Composition Of Saliva 2010

Biochemistry of saliva ,[object Object],[object Object],[object Object],Dr/ Ragaa Salama

Clinical Highlights ,[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama

Saliva Definition : Secretions of salivary glands (parotid and submandibular/sublingual) Composition of Saliva : 4 major components 1-mucus that serves as a lubricant. 2-amylase ->initiates the digestion of starch. 3-lingual lipase -> begins digestion of fat. 4-electrolyte solution (Na+,Cl - , K+, HCO3 - -> moistens food. 5-proteins& enzymes: Statherins, Proline-rich Proteins (PRPs), Histatins, Cystatins, Lysozyme, Salivary peroxidase Dr/ Ragaa Salama

[object Object],[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama

functions of saliva Dr/ Ragaa Salama Salivary Families Anti- Bacterial Buffering Digestion Mineral- ization Lubricat- ion &Visco- elasticity Tissue Coating Anti- Fungal Anti- Viral Carbonic anhydrases, Histatins Amylases, Mucins, Lipase Cystatins, Histatins, Proline- rich proteins, Statherins Mucins, Statherins Amylases, Cystatins, Mucins, Proline-rich proteins, Statherins Histatins Cystatins, Mucins Amylases, Cystatins, Histatins, Mucins, Peroxidases

Mucin Functions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama

Amylases ,[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama

Lingual Lipase ,[object Object],[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama

Statherins ,[object Object],[object Object],[object Object],Dr/ Ragaa Salama

Proline-rich Proteins (PRPs) ,[object Object],[object Object],[object Object],Dr/ Ragaa Salama

Histatins ,[object Object],[object Object],Dr/ Ragaa Salama Cystatins ,[object Object],[object Object],[object Object],[object Object]

Lysozyme ( LZ ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama

Salivary peroxidase systems ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama

Regulation of oral microorganisms by SP/MP Dr/ Ragaa Salama Food Ingestion carbohydrates Stimulation Metabolism H + Recovery O 2 thiols Inhibition Salivary Glands SCN - + H 2 O 2 OSCN - /HOSCN Autoinhibition spontaneous +SP Unstimulated bacteria Inhibited bacteria Active bacteria

Other anti-microbial activities of LZ ,[object Object],[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama

Anti-microbial activities of saliva Dr/ Ragaa Salama

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama

Composition Of Saliva 2010

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Composition Of Saliva 2010