3. *Factors determining the
extent of infection
*Microbe
*Virulence
*Dose, no of infecting microbes
*Portal of entry i.e. pulp,
periodontal, surgical wounds
*Toxic factors released
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15. *Eliminate the cause
*Extraction of the non-vital
tooth
*Debridement of necrotic tissue
*Root canal therapy
*Periodontal therapy
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