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Bio world going digital, 27 March 2015, Ireland
- 1. 1 HELLO BIO! Bio world going digital
- 3. 3 TomorrowYesterday2 weeks3 weeks1 month2 months Biohacking 5 months UNCONFERENCE
- 4. 4 Biohacking
- 5. Digital Biology Sequencing Synthesis Analog Biology Digital Biology AGTC
- 6. 6 Biochips Can run biochemical applications In-vitro diagnostics Drug discovery Biotech Ecology Digital microfluidic biochip
- 7. 7 Motivation for biochips *This slide was created by prof. K. Chakrabarty, Duke University. Used with permission. Automation Integration Miniaturization Automation Integration Miniaturization Automation Integration Miniaturization ✔ ✔ ✔ ✔ ✔
- 9. 9 Digital Microfluidic Biochip (DMB) example Moving droplets -> Biochemical application
- 11. 11 Working setup
- 12. 12 Working setup
- 13. 13 In action
- 14. 14 Challenges Development Biocompatibility Research Horizontal Open DIY Money Rüdiger Trojok Miriam Alistar Urs Gaudenz www.bioflux.eu www.hackteria.org www.gaudi.ch
Notas del editor
- What are biochips? Biochips are microfluidic platforms designed to run biochemical applications. Biochips use fluids (saliva, blood, urine) in very small amounts, at nanoscale level, to integrate on-chip all the necessary functions needed to perform a biochemical application. The focus of my phd work is on a specific type of biochips: the digital microfluidic biochips. The application areas of biochips include: point-of-care testing, biotech, drug discovery, homeland security and many others.
- We all have interacted before with the traditional laboratory, when our blood samples would have been taken in tubes, and, if you have the chance to walk in a clean room, you might have seen the more advanced robots used to run biochemical applications. Both of these methods work great. However, using microfluidic platforms, and in our case biochips, has 3 main advantages: automation: as a consequence we reduce likelihood of error due to human interventation, integration – eliminating the need of additional components, and miniaturization which mean smaller volumes of fluids which results in lower cost (reagents are expensive and some rare sample can also be expensive) and faster completion time of the application (at smaller volumes, the fluidic operations execute faster).
- In a DMB, the droplets are moved from an electrode to another by using the electrowetting-on-dielectric (EWOD) principle [60]. I will explain the principle behind it by showing a transversal view of a biochip. We can see that a droplet is sandwiched between a top ground-electrode and bottom control-electrodes. When voltage is applied at the side of the droplet, an imbalance is created in the interfacial forces between the electrode, droplet and the filler fluid. As a result, the droplet moves towards the side where the voltage was applied. For example, in Fig. 2.2, if the electrode on which the droplet is resting is turned off, and the left electrode is activated by applying voltage, the droplet will move to the left.