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protein structure prediction methods. homology modelling, fold recognition, threading, ab initio methods. in short and easy form slides. after one time read you can easily understand methods for protein structure prediction.
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Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a speciation event (orthologs), or a duplication event (paralogs), or else a horizontal (or lateral) gene transfer event (xenologs).[1] Homology among DNA, RNA, or proteins is typically inferred from their nucleotide or amino acid sequence similarity. Significant similarity is strong evidence that two sequences are related by evolutionary changes from a common ancestral sequence. Alignments of multiple sequences are used to indicate which regions of each sequence are homologous.
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Just something I did for leisure :) .You need to download PDB viewer, Yasara/Accelerys for a clear understanding of this subject.
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Homology modeling also known as comparative modeling uses homologous sequences with known 3D structures for the modelling and prediction of the structure of a target sequence Homology modeling is one of the most best performing prediction methods that gives “accurate” predicted models.
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Secondary structure prediction has been around for almost a quarter of a century. The early methods suffered from a lack of data. Predictions were performed on single sequences rather than families of homologous sequences, and there were relatively few known 3D structures from which to derive parameters. Probably the most famous early methods are those of Chou & Fasman, Garnier, Osguthorbe & Robson (GOR) and Lim. Although the authors originally claimed quite high accuracies (70-80 %), under careful examination, the methods were shown to be only between 56 and 60% accurate (see Kabsch & Sander, 1984 given below). An early problem in secondary structure prediction had been the inclusion of structures used to derive parameters in the set of structures used to assess the accuracy of the method. Some good references on the subject:
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Advance Mobile Application Development class 07
Dr. Mazin Mohamed alkathiri
God is a creative God Gen 1:1. All that He created was “good”, could also be translated “beautiful”. God created man in His own image Gen 1:27. Maths helps us discover the beauty that God has created in His world and, in turn, create beautiful designs to serve and enrich the lives of others.
Explore beautiful and ugly buildings. Mathematics helps us create beautiful d...
Explore beautiful and ugly buildings. Mathematics helps us create beautiful d...
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Explore beautiful and ugly buildings. Mathematics helps us create beautiful d...
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Homology modeling tools
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Homology Modeling
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Modeller
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