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Pre-invasive and Invasive Lesions of the Cervix
1.
Pre-invasive & Invasive
Lesions of the Cervix http://crisbertcualteros.page.tl
2.
Normal Cervix Cancer
Cervical Intraepithelial Neoplasia (CIN) Carcinogenic Factors CIN I CIN II CIN III Carcinogenesis
3.
4.
5.
6.
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Carcinogenesis Normal Cervix
Cancer Cervical Intraepithelial Neoplasia (CIN) Carcinogenic Factors CIN I CIN II CIN III
9.
Human Papilloma Virus
10.
11.
HPV E3 E1
E2 E4 E5 E6 E7 L1 L2 Human Genome p53 pRB Viral Genome Integration
12.
E6 p53 DNA
Repair Programmed Cell Death (Apoptosis) Viral Oncoprotein – Host Regulatory Protein Complex
13.
E7 pRB Viral
Oncoprotein – Host Regulatory Protein Complex S G2 M G1 G0 cell cycle
14.
15.
16.
Normal CANCER INITIATOR
PROMOTER Carcinogenesis
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Cervical Intraepithelial Neoplasia
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Colposcopy
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Colposcopy of the
Cervix
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Cervical Carcinoma
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Stage III A
Stage III B Extension to the LOWER 3rd of Vagina Extension to the PELVIC WALL
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Surgical Management
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Multimodality Treatment
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Follow-Up
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