1. Alzheimer's and Parkinson's Diseases Common Cause Erick G. Rodríguez RISE

3. The most common progressive neurologic diseases

4. Irreversible loss of neurons in various areas of the brain

5. Caused by the accumulation of proteins

8. Lewy bodies and Lewy neurities are made of ubiquitin and α-synuclein.

11. eye movement

12. body movementHOPES. 2004. The HOPES Brain Tutorial. Available: http://www.stanford.edu/group/hopes/basics/braintut/ab3.html.

14. Masliah and coworkers at the University of California, San Diego:

15. β-amyloid and α-synuclein are active proteins in both diseases

16. these two proteins work together to create a hybrid protein

19. Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, Mucke L. 2001. β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proceedings of the National Academy of Science of the United States of America 98(21):12245-12250.

20. Nussbaum R, Ellis C. 2003. Alzheimer’s Disease and Parkinson’s Disease. The New England Journal of Medicine 348(14):1356-1364.

21. Parkinson’s Disease Society [Internet]. What is Parkinson’s? [cited 2009 Sep 26]. Available from:http://www.parkinsons.org.uk/about_parkinsons/what_is_parkinsons/what_is_parkinsons.aspx.

22. Tsigelny I, Crews L, Desplats P, Shaked G, Sharikov Y, Mizuno H, Spencer B Rockenstein E, Trejo M, Platoshyn O, Yuan J, Masliah E. 2008. Mechanisms of Hybrid Oligomer Formation in the Pathogenesis of Combined Alzheimer's and Parkinson's Diseases. PLoS ONE [Internet]. [cited 2009 sept 14]; 3(9), Available from: e3135. doi:10.1371/journal.pone.0003135

23. Wasserman S. 2008. Nervous Systems. In: Campbell NA, Reece JB, editors. Biology. San Francisco (CA): Pearson Benjamin Cummings. p. 1082-1083.