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January 2010 Manish  Singh, PhD President and CEO OTC BB: IMUC.OB www.imuc.com
SEC Disclaimer Statement ,[object Object],January 2010
Mission ,[object Object],January 2010
Cancer Stem Cells:  Good Guys Turned Bad ,[object Object],[object Object],January 2010 Targeting CSCs may significantly delay or prevent disease recurrences. Normal  Stem Cell mutations Cancer  Stem Cell Mature Tissue Bulk  Tumor Progenitor cells
Technology Overview:  Utilizing Both Arms of Immune System ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],January 2010
ICT-107: Dendritic Cell-Based Vaccine Targeting Cancer Stem Cells and Tumor Associated Antigens January 2010 Antigens Tumor Expression CSC Expression gp100 Melanoma, brain cancer Trp-2 Melanoma and brain cancer High Her-2/neu Breast, ovarian cancer Medium MAGE-1 Melanoma, brain cancer AIM Breast, ovarian, colon, brain High IL-13aR2 Brain cancer
January 2010 Significant Improvement in Progression-Free Survival (Compared to Historical Controls Using Standard of Care) Radiation  +  Temozolomide*  Radiation + Temozolomide +ICT-107 ,[object Object],[object Object]
Summary of Clinical Data:  Progression-Free and Overall Survival January 2010 SOC = Standard of care (surgery + radiation + Temozolomide) Newly Diagnosed (16) SOC + ICT-107 Historical Control (SOC) Median PFS (months) 19.0 6.9 Median OS (months) > 21  14.2 % Survival at 12 months 94% 60% % Survival at 21 months 80% 30% Recurrent (3) Median OS (months) 30.5 7.0 (9.2 with Avastin+SOC)
ICT-121: Cancer Stem Cell Vaccine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],January 2010 Potential Blockbuster Product
Summary of Antibody Programs January 2010 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Value Creation Catalysts in Next 12 Months ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],January 2010
Management Team ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],January 2010
Key Opinion Leaders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],January 2010
Financial Position and Capitalization ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],January 2010
Summary  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],January 2010

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ImmunoCellular Investor Presentation

  • 1. January 2010 Manish Singh, PhD President and CEO OTC BB: IMUC.OB www.imuc.com
  • 2.
  • 3.
  • 4.
  • 5.
  • 6. ICT-107: Dendritic Cell-Based Vaccine Targeting Cancer Stem Cells and Tumor Associated Antigens January 2010 Antigens Tumor Expression CSC Expression gp100 Melanoma, brain cancer Trp-2 Melanoma and brain cancer High Her-2/neu Breast, ovarian cancer Medium MAGE-1 Melanoma, brain cancer AIM Breast, ovarian, colon, brain High IL-13aR2 Brain cancer
  • 7.
  • 8. Summary of Clinical Data: Progression-Free and Overall Survival January 2010 SOC = Standard of care (surgery + radiation + Temozolomide) Newly Diagnosed (16) SOC + ICT-107 Historical Control (SOC) Median PFS (months) 19.0 6.9 Median OS (months) > 21 14.2 % Survival at 12 months 94% 60% % Survival at 21 months 80% 30% Recurrent (3) Median OS (months) 30.5 7.0 (9.2 with Avastin+SOC)
  • 9.
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  • 11.
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  • 15.