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ROBB FRALEY
CHIEF TECHNOLOGY OFFICER


MONSANTO BIENNIAL
U.S. INVESTOR DAY
Nov. 10, 2005




                           1
OVERVIEW

Breeding and Biotech Provide Parallel R&D Paths to
Commercial Products


   BREEDING and BIOTECHNOLOGY form two R&D pathways
   Separate, but parallel, the BREEDING and BIOTECHNOLOGY pathways are linked
   by shared tools.


                 DISCOVERY          PHASE I             PHASE II
    R&D PHASE:                                                          PHASE III     PHASE IV       LAUNCH




                                              BREEDING




                                                                                        COMMERCIAL
                                                          IT PLATFORM
                                            GERMPLASM




G                                                                         ANALYTICS
                                  MARKERS
                       GENOMICS




                                                                                                     SEED
                                               ELITE




Germplasm                                                                                            SOLD TO
                                                                                                     FARMERS
           R

                                    BIOTECHNOLOGY

                                                                                                               2
OVERVIEW

Monsanto Is Partner of Choice for Technology Innovators


                     DISCOVERY                                                          PHASE I
                 Gene/Trait Identification                                           Proof of Concept

           STRUCTURE                 FUNCTION                                            APPLICATION
MONSANTO                          MENDEL                      MENDEL                       MENDEL
Gene libraries                    Transcription factor hits   Hit optimization             Drought, cold, nitrogen, disease
CERES                             ICORIA
Gene libraries                    Gene screening
                                  CERES                       CERES
                                  Gene screening              Gene screening
                                   DEVGEN
                                   Insect control
                                   DIVERGENCE
                                   Nematode control
                                                                                 MONSANTO
                                                                                 Corn & soybean trait testing
                                                                                 MODULAR GENETICS
                                                                                 Protein Optimization
                                                                                                          U of Nebraska
                                                                                 TRAIT
         MONSANTO CAPABILITIES                                                                                    KSU
                                                                                 COLLABORATIONS
                                                                                                                TGI, Inc.
         PARTNER CONTRIBUTION
                                                                                                                Arcadia

                                                                                             MONSANTO
                                                                                             Advanced lead testing in crops

                     >20K GENE/ PROMOTER
GENES TESTED:                                                 >2K GENE/ PROMOTER COMBOS IN CROPS
                     COMBOS
                                                                                                                              3
OVERVIEW

                                          Trait                                DISCOVERY                    PHASE I                  PHASE II            PHASE III     PHASE IV
                                                                                                            Proof Of Concept         Early Development   Advanced      Pre-launch
                                                                               Gene/Trait
                                          Pipeline                                                                                                       Development
                                                                               Identification
                          Roundup Ready Flex Cotton
           Tolerance
           Herbicide




                          Roundup RReady2Yield Soybeans
                          Roundup RReady2Yield Canola
                          Dicamba-tolerant Soybeans
                          2nd-Gen YieldGard Rootworm
                Control




                          2nd-Gen YieldGard Corn Borer
                 Pest
      FARMER BENEFITS




                          YieldGard Rootworm II
                          Soybean nematode-resistance
                          Drought-tolerant Corn
                          Higher-yielding Canola
                          Drought-tolerant Soybeans
Yield




                          Drought-tolerant Cotton
                          Higher-yielding Corn
                          Nitrogen Utilization Corn
                          Cold-tolerant Corn
                          Higher-yielding Soybeans
                          Mavera™ high-value corn with lysine
Enhancements
PROCESSOR




                          Mavera™ I high-value soybeans
   Protein




                          Mavera™ II high-value soybeans
                          2nd-Gen high-value corn with lysine
                          Feed corn with balanced proteins
             L




                          High oil soybeans for processing
             P




                          Improved-protein soybeans
CONSUMER




                          Vistive II Low Lin – Mid Oleic soybeans
             Lipids




                          Vistive III Low Lin – Mid Oleic – Low Sat
                          soybeans
             B




                          Omega-3 Soybeans


      Discovery Platform Abbreviations:
                                                                                                                                                                                    4
                                                      L                          P                              B
                                                          Lipid Enhancements         Protein Enhancements           Bioactive Compounds
OVERVIEW

 Corn Germplasm Improvements Are Tightly Linked to
 Market Share Gains

                                                                            U.S. CORN MARKET SHARE
             2004 CORN YIELD (BU/A)
       220
                                                                           HOLDENS/CORN STATES LICENSEES
                   MONSANTO BRANDED
       210
                                                                           AMERICAN SEEDS, INC. BRANDS
                   COMPETITORS                               60%
       200
                                                                           DEKALB AND ASGROW BRANDS
                                                             50%
       190
2004




                                                             40%
       180
                                                             30%
       170

                                                             20%
       160

       150                                                   10%
               95             100         105         110    0%
                   RELATIVE MATURITIES (DAYS)                       2001         2002     2003     2004    2005



             2005 CORN YIELD (BU/A)                                BREEDING ADVANCES AND ADVANTAGES
       200


                                                                   Strong yield in 2004 translated into
       190

                                                                   a 2-point share gain in 2005
       180
2004




                                                                   In 2005, preliminary data indicates
       170
                                                                   continued yield advantage versus
       160
                                                                   best-in-class competitors
       150
              95        100         105         110    115
                   RELATIVE MATURITIES (DAYS)

                                                                                                                  5
PIPELINE UPDATE

    Cotton States Will Launch New Source
    of Cotton Seed
                                                                                                   KEY MARKET AREAS          U.S.

                                                                                                    TARGET MARKET            7M-8M
                          Cotton States
  CREATING VALUE
                                                                                                   PERCENT PENETRATED            0%

• Licensing fee                 Germplasm licensed from third parties and developed through molecular
  reflects value of top
                                breeding by Monsanto
  quality germplasm,
  separate from value           Taking preliminary orders from licensees; Enough seed for approximately
  of trait
                                1 million acres available for licensing in 2006
• Cotton seed
                                All varieties offered in 2006 will be on a second-generation trait platform
  currently sells for
  average of $20 per
                                            2005 UNIVERSITY COTTON VARIETY TESTS
  acre retail
                                                              1,300
            UP NEXT
                                              LBS LINT/ACRE




                                                              1,200
• 4+ licensees will
  sell seed sourced
  from Cotton States
                                                              1,100
  in 2006, located
  broadly throughout
  Cotton Belt
                                                              1,000
                                                                         COTTON STATES              COMPETITIVE
                                                                           VARIETIES                 VARIETIES

                          DISCOVERY    PHASE I                                        PHASE III
                                                                  PHASE II                               PHASE IV       LAUNCH
                                       Proof of Concept                               Adv. Development
                                                                  Early Development                      Pre-Launch

                                                                                                                                      6
OVERVIEW



             Seminis       DISCOVERY                          PHASE II     PHASE III      PHASE
                                                 PHASE I
                                                                                                              LAUNCH
                                                                                             IV
                                                  Proof Of
             Pipeline
                             Gene/Trait                         Early       Advanced
                                                  Concept
                            Identification                   Development   Development   Pre-launch
                         BREED
                              ING SE
                                    LECTIO
                                             N
      VEGETABLE
       BREEDING
  FAMILIES
 SOLANACEOUS             QUALITY TARGETS                                                              2005
  Tomato                                                                                              Vencedor Hot Pepper
  Pepper                                                                                              2006/7
  Eggplant                                                                                            TYLCV Tomato
 CUCURBITS                                                                                            2005
                            Grower
  Melon    Watermelon                                                                                 MVR Squash
  Cucumber Squash         Performance                                                                 PX03913198 Melon
  Gourd                                                                                               2006/7
                                                                                                      High-Quality Watermelon
                           Horticultural
 LARGE SEED                                                                                           2005
                             Quality
  Beans     Okra                                                                                      Devotion Sweet Corn
  Peas      Sweet Corn                                                                                2006/7
                            Disease                                                                   Sweeter Peas
 BRASSICA                  Resistance                                                                 2005
                                                 DOZENS      DOZENS        DOZENS          <10
  Broccoli                                                                                            Ironman Broccoli
  Cauliflower                                                                                         2006/7
  Cabbage                   Shelf Life                                                                Curd Yield & Quality
  Brussels Sprouts                                                                                    Cauliflower
 ROOT & BULB                Consumer                                                                  2005
  Onion    Beet                                                                                       Fahrenheit Leek
                              Traits
  Leek     Carrot                                                                                     Invicta Carrot
                                                                                                      2006/7
                                                                                                      Low-Pungency onion
                             Seed
 LEAFY                                                                                                2005
                          Producibility
  Lettuce                                                                                             Boomerang Lettuce
  Spinach                                                                                             2006/7
  Celery
                                                                                                      Processing Butterhead
                                                                                                      Improved Mechanically
                                                                                                      Harvested-Spinach
                                                                                                                                7
PIPELINE UPDATE

Conversion from Open-Pollinated to Hybrid Offers
Opportunity in Mexican Market                 KEY
                                     CROP                                                                            PENETRATION
                                             MARKET
                                                                                                        (Acres)

                                                                                       SQUASH
                     Mexican OP Conversion
                                                                                                         100K             5%
CREATING VALUE
                                                                                       CARROTS            67K             10%

                                                                                       ONIONS
                2005 FIELD REPORT
                                                                                                          76K             40%

                                                                                   HOT PEPPERS           298K             40%
                                Mexican OP Conversion
               MULTI-STAGE: PHASE II THROUGH LAUNCH
                                                                            NEW MARKET OPPORTUNITY

                                                                                 $70                    CURRENT MARKET
   Not as well as                                Better than
                        As expected
                                                                                 $60
   expected                                      expected                                               POTENTIAL MARKET
                                                                                 $50




                                                                    $ MILLIONS
Quality
                                                                                 $40
                                                                                 $30
Horticultural Performance
                                                                                 $20
                                                                                 $10
New Hybrids
                                                                                  $0
                                                                                          HOT        SQUASH       ONION   CARROT
OBSERVATIONS
                                                                                        PEPPER
• Able to achieve increased uniformity, earlier maturity,
  higher produce quality
• Higher market yield and profitability
• Better disease resistance
• Value of hybrids already being recognized in the market


                    DISCOVERY      PHASE I                                        PHASE III
                                                      PHASE II                                       PHASE IV         LAUNCH
                                   Proof of Concept                               Adv. Development
                                                      Early Development                              Pre-Launch

                                                                                                                                   8
PIPELINE UPDATE

Molecular Breeding Helps Target Novel Approaches to
Disease Resistance                               EUROPE N.
                                KEY MARKET AREAS                                                                                                          JAPAN
                                                                                                                        -AFRICA          AMERICA

                      Geminivirus (Ty)                            AVAILABLE MARKET                                            57K             88K          3K

                      Resistance in Tomato
CREATING VALUE                                                    PERCENT PENETRATED                                          31%             1%           0%


                                                                         OPPORTUNITY: NOVEL DISEASE
                 2005 FIELD REPORT
                                                                         RESISTANCE, MARKERS & IP OPEN
                                                                         MARKET ACCESS
   Ty Resistance Stacked with Nematode Resistance in High
                             Flavor Pink Tomatoes (Japan)
                                                                                          PROVEN SUCCESS IN EUROPE-AFRICA
                                                 PHASE II
                                                                                                       15                                                  60
                                        Early Development




                                                                                           $ (m illio n s )




                                                                                                                                                                # OF CULTIVARS
                                                                                                       10                                                  40
    Not as well as                              Better than
                         As expected
    expected                                    expected                                                      5                                            20




                                                                   CHROMOSOME 6
                                                                                                              0                                            0
 Shelf Life
                                                                                                                  99     00         01   02     03   04
 Fruit Quality

 Horticultural Performance
                                                                                                  MARKER
                                                                                  Ty-1            ENABLED
 OBSERVATIONS
 • Demonstrating excellent disease resistance; Patents are
   pending for traits
                                                                                                                        FUTURE IN JAPAN; TY-MI +
 • Leads show promise for high-flavor pink tomatoes, high-
                                                                                                                         HIGH FLAVOR TOMATOES
   value commercial opportunities


                     DISCOVERY    PHASE I                                         PHASE III
                                                     PHASE II                                                          PHASE IV               LAUNCH
                                  Proof of Concept                                Adv. Development
                                                     Early Development                                                 Pre-Launch

                                                                                                                                                                                 9
PIPELINE UPDATE

  Herbicide-Tolerance Focus Has Shifted to Second- and Third-
  Generation Traits in Larger Product Family

CREATING VALUE




FARMER BENEFITS                                           Roundup Ready Flex for
                                                          cotton is first-ever second-
DISCOVERY PLATFORM: HERBICIDE TOLERANCE
                                                          generation trait in weed
                          PHASE   PHASE   PHASE   PHASE
                      D
         PLATFORM           I       II      III     IV
                                                          control
HERBICIDE TOLERANCE

                                                          Second-generation traits for
 ROUNDUP READY
 FLEX COTTON
                                                          soybeans and canola are in
 ROUNDUP
                                                          mid-phases of pipeline
 RREADY2YIELD
 SOYBEANS
                                                          Third-generation product
 ROUNDUP
 RREADY2YIELD
                                                          already in Phase II for
 CANOLA
                                                          soybeans, stacks two modes
 DICAMBA-TOLERANT
 SOYBEANS
                                                          of action
 DICAMBA-TOLERANT
 COTTON




                                                                                         10
PIPELINE UPDATE

Roundup RReady2Yield Soybeans Expand Weed
Control Window
                                                                     KEY MARKET ACRES           U.S.     BRAZIL ARGENTINA

                     Roundup RReady2Yield                                                                 50M       35M
                                                                                                70M
                                                                     AVAILABLE MARKET
                     Soybeans
CREATING VALUE
                                                                                                0%        0%            0%
                                                                     PERCENT PENETRATED


                  2005 FIELD REPORT                                  IMPLEMENTATION OF MARKER ASSISTED
                                                                     SELECTION IN TRAIT INTEGRATION
                        Roundup RReady2Yield Soybeans
                                             PHASE III
                                 Advanced Development
       Not as well as     As                  Better than
       expected           expected            expected

    Trait Performance

    Agronomic Performance
                                         LEAD GENE: COMPLETED
    Lead Selection                       LEAD EVENT: COMPLETED

    OBSERVATIONS
    • Lead event confirmed in April of 2005
    • Trait integration efforts started
    • Implementation of marker assisted selection




                  DISCOVERY       PHASE I                                PHASE III
                                                     PHASE II                               PHASE IV           LAUNCH
                                  Proof of Concept                       Adv. Development
                                                     Early Development                      Pre-Launch

                                                                                                                             11
PIPELINE UPDATE

 Third-Generation of Soy Weed Control Gives Farmers
 Two Unique Modes of Action
                                                                        KEY MARKET ACRES           U.S.     BRAZIL ARGENTINA

                      Dicamba-Tolerant                                                             80M       50M       35M
                                                                        AVAILABLE MARKET
                      Soybeans
CREATING VALUE
                                                                                                   0%        0%            0%
                                                                        PERCENT PENETRATED


                    2005 FIELD REPORT                                   FIELD TESTING VALIDATING TOLERANCE
                                   Dicamba-Tolerant Soybeans
                                                                               DICAMBA TOLERANT
                                                     PHASE II
                                           Early Development
   Not as well as                                 Better than
                          As expected
   expected                                       expected

Trait Performance

Agronomic Performance

                                                                                               NON TRANSGENIC
                                              LEAD GENE: COMPLETED
Lead Selection                               LEAD EVENT: IN PROGRESS

OBSERVATIONS
• Tolerance demonstrated at both pre-emergence and post-
  emergence application timing
                                                                                      Dicamba Resistant Soybean
• No visual crop injury at rates of 1.5lb/acre, 3X labeled use
                                                                                  Post Emergent Application of 1.5 lb/a
  rate

                     DISCOVERY       PHASE I                                PHASE III
                                                        PHASE II                               PHASE IV           LAUNCH
                                     Proof of Concept                       Adv. Development
                                                        Early Development                      Pre-Launch

                                                                                                                                12
PIPELINE UPDATE

Roundup RReady2Yield Canola Is Newest Addition to
Herbicide-Tolerance Family
                                                                    KEY MARKET ACRES           U.S.     EUROPE     CANADA

                      Roundup RReady2Yield                                                     TBD       TBD        TBD
                                                                    AVAILABLE MARKET
                      Canola
CREATING VALUE
                                                                                               0%         0%            0%
                                                                    PERCENT PENETRATED


                    2005 FIELD REPORT                               NEW BENEFIT TO CANOLA FARMERS
                             Roundup RReady2Yield Canola                 Enhanced crop tolerance will allow greater
                                                                                          application flexibility
                                                PHASE II
                                       Early Development
                                                                                       CURRENT EVENT
   Not as well as                             Better than
                        As expected
   expected                                   expected

Trait Performance

Agronomic Performance

                                          LEAD GENE: COMPLETED
Lead Selection                           LEAD EVENT: IN PROGRESS

OBSERVATIONS                                                                                              NEW EVENT
• Field performance shows enhanced tolerance to Roundup
  herbicide
• Stacked with yield genes to deliver enhanced yield from
                                                                        Tolerance at rates representing 8x standard
  nitrogen use efficiency and enhanced seed yield
                                                                        use rate

                    DISCOVERY    PHASE I                                PHASE III
                                                    PHASE II                               PHASE IV            LAUNCH
                                 Proof of Concept                       Adv. Development
                                                    Early Development                      Pre-Launch

                                                                                                                             13
PIPELINE UPDATE

  Insect Control Discovery Program Approaching Second-
  Generation Commercialization

CREATING VALUE




FARMER BENEFITS                                          Second-generation YieldGard
                                                         corn borer builds on triple-
DISCOVERY PLATFORM: PEST CONTROL
                                                         stack corn platform and
                         PHASE   PHASE   PHASE   PHASE
                     D
         PLATFORM          I       II      III     IV
                                                         expands potential for new
PEST CONTROL
                                                         acreage penetration
 SECOND-GENERATION
 YIELDGARD CORN
                                                         YieldGard corn rootworm
 ROOTWORM
                                                         next-generation discovery
 SECOND-GENERATION
 YIELDGARD CORN
                                                         improves production of
 BORER
                                                         stacked traits while
 YIELDGARD
 ROOTWORM CORN II                                        enhancing performance
 SOYBEAN NEMATODE-
 RESISTANCE




                                                                                        14
PIPELINE UPDATE

Second-Generation YieldGard Corn Borer Expands
Insect Spectrum and Acreage Potential
                                                                     KEY MARKET ACRES           U.S.     BRAZIL ARGENTINA

                     Second-Generation                                                          50M       15M           4M
                                                                     AVAILABLE MARKET
                     YieldGard Corn Borer
CREATING VALUE
                                                                                                0%        0%            0%
                                                                     PERCENT PENETRATED

                 2005 FIELD REPORT
                                                                   NEW BENEFIT TO CORN FARMERS
                    Second-Generation YieldGard Corn Borer
                                                                     Second-generation YieldGard Corn Borer offers
                                                 PHASE III
                                                                     unparalleled combination of insect control and
                                    Advanced Development
                                                                     resistance management
   Not as well as                             Better than
                         As expected
   expected                                   expected
                                                                                     FALL ARMYWORM
Trait Performance

Agronomic Performance

                                         LEAD GENE: COMPLETED
Lead Selection                           LEAD EVENT: COMPLETED

OBSERVATIONS
• Excellent control of targeted pests – raises bar for corn
  earworm and fall armyworm control
• Outstanding yields, including stacks for rootworm control
                                                                           2ND GEN YGCB                CONVENTIONAL
• Insect resistance management benefit unique to market
• Lead event selected for regulatory submissions

                    DISCOVERY     PHASE I            PHASE II                               PHASE IV           LAUNCH
                                                                         PHASE III
                                  Proof of Concept   Early Development                      Pre-Launch
                                                                         Adv. Development

                                                                                                                             15
PIPELINE UPDATE

Second-Generation YieldGard Corn Rootworm
Reinvents Stacked Corn Platform
                                                                      KEY MARKET ACRES                       U.S.     BRAZIL ARGENTINA

                     Second-Generation                                                                        25M                 1M
                                                                      AVAILABLE MARKET                                 5M
                     YieldGard Rootworm
CREATING VALUE
                                                                                                              0%       0%         0%
                                                                      PERCENT PENETRATED

                 2005 FIELD REPORT
                                                                    CRW INFESTATION CONTINUES TO EXPAND
                    Second-Generation YieldGard Rootworm
                                                PHASE IV
                                               Pre-Launch
   Not as well as                             Better than
                         As expected
   expected                                   expected

Trait Performance

Agronomic Performance
                                         LEAD GENE: COMPLETED
Lead Selection                           LEAD EVENT: COMPLETED

OBSERVATIONS
                                                                  Percent Acres Treated and/or Planted
• Vector-stack delivered outstanding performance for
                                                                         Corn Acres - not treated
  corn rootworm control and Roundup Ready crop safety                    0.1 - 25 % treated

• Monsanto to launch 2nd generation CRW stacked-traits                   25.1 - 50 % treated

  while competitors introduce 1st generation singles                     >50% treated



• Will introduce to seed licensees in 2006 with commercial
  sales expected in 2007 or 2008

                    DISCOVERY     PHASE I                                  PHASE III
                                                     PHASE II                                            PHASE IV        LAUNCH
                                  Proof of Concept                         Adv. Development
                                                     Early Development                                   Pre-Launch

                                                                                                                                       16
PIPELINE UPDATE


  Yield Platform Has Expanded Most Dramatically of All
  Families in Past Year

CREATING VALUE




FARMER BENEFITS                                            Drought traits have been
                                                           applied to new crops,
DISCOVERY PLATFORM: YIELD
                                                           expanded in corn
                           PHASE   PHASE   PHASE   PHASE
          PLATFORM     D
                             I       II      III     IV
                                                           Next-generation leads are
DROUGHT-TOLERANT

                                                           being developed
 CORN

                                                           simultaneously with
 SOYBEANS

                                                           advancement of first-
 COTTON
INTRINSIC YIELD                                            generation products
 CORN
 SOYBEANS
 CANOLA
NITROGEN UTILIZATION
 CORN
COLD-TOLERANT
 CORN




                                                                                       17
PIPELINE UPDATE

Drought-Tolerant Corn Is Lead Crop of Yield Family of
Traits
                                                                     KEY MARKET ACRES               U.S.          BRAZIL ARGENTINA

                                                                                                    80M             30M                     6M
                                                                     AVAILABLE MARKET
                      Drought-Tolerant Corn
CREATING VALUE
                                                                                                        0%           0%                     0%
                                                                     PERCENT PENETRATED

                                                                     CONSISTENT RESULTS FROM EARLY
                  2005 FIELD REPORT
                                                                     LEADS AND MORE LEADS EMERGING
                                                                     FROM PIPELINE
                                       Drought-Tolerant Corn
                                                    PHASE II             WITH TRAIT     WITHOUT TRAIT        WITH TRAIT    WITHOUT TRAIT
                                          Early Development
   Not as well as                             Better than
                         As expected
   expected                                   expected

 Trait Performance

 Agronomic Performance                                                                                                      o
                                                                                                                                C   32 34    40



                                          LEAD GENE: COMPLETED
 Lead Selection                          LEAD EVENT: IN PROGRESS

 OBSERVATIONS
 • Lead genes show consistent drought stress performance
   across years
 • Mid-season drought performance results in more,
   bigger ears
 • Up Next: Advance into early development
                                                                                                                    WITHOUT TRAIT
                                                                                WITH TRAIT


                     DISCOVERY   PHASE I                                 PHASE III
                                                     PHASE II                                 PHASE IV                    LAUNCH
                                 Proof of Concept                        Adv. Development
                                                     Early Development                        Pre-Launch

                                                                                                                                                  18
PIPELINE UPDATE



Drought-Tolerant Cotton Performance Encouraging in
Early Field Evaluation           KEY MARKET ACRES U.S.                                                        AUSTRALIA


                     Drought-Tolerant Cotton
                                                                     AVAILABLE MARKET               7M          0.5M
CREATING VALUE
                                                                                                    0%           0%
                                                                     PERCENT PENETRATED


                 2005 FIELD REPORT
                                                                                                          FROM
                                                                                                         GREENHOUSE
                                   Drought-Tolerant Cotton
                                                                                                         TESTING TO….
                                                  PHASE I
                                         Proof of Concept
                                                                                                               …FIRST
                                                                                       DROUGHT-             YEAR FIELD
   Not as well as                             Better than                CONTROL
                        As expected                                                    TOLERANT
                                                                                                              TRIALS
   expected                                   expected

Trait Performance

Agronomic Performance
                                         LEAD GENE: IN PROGRESS
Lead Selection                               LEAD EVENT: N/A

OBSERVATIONS
• Drought leads are working across crops
• First leads into cotton are showing promise
• Next up: Continued evaluation to assess drought
                                                                                                         DROUGHT-
                                                                              CONTROL
  performance
                                                                                                         TOLERANT


                    DISCOVERY     PHASE I                                PHASE III
                                                     PHASE II                               PHASE IV       LAUNCH
                                  Proof of Concept                       Adv. Development
                                                     Early Development                      Pre-Launch

                                                                                                                        19
PIPELINE UPDATE

Nitrogen Utilization Corn Moved From Greenhouse to
Field Work in 2005
                                                                     KEY MARKET ACRES           U.S.     BRAZIL ARGENTINA


                      Nitrogen Utilization Corn
                                                                                                80M       30M            6M
                                                                     AVAILABLE MARKET
CREATING VALUE
                                                                                                0%         0%            0%
                                                                     PERCENT PENETRATED


                  2005 FIELD REPORT                                                                               FROM
                                                                                                                 GREEN-
                                   Nitrogen Utilization Corn
                                                                                                                 HOUSE
                                                    PHASE I                                                      TESTING
                                          Proof of Concept                                                       TO…
    Not as well as                             Better than                                                          …FIRST
                         As expected
    expected                                   expected                                                               YEAR
                                                                                                  GENE H
                                                                                    Control
                                                                                                                      FIELD
 Trait Performance
                                                                                                                   TRIALS
                                                                   CONTROL          GENE F
 Agronomic Performance
                                         LEAD GENE: IN PROGRESS
 Lead Selection                              LEAD EVENT: N/A
                                                                                                                    G
                                                                                                                        en
                                                                                                                           e
 OBSERVATIONS
                                                                                                                               s
 • Enhanced nitrogen utilization is challenging trait
 • Industrial scale genomics effort is generating leads
 • Up Next: Optimization to improve trait performance and
   continued screening                                                                                              HIGH N
                                                                                                 MED N
                                                                              LOW N



                     DISCOVERY    PHASE I                                PHASE III
                                                     PHASE II                               PHASE IV            LAUNCH
                                  Proof of Concept                       Adv. Development
                                                     Early Development                      Pre-Launch

                                                                                                                                   20
PIPELINE UPDATE


  Processor Benefits Projects Represent New Approach to
  Market Not Traditionally Served by Seed Innovations

CREATING VALUE




PROCESSOR BENEFITS                                         Mavera High-Value Corn with
                                                           lysine represents first biotech
                           PHASE   PHASE   PHASE   PHASE
                                                           product from our Renessen
                       D
          PLATFORM           I       II      III     IV
                                                           collaboration
PROTEIN AND/ OR
ENHANCEMENTS
                                                           Like Vistive, Mavera
 MAVERA HIGH-VALUE
 CORN WITH LYSINE
                                                           represents a family of
 MAVERA I HIGH-VALUE
                                                           products
 SOYBEANS
 MAVERA II HIGH-
                                                           Renessen joint venture
 VALUE SOYBEANS
                                                           includes both biotech and
 HIGH OIL SOYBEANS
 FOR PROCESSING
                                                           breeding approaches to
 SECOND-GENERATION
                                                           adding value in the feed
 HIGH-VALUE CORN
 WITH LYSINE
                                                           industry
 FEED CORN WITH
 BALANCED PROTEINS




                                                                                             21
PIPELINE UPDATE

First-Generation High-Value Corn with Lysine in Final
Phases of Regulatory Reviews
                                                                        KEY MARKET ACRES           U.S.     BRAZIL ARGENTINA

                     Mavera High-Value Corn                                                         5M       2M            1M
                                                                        AVAILABLE MARKET
                     with Lysine
CREATING VALUE
                                                                                                    0%       0%            0%
                                                                        PERCENT PENETRATED


                 2005 FIELD REPORT
                                                                                                  FIELD DATA VALIDATES
                                                                                                        LYSINE TARGETS
                         Mavera High-Value Corn with Lysine
                                                 PHASE IV
                                                                             5000
                                                Pre-Launch
                                                                             4000
   Not as well as                               Better than
                          As expected
   expected                                     expected
                                                                             3000
Trait Performance
                                                                                          1ST GENERATION
                                                                             2000
Agronomic Performance
                                                                                                               MINIMUM
                                                                             1000
                                           LEAD GENE: COMPLETED
Competitive Comparison                                                                                         TARGET
                                           LEAD EVENT: COMPLETED

                                                                                0               SOUTH U.S. RESULT
                                                                                    CONTROL
OBSERVATIONS
                                                                                               AMERICA   (2004)
                                                                                               RESULT
• Final year of field trial work confirms lysine targets in                                     (2005)
  commercial-quality germplasm
• Completed FDA Consultation; USDA comment period
  underway
• Final approvals anticipated for 2007 launch

                    DISCOVERY        PHASE I                                PHASE III
                                                        PHASE II                               PHASE IV           LAUNCH
                                     Proof of Concept                       Adv. Development
                                                        Early Development                      Pre-Launch

                                                                                                                                22
PIPELINE UPDATE


  Vistive Family of Traits Continues To Offer Additive Value
  as New Consumer Products Advance

CREATING VALUE




CONSUMER BENEFITS                                            Monsanto and Solae recently
                                                             announced an agreement for
                                                             our improved-protein
                             PHASE   PHASE   PHASE   PHASE
                         D
           PLATFORM            I       II      III     IV
                                                             soybeans
PROTEIN
ENHANCEMENTS
                                                             Vistive II and III build on the
 IMPROVED-PROTEIN
                                                             low-linolenic platform
 SOYBEANS FOR FOOD
                                                             launched in 2005 with
LIPID ENHANCEMENTS

                                                             additional qualities that
 VISTIVE II LOW LIN –
 MID OLEIC SOYBEANS
                                                             improve the oil profile
 VISTIVE III LOW LIN –
 MID OLEIC – LOW SAT
 SOYBEANS
BIOACTIVE COMPOUNDS
 OMEGA-3 SOYBEANS




                                                                                               23
PIPELINE UPDATE

Improved-Protein Soybeans for Food Poised for
Commercial Track Following Solae Announcement
                                                                     KEY MARKET ACRES            U.S.     BRAZIL ARGENTINA

                      Improved-Protein                                                           <1M       TBD         TBD
                                                                     AVAILABLE MARKET
                      Soybeans for Food
CREATING VALUE
                                                                                                 0%        0%            0%
                                                                     PERCENT PENETRATED


                  2005 FIELD REPORT
                        Improved-Protein Soybeans for Food
                                                 PHASE III
                                    Advanced Development
    Not as well as                              Better than
                         As expected
    expected                                    expected                     IMPROVED SOLUBILITY PROFILE
 Trait Performance
                                                                   VINTON 81

 Agronomic Performance                                           COMMODITY

 Lead Selection                                                    MON HBC
                                                COMPLETED


 OBSERVATIONS                                                        CASEIN

 • Completed alliance with Solae                                               0     2       4        6     8     10      12
                                                                                     MEDIAN PARTICLE DIAMETER (MICRONS)
 • Early food formulation work very promising
                                                                            High beta-conglycinin presence
 • Strong yield and agronomic performance
                                                                         translates to mouth-feel more comparable
                                                                         to conventional dairy products


                     DISCOVERY    PHASE I                                PHASE III
                                                     PHASE II                               PHASE IV            LAUNCH
                                  Proof of Concept                       Adv. Development
                                                     Early Development                      Pre-Launch

                                                                                                                               24
PIPELINE UPDATE

 Vistive Family of Improved Oils Meets Multiple Needs in
 Food Industry


     TARGET: LOW LINOLENIC        TARGET: LOW LINOLENIC
                                                                      TARGET: LOW SAT
          VISTIVE SOYBEANS        VISTIVE RAPESEED                    +INCREASED OLEIC
                                                                      + LOW LINOLENIC
                 2005 LAUNCH      2005 LAUNCH
             500K ACRES IN US     40K ACRES IN EUROPE
                                                                      VISTIVE III LOW LIN –
                                                                      MID OLEIC – LOW SAT
                                            TARGET: INCREASED OLEIC
                                                                      SOYBEANS
                                            + LOW LINOLENIC
VISTIVE                                                               PHASE II
FAMILY                                      VISTIVE II LOW LIN –
                                            MID OLEIC SOYBEANS                           CONSUMER
                                            PHASE III                                     MARKET


                                                                                   OIL FOR
                                                                                   FRYING AND
                                IMPROVED SOYBEAN
                                                                                   SPRAYING
                                QUALITY FOR LIQUID OILS                            Crackers
                                                                                   Snack chips




                                                                                                    25
PIPELINE UPDATE

Vistive II Adds Improved Oleic Content to Current
Vistive Low Lin Product
                                                                       KEY MARKET ACRES           U.S.     BRAZIL ARGENTINA

                      Vistive II Low Lin –                                                        30M       TBD           TBD
                                                                       AVAILABLE MARKET
                      Mid-Oleic Soybeans
CREATING VALUE
                                                                                                   0%       0%            0%
                                                                       PERCENT PENETRATED


                  2005 FIELD REPORT
                      Vistive II Low Lin – Mid-Oleic Soybeans
                                                     PHASE III
                                       Advanced Development
    Not as well as                                Better than
                          As expected                                 50% of the oil
    expected                                      expected
                                                                      of Vistive II is
 Trait Performance                                                         mid-oleic,
                                                                          improving
 Agronomic Performance                                                     overall oil
                                                                            profile
 Lead Selection                                   COMPLETED
                                                                                                              Mid Oleic
 OBSERVATIONS                                                                   Linolenic     Linoleic                    Sats
                                                                                                                 18:1
                                                                     STANDARD
 • Achieved commercial targets of 50% oleic and 3%                        SOY
   linolenic composition in field testing
                                                                      MID-OLEIC
 • Molecular marker selection was implemented enabling
                                                                           SOY
   plant selections with compositions for line advancements



                     DISCOVERY      PHASE I                                PHASE III
                                                       PHASE II                               PHASE IV           LAUNCH
                                    Proof of Concept                       Adv. Development
                                                       Early Development                      Pre-Launch

                                                                                                                                 26
PIPELINE UPDATE

Omega-3 Oil Production in Soybeans: Initial Taste,
Smell and Oil Stability Results Promising
                                                                                   KEY MARKET ACRES         U.S.      EU         ROW

                                                                                                            TBD      TBD         TBD
                                                                                   AVAILABLE MARKET
                         Omega-3 Soybeans
CREATING VALUE
                                                                                                            0%        0%         0%
                                                                                   PERCENT PENETRATED


                    2005 FIELD REPORT
                                                                                   SDA OIL TASTES RESULTS 2005
                                                  Omega-3 Soybeans
                                                           PHASE II
                                                                                   10
                                                  Early Development
                                                                                    5
   Not as well as                                      Better than
                              As expected
   expected                                            expected
                                                                                    0
Trait Performance
                                                                                          Soy Oil         SDA Oil        Fish Oil
(INCLUDES OIL TASTE, SMELL AND STABILITY)

                                                                                             Taste Rating 0-15 Scale
Agronomic Performance
                                                                                             Score of zero indicates no taste
                                                  LEAD GENES: COMPLETED
Lead Selection                                    LEAD EVENT: COMPLETED
                                                                                       In taste-testing, stearidonic acid (SDA) oil
                                                                                     compares favorably versus fish oil and
OBSERVATIONS
                                                                                     commodity soy oil
• 2004 U.S. and 2005 Argentine field trials continue to
  confirm expression of SDA levels at concept targets
• Initial sensory data superior to fish oil
• SDA oil stability results are promising


                       DISCOVERY            PHASE I                                 PHASE III
                                                               PHASE II                                PHASE IV         LAUNCH
                                            Proof of Concept                        Adv. Development
                                                               Early Development                       Pre-Launch

                                                                                                                                       27
SUMMARY

New Traits, Trait Upgrades and New Stacked
Combinations Are Creating New Platforms for Farmers

CORN
                    2005                                    2010F                                      2015F
                           Preferred Trait                            Preferred Trait                       Preferred Trait
  Trait Offerings                             Trait Offerings                            Trait Offerings
                           Combinations                               Combinations                          Combinations
ROUNDUP READY                                ROUNDUP READY                              ROUNDUP READY
                      STACKED –                                 STACKED –                                  STACKED –
   CORN 2                                       CORN 2                                     CORN 2
                      DOUBLE:                                   TRIPLE:                                    TRIPLE + YIELD
                      YIELDGARD PLUS
  YIELDGARD                                    YIELDGARD                                  YIELDGARD        TRAITS:
                      YGCB + RR                                 YGRW+YGCB+RR
  ROOTWORM                                     ROOTWORM                                   ROOTWORM
                      YGRW + RR
YIELDGARD CORN                               2nd GENERATION                             2nd GENERATION     2nd GEN YGCB +
                                                                STACKED –
                      STACKED –
     BORER                                        YGRW                                       YGRW          2nd GEN YGRW +
                                                                2nd GEN TRIPLE:
                      TRIPLE:                                                                              RR
                                             YIELDGARD CORN                             YIELDGARD CORN
                                                                                                           + DROUGHT
                                                  BORER                                      BORER
                                                                2nd GEN YGCB +
                      YGRW+YGCB+RR                                                                         + INTRINSIC
                                                                2nd GEN YGRW +
                                             YIELDGARD CORN                             YIELDGARD CORN     + NITROGEN
                                                                RR
                                                  BORER                                      BORER
                                              HIGH-VALUE                                 HIGH-VALUE        STACKED – TRIPLE
                                                                STACKED – TRIPLE
                                             CORN W/ LYSINE                             CORN W/ LYSINE     + FEED TRAITS +
                                                                + FEED TRAITS:
                                                                                                           YIELD TRAITS:
                                                                                         2nd GEN HIGH-
                                                                                        VALUE CORN W/
                                                                HIGH-VALUE
                                                                                             LYSINE        2nd GEN HIGH-
                                                                CORN W/ LYSINE +
                                                                                        FEED CORN WITH     VALUE CORN W/
                                                                YGRW + YGCB +
                                                                                           BALANCED        LYSINE + YGRW +
                                                                RR
                                                                                           PROTEINS        YGCB + RR
       FARMER BENEFITS
                                                                                        YIELD: DROUGHT
       PROCESSOR BENEFITS
       CONSUMER BENEFITS                                                                YIELD: INTRINSIC

                                                                                        YIELD: NITROGEN




                                                                                                                              28

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monsanto 11-10-05b

  • 1. ROBB FRALEY CHIEF TECHNOLOGY OFFICER MONSANTO BIENNIAL U.S. INVESTOR DAY Nov. 10, 2005 1
  • 2. OVERVIEW Breeding and Biotech Provide Parallel R&D Paths to Commercial Products BREEDING and BIOTECHNOLOGY form two R&D pathways Separate, but parallel, the BREEDING and BIOTECHNOLOGY pathways are linked by shared tools. DISCOVERY PHASE I PHASE II R&D PHASE: PHASE III PHASE IV LAUNCH BREEDING COMMERCIAL IT PLATFORM GERMPLASM G ANALYTICS MARKERS GENOMICS SEED ELITE Germplasm SOLD TO FARMERS R BIOTECHNOLOGY 2
  • 3. OVERVIEW Monsanto Is Partner of Choice for Technology Innovators DISCOVERY PHASE I Gene/Trait Identification Proof of Concept STRUCTURE FUNCTION APPLICATION MONSANTO MENDEL MENDEL MENDEL Gene libraries Transcription factor hits Hit optimization Drought, cold, nitrogen, disease CERES ICORIA Gene libraries Gene screening CERES CERES Gene screening Gene screening DEVGEN Insect control DIVERGENCE Nematode control MONSANTO Corn & soybean trait testing MODULAR GENETICS Protein Optimization U of Nebraska TRAIT MONSANTO CAPABILITIES KSU COLLABORATIONS TGI, Inc. PARTNER CONTRIBUTION Arcadia MONSANTO Advanced lead testing in crops >20K GENE/ PROMOTER GENES TESTED: >2K GENE/ PROMOTER COMBOS IN CROPS COMBOS 3
  • 4. OVERVIEW Trait DISCOVERY PHASE I PHASE II PHASE III PHASE IV Proof Of Concept Early Development Advanced Pre-launch Gene/Trait Pipeline Development Identification Roundup Ready Flex Cotton Tolerance Herbicide Roundup RReady2Yield Soybeans Roundup RReady2Yield Canola Dicamba-tolerant Soybeans 2nd-Gen YieldGard Rootworm Control 2nd-Gen YieldGard Corn Borer Pest FARMER BENEFITS YieldGard Rootworm II Soybean nematode-resistance Drought-tolerant Corn Higher-yielding Canola Drought-tolerant Soybeans Yield Drought-tolerant Cotton Higher-yielding Corn Nitrogen Utilization Corn Cold-tolerant Corn Higher-yielding Soybeans Mavera™ high-value corn with lysine Enhancements PROCESSOR Mavera™ I high-value soybeans Protein Mavera™ II high-value soybeans 2nd-Gen high-value corn with lysine Feed corn with balanced proteins L High oil soybeans for processing P Improved-protein soybeans CONSUMER Vistive II Low Lin – Mid Oleic soybeans Lipids Vistive III Low Lin – Mid Oleic – Low Sat soybeans B Omega-3 Soybeans Discovery Platform Abbreviations: 4 L P B Lipid Enhancements Protein Enhancements Bioactive Compounds
  • 5. OVERVIEW Corn Germplasm Improvements Are Tightly Linked to Market Share Gains U.S. CORN MARKET SHARE 2004 CORN YIELD (BU/A) 220 HOLDENS/CORN STATES LICENSEES MONSANTO BRANDED 210 AMERICAN SEEDS, INC. BRANDS COMPETITORS 60% 200 DEKALB AND ASGROW BRANDS 50% 190 2004 40% 180 30% 170 20% 160 150 10% 95 100 105 110 0% RELATIVE MATURITIES (DAYS) 2001 2002 2003 2004 2005 2005 CORN YIELD (BU/A) BREEDING ADVANCES AND ADVANTAGES 200 Strong yield in 2004 translated into 190 a 2-point share gain in 2005 180 2004 In 2005, preliminary data indicates 170 continued yield advantage versus 160 best-in-class competitors 150 95 100 105 110 115 RELATIVE MATURITIES (DAYS) 5
  • 6. PIPELINE UPDATE Cotton States Will Launch New Source of Cotton Seed KEY MARKET AREAS U.S. TARGET MARKET 7M-8M Cotton States CREATING VALUE PERCENT PENETRATED 0% • Licensing fee Germplasm licensed from third parties and developed through molecular reflects value of top breeding by Monsanto quality germplasm, separate from value Taking preliminary orders from licensees; Enough seed for approximately of trait 1 million acres available for licensing in 2006 • Cotton seed All varieties offered in 2006 will be on a second-generation trait platform currently sells for average of $20 per 2005 UNIVERSITY COTTON VARIETY TESTS acre retail 1,300 UP NEXT LBS LINT/ACRE 1,200 • 4+ licensees will sell seed sourced from Cotton States 1,100 in 2006, located broadly throughout Cotton Belt 1,000 COTTON STATES COMPETITIVE VARIETIES VARIETIES DISCOVERY PHASE I PHASE III PHASE II PHASE IV LAUNCH Proof of Concept Adv. Development Early Development Pre-Launch 6
  • 7. OVERVIEW Seminis DISCOVERY PHASE II PHASE III PHASE PHASE I LAUNCH IV Proof Of Pipeline Gene/Trait Early Advanced Concept Identification Development Development Pre-launch BREED ING SE LECTIO N VEGETABLE BREEDING FAMILIES SOLANACEOUS QUALITY TARGETS 2005 Tomato Vencedor Hot Pepper Pepper 2006/7 Eggplant TYLCV Tomato CUCURBITS 2005 Grower Melon Watermelon MVR Squash Cucumber Squash Performance PX03913198 Melon Gourd 2006/7 High-Quality Watermelon Horticultural LARGE SEED 2005 Quality Beans Okra Devotion Sweet Corn Peas Sweet Corn 2006/7 Disease Sweeter Peas BRASSICA Resistance 2005 DOZENS DOZENS DOZENS <10 Broccoli Ironman Broccoli Cauliflower 2006/7 Cabbage Shelf Life Curd Yield & Quality Brussels Sprouts Cauliflower ROOT & BULB Consumer 2005 Onion Beet Fahrenheit Leek Traits Leek Carrot Invicta Carrot 2006/7 Low-Pungency onion Seed LEAFY 2005 Producibility Lettuce Boomerang Lettuce Spinach 2006/7 Celery Processing Butterhead Improved Mechanically Harvested-Spinach 7
  • 8. PIPELINE UPDATE Conversion from Open-Pollinated to Hybrid Offers Opportunity in Mexican Market KEY CROP PENETRATION MARKET (Acres) SQUASH Mexican OP Conversion 100K 5% CREATING VALUE CARROTS 67K 10% ONIONS 2005 FIELD REPORT 76K 40% HOT PEPPERS 298K 40% Mexican OP Conversion MULTI-STAGE: PHASE II THROUGH LAUNCH NEW MARKET OPPORTUNITY $70 CURRENT MARKET Not as well as Better than As expected $60 expected expected POTENTIAL MARKET $50 $ MILLIONS Quality $40 $30 Horticultural Performance $20 $10 New Hybrids $0 HOT SQUASH ONION CARROT OBSERVATIONS PEPPER • Able to achieve increased uniformity, earlier maturity, higher produce quality • Higher market yield and profitability • Better disease resistance • Value of hybrids already being recognized in the market DISCOVERY PHASE I PHASE III PHASE II PHASE IV LAUNCH Proof of Concept Adv. Development Early Development Pre-Launch 8
  • 9. PIPELINE UPDATE Molecular Breeding Helps Target Novel Approaches to Disease Resistance EUROPE N. KEY MARKET AREAS JAPAN -AFRICA AMERICA Geminivirus (Ty) AVAILABLE MARKET 57K 88K 3K Resistance in Tomato CREATING VALUE PERCENT PENETRATED 31% 1% 0% OPPORTUNITY: NOVEL DISEASE 2005 FIELD REPORT RESISTANCE, MARKERS & IP OPEN MARKET ACCESS Ty Resistance Stacked with Nematode Resistance in High Flavor Pink Tomatoes (Japan) PROVEN SUCCESS IN EUROPE-AFRICA PHASE II 15 60 Early Development $ (m illio n s ) # OF CULTIVARS 10 40 Not as well as Better than As expected expected expected 5 20 CHROMOSOME 6 0 0 Shelf Life 99 00 01 02 03 04 Fruit Quality Horticultural Performance MARKER Ty-1 ENABLED OBSERVATIONS • Demonstrating excellent disease resistance; Patents are pending for traits FUTURE IN JAPAN; TY-MI + • Leads show promise for high-flavor pink tomatoes, high- HIGH FLAVOR TOMATOES value commercial opportunities DISCOVERY PHASE I PHASE III PHASE II PHASE IV LAUNCH Proof of Concept Adv. Development Early Development Pre-Launch 9
  • 10. PIPELINE UPDATE Herbicide-Tolerance Focus Has Shifted to Second- and Third- Generation Traits in Larger Product Family CREATING VALUE FARMER BENEFITS Roundup Ready Flex for cotton is first-ever second- DISCOVERY PLATFORM: HERBICIDE TOLERANCE generation trait in weed PHASE PHASE PHASE PHASE D PLATFORM I II III IV control HERBICIDE TOLERANCE Second-generation traits for ROUNDUP READY FLEX COTTON soybeans and canola are in ROUNDUP mid-phases of pipeline RREADY2YIELD SOYBEANS Third-generation product ROUNDUP RREADY2YIELD already in Phase II for CANOLA soybeans, stacks two modes DICAMBA-TOLERANT SOYBEANS of action DICAMBA-TOLERANT COTTON 10
  • 11. PIPELINE UPDATE Roundup RReady2Yield Soybeans Expand Weed Control Window KEY MARKET ACRES U.S. BRAZIL ARGENTINA Roundup RReady2Yield 50M 35M 70M AVAILABLE MARKET Soybeans CREATING VALUE 0% 0% 0% PERCENT PENETRATED 2005 FIELD REPORT IMPLEMENTATION OF MARKER ASSISTED SELECTION IN TRAIT INTEGRATION Roundup RReady2Yield Soybeans PHASE III Advanced Development Not as well as As Better than expected expected expected Trait Performance Agronomic Performance LEAD GENE: COMPLETED Lead Selection LEAD EVENT: COMPLETED OBSERVATIONS • Lead event confirmed in April of 2005 • Trait integration efforts started • Implementation of marker assisted selection DISCOVERY PHASE I PHASE III PHASE II PHASE IV LAUNCH Proof of Concept Adv. Development Early Development Pre-Launch 11
  • 12. PIPELINE UPDATE Third-Generation of Soy Weed Control Gives Farmers Two Unique Modes of Action KEY MARKET ACRES U.S. BRAZIL ARGENTINA Dicamba-Tolerant 80M 50M 35M AVAILABLE MARKET Soybeans CREATING VALUE 0% 0% 0% PERCENT PENETRATED 2005 FIELD REPORT FIELD TESTING VALIDATING TOLERANCE Dicamba-Tolerant Soybeans DICAMBA TOLERANT PHASE II Early Development Not as well as Better than As expected expected expected Trait Performance Agronomic Performance NON TRANSGENIC LEAD GENE: COMPLETED Lead Selection LEAD EVENT: IN PROGRESS OBSERVATIONS • Tolerance demonstrated at both pre-emergence and post- emergence application timing Dicamba Resistant Soybean • No visual crop injury at rates of 1.5lb/acre, 3X labeled use Post Emergent Application of 1.5 lb/a rate DISCOVERY PHASE I PHASE III PHASE II PHASE IV LAUNCH Proof of Concept Adv. Development Early Development Pre-Launch 12
  • 13. PIPELINE UPDATE Roundup RReady2Yield Canola Is Newest Addition to Herbicide-Tolerance Family KEY MARKET ACRES U.S. EUROPE CANADA Roundup RReady2Yield TBD TBD TBD AVAILABLE MARKET Canola CREATING VALUE 0% 0% 0% PERCENT PENETRATED 2005 FIELD REPORT NEW BENEFIT TO CANOLA FARMERS Roundup RReady2Yield Canola Enhanced crop tolerance will allow greater application flexibility PHASE II Early Development CURRENT EVENT Not as well as Better than As expected expected expected Trait Performance Agronomic Performance LEAD GENE: COMPLETED Lead Selection LEAD EVENT: IN PROGRESS OBSERVATIONS NEW EVENT • Field performance shows enhanced tolerance to Roundup herbicide • Stacked with yield genes to deliver enhanced yield from Tolerance at rates representing 8x standard nitrogen use efficiency and enhanced seed yield use rate DISCOVERY PHASE I PHASE III PHASE II PHASE IV LAUNCH Proof of Concept Adv. Development Early Development Pre-Launch 13
  • 14. PIPELINE UPDATE Insect Control Discovery Program Approaching Second- Generation Commercialization CREATING VALUE FARMER BENEFITS Second-generation YieldGard corn borer builds on triple- DISCOVERY PLATFORM: PEST CONTROL stack corn platform and PHASE PHASE PHASE PHASE D PLATFORM I II III IV expands potential for new PEST CONTROL acreage penetration SECOND-GENERATION YIELDGARD CORN YieldGard corn rootworm ROOTWORM next-generation discovery SECOND-GENERATION YIELDGARD CORN improves production of BORER stacked traits while YIELDGARD ROOTWORM CORN II enhancing performance SOYBEAN NEMATODE- RESISTANCE 14
  • 15. PIPELINE UPDATE Second-Generation YieldGard Corn Borer Expands Insect Spectrum and Acreage Potential KEY MARKET ACRES U.S. BRAZIL ARGENTINA Second-Generation 50M 15M 4M AVAILABLE MARKET YieldGard Corn Borer CREATING VALUE 0% 0% 0% PERCENT PENETRATED 2005 FIELD REPORT NEW BENEFIT TO CORN FARMERS Second-Generation YieldGard Corn Borer Second-generation YieldGard Corn Borer offers PHASE III unparalleled combination of insect control and Advanced Development resistance management Not as well as Better than As expected expected expected FALL ARMYWORM Trait Performance Agronomic Performance LEAD GENE: COMPLETED Lead Selection LEAD EVENT: COMPLETED OBSERVATIONS • Excellent control of targeted pests – raises bar for corn earworm and fall armyworm control • Outstanding yields, including stacks for rootworm control 2ND GEN YGCB CONVENTIONAL • Insect resistance management benefit unique to market • Lead event selected for regulatory submissions DISCOVERY PHASE I PHASE II PHASE IV LAUNCH PHASE III Proof of Concept Early Development Pre-Launch Adv. Development 15
  • 16. PIPELINE UPDATE Second-Generation YieldGard Corn Rootworm Reinvents Stacked Corn Platform KEY MARKET ACRES U.S. BRAZIL ARGENTINA Second-Generation 25M 1M AVAILABLE MARKET 5M YieldGard Rootworm CREATING VALUE 0% 0% 0% PERCENT PENETRATED 2005 FIELD REPORT CRW INFESTATION CONTINUES TO EXPAND Second-Generation YieldGard Rootworm PHASE IV Pre-Launch Not as well as Better than As expected expected expected Trait Performance Agronomic Performance LEAD GENE: COMPLETED Lead Selection LEAD EVENT: COMPLETED OBSERVATIONS Percent Acres Treated and/or Planted • Vector-stack delivered outstanding performance for Corn Acres - not treated corn rootworm control and Roundup Ready crop safety 0.1 - 25 % treated • Monsanto to launch 2nd generation CRW stacked-traits 25.1 - 50 % treated while competitors introduce 1st generation singles >50% treated • Will introduce to seed licensees in 2006 with commercial sales expected in 2007 or 2008 DISCOVERY PHASE I PHASE III PHASE II PHASE IV LAUNCH Proof of Concept Adv. Development Early Development Pre-Launch 16
  • 17. PIPELINE UPDATE Yield Platform Has Expanded Most Dramatically of All Families in Past Year CREATING VALUE FARMER BENEFITS Drought traits have been applied to new crops, DISCOVERY PLATFORM: YIELD expanded in corn PHASE PHASE PHASE PHASE PLATFORM D I II III IV Next-generation leads are DROUGHT-TOLERANT being developed CORN simultaneously with SOYBEANS advancement of first- COTTON INTRINSIC YIELD generation products CORN SOYBEANS CANOLA NITROGEN UTILIZATION CORN COLD-TOLERANT CORN 17
  • 18. PIPELINE UPDATE Drought-Tolerant Corn Is Lead Crop of Yield Family of Traits KEY MARKET ACRES U.S. BRAZIL ARGENTINA 80M 30M 6M AVAILABLE MARKET Drought-Tolerant Corn CREATING VALUE 0% 0% 0% PERCENT PENETRATED CONSISTENT RESULTS FROM EARLY 2005 FIELD REPORT LEADS AND MORE LEADS EMERGING FROM PIPELINE Drought-Tolerant Corn PHASE II WITH TRAIT WITHOUT TRAIT WITH TRAIT WITHOUT TRAIT Early Development Not as well as Better than As expected expected expected Trait Performance Agronomic Performance o C 32 34 40 LEAD GENE: COMPLETED Lead Selection LEAD EVENT: IN PROGRESS OBSERVATIONS • Lead genes show consistent drought stress performance across years • Mid-season drought performance results in more, bigger ears • Up Next: Advance into early development WITHOUT TRAIT WITH TRAIT DISCOVERY PHASE I PHASE III PHASE II PHASE IV LAUNCH Proof of Concept Adv. Development Early Development Pre-Launch 18
  • 19. PIPELINE UPDATE Drought-Tolerant Cotton Performance Encouraging in Early Field Evaluation KEY MARKET ACRES U.S. AUSTRALIA Drought-Tolerant Cotton AVAILABLE MARKET 7M 0.5M CREATING VALUE 0% 0% PERCENT PENETRATED 2005 FIELD REPORT FROM GREENHOUSE Drought-Tolerant Cotton TESTING TO…. PHASE I Proof of Concept …FIRST DROUGHT- YEAR FIELD Not as well as Better than CONTROL As expected TOLERANT TRIALS expected expected Trait Performance Agronomic Performance LEAD GENE: IN PROGRESS Lead Selection LEAD EVENT: N/A OBSERVATIONS • Drought leads are working across crops • First leads into cotton are showing promise • Next up: Continued evaluation to assess drought DROUGHT- CONTROL performance TOLERANT DISCOVERY PHASE I PHASE III PHASE II PHASE IV LAUNCH Proof of Concept Adv. Development Early Development Pre-Launch 19
  • 20. PIPELINE UPDATE Nitrogen Utilization Corn Moved From Greenhouse to Field Work in 2005 KEY MARKET ACRES U.S. BRAZIL ARGENTINA Nitrogen Utilization Corn 80M 30M 6M AVAILABLE MARKET CREATING VALUE 0% 0% 0% PERCENT PENETRATED 2005 FIELD REPORT FROM GREEN- Nitrogen Utilization Corn HOUSE PHASE I TESTING Proof of Concept TO… Not as well as Better than …FIRST As expected expected expected YEAR GENE H Control FIELD Trait Performance TRIALS CONTROL GENE F Agronomic Performance LEAD GENE: IN PROGRESS Lead Selection LEAD EVENT: N/A G en e OBSERVATIONS s • Enhanced nitrogen utilization is challenging trait • Industrial scale genomics effort is generating leads • Up Next: Optimization to improve trait performance and continued screening HIGH N MED N LOW N DISCOVERY PHASE I PHASE III PHASE II PHASE IV LAUNCH Proof of Concept Adv. Development Early Development Pre-Launch 20
  • 21. PIPELINE UPDATE Processor Benefits Projects Represent New Approach to Market Not Traditionally Served by Seed Innovations CREATING VALUE PROCESSOR BENEFITS Mavera High-Value Corn with lysine represents first biotech PHASE PHASE PHASE PHASE product from our Renessen D PLATFORM I II III IV collaboration PROTEIN AND/ OR ENHANCEMENTS Like Vistive, Mavera MAVERA HIGH-VALUE CORN WITH LYSINE represents a family of MAVERA I HIGH-VALUE products SOYBEANS MAVERA II HIGH- Renessen joint venture VALUE SOYBEANS includes both biotech and HIGH OIL SOYBEANS FOR PROCESSING breeding approaches to SECOND-GENERATION adding value in the feed HIGH-VALUE CORN WITH LYSINE industry FEED CORN WITH BALANCED PROTEINS 21
  • 22. PIPELINE UPDATE First-Generation High-Value Corn with Lysine in Final Phases of Regulatory Reviews KEY MARKET ACRES U.S. BRAZIL ARGENTINA Mavera High-Value Corn 5M 2M 1M AVAILABLE MARKET with Lysine CREATING VALUE 0% 0% 0% PERCENT PENETRATED 2005 FIELD REPORT FIELD DATA VALIDATES LYSINE TARGETS Mavera High-Value Corn with Lysine PHASE IV 5000 Pre-Launch 4000 Not as well as Better than As expected expected expected 3000 Trait Performance 1ST GENERATION 2000 Agronomic Performance MINIMUM 1000 LEAD GENE: COMPLETED Competitive Comparison TARGET LEAD EVENT: COMPLETED 0 SOUTH U.S. RESULT CONTROL OBSERVATIONS AMERICA (2004) RESULT • Final year of field trial work confirms lysine targets in (2005) commercial-quality germplasm • Completed FDA Consultation; USDA comment period underway • Final approvals anticipated for 2007 launch DISCOVERY PHASE I PHASE III PHASE II PHASE IV LAUNCH Proof of Concept Adv. Development Early Development Pre-Launch 22
  • 23. PIPELINE UPDATE Vistive Family of Traits Continues To Offer Additive Value as New Consumer Products Advance CREATING VALUE CONSUMER BENEFITS Monsanto and Solae recently announced an agreement for our improved-protein PHASE PHASE PHASE PHASE D PLATFORM I II III IV soybeans PROTEIN ENHANCEMENTS Vistive II and III build on the IMPROVED-PROTEIN low-linolenic platform SOYBEANS FOR FOOD launched in 2005 with LIPID ENHANCEMENTS additional qualities that VISTIVE II LOW LIN – MID OLEIC SOYBEANS improve the oil profile VISTIVE III LOW LIN – MID OLEIC – LOW SAT SOYBEANS BIOACTIVE COMPOUNDS OMEGA-3 SOYBEANS 23
  • 24. PIPELINE UPDATE Improved-Protein Soybeans for Food Poised for Commercial Track Following Solae Announcement KEY MARKET ACRES U.S. BRAZIL ARGENTINA Improved-Protein <1M TBD TBD AVAILABLE MARKET Soybeans for Food CREATING VALUE 0% 0% 0% PERCENT PENETRATED 2005 FIELD REPORT Improved-Protein Soybeans for Food PHASE III Advanced Development Not as well as Better than As expected expected expected IMPROVED SOLUBILITY PROFILE Trait Performance VINTON 81 Agronomic Performance COMMODITY Lead Selection MON HBC COMPLETED OBSERVATIONS CASEIN • Completed alliance with Solae 0 2 4 6 8 10 12 MEDIAN PARTICLE DIAMETER (MICRONS) • Early food formulation work very promising High beta-conglycinin presence • Strong yield and agronomic performance translates to mouth-feel more comparable to conventional dairy products DISCOVERY PHASE I PHASE III PHASE II PHASE IV LAUNCH Proof of Concept Adv. Development Early Development Pre-Launch 24
  • 25. PIPELINE UPDATE Vistive Family of Improved Oils Meets Multiple Needs in Food Industry TARGET: LOW LINOLENIC TARGET: LOW LINOLENIC TARGET: LOW SAT VISTIVE SOYBEANS VISTIVE RAPESEED +INCREASED OLEIC + LOW LINOLENIC 2005 LAUNCH 2005 LAUNCH 500K ACRES IN US 40K ACRES IN EUROPE VISTIVE III LOW LIN – MID OLEIC – LOW SAT TARGET: INCREASED OLEIC SOYBEANS + LOW LINOLENIC VISTIVE PHASE II FAMILY VISTIVE II LOW LIN – MID OLEIC SOYBEANS CONSUMER PHASE III MARKET OIL FOR FRYING AND IMPROVED SOYBEAN SPRAYING QUALITY FOR LIQUID OILS Crackers Snack chips 25
  • 26. PIPELINE UPDATE Vistive II Adds Improved Oleic Content to Current Vistive Low Lin Product KEY MARKET ACRES U.S. BRAZIL ARGENTINA Vistive II Low Lin – 30M TBD TBD AVAILABLE MARKET Mid-Oleic Soybeans CREATING VALUE 0% 0% 0% PERCENT PENETRATED 2005 FIELD REPORT Vistive II Low Lin – Mid-Oleic Soybeans PHASE III Advanced Development Not as well as Better than As expected 50% of the oil expected expected of Vistive II is Trait Performance mid-oleic, improving Agronomic Performance overall oil profile Lead Selection COMPLETED Mid Oleic OBSERVATIONS Linolenic Linoleic Sats 18:1 STANDARD • Achieved commercial targets of 50% oleic and 3% SOY linolenic composition in field testing MID-OLEIC • Molecular marker selection was implemented enabling SOY plant selections with compositions for line advancements DISCOVERY PHASE I PHASE III PHASE II PHASE IV LAUNCH Proof of Concept Adv. Development Early Development Pre-Launch 26
  • 27. PIPELINE UPDATE Omega-3 Oil Production in Soybeans: Initial Taste, Smell and Oil Stability Results Promising KEY MARKET ACRES U.S. EU ROW TBD TBD TBD AVAILABLE MARKET Omega-3 Soybeans CREATING VALUE 0% 0% 0% PERCENT PENETRATED 2005 FIELD REPORT SDA OIL TASTES RESULTS 2005 Omega-3 Soybeans PHASE II 10 Early Development 5 Not as well as Better than As expected expected expected 0 Trait Performance Soy Oil SDA Oil Fish Oil (INCLUDES OIL TASTE, SMELL AND STABILITY) Taste Rating 0-15 Scale Agronomic Performance Score of zero indicates no taste LEAD GENES: COMPLETED Lead Selection LEAD EVENT: COMPLETED In taste-testing, stearidonic acid (SDA) oil compares favorably versus fish oil and OBSERVATIONS commodity soy oil • 2004 U.S. and 2005 Argentine field trials continue to confirm expression of SDA levels at concept targets • Initial sensory data superior to fish oil • SDA oil stability results are promising DISCOVERY PHASE I PHASE III PHASE II PHASE IV LAUNCH Proof of Concept Adv. Development Early Development Pre-Launch 27
  • 28. SUMMARY New Traits, Trait Upgrades and New Stacked Combinations Are Creating New Platforms for Farmers CORN 2005 2010F 2015F Preferred Trait Preferred Trait Preferred Trait Trait Offerings Trait Offerings Trait Offerings Combinations Combinations Combinations ROUNDUP READY ROUNDUP READY ROUNDUP READY STACKED – STACKED – STACKED – CORN 2 CORN 2 CORN 2 DOUBLE: TRIPLE: TRIPLE + YIELD YIELDGARD PLUS YIELDGARD YIELDGARD YIELDGARD TRAITS: YGCB + RR YGRW+YGCB+RR ROOTWORM ROOTWORM ROOTWORM YGRW + RR YIELDGARD CORN 2nd GENERATION 2nd GENERATION 2nd GEN YGCB + STACKED – STACKED – BORER YGRW YGRW 2nd GEN YGRW + 2nd GEN TRIPLE: TRIPLE: RR YIELDGARD CORN YIELDGARD CORN + DROUGHT BORER BORER 2nd GEN YGCB + YGRW+YGCB+RR + INTRINSIC 2nd GEN YGRW + YIELDGARD CORN YIELDGARD CORN + NITROGEN RR BORER BORER HIGH-VALUE HIGH-VALUE STACKED – TRIPLE STACKED – TRIPLE CORN W/ LYSINE CORN W/ LYSINE + FEED TRAITS + + FEED TRAITS: YIELD TRAITS: 2nd GEN HIGH- VALUE CORN W/ HIGH-VALUE LYSINE 2nd GEN HIGH- CORN W/ LYSINE + FEED CORN WITH VALUE CORN W/ YGRW + YGCB + BALANCED LYSINE + YGRW + RR PROTEINS YGCB + RR FARMER BENEFITS YIELD: DROUGHT PROCESSOR BENEFITS CONSUMER BENEFITS YIELD: INTRINSIC YIELD: NITROGEN 28