Urinary System Drugs.pdf

1. Drugs Affecting the Urinary System
Review A&P
Urinary System Drugs Diuretics: Thiazide, Potassium Sparing and Loop see
cardiovascular drugs.
Osmotic Diuretics:
Example: Osmitrol (mannitol)
MOA: Dextrose based solution’s sugar molecules
are filtered by the renal tubular cells, very little is
Review A&P and Key Terms reabsorbed. It’s presence creates as osmotic
gradient that draws water into the lumen increasing
diuresis.
Adverse Effects: dry mouth, blurred vision, low Na
Diamox (acetazolamide) Nursing Measures: Diuretics
MOA: Weak systemic osmotic diuretic. Monitor electrolytes, especially K, and renal
Produces alkaline urine which is useful in function labs. Creatinine clearance is the
increasing excretion of weakly acidic drugs in best indicator of renal function.
OD situations, lowers IOP in glaucoma by Give in AM or early afternoon.
decreasing production of aq humor by 50%. Record baseline BP and monitor closely.
Uses: Primarily glaucoma – open and acute Daily I&O, weights.
closed angle.
Monitor blood glucose if taking thiazides.
Adverse Effects: Sedation, hypokalemia.
Evaluate effectiveness: UOP, weight loss,
absence of rales, decrease in edema.
Urinary Analgesics
Example: Pyridium (phenazopyridine)
MOA: An azo dye, acts as a urinary tract
analgesic. Relieves sx of dysuria, burning,
frequency and urgency. No antiinfective
action.
Uses: Cystitis
Adverse Effects: Turns urine orange-red.
Contraindications: Renal failure, hepatitis
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