Among all diff. routes, oral has achieved more attention & quite successful. This is due to fact that GI physiology provides more flexibility then other routes.

1. 1
FIRDOUS,
M. PHARMACY.
Floating drug delivery system

2.  Introduction
 Why Floating Drug Delivery Systems ?
 Mechanism of Floating Drug Delivery System
 Types of Floating Drug Delivery System
1. Effervescent System
2. Non-Effervescent System
 Evaluation of Floating Drug Delivery System
 Advantages
 Disadvantages
 Conclusion
2

3.  Among all diff. routes, oral has achieved more attention &
quite successful.
 This is due to fact that GI physiology provides more
flexibility then other routes.
 But in oral solids, drug absorption is unsatisfactory and
variable .
 In oral controlled releases, release time was previously not
enhanced more then 12 hrs.
3

4.  This promoted the research in this direction by enhancing
gastric retention time.
 By this method, bioavailability enhanced, drug waste
reduced & solubility increased for insoluble drugs at high
pH levels.
4

5.  Various approaches followed to enhance GR (Gastric
Retention) Time for oral dosage form.
 Floating system has low bulk density & they can float on
gastric juice in the stomach.
 They can retain drug for longer time.
 This system can enhance drug's safety and reduce side effect .
 Thus ultimately, bioavailability enhanced.
5

6. 6

7.  Mainly FDDS categorized into 2 brief Categories.
1. Effervescent System,
2. Non-Effervescent System.
 These both then further divided into sub-categories.
 Chart of FDDS classification is shown as…..
7

8. Floating Drug Delivery System
Effervescent
System
Gas
generating
system
Volatile
liquid/
vacuum
containing
system
Non-Effervescent
System
Single
Layer
Floatin
g
Tablet
Bilayer
Floatin
g
Tablet
Alginat
e Beads
Hollow/
floating
Microsp
heres
8

9.  Use of gas generating carbonates (Citric acid, tartaric
acid) to produce CO2 gas and reducing the density of the
system, this may let them float.
 Another method is, to incorporate matrix containing
liquids, which produce gas .
 Thus 2 sub types of effervescent system are..
1. Gas Generating System,
2. Volatile Liquid/Vacuum Containing System.
9

10. 1. Gas
Generati
ng
System
Intra gastric single layer
floating tablet
Intra gastric bilayer
floating tablet
Multiple unit floating pills
10

11. 2.
Volatile
liquid
/vacuum
containi
ng
System
Intra gastric floating
GIDDS
Inflatable GIDDS
Intra gastric osmotically
CDDS
11

12.  Based on mechanism of swelling of polymer or bioadhesion
to mucosal layer in GI tract.
 Gel forming or Highly swallable cellulose type of
hydrocolloids, polysaccharides & matrix forming materials
as polycarbonate, polymethacrylate, polyacrylate used.
12

13. Non
Effervesce
nt System
Single Layer Floating Tablet
Bilayer Floating Tablet
Alginate Beads
Hollow Microspheres/
Microballoons
13

14.  Floating duration
 Dissolution profiles
 Specific gravity
 Content uniformity
 Differential scanning
calorimetry
 Particle size analysis
 Flow properties
14

15. Sr
No.
Dosage
Form
Drugs
1. MICROSPHER
E
Aspirin, Griseofulvin, p-nitroglycerine, ibuprofen,
Terfinadine, Tranilast.
2. GRANULES Diclofenac sodium, Indomethacin, Prednisolone
3. FILMS Cinnarizine
4. CAPSULE Chlrdiazepoxide, Diazepam, Furosemide, L-Dopa,
Benserazide, Misoprostol, Propanolol
5. TABLET/
PILLS
Acetaminophen, ASA, Amoxicilin
Trihydrate,Ampicilin, Atenolol,
Chlorphenarimine,Cinnazirine,
Diltiazem,Flourouracil, Isosorbide Mononitrate &
dinitrate, p-aminobenzoic acid, Prednisolone,
Quinidine Gluconate,Ribiflavin 5-p,
Sotalol,Theophylline, Verapamil 15

16. 16
S.No Product Active Ingredient
1 Madopar Levodopa and benserzide
2 Valrelease Diazepam
3 Topalkan Aluminum magnesium
antacid
4 Almagate
flatcoat
Antacid
5 Liquid gavison Alginic acid and sodium
bicarbonate

17.  Used easily for drugs that absorbed specially from stomach
or proximal part of small intestine.
 Fluctuation in plasma drug are minimized, which is used for
drugs with narrow therapeutic index.
 Maximum absorption expected even at alkaline pH of the
intestine.
 FDDS improves patient compliance by decreasing dosing
frequency.
17

18.  Gastric retention is influenced by many factors such as
gastric motility, pH and presence of food. These factors are
never constant and hence the buoyancy cannot be
predicted.
 Drugs with stability, irritation and solubility problems in
GIT, not suggested for FDDS.
 Drugs that goes first pass metabolism also not used. eg.
Nifedipine.
 Drug that is if unstable in acidic condition of stomach, not
to be use.
18

19. 19
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