CREAMS MS.WAJIHA IFFAT OBJECTIVES: After the end of this topic, the student will be able to : -->Define creams -->Classify creams --->Method of preparation --->prepare a cream from first principles incorporate solids and liquids into a cream base

1. CREAMSCREAMS
MS.WAJIHA IFFATMS.WAJIHA IFFAT
OBJECTIVES:
After the end of this topic, the student will be
able to :
•Define creams
•Classify creams
•Method of preparation
•prepare a cream from first principles
• incorporate solids and liquids into a cream base

2. CreamsCreams
BP DEFINES :
“Creams are formulated to provide
preparation that are essentially miscible
with skin secretion. they are intended to
be applied to the skin or certain mucous
membranes for protective ,therapeutic,
or prophylactic purposes especially when
occlusive effect is not necessary.”

3. CreamsCreams
In USPXVIII ,creams are defined as
“ semisolid emulsions of either oil in
water or water in oil type.”
“ semisolid emulsions usually medicated
,intended for external application.”

4. CreamsCreams
Aqueous cream: aqueous cream ,
cetrimide cream, cetomacrogol cream
Oily cream: oily cream /hydrous
ointment
Cosmetic creams:
All purpose cream, baby cream, barrier
cream, bleaching cream, cleansing cream
cold cream, hair cream, hand cream,
vanishing cream.
Medicated creams:

5. CreamsCreams
Creams are reserved for external
preparation.
A cream may be water in oil or oil in water
depending on the emulsifying agent used.
They are soft ,easy to apply ,cooling to
skin ,easily water-removable.
w/o cream: oily creams
Contains: emulsifying agents of natural
origins( bees wax, wool alcohols, wool fat
properties :Emollient.
Creamy, white or translucent and stiff.

6. CreamsCreams
o/w creams: aqueous creams
Contains: synthetic waxes e.g.,
cetomacrogols & macrogols
Properties:
Causes rapid absorption & penetration
Thin ,white & smooth consistency

7. CreamsCreams
METHOD OF PREPARATION:
TRITURATION:
Used for finely divided insoluble powder particles
or liquids
insoluble powder are added by geometric dilution
Liquids are added by making well in centre.
Air pocket formation avoided.
Involved the use of glass slab when small quantities
are used
Mortar and pestle used when we have large
quantities.

8. CreamsCreams
LEVIGATION:
Incorporation of insoluble coarse particles.
Also known as “Wet grinding”.
insoluble coarse powder is rubbed with
molten base or liquid or a semi solid base.
A considerable shearing force is applied to
avoid grittiness.

9. CreamsCreams
Hygiene: ( aseptic condition)
All equipment & spatula to be cleaned by IMS. (70%
ethanol should be used)
Determine the miscibility of the substances being
incorporated.
Melt the fatty base .substances with the highest
melting point to be melt first. These bases then
cooled to 60°C.
Temperature of the aqueous phase to be adjusted
to 60°C.
The disperse phase to be incorporated to the
continuous phase at the same temperature.
Avoid air pockets & hasty cooling.

10. CreamsCreams
Incorporation Of solid Ingredients
Into Cream Base:
Solid particles can be incorporated after
the bases cools
Soluble solids: added to the molten cream
at the lowest possible temperature& the
mixture stirred until cold.
Insoluble solids: incorporated by using tile
& spatula or mortar and pestle using
doubling technique.

11. CreamsCreams
Coarse powder: minimum quantity of
cream should be placed in the centre of
the tile & used to levigate the powders.
Fine powders : may be triturated to into
other wise finished creams on ointment
tile. (geometric dilutions.

12. CreamsCreams
Incorporation Of Liquids:
Non volatile ,miscible liquids: may be mixed
with molten cream in evaporating basin. if a
pre-prepared base is used then follow
procedure for volatile or immiscible liquids.
Volatile or immiscible liquids:
E.gs coal tar should be triturated with creams
on tile .a very small amount of creams should
be placed on tile and a well made in centre.
small quantities are folded gently to avoid
splashing.

13. CreamsCreams
Diluted creams:
If the diluents is stated in the
manufacturer data sheet
Freshly prepared
No heating should be involved.
Should be carried out in aseptic
conditions.
Should not be used more than 2 wks.

14. REFERENCESREFERENCES
Compounding and Dispensing by
Christopher A Langley & Dawn Belcher pg.
65-91.
Compounding and Dispensing by john F.
Marriot, Keith A. Wilson Christopher A
Langley & Dawn Belcher pg.147-151
Pharmaceutical Practice by D M Collett
pg:116-117
Sprowls’ American Pharmacy pg:273-274
Pharmaceutics practice by Winfield.

15. CreamsCreams
THANK YOU!!
ANY QUESTION???
ASSIGNMENT :
MAKE A LIST OF MEDICATED CREAM
WITH THEIR BRAND NAME.