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Pre-invasive & Invasive Lesions of the Cervix http://crisbertcualteros.page.tl
Normal Cervix Cancer Cervical Intraepithelial Neoplasia (CIN) Carcinogenic Factors CIN I CIN II CIN III Carcinogenesis
 
 
 
 
 
Carcinogenesis Normal Cervix Cancer Cervical Intraepithelial Neoplasia (CIN) Carcinogenic Factors CIN I CIN II CIN III
Human Papilloma Virus
Predisposing Factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
HPV E3 E1 E2 E4 E5 E6 E7 L1 L2 Human Genome p53 pRB Viral Genome Integration
E6 p53 DNA Repair Programmed Cell Death (Apoptosis) Viral Oncoprotein – Host Regulatory Protein Complex
E7 pRB Viral Oncoprotein – Host Regulatory Protein Complex   S G2 M G1 G0 cell cycle
Predisposing Factors ,[object Object],[object Object],[object Object],[object Object],[object Object]
Predisposing Factors ,[object Object],[object Object],[object Object],[object Object],[object Object]
Normal CANCER INITIATOR PROMOTER Carcinogenesis
Predisposing Factors ,[object Object],[object Object],[object Object],[object Object]
Predisposing Factors ,[object Object],[object Object],[object Object],[object Object]
Cervical Intraepithelial Neoplasia
Cervical Intraepithelial Neoplasia ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Cervical Intraepithelial Neoplasia ,[object Object],[object Object],[object Object],[object Object]
 
Cervical Intraepithelial Neoplasia ,[object Object],[object Object],[object Object],[object Object]
Cervical Intraepithelial Neoplasia ,[object Object],[object Object],[object Object],[object Object]
Cervical Intraepithelial Neoplasia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
 
Cervical Intraepithelial Neoplasia ,[object Object],[object Object],[object Object],[object Object]
Cervical Intraepithelial Neoplasia ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cervical Intraepithelial Neoplasia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cervical Intraepithelial Neoplasia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cervical Intraepithelial Neoplasia ,[object Object],[object Object],[object Object],[object Object],[object Object]
Colposcopy
Cervical Intraepithelial Neoplasia ,[object Object],[object Object],[object Object],[object Object],[object Object]
Colposcopy of the Cervix
 
Cervical Intraepithelial Neoplasia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cervical Intraepithelial Neoplasia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cervical Intraepithelial Neoplasia ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Cervical Carcinoma
Cervical Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Cervical Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cervical Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cervical Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cervical Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cervical Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cervical Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cervical Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Cervical Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Cervical Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cervical Carcinoma ,[object Object],[object Object],[object Object],[object Object]
Cervical Carcinoma ,[object Object],[object Object],[object Object]
Cervical Carcinoma ,[object Object],[object Object],[object Object],[object Object]
 
Stage III A Stage III B Extension to the LOWER 3rd of Vagina Extension to the PELVIC WALL
Surgical Management
Cervical Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Cervical Carcinoma  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cervical Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Multimodality Treatment
MultiModality Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
 
Cervical Carcinoma ,[object Object],[object Object],[object Object]
Cervical Carcinoma in Pregnancy ,[object Object],ChemoRT Stage IB2, IIB, III & IV RHBLND Stage IA2, IB1 & IIA < 20 weeks Management Stage of Cancer Age of Gestation
Cervical Carcinoma in Pregnancy ,[object Object],* Once with fetal lung maturity  CS* + ChemoRT postpartum Stage IB2, IIB, III & IV CS* + RHBLND Stage IA2, 1B1 & IIA >20 weeks Management Stage of Cancer Age of Gestation
Follow-Up
Cervical Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
[object Object],[object Object]

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