12 ème journée-Hyperchylomicronémie : nouvelles perspectives de thérapie génique
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4. Pancreatitis over 350 times more common in LPLD than in healthy controls Gaudet et al Atherosclerosis Suppl 2010 Severe HyperTG (> 10.0 mmol/L) n = 354 Moderate HyperTG (5.0 - 9.0 mmol/L) n = 487 All n = 354 LPLD only n = 28 15.8 ± 16.3 (0.008) 55.8 ± 56.9 (< 0.001) 361.4 ± 401.2 (< 0.001) Odd Ratio ± SE (p-value)
5. Postprandial Chylomicronemia Causes Pancreatitis in LPL Deficiency fat intake high levels of newly-formed chylomicrons in circulation post meal lodging of aggregates in capillaries - reduced blood flow - oedema - increased pressure acute pancreatitis
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7. Glybera Administration Injections ultrasound or electro-physiologically guided Spinal anesthesia