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Mobile Diabetes Management Service
                with Diabetes Phone




 18 June 2009
 Kevin K. Yi

      Mobile Diabetes Management System_ Healthpia Co., Ltd.   1
CONTENTS


     Hardware


     Why Mobile Phone?


     System Structure


     Operation


     Reliability Test


     Usability Test


     Trial Test


     Conclusion




      Mobile Diabetes Management System_ Healthpia Co., Ltd.   2
Hardware

                                                              Dongle Type
                                                              Dongle Type


Two types;
Dongle & Phone embedded

The Dongle type can be
connected through the
interface or USB port.

The Embedded type is a
battery cover that contains
measuring circuit and a port
to connect with phone.



                                                        Phone Embedded Type
                                                        Phone Embedded Type


           Mobile Diabetes Management System_ Healthpia Co., Ltd.             3
Why Mobile Phone?


     The best way to monitor vital sings of our body for 24/7,
     is to use cellular phone as a mobile gate way.

     The reasons are:
            - Personal device
            - Popularity
            - Power on always
            - Portability
            - Possibility of Data Communication




        Mobile Diabetes Management System_ Healthpia Co., Ltd.   4
System Structure
   Measuring glucose level with Mobile Phone
    Transmit the Results through Mobile Wireless Network
    Data saved in the Data Center
    Analyzing and Retrieving Data (WEB and WAB)
    Feedback the Analyzed Results to Doctor and/or to Guardians
    Managing Nutrition & Exercise



        Data
                                            Guardian Feedback
        Feedback
                                                                                  Guardian Service

                                                                   Customer Center
                                           Data/Results
                                                                   D/B      Call Center
               Measuring
               Glucose Level           Healthcare Information                             Hospital




                                                                                Medical Doctor
                               Analyzing Data
                               And Feedback

                     Emergency
                                                                                     Emergency

                                                  Direct Counsel



           Mobile Diabetes Management System_ Healthpia Co., Ltd.                                    5
Operation

 (1) Measuring: Dongle Type




                  Connect the
                  Dongle Type Gluco+                    Inset Strip and
                  to the Mobile Phone            Check the Blood Glucose Level


          Mobile Diabetes Management System_ Healthpia Co., Ltd.                 6
Operation

 (2) Transmitting Data


    Test Result
                            Transmit
                                                               On the WEB



       110




                                     HealthPia
                                     Data Center


             Mobile Diabetes Management System_ Healthpia Co., Ltd.         7
Operation

 (3) Guardian Service :
    Test results can be transmitted to a designated patient’s family
    member, a medical doctor, or a guardian




         110                                                         06/30/06
                                                                     12:30 pm
                                                                     James blood
                                                                     sugar
                                                                     110 mg/dl




                                                        SMS
                                                       message

        Patient’s             HealthPia                            Guardian’s
         Phone                Data Center                           Phone



          Mobile Diabetes Management System_ Healthpia Co., Ltd.                   8
Operation

 (4) Auto Consultation :
    Based on the test results, programmed automatic message is
    transmitted to the patient in real time.




                                                                    The sugar level is
         110                                                        too low, eat sugar
                                                                    and redo the test
                                                                    in 30 minutes




                          HealthPia
                          Data Center
                                                      Programmed Message


           Mobile Diabetes Management System_ Healthpia Co., Ltd.                        9
Operation

 (5) Data Retrieving from the Data Server




          Mobile Diabetes Management System_ Healthpia Co., Ltd.   10
On the WEB




                                                                    Setting the Details




Personal Information




                                                                    Test Results



           Mobile Diabetes Management System_ Healthpia Co., Ltd.                         11
Nutrition Guide Process

                                       Basic Data




                            +
                                        Nutrition Diary                 Calorie
      Questionnaire                 (Food list and Volume)            Assessment




                                                                        Measuring
        Feedback                                                         System




                                                                    Nutrition Assessment
     Practice Checking                  Nutrition Guide
        Counseling                                                           Data




           Mobile Diabetes Management System_ Healthpia Co., Ltd.                          12
Exercise Guide Process


                              Basic Data




                       +                                                         +
   Questionnaire            Self Examination                Measuring                Activity Check
                           of Physical Strength             BMI, WHR




                                                                  Measuring
                                                                   System
            Feedback




                             Practice Checking
                                Counseling                      Exercise Guide




             Mobile Diabetes Management System_ Healthpia Co., Ltd.                                   13
Prominent Services of MDMS
  The key point is that Healthpia solution enables to form a de facto monitoring
  group for each patient, composed of MDs, nursing agency, parents, friends,
  etc., while all other competing products perform as a stand-alone device.

                                                                                               Glucose
                         Functions and Services                                       Mobile
                                                                                                Meter
  (1) Measuring Glucose Level                                                          Yes      Yes
  (2) Automatic recording and storing the measuring result (Personal
                                                                                       Yes      Yes
  DB)
  (3) The phone speaks the result to the patient                                       Yes       No
  (4) Retrieving all the former data                                                   Yes       No
  (5) Alerting the abnormal result through SMS                                         Yes       No
  (6) Alarming the measuring time                                                      Yes       No
  (7) Checking daily step counts and managing exercise level                           Yes       No
  (8) Periodic diabetes news and dietary contents (ex: calorie book)                   Yes       No
  (9) Analyzing the result by hour, day, and month with graph and/or
                                                                                       Yes       No
  chart
  (10) Automatically sends the result to the family or guardian (**)                   Yes       No
  (11) Direct counsel from doctor or professional institution                          Yes       No

                    Unique Service of Mobile Diabetes Management System
 (**) Called “Guardian service” as a killer application of Healthpia Diabetes Phone



                Mobile Diabetes Management System_ Healthpia Co., Ltd.                                   14
Reliability Test

  Hospital: Seoul National University, College of Medicine, Seoul, Korea
              Department of Medicine Laboratory
  Title: Evaluation of Gluco-phone as a POCT Glucometer
  MD: Hyung-Doo Park, Kyoung Un Park, Junghan Song, and Jin Q Kim
  Year: 2004
  Background : To prevent complications of diabetes, diabetic patients should test blood glucose
  level frequently. In these days, glucometers are widely used for self-monitoring, and many kinds
  of products are introduced. We performed the present study to evaluate the performance of
  glucophone (Healthpia,Co,Ltd.,Seoul,Korea) as a point-of-care testing glucometer.


  Methods : Glucometers including glucophone and FinetestTM (Infopia Co. Ltd., Anyang, Korea)
  were evaluated for its precision, linearity, and accuracy. The interpersonal variation by different
  operators, reagent stability, comparison capillary blood with venous blood, and user
  acceptability were also evaluated.
  Conclusions : Glucophone showed excellent precision, linearity, and correlation with the
  reference method. Since POCT glucometers are influenced by operator and multiple external
  factors, it is important that users recognize interfering factors and preservation conditions of test
  strips. It is hoped that glucophone becomes a good POCT glucose monitoring tool by
  establishing continuous quality control system and improved operation.


                Mobile Diabetes Management System_ Healthpia Co., Ltd.                                    15
Usability Test

  Hospital: Samsung Medical Center, Seoul, Korea
  Title: The Study of Effectiveness of Using Diabetes Phones for Juvenile
          Diabetes Patients
  CN: Eun Kyoung Kwon, Dong Kyu Jin, Kyoung Hoon Baek, Seong Joo Han
  Year: 2004

  Total 26 patients (type 1 : juvenile diabetes patient) during 3 months.
  The parents’ opinions are reflected because the participants are teenagers or less.
                               Questions                                 A   B     C      D      E
   Easiness of usage (for measuring and using contents)                                   O
   Portability (as a medical device)                                                             O
   Accuracy (compare to others)                                                           O
   SMS and Guardian Service                                                                      O
   Effectiveness of glucose control (compare to previous data)                            O
   Direct Counseling Service                                                       O
   Overall customer satisfaction                                                          O

                                                                   Evaluation: “A(Bad) E(Excellent)”


                Mobile Diabetes Management System_ Healthpia Co., Ltd.                               16
Trial Test (1)

  Hospital: Kangnam Saint Mary’s Hospital, Seoul Korea
  Title: The Case Study of HbA1c Level Change
          by Monitoring Internet Diabetes System
  MD: Gun Ho Yoon
  Year: 2005

    Total 120 patients during 12 weeks
    Intervention Group: Monitored with GlucoPack (Diabetes Phone) and Internet.
    Control Group: Monitored with their own glucose meters (normal self testing device)

                                    Intervention                             Control
                           Before                  After          Before               After
    HbA1c                   7.59                   6.94                7.2             7.62
    Normal Criteria      HbA1c<7.0                 6.38         HbA1c<7.0              6.99
    Normal Criteria      HbA1c≥7.0                 7.38         HbA1c≥7.0              8.12


    Conclusion : After 12 weeks, the average HbA1c of Intervention
    Group is decreased 8.5% from the initial value. It means that
    GlucoPack (Diabetes Phone) with Internet Diabetes System is a very
    effective method to control patients’ glucose level.

              Mobile Diabetes Management System_ Healthpia Co., Ltd.                           17
Trial Test (2)

  Hospital: Yi Yong Ro Hospital, Beijing, China
  Title: The Effectiveness of Diabetes Phone for Diabetes.
  MD: Hae Lin Ko
  Year: 2004

    Total 10 patients during 12 weeks.
                      Before Test                                       After Test

        Before Meal        10.96mmol/l (197mg/dl)         Before Meal        7.98mmol/l (144mg/dl)

        After Meal          12.5mmol/l (225mg/dl)         After Meal         9.12mmol/l (164mg/dl)


    Conclusion: Overall 27% of glucose level decreased during the test
    period.

    According to this pilot test, GlucoPack users have kept far more close
    relationship with their doctors. It concluded that the intensive care could
    be done and the effectiveness of managing diabetes is dramatically
    increased.
    Finally, this result ensure that GlucoPack (Diabetes Phone) is the most
    favorable self managing system for diabetes.

              Mobile Diabetes Management System_ Healthpia Co., Ltd.                                 18
Trial Test (3)

  Company: Green Cross Co., Ltd., Seoul Korea
              (One of the largest Pharmaceutical Company in Korea)
  Title: The Effectiveness of Intensive Diabetes Management
  Dpt.: Customer Satisfaction
  Year: 2006


     Total 20 patients were participated in this trial voluntarily for 3months.
                                                                      (from May to July 2006)
     Customer center have monitored and sent messages continually.


   Conclusion: Overall the GlucoPlus is the most effective device for the
   intensive care.
    Patient A : MD recommended stop taking medicine.
    Patient B : Dramatically decreased Glucose level from 500 to 140.




             Mobile Diabetes Management System_ Healthpia Co., Ltd.                             19
Conclusions



• The Mobile Diabetes Management System is

  – Effective for controlling glucose level

  – Efficient for disease management

  – Economic due to saving total medical
    expenses



       Mobile Diabetes Management System_ Healthpia Co., Ltd.   20
Mobile Diabetes Management System_ Healthpia Co., Ltd.   21

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Healthpia : Mobile Diabetes Management Service with Diabetes Phone

  • 1. Mobile Diabetes Management Service with Diabetes Phone 18 June 2009 Kevin K. Yi Mobile Diabetes Management System_ Healthpia Co., Ltd. 1
  • 2. CONTENTS Hardware Why Mobile Phone? System Structure Operation Reliability Test Usability Test Trial Test Conclusion Mobile Diabetes Management System_ Healthpia Co., Ltd. 2
  • 3. Hardware Dongle Type Dongle Type Two types; Dongle & Phone embedded The Dongle type can be connected through the interface or USB port. The Embedded type is a battery cover that contains measuring circuit and a port to connect with phone. Phone Embedded Type Phone Embedded Type Mobile Diabetes Management System_ Healthpia Co., Ltd. 3
  • 4. Why Mobile Phone? The best way to monitor vital sings of our body for 24/7, is to use cellular phone as a mobile gate way. The reasons are: - Personal device - Popularity - Power on always - Portability - Possibility of Data Communication Mobile Diabetes Management System_ Healthpia Co., Ltd. 4
  • 5. System Structure Measuring glucose level with Mobile Phone  Transmit the Results through Mobile Wireless Network  Data saved in the Data Center  Analyzing and Retrieving Data (WEB and WAB)  Feedback the Analyzed Results to Doctor and/or to Guardians  Managing Nutrition & Exercise Data Guardian Feedback Feedback Guardian Service Customer Center Data/Results D/B Call Center Measuring Glucose Level Healthcare Information Hospital Medical Doctor Analyzing Data And Feedback Emergency Emergency Direct Counsel Mobile Diabetes Management System_ Healthpia Co., Ltd. 5
  • 6. Operation (1) Measuring: Dongle Type Connect the Dongle Type Gluco+ Inset Strip and to the Mobile Phone Check the Blood Glucose Level Mobile Diabetes Management System_ Healthpia Co., Ltd. 6
  • 7. Operation (2) Transmitting Data Test Result Transmit On the WEB 110 HealthPia Data Center Mobile Diabetes Management System_ Healthpia Co., Ltd. 7
  • 8. Operation (3) Guardian Service : Test results can be transmitted to a designated patient’s family member, a medical doctor, or a guardian 110 06/30/06 12:30 pm James blood sugar 110 mg/dl SMS message Patient’s HealthPia Guardian’s Phone Data Center Phone Mobile Diabetes Management System_ Healthpia Co., Ltd. 8
  • 9. Operation (4) Auto Consultation : Based on the test results, programmed automatic message is transmitted to the patient in real time. The sugar level is 110 too low, eat sugar and redo the test in 30 minutes HealthPia Data Center Programmed Message Mobile Diabetes Management System_ Healthpia Co., Ltd. 9
  • 10. Operation (5) Data Retrieving from the Data Server Mobile Diabetes Management System_ Healthpia Co., Ltd. 10
  • 11. On the WEB Setting the Details Personal Information Test Results Mobile Diabetes Management System_ Healthpia Co., Ltd. 11
  • 12. Nutrition Guide Process Basic Data + Nutrition Diary Calorie Questionnaire (Food list and Volume) Assessment Measuring Feedback System Nutrition Assessment Practice Checking Nutrition Guide Counseling Data Mobile Diabetes Management System_ Healthpia Co., Ltd. 12
  • 13. Exercise Guide Process Basic Data + + Questionnaire Self Examination Measuring Activity Check of Physical Strength BMI, WHR Measuring System Feedback Practice Checking Counseling Exercise Guide Mobile Diabetes Management System_ Healthpia Co., Ltd. 13
  • 14. Prominent Services of MDMS The key point is that Healthpia solution enables to form a de facto monitoring group for each patient, composed of MDs, nursing agency, parents, friends, etc., while all other competing products perform as a stand-alone device. Glucose Functions and Services Mobile Meter (1) Measuring Glucose Level Yes Yes (2) Automatic recording and storing the measuring result (Personal Yes Yes DB) (3) The phone speaks the result to the patient Yes No (4) Retrieving all the former data Yes No (5) Alerting the abnormal result through SMS Yes No (6) Alarming the measuring time Yes No (7) Checking daily step counts and managing exercise level Yes No (8) Periodic diabetes news and dietary contents (ex: calorie book) Yes No (9) Analyzing the result by hour, day, and month with graph and/or Yes No chart (10) Automatically sends the result to the family or guardian (**) Yes No (11) Direct counsel from doctor or professional institution Yes No Unique Service of Mobile Diabetes Management System (**) Called “Guardian service” as a killer application of Healthpia Diabetes Phone Mobile Diabetes Management System_ Healthpia Co., Ltd. 14
  • 15. Reliability Test Hospital: Seoul National University, College of Medicine, Seoul, Korea  Department of Medicine Laboratory Title: Evaluation of Gluco-phone as a POCT Glucometer MD: Hyung-Doo Park, Kyoung Un Park, Junghan Song, and Jin Q Kim Year: 2004 Background : To prevent complications of diabetes, diabetic patients should test blood glucose level frequently. In these days, glucometers are widely used for self-monitoring, and many kinds of products are introduced. We performed the present study to evaluate the performance of glucophone (Healthpia,Co,Ltd.,Seoul,Korea) as a point-of-care testing glucometer. Methods : Glucometers including glucophone and FinetestTM (Infopia Co. Ltd., Anyang, Korea) were evaluated for its precision, linearity, and accuracy. The interpersonal variation by different operators, reagent stability, comparison capillary blood with venous blood, and user acceptability were also evaluated. Conclusions : Glucophone showed excellent precision, linearity, and correlation with the reference method. Since POCT glucometers are influenced by operator and multiple external factors, it is important that users recognize interfering factors and preservation conditions of test strips. It is hoped that glucophone becomes a good POCT glucose monitoring tool by establishing continuous quality control system and improved operation. Mobile Diabetes Management System_ Healthpia Co., Ltd. 15
  • 16. Usability Test Hospital: Samsung Medical Center, Seoul, Korea Title: The Study of Effectiveness of Using Diabetes Phones for Juvenile Diabetes Patients CN: Eun Kyoung Kwon, Dong Kyu Jin, Kyoung Hoon Baek, Seong Joo Han Year: 2004 Total 26 patients (type 1 : juvenile diabetes patient) during 3 months. The parents’ opinions are reflected because the participants are teenagers or less. Questions A B C D E Easiness of usage (for measuring and using contents) O Portability (as a medical device) O Accuracy (compare to others) O SMS and Guardian Service O Effectiveness of glucose control (compare to previous data) O Direct Counseling Service O Overall customer satisfaction O Evaluation: “A(Bad) E(Excellent)” Mobile Diabetes Management System_ Healthpia Co., Ltd. 16
  • 17. Trial Test (1) Hospital: Kangnam Saint Mary’s Hospital, Seoul Korea Title: The Case Study of HbA1c Level Change by Monitoring Internet Diabetes System MD: Gun Ho Yoon Year: 2005 Total 120 patients during 12 weeks Intervention Group: Monitored with GlucoPack (Diabetes Phone) and Internet. Control Group: Monitored with their own glucose meters (normal self testing device) Intervention Control Before After Before After HbA1c 7.59 6.94 7.2 7.62 Normal Criteria HbA1c<7.0 6.38 HbA1c<7.0 6.99 Normal Criteria HbA1c≥7.0 7.38 HbA1c≥7.0 8.12 Conclusion : After 12 weeks, the average HbA1c of Intervention Group is decreased 8.5% from the initial value. It means that GlucoPack (Diabetes Phone) with Internet Diabetes System is a very effective method to control patients’ glucose level. Mobile Diabetes Management System_ Healthpia Co., Ltd. 17
  • 18. Trial Test (2) Hospital: Yi Yong Ro Hospital, Beijing, China Title: The Effectiveness of Diabetes Phone for Diabetes. MD: Hae Lin Ko Year: 2004 Total 10 patients during 12 weeks. Before Test After Test Before Meal 10.96mmol/l (197mg/dl) Before Meal 7.98mmol/l (144mg/dl) After Meal 12.5mmol/l (225mg/dl) After Meal 9.12mmol/l (164mg/dl) Conclusion: Overall 27% of glucose level decreased during the test period. According to this pilot test, GlucoPack users have kept far more close relationship with their doctors. It concluded that the intensive care could be done and the effectiveness of managing diabetes is dramatically increased. Finally, this result ensure that GlucoPack (Diabetes Phone) is the most favorable self managing system for diabetes. Mobile Diabetes Management System_ Healthpia Co., Ltd. 18
  • 19. Trial Test (3) Company: Green Cross Co., Ltd., Seoul Korea (One of the largest Pharmaceutical Company in Korea) Title: The Effectiveness of Intensive Diabetes Management Dpt.: Customer Satisfaction Year: 2006 Total 20 patients were participated in this trial voluntarily for 3months. (from May to July 2006) Customer center have monitored and sent messages continually. Conclusion: Overall the GlucoPlus is the most effective device for the intensive care.  Patient A : MD recommended stop taking medicine.  Patient B : Dramatically decreased Glucose level from 500 to 140. Mobile Diabetes Management System_ Healthpia Co., Ltd. 19
  • 20. Conclusions • The Mobile Diabetes Management System is – Effective for controlling glucose level – Efficient for disease management – Economic due to saving total medical expenses Mobile Diabetes Management System_ Healthpia Co., Ltd. 20
  • 21. Mobile Diabetes Management System_ Healthpia Co., Ltd. 21