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By Ehab Abusinna
OSTEOMALACIA
OSTEOPOROSIS
RICKETS
OSTEOPOROSIS - WHO
Systemic skeletal disease characterized by low bone
mass and micro architectural deterioration of bone
tissue with a consequent increase in bone fragility
and susceptibility to fracture which usually involves
the wrist ,spine, hip, pelvis, ribs or humerus.
 Most common of all metabolic bone disorders
 Significant morbidity(50% for hip fractures)
and mortality(20% for hip fractures in 1 year)
 Lifetime Osteoporotic Fracture Risk(Caucasian)
Woman- 40%
Men - 20%
 Preventive therapies available.
Osteoporosis
 Low bone density
 Micro architectural deterioration
 Fractures
Osteoporosis
Target Sites for Osteomalacia
TYPES OF OSTEOPOROSIS
 Primary Osteoporosis
 Postmenopausal Osteoporosis
 Senile Osteoporosis
 Secondary Osteoporosis
 Diet
 Drug
Endocrine disease
Other Systemic Disorders.
Senile or post-menopausal – 95%
Indiopathic
Primary Osteoporosis
SECONDARY OSTEOPOROSIS
Endocrine:
cushing + exog steroids
Hyperthyroidism
Hypogonadism
Hyperparathyroidism
Dm
Proclatinoma
Acromegaly
Preg & lactation
RENAL
C R F
Malabsorption, Celiac
Gastrectomy
T P N
Hepatobiliary disease
Chronic hypophosphatemia
NUTRITION AND GIT
DRUGS
Heparin
Steroids
Anti-convulsants
 Diet
 Low calcium intake
 Low vitamin D intake
 Excessive intake of
protein, sodium and caffeine
 Inactive lifestyle
 Smoking , Alcohol abuse
Risk factors…
RISK INCREASED BY:
F – sex
Menopause
Decreased Ca
Smoking
Alcohol
Inactivity
White Race (↓ black)
• Osteoporosis, the "silent
disease," has bone loss
without symptoms.
• Onset only occurs with
sudden strains, bumps,
or fall causes a fracture
or a vertebra to collapse.
• Collapsed vertebrae may
initially be felt or seen in the form of severe back
pain, loss of height, or spinal deformities such as
kyphosis or stooped posture.
SYMPTOMS
RICKETS
RICKETS
RICKETS
RICKETS
OSTEOMALACIA – LOOSER ZONE
OSTEOMALACIA – LOOSER ZONE
CHEMISTRY: NORMAL
WHY ↑ALK, BUT NOT PERSISTENT
PREVENTION:
Exercise
Good Ca intake
Non-smoking
LIFESTYLE ISSUES
 Tobacco- eliminate it
Food – eat it
 Exercise – do it
 Fall Prevention – work on it
Avoid smoking, alcohol and excess soft drink and coffee
Eat a health diet
lean meat, fish, green leafy vegetables, and oranges and
Off course Plenty Milk
Healthy bone balance
• Prevent further bone loss
• Increase or at least stabilize bone density.
• Relieve pain and prevent fracture.
• Increase level of physical functioning
• Increase quality of life
Goals of management
TREATMENT
Ca 1200 mg/day
Vitamin D:- 400-2000 IU / day
HRT
Biphosphonates
Calcintonin
S E R M S
Parathyroid hormone
Vertebral Fracture Cascade
COMPLICATIONS
FRACTURE ,
The most serious complication of
Osteoporosis that leads to
 Increased morbidity
 Increased mortality
 Decreased quality of life
THE TIP OF THE ICEBERG
ASSESSMENT MANAGEMENT
Each year, one in three Ontarians over
the age
of 65 will take a serious tumble that
may land
them in hospital with a broken hip.
One in three
of those who do break their hip will
die within
a year. Two thirds will experience
dementia-like
symptoms. Most will never see home
again.
Osteoporosis, is it only for women??
OSTEOPOROSIS IN
MEN
HAS ITS TIME COME?
Osteoporosis, only for older
people ??
Ca defecancy syndrom
Ca defecancy syndrom

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Ca defecancy syndrom