Screening Venture Opportunities provides 4 anchors for evaluating business opportunities: 1) Create significant value for customers by solving problems or meeting needs they are willing to pay for. 2) Target a big market with high growth, margins, and cash flow. 3) Ensure a good fit with founders/management skills and market. 4) Investors look for strong teams with relevant experience, businesses with high returns and exit routes, and deals with realistic valuations and shareholder agreements.