8. Unconference
From
Wikipedia,
the
free
encyclopedia
facilitated,
par-cipant-‐
An
unconference
is
a
driven
conference
centered
around
a
theme
or
purpose.
The
term
"unconference"
has
been
applied,
or
self-‐applied,
to
a
wide
range
of
gatherings
that
try
to
avoid
one
or
more
aspects
of
a
convenGonal
conference,
such
as
high
fees
and
sponsored
presentaGons.
For
example,
in
2006,
CNNMoney
applied
the
term
to
diverse
events
including
BarCamp,
Bloggercon,
and
Mashup
Camp.[1]
The
term
is
primarily
used
in
the
geek
community.
13. “Community
is
the
Framework”
h<p://davidcrow.ca/
h<p://www.flickr.com/photos/kk/2405563687/
14. “we
don’t
offer
crap—except
good
company
(in
the
form
of
demos
from
passionate
developers
and
entrepreneurs)”
–
Albert
Lai
Read
this!
h<p://bit.ly/6S8DMB
18. BarCampWaterloo
• Started
with
30
people
in
the
room
in
September
of
2005
19. Growth
in
our
community.
• DemoCampGuelph
• StartupCampWaterloo
• DevHouseWaterloo
• Social
Media
meetup
• Web
Design
and
developer
meetup
• StartupDrinks
• Etc…
23. ChangeCamp spreads the emerging ideas, tools
and methods of a networked society and builds
social capital to accelerate community
transformation. ChangeCamp is both a platform
and a community.
35. Changing Weather Patterns
• More high intensity rain events
• More days above freezing
• More lake-effect snow
• Inland - less snow and more rain in winter
54. My technique
Layer-by-layer
Jasmine Lee's beginner's solution to
cube
Fast first-two-layers
Doug Reed's intuitive F2L
Good foundation for advancing to
Friedrich method
Based on intuition, 9 algorithms
and their mirrors
00101
148. THE
PROFESSORS
WHO
REMAIN
RELEVANT
WILL
HAVE
TO
ABANDON
THE
TRADITIONAL
LECTURE
AND
START
LISTENING
AND
CONVERSING
WITH
THE
STUDENTS
-‐
DON
TAPSCOTT
179. Solar Power is now a viable
investment, not just a
showpiece
=
180. What about when it’s not
sunny?
-Turn off coal/natural
gas plants (or let
water build behind a
dam) when it’s
sunny
-Turn those badboys
back on when it’s
dark.
181. Solar creates jobs!
-Germany has 40,000 jobs in solar
manufacturing as of May
-On track for another 50,000 by year end
-90,000 jobs.
Source: New York Times, May 16, 2008
182. Jobs lost in Ontario by sector
Hmm… we’ve lost 90,000 jobs…
186. Left: An off grid, solar powered data collector in
Antarctica
Right: An off grid, solar powered house in rural
Colorado
187. Copper wires are stolen for
scrap frequently.
-An ongoing issue in
Africa
-The FBI has warned
about this being a
threat to ‘critical’
infrastructure in the
US.
233. Vlade
Statosky:
im
asking
you
are
they
really
married
or
is
it
a
virtual
marriage
because
i'm
not
apologizing
if
it's
fake
and
i'm
also
not
apologizing
to
the
idiot
who
thought
up
having
their
marriage
in
a
video
game.
PerpetualJ
Valkyrie:
You
dont
think
that
this
could
be
just
as
real?
Vlade
Statosky:
what
the
hell
are
you
talking
about.
this
is
a
game.
PerpetualJ
Valkyrie:
A
game?
Vlade
Statosky:
a
game.
PerpetualJ
Valkyrie:
How
so?
Vlade
Statosky:
game,
"virtual"
reality,
not
reality
Vlade
Statosky:
game.
Vlade
Statosky:
it's
on
your
computer
282. Definitions
๏ High altitude:
4950 to 11500 feet (1500-3500 m)
Increased ventilation, decreased exercise tolerance
๏ Very high altitude:
11500 to18050 feet (3500-5500 m)
PaO2 60mm Hg, SaO2 90%
๏ Extreme altitude:
18050 feet ( 5500 m)
Hypoxia, hypercarbia
Cannot acclimate
283. High Altitude Illness
๏ Acute Mountain Sickness
๏ High Altitude Pulmonary Edema
๏ High Altitude Cerebral Edema
284.
285. Acute Mountain Sickness
๏ Common with rapid ascent above 8000
feet (2400m)
Can occur at lower altitudes 4000-6000 feet (1200 – 1800m)
Incidence ~ 50% at 14000 feet (4300m)
Onset 8-96 hours after reaching altitude
๏ Symptoms
Headache
Bitemporal of occipital, throbbing
Worse with valsalva, bending over
And 1 or more of:
Anorexia/nausea/vomiting
Sleep disturbance
Fatigue
Dizziness
286. High Altitude Cerebral Edema
๏ Progression of AMS
Lethargy
Confusion, can progress to coma
Ataxia
Abnormal tandem gait, finger to nose diagnostic
Life threatening
๏ Onset hours to days
๏ White matter edema on MRI
๏ Descent mandatory
288. High Altitude Pulmonary
Edema
๏ May occur alone or with AMS/HACE
๏ Dyspnea disproportionate to exertion,
progressing to at rest
Noncardiogenic pulmonary edema
Exaggerated hypoxic vasoconstriction,
capillary leak
Diagnosis based on dyspnea unrelieved with
rest
May be progressive, fatal
Descent mandatory
289. Diagnosis of HAPE
๏ Symptoms (=2) ๏ Signs (=2)
Dyspnea at rest Crackles or wheezing
Cough Cyanosis
Decreased exercise Tachypnea
tolerance Tachycardia
Chest tightness/
congestion
291. Why Does HAPE Occur?
• Hypothesis 1: Pulmonary
endothelium barrier fragility
• Pulmonary endothelium barrier susceptible to:
• Mechanical stress
Stretching of the endothelium gaps passage of proteins
and red blood cells
• Inflammation
Mediators release permeability gaps passage of
proteins, red blood cells and inflammatory mediators
• Questions:
1. Inflammation = 1st culprit?
2. High pressure alone enough to result in extra vascular leak?
292. Inflammation in HAPE?
• Schoene et al., 1986, 1998
– Leukotrienes (marker of
inflammation) very high in BAL
in subjects acutely ill with HAPE
• But inflammation present at the
start or as a result of HAPE ?
• Swenson et al., 2002
– RBC and proteins present in BAL
in people at onset of HAPE
– But no inflammatory markers
present
๏ Inflammation not the
causative factor
293. Hypoxic Pulmonary
Vasoconstriction
๏ The Stress Failure Theory (West et Mathieu-
Costello, 1998, 1999)
Alveolar hypoxia
Hypoxic pulmonary vasoconstriction (uneven)
capillary pressure (some capillaries) VA/Q heterogeneity
Damage to capillary wall (stress failure)
Exposed basement membrane
EDEMA
Inflammatory mediators
294. Circular break of the epithelium
Full break of the blood-gas barrier
Costello et al., 1992
Red cell moving out of the capillary lumen
(c) into an alveolus (a)
295. Exercise Induced Hypoxemia
EXERCISE +/- Alveolar hypoxia
Hypoxic pulmonary vasoconstriction (uneven)
capillary pressure (some capillaries) VA/Q heterogeneity
Damage to capillary wall (stress failure)
EDEMA Exposed basement membrane
Inflammatory mediators
O2
HYPOXEMIA ! in about ½ endurance athletes
(Powers et al., 1988)
296. Pulmonary Barrier Integrity in
Athletes
• Hopkins et al., 1997
– BAL in 6 athletes after a 7min exercise at maximal intensity
– Post exercise:
• RBC
• Total protein
• Albumin
• Leukotrienes B4
• Hopkins et al., 1998
– 1h at 70% VO2max no signs of alteration
Impairment of the integrity of blood-gas
barrier only at extreme level of exercise in
elite athletes
297. Why Does HAPE Occur?
๏ Hypothesis 2: Pertubation of
alveolar fluid clearance
Role of fluid in extravascular space
depends on:
– Its accumulation
– Efficiency of its rate of clearance
• Hypoxia Na,K-ATPase activity (Dada et al.,
2003)
298. Treatment
๏ DESCENT
๏ Oxygen 4 L/min
๏ Strict bedrest if descent not
possible
๏ Nifedipine
๏ Nitric oxide
๏ Dexamethasone
๏ Hyperbaric chamber
Gamow Bag
319. Remember
๏ Jump right in but pay attention
๏ Build on others ideas
๏ Don’t talk about it, do it
๏ Success for the group
๏ Take risks
๏ When you do talk, make it matter
๏ Practice
320. Thank you
๏ Improv Theatre - Theatre on the Edge, www.tote.ca,
every Thursday @ 8pm
๏ Improv Consulting - Karen Lucas,
karenlucas@rogers.com or Bernie Roehl,
broehl@gmail.com
๏ Me - Nick Oddson, noddson@rogers.com, @noddson
Phil Kalina for Stan Hywet Hall Gardens
Thomas Hawk Strocchi
Christiana Care jugbo
Ryancrs brainware3000
Bluerock Flickr bingisser
.Hessam BombDog
Images Rusty Stewart
thomas.merton
Aaron Webb Marcin Wichary
JosephGilbert.org dresmall
Knivesout totalAldo
B_Zedan