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  P ositron  E mission  T omography in Clinical Oncology ,[object Object],[object Object],[object Object]
 
 
Commonly used PET Radiotracers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Potential PET Radiotracers
PET Radiotracer approved by FDA ,[object Object],[object Object]
 
NORMAL TUMOR ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
Gallium  PET
Metastatic Thyroid Ca. to Lung, Mediastinum, and Skeleton
 
General Indications for FDG-PET Tumor Imaging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
New Medicare Coverage Policy for FDG PET ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Lung Cancer ,[object Object],[object Object],[object Object]
Solitary Pulmonary Nodule ,[object Object],[object Object],[object Object],[object Object]
CT:  an indeterminant LUL nodule.
 
Efficacy of PET  Solitary Pulmonary Nodule ,[object Object],[object Object],[object Object]
False Positives: Active Infection/Inflammation TB Pneumonia Cryptococcosis Histoplasmosis Aspergillosis Inflammatory
Staging
 
 
60/M:  Lung Ca.
62y/o Lung Ca. with adrenal mass
 
Colorectal Cancer: Clinical Indications for PET Imaging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Staging before resection of recurrent disease
63 y/o woman with a H/O Colon Ca.  and liver metastases
79/M.  Resection of Rectal Ca (Dukes B) 4 mos earlier,     CEA,  CT:  possible local relapse.
T1 T2 T1  enhanced T1  enhanced ,[object Object],[object Object],[object Object],[object Object]
Sagittal  Transverse   Coronal
[object Object],[object Object],[object Object],[object Object],[object Object]
58/M - S/P Colon Ca Rising CEA  Coronal  Coronal  Transverse
58/M - S/P Colon Ca Rising CEA  Local recurrence Hemangioma
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
N. G. 8/15/00 Colon cancer with a Hx of UC Proven mesenteric carcinomatosis
1756441
Huebner et al.   J Nucl Med 2000;41:1177-1189
Huebner et al.   J Nucl Med 2000;41:1177-1189
Colorectal Cancer:  A possible algorithm CT evidence of resectable disease in patient suitable for surgery Whole Body PET imaging
Colorectal Cancer:  A possible algorithm CT evidence of resectable disease in patient suitable for surgery Whole Body PET imaging Further evaluation  of CT abnormality All sites negative
Colorectal Cancer:  A possible algorithm CT evidence of resectable disease in patient suitable for surgery Whole Body PET imaging Further evaluation  of CT abnormality Surgery All sites negative PET = CT and other sites negative
Colorectal Cancer:  A possible algorithm CT evidence of resectable disease in patient suitable for surgery Whole Body PET imaging Further evaluation  of CT abnormality Non-surgical management Surgery All sites negative + ve at multiple Sites  PET = CT and other sites negative
44/F with Colon Ca, S/P primary resection. CT: multiple liver mets and a lung nodule Treated with  systemic chemoTx  instead of  intra-arterial chemoTx . Staging:
Colorectal Cancer: Clinical Indications for PET Imaging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
S/P ChemoRx
Before  2mo after  Adjuvant chemo and radioTx Prior to surgery for rectal Ca.
Optimal time to scan after treatment?? Uptake may be seen in inflammatory tissue / macrophages. Residual FDG activity after treatment: Not always active tumor ,[object Object],[object Object],[object Object],[object Object]
Lymphoma: Indications for PET Imaging ,[object Object],[object Object],[object Object],[object Object]
Evaluation of early therapeutic response:  Is treatment effective? FDG uptake represents cell viability. ,[object Object],[object Object]
1846641 Lymphoma Before After 2 cylcles of Chemo
Lymphoma Before After 2 cylcles of Chemo
56y/o : Lymphoma
Before  1 month after XRT
Esophageal/Gastro-esophageal Cancer: Clinical Indications for PET Imaging ,[object Object],[object Object],[object Object],[object Object]
Esophageal/   Gastro-esophageal Cancer: Clinical Indications for PET Imaging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
( Choi et al: J Nucl Med 2000) Evaluation of N stage of patients with Esophageal Cancer:   48 patients underwent esohagectomy and lymph node dissection (2 field=35pts, 3 field=13pts)
Evaluation of metastases in Esophageal Cancer:   CT versus PET CT PET Kole 1998 Lymph nodes 62% 90% Resectability 65% 88% Choi 2000 Lymph nodes 78% 86% N staging 60% 83% Luketich 1999 Distant mets 63% 84%
Rt. Paratracheal Subcarinal Lt. Gastric Common hepatic &  Celiac Rt. Paratracheal Subcarinal Lt. Gastric Common hepatic &  Celiac
62F:  Gastric Ca. S/P Resection CT:  Recurrence PET  performed to exclude other sites of tumor Ultrasound:  confirmed a liver mets Surgery cancelled and the patient treated with Chemo
 
Gastro-esophageal Cancer: Clinical Indications for PET Imaging ,[object Object],[object Object],[object Object],[object Object]
Before sagittal  coronal After Radiochemo 49M: large squamous esophageal Ca. Echo-endoscopy – an enlarged node
Gastro-esophageal Cancer: Clinical Indications for PET Imaging ,[object Object],[object Object],[object Object],[object Object]
45M:  S/P esophagectomy,  Patient is clinically asymptomatic    alkaline phosphatase
Gastro-esophageal Cancer: Clinical Indications for PET Imaging ,[object Object],[object Object],[object Object],[object Object]
Surviavl based on initial PET scan identification of  distant versus local disease only:  (Luketich et al:   Ann Thorac Surg 1999;68)
Pancreatic Cancer: Potential Indications for PET Imaging ,[object Object],[object Object],[object Object],[object Object]
53/F:   Pancreatic mass
51F:   CT:  (1) Mass forming pancreatitis vs Cancer (2) Hepatic Hemangioma vs Metastasis  Coronal  Sagittal
Pancreatic Cancer: DDx: Chronic pancreatic mass vs. Cancer Delbeke et al: J Nucl Med 1999
Brain Tumor   ,[object Object],[object Object],[object Object]
High Grade Low Grade
Kim CK et al. J Neuro-Oncol 1991
 
Thyroid Cancer   Thyroglobulin (+) Iodine-131 scan (-) ,[object Object]
I V M L FDG-PET I-131 Anterior  Posterior M 2 Coronal slices
62 y/o male  S/P  Resection of transglottic right laryngeal cancer R/O  Recurrence
FDG PET Imaging     Determination of the site of  unknown primary tumor 20~30%
Prediction of tumor response to treatment: Will the tumor respond to treatment? ,[object Object],[object Object]
FDG-PET Tumor Imaging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Summary:  PET ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The influence of blood glucose levels  on 18FDG uptake in cancer (Crippa et al. Tumori 1997:83:748-752) ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
 
Coronal  Sagittal
55 y/o woman Dx’ed with colon ca. S/P resection 2 yrs ago CEA level is rising No evidence of recurrence.  CT: normal .

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817731 slides
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Radiobiology behind dose fractionation
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2012-michael joiner-hypofractionation
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RECTAL CA - VAKALIS . X
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Pet

  • 1.
  • 2.  
  • 3.  
  • 4.
  • 5.
  • 6.
  • 7.  
  • 8.
  • 9.
  • 11. Metastatic Thyroid Ca. to Lung, Mediastinum, and Skeleton
  • 12.  
  • 13.
  • 14.
  • 15.
  • 16.
  • 17. CT: an indeterminant LUL nodule.
  • 18.  
  • 19.
  • 20. False Positives: Active Infection/Inflammation TB Pneumonia Cryptococcosis Histoplasmosis Aspergillosis Inflammatory
  • 22.  
  • 23.  
  • 24. 60/M: Lung Ca.
  • 25. 62y/o Lung Ca. with adrenal mass
  • 26.  
  • 27.
  • 28. Staging before resection of recurrent disease
  • 29. 63 y/o woman with a H/O Colon Ca. and liver metastases
  • 30. 79/M. Resection of Rectal Ca (Dukes B) 4 mos earlier,  CEA, CT: possible local relapse.
  • 31.
  • 33.
  • 34. 58/M - S/P Colon Ca Rising CEA Coronal Coronal Transverse
  • 35. 58/M - S/P Colon Ca Rising CEA Local recurrence Hemangioma
  • 36.
  • 37.
  • 38. N. G. 8/15/00 Colon cancer with a Hx of UC Proven mesenteric carcinomatosis
  • 40. Huebner et al. J Nucl Med 2000;41:1177-1189
  • 41. Huebner et al. J Nucl Med 2000;41:1177-1189
  • 42. Colorectal Cancer: A possible algorithm CT evidence of resectable disease in patient suitable for surgery Whole Body PET imaging
  • 43. Colorectal Cancer: A possible algorithm CT evidence of resectable disease in patient suitable for surgery Whole Body PET imaging Further evaluation of CT abnormality All sites negative
  • 44. Colorectal Cancer: A possible algorithm CT evidence of resectable disease in patient suitable for surgery Whole Body PET imaging Further evaluation of CT abnormality Surgery All sites negative PET = CT and other sites negative
  • 45. Colorectal Cancer: A possible algorithm CT evidence of resectable disease in patient suitable for surgery Whole Body PET imaging Further evaluation of CT abnormality Non-surgical management Surgery All sites negative + ve at multiple Sites PET = CT and other sites negative
  • 46. 44/F with Colon Ca, S/P primary resection. CT: multiple liver mets and a lung nodule Treated with systemic chemoTx instead of intra-arterial chemoTx . Staging:
  • 47.
  • 49. Before 2mo after Adjuvant chemo and radioTx Prior to surgery for rectal Ca.
  • 50.
  • 51.
  • 52.
  • 53. 1846641 Lymphoma Before After 2 cylcles of Chemo
  • 54. Lymphoma Before After 2 cylcles of Chemo
  • 56. Before 1 month after XRT
  • 57.
  • 58.
  • 59. ( Choi et al: J Nucl Med 2000) Evaluation of N stage of patients with Esophageal Cancer: 48 patients underwent esohagectomy and lymph node dissection (2 field=35pts, 3 field=13pts)
  • 60. Evaluation of metastases in Esophageal Cancer: CT versus PET CT PET Kole 1998 Lymph nodes 62% 90% Resectability 65% 88% Choi 2000 Lymph nodes 78% 86% N staging 60% 83% Luketich 1999 Distant mets 63% 84%
  • 61. Rt. Paratracheal Subcarinal Lt. Gastric Common hepatic & Celiac Rt. Paratracheal Subcarinal Lt. Gastric Common hepatic & Celiac
  • 62. 62F: Gastric Ca. S/P Resection CT: Recurrence PET performed to exclude other sites of tumor Ultrasound: confirmed a liver mets Surgery cancelled and the patient treated with Chemo
  • 63.  
  • 64.
  • 65. Before sagittal coronal After Radiochemo 49M: large squamous esophageal Ca. Echo-endoscopy – an enlarged node
  • 66.
  • 67. 45M: S/P esophagectomy, Patient is clinically asymptomatic  alkaline phosphatase
  • 68.
  • 69. Surviavl based on initial PET scan identification of distant versus local disease only: (Luketich et al: Ann Thorac Surg 1999;68)
  • 70.
  • 71. 53/F: Pancreatic mass
  • 72. 51F: CT: (1) Mass forming pancreatitis vs Cancer (2) Hepatic Hemangioma vs Metastasis Coronal Sagittal
  • 73. Pancreatic Cancer: DDx: Chronic pancreatic mass vs. Cancer Delbeke et al: J Nucl Med 1999
  • 74.
  • 75. High Grade Low Grade
  • 76. Kim CK et al. J Neuro-Oncol 1991
  • 77.  
  • 78.
  • 79. I V M L FDG-PET I-131 Anterior Posterior M 2 Coronal slices
  • 80. 62 y/o male S/P Resection of transglottic right laryngeal cancer R/O Recurrence
  • 81. FDG PET Imaging Determination of the site of unknown primary tumor 20~30%
  • 82.
  • 83.
  • 84.
  • 85.
  • 86.
  • 87.  
  • 89. 55 y/o woman Dx’ed with colon ca. S/P resection 2 yrs ago CEA level is rising No evidence of recurrence. CT: normal .