1. Assessing Cost-Effectiveness (ACE) of interventions to reduce burden of harm from alcohol misuse: ACE Alcohol Associate Professor Chris Doran National Drug and Alcohol Research Centre, University of New South Wales

13. ACE-Alcohol model ACE-Alcohol model Epidemiological data Intervention data – costs – effects Disease & injury treatment costs Health gain (DALYs) Costs (AUS$) Cost-effectiveness ratio ($/DALY) Cost-effectiveness planes Acceptability curves Uncertainty analysis

16. Results for each intervention against partial null $14,000 $28 $39 -$11 1,500 Drink driving mass media Dominant -$0.16 $0.64 -$0.8 150 Min. legal drink age to 21 $24,000 $54 $71 -$17 2,300 Random breath testing $120,000 $55 $59 -$4.4 460 Res. treat. + naltrexone $190,000 $35 $37 -$1.7 190 Res. treat. $10,000 $3.5 $6.1 -$2.6 340 Brief int. + tele. + support $6,800 $1.1 $2.3 -$1.2 160 Brief int. $3,300 $8.7 $20 -$11 2,700 Licensing controls Dominant -$12 $20 -$31 7,800 Advertising bans Dominant -$56 $0.58 -$57 11,000 Taxation Median CER ($/DALY) Net Cost ($million) Intervention Cost ($million) Cost Offsets ($million) DALYs averted Intervention

17. Brief intervention

18. Residential treatment

20. Acceptability of intervention against partial null 0% 0% Res. treat. + naltrexone 90% 0% Random breath testing 81% 0% Drink driving mass media 100% 5% Licensing controls 100% 0% Brief int. 100% 61% Min. legal drink age to 21 100% 85% Advertising bans 100% 100% Taxation Probability of being < $50,000/DALY Probability of being cost-saving Intervention

21. CEA results of optimal expansion path 0% 0% $120,000 Res. treat. + naltrexone 88% 0% $26,000 Random breath testing 80% 0% $14,000 Drink driving mass media 100% 4% $3,500 Licensing controls 100% 0% $7,000 Brief int. 100% 59% Dominant Min. legal drink age to 21 100% 85% Dominant Advertising bans 100% 100% Dominant Taxation Probability of being < $50,000/DALY Probability of being cost-saving Median ICER ($/DALY) Intervention

22. Intervention pathway

31. Key project staff Linda Cobiac, Angela Wallace, Shamesh Naidoo, Isaac Asamoah, Kathryn Arnett Christopher Doran, Theo Vos, Wayne Hall, Greg Fowler Investigators on ACE-Alcohol This project was funded by the Alcohol Education Rehabilitation Foundation (AERFDOCS/2005-MW/GF1069).