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Presented by : H. Al-Buainain Supervised : Prof. Parashar PATHOGENESIS OF GALLSTONES

Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],ANATOMY

[object Object],[object Object],[object Object],[object Object],Composition of Bile

Cholesterol Metabolism ,[object Object],[object Object],[object Object],[object Object]

SYNTHESIS OF CHOLESTEROL ,[object Object],[object Object]

[object Object],Chenodeoxycholic acid cholic acid Glycine or Taurine Glycocholic Acid Taurocolic Acid

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Role of Bile In Fat Digestion Absorption ,[object Object]

[object Object],[object Object],[object Object],[object Object]

Role Of Bile Acid In Cholesterol Homeostasis ,[object Object],[object Object]

CONTROL OF BILE SECRETION ,[object Object],[object Object],[object Object],- Bile salt

SIGNIFICANCE OF BILE ACID ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],GALLSTONES

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Cholesterol Stones

Cholesterol Gallstones Formation ,[object Object]

Risk factors Gallstones Formation

Types of Cholesterol stones ,[object Object],90-100% Solitary , Whitish > 2.5 cm 50 - 90% Multiple , Small ,# Variety of shape

PIGMENTED GALLSTONES - Calcium bilirubinate - Ca Soap - Bacteria has role in the synthesis - > in Asia - Mainly at bile duct -Periumpullary duodenal diverticula -Excess Bilirubin - > in : -Elderly Pt. - Chronic haemolysis - Alcoholic

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Complications

Conclusion ,[object Object],[object Object],[object Object]

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