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BIOWEAPONS
CONTENTS
•
•
•
•
•
•

INTRODUCTION
HISTORY
TYPES
PREVENTIVE MEASURES
ADVANTAGES
DISADVANTAGES
WHAT ARE BIOWEAPONS
 Toxic materials or pathogenic substances(usually
microbes).
 Biological weapons are potentially deadlier than
chemical weapons.
 These substances work to kill or incapacitate the host.
 Biological weapons may be used to target living
organisms such as humans, animals or vegetation.
HISTORY AT A GLANCE
 In 1942, British bioweapons trials severely
contaminated Gruinard Island in Scotland with
anthrax spores.
 In 1979, the Soviet Union accidently released
airborne anthrax, killing 66 people in the process.
 1939-1949—Second World War, Japanese army
poisoned more than 1,000 water wells in Chinese
villages to study cholera and typhus outbreaks.
MOST POTENTIAL BIOWEAPONS
•
•
•
•
•

CHIMERA
NIPAH VIRUS
BOTULINUM TOXIN
TULERAMIA
ANTHRAX
ANTHRAX
 Anthrax is an acute disease caused by the
bacterium Bacillus anthracis.

 The bacteria live in the soil, where grazing animals typically come
into contact with spores while rooting around for food.
 Symptoms are fever, respiratory problems, fatigue, muscle
aches, enlarged lymph nodes, nausea, vomiting, diarrhea.
 1945: Iran  outbreak causes 1 million sheep deaths.

WHY USE ANTHRAX
 Relatively easy to acquire, in vitro growth (any lab media @ 37 C)
and induction of sporulation is easy.
TULERAMIA
 Tularemia also known as rabbit fever is a
serious infectious disease caused by the
bacterium Francisella tularensis.
 Humans typically acquire the disease through
contact with infected animals, infected insect bites, the consumption of
contaminated foods or the inhalation of the bacteria in aerosol form.

 Symptoms  fever, headache, diarrhea, muscle aches, joint pain, dry cough and
progressive weakness.
 Outbreak of tularemia among German soldiers-siege of Stalingrad was due to the
release of F. tularensis by Soviet forces.

WHY USE TULERAMIA
 It is easy to aerosolize
 It is highly infective; between 10 and 50 bacteria are sufficient to infect victims.
BOTULINUM TOXIN
 Botulinum toxin is a protein and neurotoxin
produced by the bacterium Clostridium
Botulinum.
 Clostridium botulinum can kill in 24 to 72 hours, which
makes it a harmful bioweapon.
 Symptoms Blurred vision, vomiting and difficulty
swallowing.

 In 1990 the Japanese cult Aum Shinrikyo released an
aerosol of the toxin.
NIPAH VIRUS
The virus naturally occurs in fruit bats.
Symptoms fever, muscle pains or
inflammation of the brain.
The outbreak occurred in the Nipah region of
Malaysia, infecting 265 and killing 105.
CHIMERA
 In Greek and Roman mythology, the
chimera combined elements of lion,
goat and serpent into one monstrous form.
 In modern genetic science, a chimeric organism is a life
form that contains genes from a foreign species.
 Chimera, which combines the common cold with polio, may
help cure brain cancer.

 1980 Soviet Union's Chimera Project(combining of
Smallpox and Ebola).
Defense against biological agents
• Military defense
– good protective mask equipped with filters-blocking bacteria, virus
– effective biological weapon sensors-alarms to make sure of
overgarments, gloves.

• Civil defense
– improved since the September 11, 2001, attacks in the United States.
– Ex. the U.S. government incorporated smallpox vaccine for every
military personel.
– Long-term medical research-improved vaccines.
ADVANTAGES
 Small amount needed
 Extremely toxic
 Easy/inexpensive to grow
 Large amount produced in short period of time

 Potential for panic
DISADVANTAGES
 Quality control
– Particles must be aerosolized .

 Delivery problems
– Rain, wind, UV light
– Bombs, and shells produce poor, localized aerosols
– Heat and shock waves (explosions) kill most organisms

 Poor storage survival
Bioweapons 2

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Bioweapons 2

  • 3. WHAT ARE BIOWEAPONS  Toxic materials or pathogenic substances(usually microbes).  Biological weapons are potentially deadlier than chemical weapons.  These substances work to kill or incapacitate the host.  Biological weapons may be used to target living organisms such as humans, animals or vegetation.
  • 4. HISTORY AT A GLANCE  In 1942, British bioweapons trials severely contaminated Gruinard Island in Scotland with anthrax spores.  In 1979, the Soviet Union accidently released airborne anthrax, killing 66 people in the process.  1939-1949—Second World War, Japanese army poisoned more than 1,000 water wells in Chinese villages to study cholera and typhus outbreaks.
  • 5. MOST POTENTIAL BIOWEAPONS • • • • • CHIMERA NIPAH VIRUS BOTULINUM TOXIN TULERAMIA ANTHRAX
  • 6. ANTHRAX  Anthrax is an acute disease caused by the bacterium Bacillus anthracis.  The bacteria live in the soil, where grazing animals typically come into contact with spores while rooting around for food.  Symptoms are fever, respiratory problems, fatigue, muscle aches, enlarged lymph nodes, nausea, vomiting, diarrhea.  1945: Iran  outbreak causes 1 million sheep deaths. WHY USE ANTHRAX  Relatively easy to acquire, in vitro growth (any lab media @ 37 C) and induction of sporulation is easy.
  • 7. TULERAMIA  Tularemia also known as rabbit fever is a serious infectious disease caused by the bacterium Francisella tularensis.  Humans typically acquire the disease through contact with infected animals, infected insect bites, the consumption of contaminated foods or the inhalation of the bacteria in aerosol form.  Symptoms  fever, headache, diarrhea, muscle aches, joint pain, dry cough and progressive weakness.  Outbreak of tularemia among German soldiers-siege of Stalingrad was due to the release of F. tularensis by Soviet forces. WHY USE TULERAMIA  It is easy to aerosolize  It is highly infective; between 10 and 50 bacteria are sufficient to infect victims.
  • 8. BOTULINUM TOXIN  Botulinum toxin is a protein and neurotoxin produced by the bacterium Clostridium Botulinum.  Clostridium botulinum can kill in 24 to 72 hours, which makes it a harmful bioweapon.  Symptoms Blurred vision, vomiting and difficulty swallowing.  In 1990 the Japanese cult Aum Shinrikyo released an aerosol of the toxin.
  • 9. NIPAH VIRUS The virus naturally occurs in fruit bats. Symptoms fever, muscle pains or inflammation of the brain. The outbreak occurred in the Nipah region of Malaysia, infecting 265 and killing 105.
  • 10. CHIMERA  In Greek and Roman mythology, the chimera combined elements of lion, goat and serpent into one monstrous form.  In modern genetic science, a chimeric organism is a life form that contains genes from a foreign species.  Chimera, which combines the common cold with polio, may help cure brain cancer.  1980 Soviet Union's Chimera Project(combining of Smallpox and Ebola).
  • 11. Defense against biological agents • Military defense – good protective mask equipped with filters-blocking bacteria, virus – effective biological weapon sensors-alarms to make sure of overgarments, gloves. • Civil defense – improved since the September 11, 2001, attacks in the United States. – Ex. the U.S. government incorporated smallpox vaccine for every military personel. – Long-term medical research-improved vaccines.
  • 12. ADVANTAGES  Small amount needed  Extremely toxic  Easy/inexpensive to grow  Large amount produced in short period of time  Potential for panic
  • 13. DISADVANTAGES  Quality control – Particles must be aerosolized .  Delivery problems – Rain, wind, UV light – Bombs, and shells produce poor, localized aerosols – Heat and shock waves (explosions) kill most organisms  Poor storage survival