11. Drug Response Dependent on 3 Variables: 2. Drug Concentration Absorption Distribution Metabolism Elimination 1. Affinity Receptors Enzymes Uptake Pumps 3. Patient Genetics Age Disease Environment Clinical Response Adapted from Preskorn S. J Pract Psychiatry Behav Health . 1999;5:50-55.
Drug Response Dependent on 3 Variables As noted above. Reference Preskorn S. The slippery slide. J Pract Psychiatry Behav Health . 1999;5:50-55.
The fact that younger age predicted polypharmacy is difficult to explain given treatment recommendation of lower doses for first-episode patients. One possible explanation may be that schizophrenia can be associated with more florid symptoms in younger patients