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LOCAL ANESTHETICS.pptx
1.
LOCALANESTHETICS DR.FOUZIA
2.
LOCALANESTHETICS Definition: “Drugs that produce
reversible inhibition of initiation and propagation of impulses in nervous and other excitable tissues when applied locally”
3.
CLASSIFICATION OF LOCALANESTHETICS Chemical
classification: A-ESTERS Procaine Cocaine Tetracaine Benzocaine
4.
CLASSIFICATION OF LOCALANESTHETICS Chemical
classification: A-AMIDES Lignocaine /Lidocaine Bupivacaine Prilocaine Ropivacaine Articaine
5.
LOCALANESTHETICS Mechanism of action: 1-Diffusion
into the nerve fiber 2-Blockade of sodium channels.
6.
7.
M.O.A OF LOCALANESTHETICS Result
of action of a local anesthetic 1-The threshold for excitation increases 2-Impulse conduction slows 3-Action potential amplitude ↓ 4-Ability to generate an action potential is completely abolished
8.
LOCALANESTHETICS Order of blockade: 1-Pain 2-Temperature 3-Touch 4-Deep
pressure 5-Motor Recovery is in reverse order
9.
THERAPEUTIC INDICATIONS OF
LOCALANESTHESIA 1-Surface anesthesia 2-Infiltration anesthesia & field block anesthesia 3-Nerve block anesthesia 4-Spinal anesthesia 5-Epidural anesthesia 6-Used in ophthalmology 7-Used in dentistry
10.
ADVERSE EFFECTS OF
LOCALANESTHETICS To ↓ the adverse effects of local anesthetics, add vasoconstrictor adrenaline. 1-CNS effects: Light headedness Restlessness Sleepiness Auditory/visual disturbance Metallic taste
11.
ADVERSE EFFECTS OF
LOCALANESTHETICS 1-CNS effects: Tongue numbness Muscle twitching Nystagmus Tonic clonic convulsions 2- CVS effects: Vasodilatation Hypotensive effects Cardiac arrythmias 3-Local injury: Neural injury
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