32. 一年一針具有「雙氮環」加強骨頭礦物質與鄰近雙
磷酸鹽的結合能力維持長期療效的特性
When R1 is an OH group, binding to
bone is enhanced
O
OH
P OH
R1
R2 site determines antiresorptive potency and
affects binding to
hydroxyapatite
C
R2
P
OH
OH
O
R1 = –OH, R2 = –(CH2)2NH2
R1 = –OH, R2 = –(CH2)3NH2
R1 = –OH, R2 = –CH2
N
pamidronate
alendronate
risedronate
R1 = –OH, R2 = –CH2 N N zoledronic acid
32
治療骨鬆新趨勢 一箭「雙」鵰 | 台北榮總 賴建志醫師
Both phosphonate
groups act as a “bone
hook” and are essential
both for binding to
hydroxyapatite and
biochemical
mechanism of action