Carcinogenesis

"I think of life itself now as a wonderful play that I've written for myself... and so my purpose is to have the utmost fun playing my part…!" Shirley MacLaine, Actress and Author

Etiology of Cancer Dr Ejaz Waris

Non-lethal Genetic damage lies at the center of carcinogenesis. ,[object Object],[object Object],[object Object],[object Object]

We owe, Sir Percival Pott the knowledge of carcinogenesis. Pott, related the increased incidence of scrotal cancer in chimney sweeps. On his findings, Danish Chimney Sweeps Guild ruled that it’s members must bathe daily . No public health measure since that time, has so successfully controlled a form of cancer……!!!

Etiology of Neoplasia ,[object Object],[object Object],[object Object],[object Object],[object Object]

Point to be noted ! ,[object Object]

Preneoplastic conditions ,[object Object],[object Object],[object Object],[object Object],[object Object]

IT’S A MULTISTEP PROCESS ,[object Object],[object Object],[object Object]

Chemical Carcinogenesis: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Chemical Carcinogenesis: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Known Chemical carcinogens ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Lets see mode of action of any one of the chemical carcinogens ! ,[object Object]

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Viral Oncogenesis: ,[object Object],[object Object]

Oncogenic DNA Viruses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Oncogenic DNA Viruses ,[object Object],[object Object]

Oncogenic RNA viruses ,[object Object]

Radiation Carcinogenesis: ,[object Object],[object Object],[object Object],[object Object],Mutations Neoplasia

Molecular Basis of Neoplasia: Proto-oncogene Oncogene V-Onc Other Heredity Radiation Chemical

Remember - Multi-step Process ,[object Object],[object Object],[object Object]

Multi-step Theory ,[object Object],[object Object],[object Object],[object Object]

Summary ,[object Object],[object Object],[object Object],[object Object],[object Object]

It is easy to kill cancer cells, but the challenge is keeping the patient alive at the same time…..!

Do not fear mistakes… fear only the absence of constructive and corrective responses to those mistakes…

Carcinogenesis

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Carcinogenesis