingredients
supplements
foie gras
meat etc.
High
Low
Unit
price
Unit
price

16. 16
Cosmetics market
“Early
adopters”
✅Contamination free
✅Animal cruelty free
✅Stable supply
✅Can use human cells
✅Already gaining traction
Youth Elderly
High-end
Low-end
$1.5B market
capitalization
(Japan)
“Customizable Cellular Cosmetics”
EGF
HGF
VEGF
etc.

17. 2020 2023 2026
100kg/mon.
3~100t
/month
300t/day
Cell-ag
plant
120,000
1,200
1.2
Annual volume(tn)
〰〰〰
〰〰〰
〰〰〰
〰〰〰
Product roadmap: Volume & price projection
Ingredients,
Bio-reagents
Cosmetics,
supplements
Supplements, food

18. Series A (12~15M)
2019/11
Seed($3M) Closed on
2018/04/25
Cell culture： $600M
(Japan, 2015, Fuji Keizai)
Skincare：$115B
(Japan, 2017, Yano Keizai)
Global protein：$2T
(2013 Rabobank)
Product development
Market & financial projections
Cosmetics⇒Supplements⇒Food

19. Partnerships
Cells, Bio-reagents and
functional compounds
Product development, S&D
Supplements and food
Mid-term joint R&D
Cellular agriculture plants
R&D, construction, operation

20. Meat by cellular agriculture One of many
possibilities
Large scale suspension
culture in a bioreactor
Fat cell
coculture
Immunity
cell culture
Growth factor
source (liver cells)
Myoblasts
bioreactor
Cell cluster suspension
culture, further scalable

21. Seafood by cellular agriculture

22. Food production on Mars

23. Orbital Cell-Ag Facility