1. By: Cassandra Petrilla

2. It is an inherited disease of your secretory
glands, including the glands that make
mucus and sweat.

3.  Cystic fibrosis of the Pancreas
 Fibrocystic Disease of the Pancreas
 Mucoviscidosis
 Mucoviscidosis of the Pancreas
 Pancreas Fibrocystic Disease
 Pancreatic Cystic Fibrosis

4. What causes CF?
 When a mutation called delta-F508 occurs in a single gene on chromosome 7.
 The gene that is infected contains instructions for building a protein called cystic fibrosis
transmembrane (CFTR).
 The gene will there forth produce CFTR that does not work and chloride ions can not
pass through the membrane.
 In 70-80% of the cases in the US the gene is completely missing from the membrane.
 If CFTR is missing, chloride ions are not reabsorbed.

5. How is CF
inherited?
 A person gets CF when they inherit 2 mutated CFTR genes
, one from each parent.
 The parents might not have the disease because they have a
normal copy of the gene on their other chromosome.
 CF is a recessive disorder.

6. 1. Your sweat is saltier than most people.
2. The doctors then use the “sweat test”.
3. During the test, the doctors use a sweat-inducing
chemical called pilocarpine.
4. If the reading comes back that your chloride ion
is above 60 mmol/liters, then you have CF.

7. Intestines
 The digestive enzyme that your pancreas makes (breaks down your food so you can
eat) cannot reach your small intestines.
 Without this enzyme you cannot fully absorb fats and proteins.
 This can then lead to vitamin deficiency and malnutrition because nutrients leave
your body unused.
Lungs
Your mucus becomes thick and sticky.
 The mucus will eventually build up in
your lungs and block the airways.
 This buildup makes it easy for bacteria to
grow.
 This leads to serious lung infections and
over time can severely damage your lungs.

8. • CF causes your sweat to leave your body 5 times saltier.
• This leads to abnormal heart rhythms.
• Your balance of minerals in your blood becomes upset
and can cause health problems.
• Have increased risk for diabetes or osteoporosis.
• Causes infertility in men and makes it harder for
women to get pregnant.
• Most common death of people with CF is respiratory
failure.

9. NO CURE
FOR CF!!!
 You can take supplements containing enzymes to help digestion.
 You can take replacement enzymes such as pancreatin.
 You can reduce chest infections with frequent physiotherapy
and either occasional or continuous antibiotics.
 You can take physiotherapy which involves vigorous massage to
help loosen the sticky mucus.
 In severe cases a lung or heart and lung transplant operation is
necessary.

10. Prevalance Rate of CF-1 in
31,000 in U.S. get it

11.  Cystic Fibrosis Worldwide
 Canadian Cystic Fibrosis
 Cystic Fibrosis Research, Inc.
 Karen’s Climb Foundation
Pennsylvania Cystic Fibrosis, Inc.
 Reaching Out Foundation
 St. Louis Second Wind Transplant Association

12.  http://www.nhlbi.nih.gov/health/dci/Diseases/cf/cf_what.html
 http://www.yourgenesyourhealth.org/cf/have.htm
http://www.ask.com/bar?q=how+do+you+treat+cystic+fibrosis&page=1&qs
rc=0&ab=2&u=http%3A%2F%2Fhcd2.bupa.co.uk%2Ffact_sheets%2FMosb
y_factsheets%2FCystic_fibrosis.html
 http://www.nhlbi.nih.gov/health/dci/Diseases/cf/cf_what.html
http://www.lpch.org/clinicalSpecialtiesServices/COE/PulmonaryCareCF/ov
erview.html