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Alex Lightman
Executive Director, Humanity+
   Chairman, H+ Summit
The Rise of the Citizen-Scientist
   in the Eversmarter World
A Scientific Call to Arms
Combating aging                  Economic instability
 means more                      Geopolitical instability
 existential risks are
 likely to occur within          Peak everything
 our lifetimes. [Bostrom 2002]   Climate change
We will be forced to             (biome instability)
 adopt a longer-term             Once-in-a-century
 view, as we will be the         storms, floods
 generation to face
 these challenges.               Tectonic shifts
                                 The unforeseen
The Rise of Open Science
Aristotle programmed Alexander the Great to be
  an Citizen-Scientist-Conqueror; flora, fauna, soil
  samples
Boom in the 16th through the 18th centuries:
Networks of mathematicians corresponded and
 shared results, issued challenges, and
 competed for prizes.
Reputation became currency for intellectuals
 competing for sponsorship by patrons.
 Patronage motivations were both practical and
 ornamental. [David 2003]
Historical Citizen-Scientists
   Sir Isaac Newton: after graduation from Cambridge,
    worked at home from 1665-7 to develop theories of
    calculus, optics, and law of gravitation
   Benjamin Franklin: measured ocean temperatures
    while crossing the Atlantic, mapping the Gulf Stream
   Albert Einstein: developed special relativity as a hobby
    while working as a patent clerk
   Steve Wozniak and Homebrew Computer Club: early
    DIY computer hobbyists, produced hackers and IT
    entrepreneurs
Big Science                   Small Science
   Manhattan Project,       Typically done at
    Apollo Program, LHC       universities by teams
                              and communities
   Scale necessitates
    funding from             Interface between
    government(s) and/        science and society
    or industry              Publish or perish:
                              research geared to
                              winning grants
Rise of the Citizen-Scientist
   Moore's Law-like Learning Curve for
    Laboratories
   The Return of the Individual Inventor
   The Revival of the Mania for Measurement
   The FaceBook Ever-Smarter Friend Effect
   Prizes and Grants
Instruments Following Moore's Law
    Falling cost of equipment. E.g., one can buy an
     education thermal cycler for $1K (MyCube
     Personal); the LavaAmp pocket PCR will be
     smaller and cheaper (hundreds not K’s!)
    Computer simulations and analysis: better,
     faster, cheaper as per Moore's Law.
    Instruments are increasingly portable.
     Disposable bioreactors and hollow fiber cell
     cartridges can easily fit in a basement lab.
The price of genomic sequencing
   2003 - $300M(est) - first
    human genome
   2007 - $2M(est) - first
    personal genome
   2008 - $60K - Applied
    Biosystems
   2009 - $5K - Complete
    Genomics
   2010 - $1K?
Return of the Individual Inventor
   COTS (commercial off-the-shelf) provides
    increasingly affordable technological capability.
   Open source manufacturing empowers
    inventors to create prototypes and improved
    tools.
   Novel combinations of cheap technologies can
    be readily combined in DIY projects, from gas
    turbines, to mobile microscopes (CellScope), to
    cruise missiles(!).
The Measure of the World
   Advances in measurement and precision drive
    science and technology.
   Measurements enable models, simulations,
    allowing visions to be made real.
   Cheaper sensors and networking enables
    citizen-scientists to cooperate and enhance
    measurement capability.
   What's needed: quantitative literacy.
Eversmarter Networks
   Social networking provides the unprecedented
    freedom to meet like minds.
   Tools like Facebook can be leveraged. Please
    raise your hand if you are a Facebook friend of
    mine. Smarter “curators” get more smart
    friends. Less smart are spammy, lose friends
    fast.
   The result: emergent, self-organizing R&D
    networks and teams out of intelligent kind
    commenters on Facebook links.
Fame, Glory, and Cash Prizes
   “Whuffie”, reputation capital
   Challenges, X PRIZEs
   So-called “crowdsourcing”: actually markets/
    networks/exchanges connecting patrons and
    citizen-scientists: e.g., InnoCentive
   Proposal: scientific seed micro-grants to
    bootstrap citizen-scientist efforts
Citizen-Scientists in Action
   Emergence of collaboratories, as DIY and
    networking enable sharing of homebrew
    infrastructure, perhaps in the form of Dave
    Orban's vision of an open Internet of Things.
   Entrepreneurs may emerge. Nolan Bushnell's
    talk will offer perspective on how this may
    unfold.
   Not tied to corporate ROI or academic publish-
    or-perish constraints: free to publish negative
    results.
The Iceberg of Results
   Positive results are above water, rewarded and
    brought to the top by a publish-or-perish
    system.
   Negative results are mostly under water.
If the studies are small … the findings often are never
   published, leading future researchers to waste time
   and money going down the same blind alley. Or, if a
   study that fails to support a popularly held idea …
   goes unpublished, people may continue to believe in
   an association that has never actually been proven.
    [Kolata/NYT 2002]
Kudos as Currency
Freedom from external funding constraints
  means that worthy projects that will benefit
  humanity don't require a business case for
  justification. Reputation can suffice, as one
  creates an enduring legacy.


     It amuses me to see how afraid you are,
        lest the people should accuse you of
        recommending useless studies.
     Socrates
The Entry-Level Cost of Science
   Theoretical physics: LHC = $9 billion
   For a citizen-scientist: as little as a smartphone
    and broadband!
   See Darlene Cavalier's talk on citizen-scientists
    disrupting science in a good way!
A Perfect Storm

   Commoditization
   Democratization
   Connectivity in an Ever-Smarter World
   Cheaper, smaller sensors enable more
    measurements to be accumulated
   Citizen-scientists will be increasingly
    empowered
Hindrances
   Imposed barriers: embargo, onerous tollgates,
    silos. Does Cuba have unique treatments?
   Publish-or-perish: selection pressure for grant-
    worthy results
   Commercial bias: selection pressure against
    unfavorable results being published
   ROI optimization bias: selection pressure for
    projects that are low-hanging fruit
An Open Cornucopia of Knowledge

    Open courseware online provides university
     education
    Free access to scientific journals
    Open software and data sets enables direct
     participation
    Free tools enhance investigation: e.g.,
     Wolfram Alpha
    Other citizen-scientists
Accelerating Knowledge
   Scientific inquiry is wed to liberty: “Tear down
    that wall!” Free communication and inquiry is
    vital for communities of practice to thrive.
   Proposal: public access sharing of research
    infrastructure with citizen-scientists, forging new
    participatory networks.
   Idle infrastructure can be shared and/or rented,
    increasing net research throughput.
   Sharing and coordinating research proposals
    can reduce duplication of effort.
A View to a Future
   Science fiction inspires technology, which
    further inspires SF. Citizen-scientists can be
    “future engines”.
   See Ray Kurzweil's talk!
   On the horizon:
       DIY 3D bioprinters
       DIY tricorders
       DIY synthetic genomics
       DIY pandemic response
Forthcoming H+ Summits


H+ Summit 2010 West - Live Long and Prosper
        November 5-6-7, 2010, Los Angeles

             H+ Summit Europe
           January 29-30 2011, London

            H+ Summit 2011 East
                   May, 2011
The Rise of Citizen-Scientists in the Eversmarter World - Alex Lightman - H+ Summit @ Harvard

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The Rise of Citizen-Scientists in the Eversmarter World - Alex Lightman - H+ Summit @ Harvard

  • 1. Alex Lightman Executive Director, Humanity+ Chairman, H+ Summit
  • 2. The Rise of the Citizen-Scientist in the Eversmarter World
  • 3. A Scientific Call to Arms Combating aging Economic instability means more Geopolitical instability existential risks are likely to occur within Peak everything our lifetimes. [Bostrom 2002] Climate change We will be forced to (biome instability) adopt a longer-term Once-in-a-century view, as we will be the storms, floods generation to face these challenges. Tectonic shifts The unforeseen
  • 4. The Rise of Open Science Aristotle programmed Alexander the Great to be an Citizen-Scientist-Conqueror; flora, fauna, soil samples Boom in the 16th through the 18th centuries: Networks of mathematicians corresponded and shared results, issued challenges, and competed for prizes. Reputation became currency for intellectuals competing for sponsorship by patrons. Patronage motivations were both practical and ornamental. [David 2003]
  • 5. Historical Citizen-Scientists  Sir Isaac Newton: after graduation from Cambridge, worked at home from 1665-7 to develop theories of calculus, optics, and law of gravitation  Benjamin Franklin: measured ocean temperatures while crossing the Atlantic, mapping the Gulf Stream  Albert Einstein: developed special relativity as a hobby while working as a patent clerk  Steve Wozniak and Homebrew Computer Club: early DIY computer hobbyists, produced hackers and IT entrepreneurs
  • 6. Big Science Small Science  Manhattan Project,  Typically done at Apollo Program, LHC universities by teams and communities  Scale necessitates funding from  Interface between government(s) and/ science and society or industry  Publish or perish: research geared to winning grants
  • 7. Rise of the Citizen-Scientist  Moore's Law-like Learning Curve for Laboratories  The Return of the Individual Inventor  The Revival of the Mania for Measurement  The FaceBook Ever-Smarter Friend Effect  Prizes and Grants
  • 8. Instruments Following Moore's Law  Falling cost of equipment. E.g., one can buy an education thermal cycler for $1K (MyCube Personal); the LavaAmp pocket PCR will be smaller and cheaper (hundreds not K’s!)  Computer simulations and analysis: better, faster, cheaper as per Moore's Law.  Instruments are increasingly portable. Disposable bioreactors and hollow fiber cell cartridges can easily fit in a basement lab.
  • 9. The price of genomic sequencing  2003 - $300M(est) - first human genome  2007 - $2M(est) - first personal genome  2008 - $60K - Applied Biosystems  2009 - $5K - Complete Genomics  2010 - $1K?
  • 10. Return of the Individual Inventor  COTS (commercial off-the-shelf) provides increasingly affordable technological capability.  Open source manufacturing empowers inventors to create prototypes and improved tools.  Novel combinations of cheap technologies can be readily combined in DIY projects, from gas turbines, to mobile microscopes (CellScope), to cruise missiles(!).
  • 11. The Measure of the World  Advances in measurement and precision drive science and technology.  Measurements enable models, simulations, allowing visions to be made real.  Cheaper sensors and networking enables citizen-scientists to cooperate and enhance measurement capability.  What's needed: quantitative literacy.
  • 12. Eversmarter Networks  Social networking provides the unprecedented freedom to meet like minds.  Tools like Facebook can be leveraged. Please raise your hand if you are a Facebook friend of mine. Smarter “curators” get more smart friends. Less smart are spammy, lose friends fast.  The result: emergent, self-organizing R&D networks and teams out of intelligent kind commenters on Facebook links.
  • 13. Fame, Glory, and Cash Prizes  “Whuffie”, reputation capital  Challenges, X PRIZEs  So-called “crowdsourcing”: actually markets/ networks/exchanges connecting patrons and citizen-scientists: e.g., InnoCentive  Proposal: scientific seed micro-grants to bootstrap citizen-scientist efforts
  • 14. Citizen-Scientists in Action  Emergence of collaboratories, as DIY and networking enable sharing of homebrew infrastructure, perhaps in the form of Dave Orban's vision of an open Internet of Things.  Entrepreneurs may emerge. Nolan Bushnell's talk will offer perspective on how this may unfold.  Not tied to corporate ROI or academic publish- or-perish constraints: free to publish negative results.
  • 15. The Iceberg of Results  Positive results are above water, rewarded and brought to the top by a publish-or-perish system.  Negative results are mostly under water. If the studies are small … the findings often are never published, leading future researchers to waste time and money going down the same blind alley. Or, if a study that fails to support a popularly held idea … goes unpublished, people may continue to believe in an association that has never actually been proven. [Kolata/NYT 2002]
  • 16. Kudos as Currency Freedom from external funding constraints means that worthy projects that will benefit humanity don't require a business case for justification. Reputation can suffice, as one creates an enduring legacy. It amuses me to see how afraid you are, lest the people should accuse you of recommending useless studies. Socrates
  • 17. The Entry-Level Cost of Science  Theoretical physics: LHC = $9 billion  For a citizen-scientist: as little as a smartphone and broadband!  See Darlene Cavalier's talk on citizen-scientists disrupting science in a good way!
  • 18. A Perfect Storm  Commoditization  Democratization  Connectivity in an Ever-Smarter World  Cheaper, smaller sensors enable more measurements to be accumulated  Citizen-scientists will be increasingly empowered
  • 19. Hindrances  Imposed barriers: embargo, onerous tollgates, silos. Does Cuba have unique treatments?  Publish-or-perish: selection pressure for grant- worthy results  Commercial bias: selection pressure against unfavorable results being published  ROI optimization bias: selection pressure for projects that are low-hanging fruit
  • 20. An Open Cornucopia of Knowledge  Open courseware online provides university education  Free access to scientific journals  Open software and data sets enables direct participation  Free tools enhance investigation: e.g., Wolfram Alpha  Other citizen-scientists
  • 21. Accelerating Knowledge  Scientific inquiry is wed to liberty: “Tear down that wall!” Free communication and inquiry is vital for communities of practice to thrive.  Proposal: public access sharing of research infrastructure with citizen-scientists, forging new participatory networks.  Idle infrastructure can be shared and/or rented, increasing net research throughput.  Sharing and coordinating research proposals can reduce duplication of effort.
  • 22. A View to a Future  Science fiction inspires technology, which further inspires SF. Citizen-scientists can be “future engines”.  See Ray Kurzweil's talk!  On the horizon:  DIY 3D bioprinters  DIY tricorders  DIY synthetic genomics  DIY pandemic response
  • 23. Forthcoming H+ Summits H+ Summit 2010 West - Live Long and Prosper November 5-6-7, 2010, Los Angeles H+ Summit Europe January 29-30 2011, London H+ Summit 2011 East May, 2011