Patent landscape report on optogenetics by PatSeer

OPTOGENETICS
PATENT LANDSCAPE REPORT BY PATSEER
Disclaimer: The analysis and charts shown in this report have been prepared using PatSeer. This report should not be
construed as business advice and the insights are not to be used as the basis for investment or business decisions of any kind
without your own research and validation. Gridlogics Technologies Pvt. Ltd disclaims all warranties whether express, implied
or statutory, of reliability, accuracy or completeness of results, with regards to the information contained in this report.

© 2019 Gridlogics. All Rights Reserved. Page 2 of 43
OPTOGENETICS - OVERVIEW
Optogenetics is a method that uses light to modulate molecular events in a targeted manner in
living cells or organisms. It relies on the use of genetically-encoded proteins that change
conformation in the presence of light to alter cell behaviour, for example, by changing the
membrane voltage potential of excitable cells.
It can also be defined as a biological technique that involves the use of light to control cells in living
tissue, typically neurons that have been genetically modified to express light-sensitive ion channels.
It is a neuromodulation method that uses a combination of techniques from optics and genetics to
control and monitor the activities of individual neurons in living tissue even within freely moving
animals and to precisely measure these manipulation effects in real-time.
The key reagents used in optogenetics are light-sensitive proteins. Neuronal control is achieved
using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while an
optical recording of neuronal activities can be made with the help of optogenetic sensors for calcium
(GCaMP), vesicular release (synapto-pHluorin), neurotransmitter (GluSnFRs), or membrane voltage
(arc lightning, ASAP1), Control (or recording) of activity is restricted to genetically defined neurons
and performed in a spatiotemporal-specific manner by light.
Optogenetics provides millisecond-scale temporal precision which allows the experimenter to keep
pace with fast biological information processing (for example, in probing the causal role of specific
action potential patterns in defined neurons). Indeed, to probe the neural code, optogenetics by
definition must operate on the millisecond timescale to allow addition or deletion of precise activity
patterns within specific cells in the brains of intact animals, including mammals. By comparison, the
temporal precision of traditional genetic manipulations (employed to probe the causal role of
specific genes within cells, via "loss-of-function" or "gain of function" changes in these genes) is
rather slow, from hours or days to months. It is important to also have fast readouts in optogenetics
that can keep pace with the optical control. This can be done with electrical recordings ("optrodes")
or with reporter proteins that are biosensors, where scientists have fused fluorescent proteins to
detector proteins.

PATENT SEARCH STRATEGY
Using PatSeer, we searched individual publications and then collapsed them to one member per
Invention (Simple Families). Patent families are a group of patent applications in multiple countries
which represent the same invention.
The publications included in the report are updated as of 14th
January 2019.
Summary of Search Results:
 We started with a set of 3452 search results
 We then deduplicated them to unique inventions (Families) and got 1728 Families
 We browsed through the resulting set of record to remove any record that was irrelevant to
the search topic
 We then filtered, analyzed and came across some unwanted terms/Keywords. These records
were then removed from the resulting set.
 We flagged/rated each individual record using Search Recall™ option present in PatSeer
NOTE: All analysis in this report has been done on Simple Family (one member per family) and so the
data in the charts should be construed accordingly.

TECHNICAL SEGMENTATION (PATENT CATEGORIZATION)
To know the detail of Technical Segmentation image Contact us here:

INNOVATION TRENDS
The chart below shows a number of filings and grants for optogenetics. The chart was generated on
overall records (3452 Records) and the trend analysis is for the last 15 years.
Trend analysis based on the filing of priority application indicates a gradual increase in number of
applications being filed post-2013. The maximum number of patent applications (236) taking/having
priority were filed during 2016.
How we did it?
Application and patents with their respective counts were exported as CSV and were converted to a column chart
from excel.
“Maximum number of patent applications (236) taking/having priority
were filed during 2016”
OPTOGENETICS: TRENDS

TREND FOR VARIOUS APPLICATION AREAS OF OPTOGENETICS OVER
THE LAST 15 YEARS
 The chart below represents the growth of different applications of optogenetics in the last 15 years
 Research for the cure of neurological diseases like Alzheimer’s, epilepsy, seizure or depression
using optogenetics has seen an exponential increase since 2014.
How we did it?
First records were classified under different application areas. Then these were added as layer on the application
year chart. The resulting chart was exported as an image. Note that for analysis the records of 2017 and onwards
were excluded as there is a time gap of 18 months for new filings to be published.
“Exponential increase in research for the cure of neurological diseases like
Alzheimer’s, epilepsy, seizure or depression using optogenetics from 2014”

TREND FOR VARIOUS TARGETING TECHNIQUES OF OPTOGENETICS
OVER THE LAST 15 YEARS
 The chart below represents the growth of different targeting techniques of optogenetics in the last
15 years
 Targeting techniques such as Transgene and Recombinase are more researched and used
techniques as companied to Viral Vectors(Retroviruses, Lentiviruses, Adenoviruses)
How we did it?
First records were classified according to different targeting techniques. Then these were added as layer on the
application year chart. The resulting chart was exported as an image. Note that for analysis the records of 2017
and onwards were excluded as there is a time gap of 18 months for new filings to be published.

INVENTIONS ABANDONED AND RENEWED
 The chart below gives an account of the inventions abandoned or renewed for optogenetics in the
last eight years
 Rate of abandonments was high in 2010 but has reduced considerably after that
How we did it?
First records were added using a query within the Search Query option. Then from the Dashboard for the
particular query, the chart for inventions Abandoned or Renewed was downloaded

TECHNOLOGY CYCLE TIME
 The chart below gives the measure of how quickly new technologies/inventions are replacing the
older once in optogenetics
 It is the median age of the patents cited on the front page of a patent document. The measure
assumes that the more recent the age of the cited patents, the more quickly one generation of
inventions is replacing another
 At the current rate it can be seen that the average time technology cycle time is 5.9 years.
How we did it?
First records were added using a query within the Search Query option. Then from the Dashboard for the
particular query, the chart for Technology Cycle Time was downloaded.
“Average technology cycle time is 5.9 years.”

KEY AREAS OF RESEARCH FOR OPTOGENETICS
RESEARCH ACTIVITY AROUND THE WORLD
 Map below represents the geographical filing relating to Optogenetics. The map helps provide an
indication of where innovation in this area is originating from.
 United States is the leading country in this field with 926 families followed by Japan (119) and China
(109). The strength of the coloring represents the proportion of patent applications.
How we did it?
The map was generated using the Priority country tab under the Quick Stats option.
Country Total
US 926
JP 119
CN 109
KR 56
DE 54
OPTOGENETICS: CURRENT RESEARCH LANDSCAPE

ACTUATORS ACROSS DIFFERENT TYPES OF APPLICATIONS
 The chart below shows the different types of actuators used in various optogenetics applications to
trigger the manipulation of neuronal activity with light activation
 Channelrhodopsin along with Halorhodopsin are used primarily for neurodegenerative diseases
How we did it?
First records were classified under different actuators and applications of optogenetics. Then using co-occurrence
tool a matrix was generated for the actuators and applications and the resulting matrix was converted to a
Stacked Column Chart.
“Channelrhodopsin along with Halorhodopsin are used primarily for
neurodegenerative diseases”

SENSORS ACROSS DIFFERENT TYPES OF APPLICATION
 The chart below shows the different types of sensors used in various optogenetics applications
 pH sensors are mainly used for cardioversion and neurotransmitter sensors are used to monitor
conditions in live tissues for neurodegenerative diseases
How we did it?
First records were classified under different sensors and applications of optogenetics. Then using co-occurrence
tool a matrix was generated for the sensors and applications and the resulting matrix was converted to a Column
Chart.
“pH sensors are mainly used for cardioversion and neurotransmitter sensors are
used to monitor conditions in live tissues for neurodegenerative diseases”

TOP CPC CLASSIFICATIONS
 The chart below shows the top 10 CPC classifications around which the patents for optogenetics
were filed
How we did it?
Top CPC classifications were loaded form the Quick Stats and converted to a Table Chart.

PROMINENT AREAS OF RESEARCH
 The chart below shows top technology extracted from the records filed for optogenetics
How we did it?
Top topics were loaded for the Technology tab within the Quick Stats tab and downloaded as an image.

TOP APPLICANTS* PORTFOLIO ANALYSIS
(QUANTITATIVE)
* Analysis is shown by Ultimate Owners. So the applications of
subsidiaries have been merged into their parent organizations

PatSeer 360 correlates patents, business and legal data points in a powerful business-friendly
dashboard that makes it easy to identify technology and competitor trends, gaps and opportunities and
predict your next move. It includes specialized scoring models which incorporate more than 40
different quality parameters to give you an accurate perspective of the market challengers, leaders,
and niche players. For more information on scoring model visit appendix.
TOP APPLICANTS - PORTFOLIO SIZE AND QUALITY
 The chart represents the top 20 applicants for optogenetics
 The 360° Quality score is the weighted average of all the 3 scores, i.e. Citation score (CQ), Legal
score (LQ) and Document score (DQ).
 It can be seen that there are more number of Universities and research originations in the top
applicants with the University of Stanford leading the record count
 The pie chart represents the total percentage of the applicant type with all the companies clubbed
under Firm. It suggested that even if there more number of universities with the top applicants but
the overall filings are dominated by the Firms followed by universities
Note: For details about the PatSeer 360 Quality scores please refer the section at end of this report
“More number of Universities and
research originations in the top
applicants with University of
Stanford leading the record count”
OPTOGENETICS: TOP APPLICANTS* PORTFOLIO ANALYSIS (QUANTITATIVE)

INVENTOR GROUPS OF TOP APPLICANTS FOR OPTOGENETICS
 The generated maps below highlight the key inventor groups of top five applicants. In the map
below the groups are created using network relationships between the Applicants and the
inventors listed on the graph
 Key inventors present in the map, for instance, Boyden Edward who appears in between the two
clusters of University of Stanford and MIT has collaborative research for the neurodegenerative
application for both the universities and hence it is in between the two respective clusters. Similar
is the case with Alder Jon Elliot who has filings for University of California and Synomix Inc and Lee
Jin Hyung who has filings for University of California and University of Stanford.
How we did it?
Using the VizMAP tool, patents of top five applicants were loaded on the map. These were then
expanded by their respective inventor names. The VizShade option was used to shade the inventors and
assignees with potential overlapping patents between them.

PORTFOLIO ANALYSIS OF APPLICANTS ACROSS TECHNICAL
SEGMENTS
APPLICANTS ACROSS DIFFERENT TYPES OF APPLICATIONS
 The table below shows research activity of top applicants across different applications of
optogenetics
 Univ Stanford leads the records count for research around neurodegenerative disease and
cardioversion
 Acucela has optogenetics application for only retinal diseases
How we did it?
First records were classified under different application of optogenetics. The applicants were normalized with the
help of custom fields. Then using co-occurrence tool a matrix was generated for the applicants and their
applications and the resulting matrix was converted to a Column Chart.
“Univ Stanford leads the records count for research around neurodegenerative
disease and cardioversion”

APPLICANTS ACROSS DIFFERENT TARGETING TECHNIQUES
 The table below shows research activity of top applicants across different targeting techniques for
the use optogenetics
 Viral vector is the most popular targeting technique for optogenetics
How we did it?
First records were classified under different targeting techniques of optogenetics. The applicants were normalized
with the help of custom fields. Then using co-occurrence tool a matrix was generated for the applicants and
targeting techniques and the resulting matrix was converted to a Bar Chart.

APPLICANTS ACROSS DIFFERENT SENSORS
 The heat map below shows research activity of top applicants across different sensors used in
optogenetics
 Synomix leads the research for voltage sensitive and neurotransmitter sensors followed by
University of California
 pH sensors are widely used for optogenetic applications
How we did it?
First records were classified under different sensors used for optogenetics. The applicants were normalized with
the help of custom fields. Then using co-occurrence tool a matrix was generated for the applicants and sensors
and the resulting matrix was converted to a Column Heat Map.
“Synomix leads the research for voltage sensitive and neurotransmitter sensors”

APPLICANTS ACROSS DIFFERENT LIGHT EQUIPMENTS
 The map below shows research activity of Applicants across different light equipments used for
optogenetics to expose the cells to light
 Univ Stanford has the maximum records for light equipments amongst the universities and Acucela
leads the research for the same amongst the Applicants
How we did it?
First records were classified under different light equipments used for optogenetics. The applicants were
normalized with the help of custom fields. Then using co-occurrence tool a matrix was generated for the
applicants and light equipments and the resulting matrix was converted to a Tree Map.

APPLICANTS ACROSS DIFFERENT ACTUATORS
 The heat map below shows research activity of Applicants across different actuators used to
control genetically targeted cells. These are primarily light driven actuator proteins
 University of Stanford, MIT and Friedrich Miescher Institute lead the research for developing
Channelrhodopsin and Halorhodopsin derivatives for the facilitation of neuronal activity which
provides insights into light drivable
How we did it?
First records were classified under different actuators used for optogenetics. The applicants were normalized with
the help of custom fields. Then using co-occurrence tool a matrix was generated for the applicants and actuators
and the resulting matrix was converted to a Column Chart.
“University of Stanford, MIT and Friedrich Miescher Institute lead the research for
developing Channelrhodopsin and Halorhodopsin”

TECHNOLOGY LANDSCAPE FOR OPTOGENETICS
 The landscape map below represents key concepts for different Applicants generated across title,
abstract and claims. Themes are collection of prominent topics extracted from the patent data and
grouped under relevant parent tags.
 Clusters for Taste Receptors and Taste Gene are together as both the clusters are related to each
other with high degree of relevance with respect to the text. The nodes were then colored by the
assignees.
How we did it?
The VizMAP tool in PatSeer Pro was used for this analysis. First the clusters were generated on title, abstract and
claims using the Advanced Clustering option. Once the clusters were generated these were loaded using the
Landscape mode and then the themes were colored by assignees.
TECHNOLOGY LANDSCAPE FOR OPTOGENETICS
The nodes colored red are for Senomyx which has the maximum number of
filings for taste receptor and gene encoding out of the top applicants. Out of
its total portfolio 95% relates to the above mentioned technology theme.
Some of those family members are US10114009B2, EP3312194A1,
CA2827128C, and AU2011236059A1

TOP APPLICANTS PORTFOLIO ANALYSIS
(QUALITATIVE)

TOP APPLICANTS THAT ARE COMPANIES (FIRMS) AND THEIR
QUALITY ANALYSIS
INNOVATION SUMMARY OF TOP APPLICANTS
 The chart below shows innovation summary for the top 10 applicants for optogenetics
 It compares the 360 quality of the portfolio of the top companies with their invention age.
 Bristol Myers has the largest portfolio but the overall invention age for its portfolio is more than 20
years
 While companies like Immunolight and Acucela have better 360 quality and their invention age is
around 6 and 9 years respectively; which can be considered as being the new challengers in the
field of optogenetics
How we did it?
Once the records were added to the interface click on Companies-By ownership to load the overview. Then click
on Innovation Summary to generate the chart. The chart was downloaded as an image after marking the
individual companies on the chart
“Bristol Myers has the largest portfolio but the overall invention age for its
portfolio is more than 20 years”
OPTOGENETICS: TOP APPLICANTS PORTFOLIO ANALYSIS (QUALTITATIVE)
The 360° score is the weighted average of all the 3 scores, i.e. Citation score (CQ), Legal score (LQ) and
Document score (DQ). The patent with a higher 360° score indicates the impact to the market,
technological strength, defensiveness, aggressiveness of the company.
Invention age is the number of years since filing of the invention

TOP APPLICANTS WITH CITATION AND LEGAL QUALITY
 The chart below shows top applicants with the citation and legal quality of their portfolio
 Applicants like Canon and Cardiome have low citation and legal quality which indicates that their
offensive and defensive potential against any lawsuit is low
 Senomyx and Euro Celtique have high citation as well as legal Quality so these companies are high
on their defensive and offensive quality
How we did it?
Once the records were added to the interface click on Companies-By ownership to load the overview. Then click
on Assert Vs Defend to generate the chart. The chart was then downloaded as an image after marking the
individual companies on the chart
OPTOGENETICS: TOP APPLICANTS PORTFOLIO ANALYSIS (QUALTITATIVE)
Citation quality indicate the impact of the record in the technology. The probability of a record with a
higher citation score being used in company’s offensive strategy or for monetization is higher
Legal quality indicate the aggressiveness and investments of the company to protect the invention and
also a measure of its perceived threat to the competition

TOP APPLICANTS THAT ARE UNIVERSITIES (UNIV) AND THEIR
QUALITY ANALYSIS
INNOVATION SUMMARY OF TOP UNIVERSITIES
 The chart below shows innovation summary for the top 10 Universities for optogenetics
 Its compares the 360 quality of the portfolio of the top Universities with their invention age.
 University of Stanford has the largest portfolio and 360 quality, which indicates that it can
challenge other innovators in this field
How we did it?
Once the records were added to the interface click on Companies-By ownership to load the overview. Filter the
top universities for the filters available by clicking on Company Type option within the filters. Then click on
Innovation Summary to generate the chart. The chart was downloaded as an image after marking the individual
companies on the chart
“University Of Stanford has the largest portfolio and 360 quality, which indicates
that it can challenge other innovators in this field”
OPTOGENETICS: TOP UNIVERSITIES QUALITY ANALYSIS

TOP UNIVERSITIES AND THEIR RESEARCH CALIBER
 The chart below shows top 10 universities with respect to their Originality and Generality scores
 University of Stanford has the largest portfolio size amongst the top universities but still it is behind
University TUFTS in terms of the overall radical idea of its invention and its applications
 MIT also has a large portfolio but their inventions cannot be considered as radical or unique owing
to its Originality score thereby earning limited economic potential
How we did it?
top universities for the filters available by clicking on Company Type option within the filters. Then click on the
Citation tab and then on R&D Caliber to generate the chart. The chart was downloaded as an image after marking
the individual companies on the chart
Originality shows a measure of how radical an invention is
Generality shows a measure of how generic (applicable to multiple areas) an invention is

TOP UNIVERSITIES RANKED BY ORIGINALITY
 The chart below represents the top universities ranked on the basis of their radical ideas
 It can be seen that University Florida has a small portfolio but its inventions are radical and at the
same time have high generality value which indicates that the inventions will have multiple
applications
 University TUFTS has the Generality amongst the top universities innovating in optogenetics
How we did it?
top universities for the filters available by clicking on Company Type option within the filters. The resulting table
was downloaded as an image.
“University Florida has a small portfolio but its inventions are radical and at the
same time have high generality value which indicates that the inventions will
have multiple applications”

NEW ENTRANTS PORTFOLIO ANALYSIS
(QUANTITATIVE)

NEW ENTRANTS IN THE LAST 5 YEARS
The New Entrants in this section are the new entrants in the field of optogenetics in the last five years.
1. CIRCUIT THERAPEUTICS INC
2. CARIS SCIENCE INC
3. GALVANI BIOELECTRONICS
4. ALDEYRA THERAPEUTICS INC
5. FUNCTIONAL NEURMODULATION INC
6. AXION BIOSYSTEM INC
7. DR NONA INTERNATIONAL LTD
8. INSCOPIX INC
9. KYUNGPOOK NAT UNIV IND ACAD
INNOVATION TIMELINE FOR THE NEW ENTRANTS
 The chart below shows the innovation timeline representing patenting activity for the new
entrants for optogenetics in the last 5 years
 Kyungppok National University was one of the early fliers and had its first filing in the year 2013,
but their filings have dropped in the last five years
 Circuit Therapeutics leads the list of new entrants
How we did it?
Once the patents were added to PatSeer Projects, key assignees (identified by online research) were filtered and
a filter set was created for the same. Then from the Quick Stats Tab innovation timeline was generated and
converted to a bubble chart.
NEW ENTRANTS PORTFOLIO ANALYSIS (QUANTITATIVE)

INNOVATIONS ACROSS DIFFERENT TARGETING TECHNIQUES FOR THE
NEW ENTRANTS IN OPTOGENETICS
 The chart below shows number of patents held by new entrants across various Targeting
techniques of optogenetics
How we did it?
First new entrants in optogenetics were identified by online review and these were analyzed with respect to the
targeting techniques of optogenetics. The resulting matrix was the converted to a Tree Map and the chart was
exported as an image.
NEW ENTRANTS PORTFOLIO ANALYSIS (QUANTITATIVE)

NEW ENTRANTS ACROSS SENSORS
 The chart below shows activity of new entrants across different sensors used for optogenetics
 Functional Neuromodulation Inc leads the records count for neurotransmitter and pH sensors
How we did it?
Once the patents were added to PatSeer Projects, key assignees were filtered and a filter set was created for the
same. Co-occurrence analyzer was used to generate a matrix for new Applicants and sensors. The resulted matrix
was then converted to a Bar Chart and exported as image.
“Functional Neuromodulation Inc leads the records count for
neurotransmitter and pH sensors”
OPTOGENETICS: COMPANY SPOTLIGHT WRT NEW ENTRANTS

NEW ENTRANTS ACROSS ACTUATORS
 The chart below shows activity of new entrants across actuators used for optogenetics
 Circuit Therapeutics Inc leads the records count for all the actuators used in optogenetics
How we did it?
Once the patents were added to PatSeer Projects, new assignees were filtered and a filter set was created for the
same. Co-occurrence analyzer was used to generate a matrix for key Applicants and actuators. The resulted
matrix was then converted to a Column Chart and exported as an image.

NEW ENTRANTS ACROSS APPLICATIONS
 The chart below shows activity of new entrants across different applications of optogenetics
 Circuit Therapeutic Inc and Functional Neuromodulation Inc have research interest for the cures of
neurodegenerative diseases
 Caris Science Inc leads the research for cardioversion and retinal diseases
How we did it?
Once the patents were added to PatSeer Projects, new entrants were filtered and a filter set was created for the
same. Co-occurrence analyzer was used to generate a matrix for key Applicants and application. The resulted
matrix was then converted to a Column Chart and exported as an image.
“Caris Science Inc leads the research for cardioversion and retinal diseases”

NEW ENTRANTS SUMMARY REPORT
 The chart below shows summary report for new entrants with respect to their technology sub
domain and industry
Parent Assignee Total Current Assignee Tech Sub Domain Industry
CIRCUIT THERAPEUTICS
INC
9(0.52)% CIRCUIT THERAPEUTICS INC
: 9
BOARD OF TRUSTEES OF
LELAND STANFORD : 1
STAHLER KATHRYN J : 1
UNIV LELAND STANFORD
JUNIOR : 1
MEDICAL TECHNOLOGY :
9
PHARMACEUTICALS : 6
BIOTECHNOLOGY : 1
IRRADIATION, ELECTROMEDICAL AND
ELECTROTHERAPEUTIC EQUIPMENT: 9
BASIC PHARMACEUTICAL PRODUCTS
AND PHARMACEUTICAL PREP. : 6
MEDICAL AND DENTAL INSTRUMENTS
AND SUPPLIES : 4
CARIS SCIENCE INC 6(0.35)% CARIS SCIENCE INC : 6 BIOTECHNOLOGY : 5
ANALYSIS OF BIOLOGICAL
MATERIALS : 4
ORGANIC FINE
CHEMISTRY : 2
PHARMACEUTICALS : 1
MEASURING, TESTING AND
NAVIGATION INSTRUMENTS;
WATCHES AND CLOCKS : 4
OTHER CHEMICAL PRODUCTS : 1
ALDEYRA
THERAPEUTICS INC
4(0.23)% ALDEYRA THERAPEUTICS
INC : 4
ORGANIC FINE
CHEMISTRY : 3
PHARMACEUTICALS : 3
AXION BIOSYSTEM INC 3(0.17)% AXION BIOSYSTEM INC : 3 ANALYSIS OF BIOLOGICAL
MATERIALS : 3
MEASUREMENT : 2
CHEMICAL ENGINEERING
: 1
DIGITAL
COMMUNICATION : 1
1
AND SUPPLIES : 2
COMMUNICATION EQUIPMENT : 1
INSCOPIX INC 3(0.17)% INSCOPIX INC : 3 MEASUREMENT : 3
OPTICS : 3
2
AUDIO-VISUAL
TECHNOLOGY : 1
COMPUTER TECHNOLOGY
: 1
OPTICAL INSTRUMENTS AND
PHOTOGRAPHIC EQUIPMENT : 3
AND SUPPLIES : 2
COMMUNICATION EQUIPMENT : 1
COMPUTERS AND PERIPHERAL
EQUIPMENT : 1
KYUNGPOOK NAT UNIV
IND ACAD
3(0.17)% KYUNGPOOK NAT UNIV IND
ACAD : 3
ANALYSIS OF BIOLOGICAL
MATERIALS : 3
DR NONA
INTERNATIONAL LTD
2(0.12)% DR NONA INTERNATIONAL
LTD : 2
PHARMACEUTICALS : 2 BASIC PHARMACEUTICAL PRODUCTS

BOARD OF TRUSTEES
OF LELAND STANFORD
1(0.06)% BOARD OF TRUSTEES OF
LELAND STANFORD : 1
CIRCUIT THERAPEUTICS INC
: 1
JUNIOR : 1
1
PHARMACEUTICALS : 1
ELECTROTHERAPEUTIC EQUIPMENT :
1
FUNCTIONAL
NEURMODULATION
INC
2(0.06)% FUNCTIONAL
NEURMODULATION INC : 2
FUNCTIONAL
NEUROMODULATION INC :
2
2
ELECTROTHERAPEUTIC EQUIPMENT :2
AND SUPPLIES : 2
GALVANI
BIOELECTRONICS LTD
1(0.06)% GALVANI BIOELECTRONICS
LTD : 1
1
1
AND SUPPLIES : 1
STAHLER KATHRYN J 1(0.06)% CIRCUIT THERAPEUTICS INC
: 1
STAHLER KATHRYN J : 1
1
PHARMACEUTICALS : 1
1
AND SUPPLIES : 1
UNIV LELAND
STANFORD JUNIOR
1(0.06)% BOARD OF TRUSTEES OF
LELAND STANFORD : 1
CIRCUIT THERAPEUTICS INC
: 1
JUNIOR : 1
1
PHARMACEUTICALS : 1
1
How we did it?
First new entrants in the last 5 years in optogenetics were identified by online review and these were filtered
from the Apply Filter option present. Once this was done then Summary Report option was selected. Then under
“generate report for” option Applicants (under custom fields) option were selected. Parameters required for
analysis were selected from the option “Patent Fields” and the resulting chart was generated and then exported
as an excel file.

NEW ENTRANTS PORTFOLIO ANALYSIS
(QUALITATIVE)

INNOVATION SUMMARY OF NEW ENTRANTS IN THE LAST 5 YEARS
 The chart below shows the new entrants and their innovation summary
 Axion Biosystem has its originality at 0.8; which means that even if its portfolio size or the total
inventions are less but the inventions are radical or original
How we did it?
New entrants were identified from PatSeer 360 and online research. Once the records for those were added to
the interface click on Companies-By ownership to load the overview. Then click on Innovation Summary to
generate the chart. The chart was downloaded as an image after marking the individual companies on the chart
“Axion Biosystem has its originality at 0.8; which means that even if its portfolio
size or the total inventions are less but the inventions are radical or original”
OPTOGENETICS: NEW ENTRANTS PORTFOLIO ANALYSIS (QUALITATIVE)

SUMMARY
This report analyzes research trends of optogenetics with a focus on Targeting Techniques, Sensors,
Light Equipments, Actuators and Applications and also highlights the key Applicants involved in this
space.
The field of optogenetics has furthered the fundamental scientific understanding of how specific cell
types contribute to the function of biological tissues such as neural circuits in vivo (see references from
the scientific literature below). Moreover, on the clinical side, optogenetics-driven research has led to
insights into Parkinson's disease and other neurological and psychiatric disorders. Indeed, optogenetics
papers in 2009 have also provided insight into neural codes relevant to autism, Schizophrenia, drug
abuse, anxiety, and depression.
The use of the optogenetic tools is mostly seen in the American and European region. The awareness
about the products of optogenetic is increasing in the other region as compared to the developed
regions.
To get this project shared with you via PatSeer’s Patent Dashlet and to obtain access of dataset behind
this report, Contact us here:

PATSEER 360° QUALITY SCORES
The Legal Quality Score factors the following parameters:
 Legal Status: Alive or Dead - Legal Quality Score is 0 if record is Dead
 Alive Status: Granted / Pending - Positive Correlation
 Invention Coverage: Distinct Countries the invention is filed in - Positive Correlation
 Countries where the invention is filed - Higher GDP countries have higher weightage
 Count of family members - Positive Correlation
 Remaining Life of Invention - Positive Correlation
 Litigations - Positive Correlation
PATSEER 360° QUALITY SCORES
PatSeer 360° includes a 360° Quality Score
that comprehensively represents the overall
quality of the patent family. It covers a total
of 30+ different parameters associated with
the patent family. The 360° Score is
calculated as a weighted average of three
scores that cover three independent
viewpoints to the patent family – namely
Citation, Legal and Document (Intrinsic)
Qualities.
Each Score is evaluated for an invention (=
patent simple family) and is a value between
0 and 100. The scores calculated are absolute
values and are not relative to the analyzed
dataset.
The Scoring Model comprises:
1. Citation Quality Score (CQ)
2. Legal Quality Score (LQ)
3. Document/Intrinsic Quality Score (DQ)
4. 360° Quality Score
Patents ranking higher on score tend to be of
better quality and the probability of higher
quality patents being used for assertion,
licensing or litigation, in a company's IP
strategy is higher.
CITATION QUALITY SCORE (CQ)
CQ Scores indicate the impact of the record in the
technology. The probability of a record with a
higher citation score being used in company’s
offensive strategy or for monetization is higher.
Citation Quality Score considers all the citation
related parameters to quantify the quality of a
document. These are:
 No. of Forward citations (Family) - Positive
Correlation
 Last 5 years forward citation count - Positive
Correlation
 X, Y, I category forward citations - Positive
Correlation
 Generality - Positive Correlation
 Originality - Positive Correlation
 Number of References - Positive Correlation
 Number of Backward Citations - Positive
Correlation
 Examiner vs Inventor Citations – Negative
Correlation
For each patent family its individual values are
ranked statistically against the reference
technology domain it falls into and the final
Quality Score is the Weighted Average of the
ranking of the family across the parameters.
LEGAL QUALITY SCORE (LQ)
The legal score indicate the aggressiveness and
investments of the company to protect the
invention and also a measure of its perceived
threat to the competition. A higher LQ portrays
that the invention is well covered across different
geographies and reflects the patenting strategies
of innovators and peculiarities in the different
patenting systems providing insightful indicator of
the value of patented innovations.

 Oppositions - Positive Correlation
 Re-examinations - Positive Correlation
 NPE owned? - Positive Correlation
 Ongoing Collateral – Negative Correlation
DOCUMENT/INTRINSIC QUALITY SCORE (DQ)
Document Quality Score is the technical quality indicator of the patent. A likelihood of a patent with
higher DQ indicates innovation quotient and the capabilities of the company to innovate. Some of the
parameters taken in consideration are:
 Science linkage - Positive Correlation
 Co applicants - Positive Correlation
 Technological Scope: Unique 4 digit IPC/CPC Classes - Positive Correlation
 Number of total and independent claims - Positive Correlation
 First Claim word count – Negative Correlation
 Count of Inventors - Positive Correlation
 SEP - Positive Correlation
 Orange Book - Positive Correlation
 Time to grant - Positive Correlation
DQ scores indicate the corporate technical strength and the R&D quality of the company.
360° QUALITY SCORE
The 360° score is the weighted average of all the 3 scores, i.e. Citation score (CQ), Legal score (LQ) and
Document score (DQ). The patent with a higher 360° score indicates the impact to the market,
technological strength, defensiveness, aggressiveness of the company. The probability of company
using the patents with good 360° scored for their products, economic progress and their core strategies
is higher.

ABOUT PATSEER
PatSeer is a web based global patent database
and research platform with integrated analytics,
project workflow, and collaboration capabilities.
Built using latest web technologies, PatSeer
hides the complexities of searching across
worldwide data with its intuitive interface. With
updates and features added almost monthly /
bimonthly PatSeer is serving the varying
operational and strategic needs of IP
community.
ABOUT PATSEER 360
PatSeer 360 correlates patents, business and
legal data points in a powerful business-friendly
dashboard that makes it easy to identify
technology and competitor trends, gaps and
opportunities and predict your next move. It
provides unique insights into technologies, companies and the quality and quantity of patent
portfolios they hold, with a pioneering dashboard, PatSeer 360 opens a whole new realm of
possibilities for IP decision making.
For more information visit: www.patseer.com/360-edition/
ABOUT PATSEER PRO
PatSeer Pro is a powerful and flexible web-based Patent Search, Analytics and Landscaping
Platform. It includes a comprehensive set of analytical tools needed for precise technology
landscaping and competitive intelligence projects such as Assignee cleanup tools, Co-
occurrence Matrices, configurable Chart Dashboards, multi-generation Citation Analysis, Text
Clustering and VizMAP – a spatial exploration and contour mapping visualization engine.
For more information visit: www.patseer.com/pro-edition/
© 2019 Gridlogics. All Rights Reserved.
PatSeer™ is a trademark of Gridlogics Technologies Pvt. Ltd.
Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
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