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MCB: Enzymatic Pathways and Regulation
1.
Cell & Molecular Biology
2.
Enzyme and Generally Protein Regulation
3.
Chapters 3 &
4
4.
5.
Enzyme Kinetics
6.
Turnover Number
7.
“...how rapidly the substrate can
be processed.”
8.
Figure 3-26a Essential
Cell Biology (© Garland Science 2010)
9.
Figure 3-26b Essential
Cell Biology (© Garland Science 2010)
10.
Figure 3-24 Essential
Cell Biology (© Garland Science 2010)
11.
Enzymes and substrates encounter
each other through diffusion.
12.
Figure 3-22 Essential
Cell Biology (© Garland Science 2010)
13.
Inhibitors
14.
Estrogen receptor with DNA
and estradiol bound http://www.pdb.org/pdb/static.do? p=education_discussion/ molecule_of_the_month/pdb45_1.html
15.
Tamoxifen
blocks the action of estrogen http://www.pdb.org/pdb/static.do? p=education_discussion/ molecule_of_the_month/pdb45_1.html
16.
Competitive Inhibition
17.
Figure 3-28a Essential
Cell Biology (© Garland Science 2010)
18.
Figure 3-28b Essential
Cell Biology (© Garland Science 2010)
19.
Trypsin
h"p://cnx.org/content/m11456/latest/ Benzamidine
20.
21.
Noncompetitive Inhibition
22.
Feedback Inhibition
23.
Figure 4-34 Essential
Cell Biology (© Garland Science 2010)
24.
Negative Regulation
25.
Figure 4-35 Essential
Cell Biology (© Garland Science 2010)
26.
Figure 4-36 Essential
Cell Biology (© Garland Science 2010)
27.
Allosteric Regulation
28.
Protein Phosphorylation
29.
The reversible addition of
a phosphate group to a protein.
30.
Figure 4-38a Essential
Cell Biology (© Garland Science 2010)
31.
Figure 4-38b Essential
Cell Biology (© Garland Science 2010)
32.
GTP Binding
33.
Figure 4-39 Essential
Cell Biology (© Garland Science 2010)
34.
Elongation Factor EF-Tu tRNA
http://www.rcsb.org/pdb/ 101/motm.do?momID=81
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