Antigens

Eugene P. Mayer Office: Bldg. #2, Rm. B19 Phone: 733-3281 Email: MAYER@MED.SC.EDU

Overview of the Immune System Immune System Innate (Nonspecific) Adaptive (Specific) Cellular Components Humoral Components Cell-Mediated Humoral (Ab)

Definitions ,[object Object],[object Object],[object Object],[object Object],[object Object]

Factors Influencing Immunogenicity Contribution of the Immunogen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Conformational determinants Sequence determinants

Factors Influencing Immunogenicity Contribution of the Immunogen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Factors Influencing Immunogenicity Contribution of the Biological System ,[object Object],[object Object],[object Object],[object Object],[object Object]

Factors Influencing Immunogenicity Method of Administration ,[object Object],[object Object],[object Object],[object Object],[object Object]

Chemical Nature of Immunogens ,[object Object],[object Object],[object Object],[object Object],[object Object]

Types of Antigens T-independent ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Types of Antigens T-dependent ,[object Object],[object Object],[object Object],[object Object],[object Object]

Hapten-carrier conjugates ,[object Object],[object Object],[object Object],[object Object],Native determinants Haptenic determinants

Antigenic Determinants Recognized by B cells and Ab ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antigenic Determinants Recognized by B cells and Ab ,[object Object],[object Object],[object Object],[object Object],[object Object],Fe

Antigenic Determinants Recognized by T cells ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Superantigens Monoclonal/Oligoclonal T cell response 1:10 4 - 1:10 5 ,[object Object],Conventional Antigen Superantigen Polyclonal T cell response 1:4 - 1:10

Superantigens ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Determinants Recognized by the Innate Immune System ,[object Object],[object Object],[object Object],[object Object]

Determinants Recognized by the Innate Immune System ,[object Object],[object Object]

Macrophage activation; Secretion of inflammatory cytokines TLR-2 (Toll-like receptor 2) Lipoproteins of Gram + bacteria Yeast cell wall components Phagocytosis Scavenger receptors Polyanions Opsonization; Complement activation Mannose-binding protein Mannose-containing carbohydrates Opsonization; Complement activation Complement Microbial cell wall components Biological Consequence of Interaction PRR PAMP

Production of interferon (antiviral) TLR-3 Double stranded RNA Macrophage activation; Secretion of inflammatory cytokines TLR-5 Flagellin (bacterial flagella) Macrophage activation; Secretion of inflammatory cytokines TLR-4 LPS (lipopolysaccharide of Gram – bacteria Biological Consequence of Interaction PRR PAMP

Macrophage activation; Secretion of inflammatory cytokines TLR-9 CpG containing DNA Production of interferon (antiviral) TLR-7 U-rich single stranded viral RNA Biological Consequence of Interaction PRR PAMP

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