The 20 most disruptive healthcare solution providers 2018 converted

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November 2018
20Most
Laurie Goodman
CEO & Board Manager
CLEARLIGHT
BIOTECHNOLOGIES
DevelopingaNext-Generation3DTissueProcessing
PlatformbyLeveragingCLARITY
DISRUPTIV E
HEALTHCARE SOLUTION
PROVIDERS
2018
THE

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nnovation is the key to unlock the future in every sector. Same is the case with
healthcare. The need of innovation in this segment is being fed by the numerous
Istart-ups as well as the big giants in this sector, and rather disruptively. Yet, there is
place for more. With so many emerging trends and changes in healthcare, one question
Kick-Starting
Your Way in Healthcare
that comes to the mind of any professional willing to establish a new business is- How
can it be done in a better way?
In healthcare, success of a business is not determined by only the ordinary terms. There
are some industry-specific points that one has to consider.
To start with, one must know that it is not a consumer market. In most of the cases,
patients are not the ones paying their own bills and selecting their own products. Here's
where the doctors and insurance companies play a role and should be considered as
well. Also, the investment needed in a healthcare start-up is long term. Even if the
company manages to incur decent amount of money to initiate the business, there comes
a need for second and third and more rounds of investments required. It is of
significance to have a proper business model.
Another important factor to consider is the regulations that are to be abided in
healthcare. Various regulations such as HIPAA, the Affordable Healthcare Act, and
many more are unavoidable. The companies need to embrace these, in order to remain
in the picture. Alongside, while thinking of disruptive technology, in healthcare there
are already several giants and companies present that are working on the same. It is of
benefit to learn to work with them, rather than against them. A lot of start-ups do not
think sufficiently over this.
There are various other things to be thought of while establishing a new business in the
healthcare space. An idea is the path laid; to walk through it is the execution of that
idea; and to end up successfully, requires a lot more than just idea and execution. So,
with the right ingredients, one can embark on this path and disrupt!
Aishwarya Nawandhar
Editor
Editor’s Column

Behavioral Health Works
Restoring Hope for Families
Facing Autism with Premium
Service Delivery
Clearsense
Driving Innovations to Bring
an End to the Eraof
Disconnected Data
Genpharm
A ForemostPharmaceutical
Organization Offering Tailor-
made and Comprehensive
Solutions
20 22 28
08
ClearLight Biotechnologies
Developing a Next-Generation
3D TissueProcessingPlatform by
Leveraging CLARITY
- Cover Story

Phronetik
Unmasking Genetics to
Improve Health
Sunny Days In-Home
Care
Re-shaping the Healthcare
Landscape with In-Home Care
The TeleDentists
Delivering Top-notch Dentistry
Services at YourDoorstep in a
Cost-effective Way
30 38 46
Articles
HIV Awareness Month
HIVStillan Impending
Threatto Mankind
24
34
44
CXO
Proteinsare Better
Biomarkersthan Genes
Expert’s View
Why isitimportant for
healthcare providersto
move towardspatient-
personalisedservices?
C O N T E N T S
18 40
Science Scoop
Never MissaDose
Medication Apps
Editor’s Insight
Telemedicine
A RevolutionaryStep
in Healthcare
Exclusive

Innovators
Disrupting the
Healthcare Industry
he term “Disruptive Innovation” was first coined by a Harvard Professor, Clayton M. Christensen. Today, it is
a word widely heard and spoken across the entire business landscape. According to Clayton, it isa
Tcircumstance in which an innovation starts reshaping an industry or a market by making it simpler,
convenient, accessible, and affordable. The process initiates in a niche area that may be inconsequential to the whole
market, but eventually ends up transforming the entire industry.
Healthcare is one of the spheres that highly need disruptive innovation. With the numerous new technologies
launched, the opportunity for this is greater than it has ever been. It is expected that in the future, with disruptive
innovation, patient care will be provided at reduced costs and improved quality.
With an idea to acknowledge the fast-growing companies, contributing extraordinarily to the revolution of disruption
in healthcare, we bring to you the special edition of “The 20 Most Disruptive Healthcare Solution Providers
2018”.
Featured on its “Cover” is ClearLight Biotechnologies. It is harnessing next generation technologies to revolutionize
the diagnostic, prognostic, and predictive treatment of disease.
Apart from this insightful cover story, we have also enlisted the leading companies transforming the healthcare
landscape. This list includes Behavioral Health Works, a company focused on improving autism and related-disorder
treatment; Clearsense, which is solving all the fundamental problems of data in healthcare; Genpharm, offering
comprehensive solutions to the pharmaceutical companies; Phronetik, answering the unanswered questions of
healthcare and advancing precision medicine; Sunny Days In-home Care, providing best-in-class and affordable in-
home care services; The Teledentists that has enabled top-notch dental care anytime, anywhere; American
Telepsychiatrists; Avera eCARE; Bikham Information Technology; Cydar Ltd; Direct Radiology; KPMG LLP;
LiveProcess; Livio Health Group; Medivizor; NaphCare, Inc.; Rethink; Singapore O&G Ltd; and Zilico.
In addition to this, we have also featured two interesting articles from the industry experts Stephen Critchlow and
Steven Pelech. To further engage your thoughts, we have incorporated a few gripping write-ups from our in-house
editors.
Flip through the pages and enjoy a good read!
DISRUPTIVE
MOST
HEALTHCARESOLUTION PROVIDERS2018

ClearLIGHT
BIOTECHNOLOGIES
DevelopingaNext-Generation
3DTissueProcessingPlatformbyLeveragingCLARITY
Wearedevelopinga novel,nextgeneration
technologyplatfam fa processing
andvisualizingtissuein 3D
,
,
DISRUPTIVE
MOST
HEALTHCARE SOLUTIONPROVIDERS2018

CoverStay
LaurieGoodman,Ph.D.
CEO&BoardManager

Healthcare presents a paradox
when it comes to innovation.
Although many of the highly
innovative discoveries come at a very
swift pace, ideas that can transform
healthcare occur gradually, over a
prolonged period of time. These
gradual transformations are also known
as ‘Disruptive Innovations’. In this, the
existing methods or traditions are
improved to increase the quality of
care and simultaneously make it
affordable by leveraging the existing or
up and coming technologies. This
allows the whole population to
significantly seek the benefits of
various healthcare technologies and
thereby promoting population
health. Looking at the scenario
of the health space today,
disruptive innovation in
healthcare is a significant
revolution that the world
needs.
A smallBiotechnology
startup, ClearLight
Biotechnologies,
LLC, is leading the
revolution of a
positively
disruptive
innovation in
healthcare.
Formerly known

as Clearlight Diagnostics, LLC, it was founded in 2014 by
Karl Deisseroth, MD, PhD, the inventor of CLARITY,
Optogenetics, and STARmap technologies and D.H. Chen,
Professor of Bioengineering and Psychiatry & Behavioral
Sciences at Stanford University as well as the Investigator
of the Howard Hughes Medical Institute.
ClearLight is an early stage company, focused on
developing automated instrumentation and associated
reagents to simplify and expedite non-destructive
3-Dimensional (3D) tissue analysis to facilitate preclinical
and clinical research applications. It is creating a platform
that will enable an end-to-end solution for 3D analysis of
preclinical and clinical models of disease. It will consist of
an automated multi-sample and individualized 3D tissue
processor paired with optimized biomarker panels as well
as multi-sample imaging and custom 3D image analysis
software.
Focus Areas
The current focus of the company is in the area of oncology
prognostic and predictive applications. In this, it
emphasizes on predictive biomarker applications for
immune-oncology T-cell based drugs as well as standard of
care (SOC) biomarkers. Neuroscience is another area of
interest for ClearLight Biotechnologies. In neuroscience, it
emphasizes on the models of Alzheimer’s disease.
However, the technology could be easily applied to any
biological area that relies on 2D thin-section analysis of a
tissue.
The Visionary Leader
Laurie Goodman, Ph.D. is the current CEO and Board
Manager of ClearLight Biotechnologies and previously
served as the Chief Scientific Officer since 2015 before
assuming her new role. Dr. Goodman is a seasoned
professional with more than 25 years of experience in
innovative technology development, clinical cancer
diagnostics, and translational cancer research within the
biotechnology industry. She holds a BS degree in Biology
with a minor in Chemistry from Arizona State University
and a PhD in Cell and Molecular Biology from University
of California Berkeley. Following a postdoctoral fellowship
at Genentech, she began her career at Lynx Therapeutics
(currently Illumina) where she initiated and developed a
breast cancer scientific program to validate the company’s
next generation sequencing platform. Dr. Goodman is also
an author on several key publications and patents related to
analytic and clinical cancer biomarkers.
She has worked in broad senior level roles encompassing
research and development as well as clinical and medical
affairs. Prior to joining ClearLight, Dr. Goodman held the
position of Senior Director of Scientific and Medical Affairsfor
Biodesix, an innovator of blood-based cancer diagnostics.
She was instrumental in building and leading the
company’s first scientific and medical affairs team, as well
as initiating key academic collaborations in the areas of
lung and breast cancer. Her other senior level roles include
directing the analytic team involved in the CLIA validation
and commercialization of Monogram Biosciences’ first
oncology diagnostic product, HERmark®.
The Problem in the Already Existing Techniques
Current gold standard techniques, for the analysis of
diseased and normal tissues are outdated and around a
century old. It relies on the analysis of 2D thin-section
formalin fixed paraffin embedded (FFPE) tissue techniques.The
spatial analysis of a potentially heterogeneous tissue
microenvironment can be highly limited by such
techniques, as can the analysis of the tissue morphology.
Furthermore, 2D analysis is destructive, slide-based,
variable and highly manual, and does not represent the
entire biology. Mathematically speaking, a single
5-micron tissue section from a 2 cm3 breast carcinoma is
exactly the same as the ratio of a single Manhattan block to
all of Manhattan (adapted from a personal communication
with Dr. Geoffrey Baird MD PhD). It is not representative
of the more comprehensive biology of that tumor and
therefore may hinder successful treatment outcomes for
patients.
At ClearLight, we are
focused on improving
the future of predictive
treatment
,
,

ClearLight’s Ingenious Solution
ClearLight is developing a next generation instrument,
reagent and software platform for volumetric tissue
processing and 3D image analysis. It is developing this
solution by leveraging the revolutionary technology called
CLARITY, which is an acronym for Clear Lipid-exchanged
Acrylamide-hybridized Rigid Imaging/Immunostaining/In-
situ hybridization-compatible Tissue-hYdrogel.
“CLARITY is a novel approach that is innovative in both
function and utility, and has been applied broadly to the
field of neurobiology, primarily as a qualitative tool,” says
Dr. Goodman. The company believes in the technology as it
enables the formation of a hydrogel matrix (HM) by
crosslinking biological molecules to a 3D network of
hydrophilic polymers, followed by lipid removal to
generate a transparent and structurally intact tissue. This
tissue retains its original structural features, can be labeled
with macromolecules, and imaged without destruction of
the tissue morphology.
Another advantage of the CLARITY technology, is that it is
compatible with previously frozen, fresh, formalin-fixed,
and FFPE research and clinical human or rodent tissue. It is
non-destructive, and therefore fewer samples are required,
thus allowing recapitulation of spatial heterogeneity without
laborious sectioning and registering of samples. It is
compatible with standard nucleic acid and antibody
interrogation techniques. This technique also allows for
multiple interrogations of a single sample to increase 3D
biomarker information. Importantly, the technology enables
the storage of samples indefinitely for future analysis and
the microscopic imaging capabilities including confocal,
light sheet, and SPIM.
The workflow of this platform is very simple and includes:
 Embedding the tissue in a hydrogel matrix
solution;
 Removal of light scattering lipids that impede the
ability to image deeply within a tissue;
 Multiplexed interrogation with directly or
indirectly fluorescently labeled antibodies or
nucleic acids to identify key structural and
microenvironment biomarkers and refractive index
matching;
 Microscopic imaging of the tissues, using long
working distance objectives and either confocal,
light sheet, or SPIM;
 3D image analysis using Artificial Intelligence
(AI) and machine learning techniques.
The development program of the company is a combination
of external software and hardware engineering contractors,
as well as strategic academic and business partnerships.
Team ClearLight
The internal team of ClearLight is comprised of a Director
of Operations, two Directors of Research and Development,
a Head of Lab Operations along with the CEO. In order to
keep costs to a minimum, the company operates primarily
with an extensive external network support that handle
human resources, IT, accounting & taxes, engineering,
animal facility CRO, marketing/website support, and legal
works (corporate and IP). It also has key academic
collaborations in the area of oncology and neuroscience.
Determined to Revolutionize the Future of Medicine
The mission of ClearLight is to revolutionize the
diagnostic, prognostic, and predictive treatment of disease
by enabling next generation technologies for non-
destructively and digitally analyzing diseased and normal
tissues in 3D. It predicts a similar future of this industry as
to that of the adoption of next generation sequencing (NGS)
into clinical decision making that took more than 20 years
and has now become a billion-dollar industry.
Dr. Goodman says, “We predict a similar steady trajectory
with
Revolutionizing the
treatment of
cancer is ourgoal
,
,

3D processing and imaging of diseased tissue being
adopted initially into the research use only (RUO) market
and eventually entering the clinical market as adoption
increases and clinical utility is established.”
Future Business Plans
Reorganization of leadership in recent months, has resulted
in changes to several aspects of the company, including a
name change to more accurately portray the revised
business model of the company and future potential
commercialization plan. By the fourth quarter of 2019 or
first quarter of 2020, the company will be launching a
Research Use Only (RUO) in-house service model along
with limited beta platform testing in the field, for 3-4
academic sites. The in-house custom service model will be
offered to academic and pharmaceutical customers in any
field, like preclinical, clinical drug development,
exploratory inclusion in clinical trials; as a means to grow a
profitable business over the next five years. These Beta
platform studies will allow the company to validate the
system and facilitate the generation of key clinical utility
data, informing about its future potential.
Following long term adoption of the RUO product by
pharma, academics, and CROs, ClearLight has plans to
enter the Laboratory-Derived Testing Clinical Market or a
Potential FDA-cleared platform/companion diagnostic with
potential partners, although the plans for this have not been
established at this time. The strategy of the company is to
first establish the RUO and potential clinical utility and
develop the market for the technology. It foresees this
timeline for FDA approval and clinical utility to be similar
to NGS technology market adoption.
“With any new disruptive and revolutionary technique,
adoption takes time and patience but the rewards are
extensive for a company like ClearLight Biotechnologies
since it holds exclusive intellectual property rights to
develop the CLARITY technology for diagnostic,
prognostic, and predictive future clinical applications,”
asserts the CEO.
Weaimto
deliver an
unprecedented
way to visualize
and quantify
3D relationships
within the tissue
microenvironment
,
,

Company Name Management Brief
American
Telepsychiatrists
atpsnetwork.com
John SchaefferCEO American Telepsychiatrists work exclusively through
Telepsychiatry and TeleMental Health.
Avera eCARE
averaecare.org
Deanna Larson
CEO
Avera eCARE is helping bring advanced medicine to the
community so more patients can be treated in a place.
bhwcares.com
Rob Douk
Founder, Chaiman & CEO
Behavioral Health Works is a leading provider of treatment
for individuals with autism and related disorders.
Bikham Information
Technology
bikham.com
Sonia Dhawan
CEO
Bikham Information Technology is a Knowledge Process
Management company, initiated in 2005.
ClearLight
Biotechnologies, LLC
clearlightbiotechnologies
.com
Laurie Goodman
CEO & Board Manager
ClearLight is focused on developing automated
instrumentation and associated reagents to simplify and
expedite non-destructive 3D tissue analysis to facilitate
preclinical and clinical research applications.
Clearsense
clearsense.com
Charles Boicey
Co-founder & CIO
Clearsense is a technology-based company that provides a
platform to solve the fundamental problem of data in
healthcare.
Cydar Ltd
cydarmedical.com
TomCarrell
CEO
Cydar has developed computer vision software that produces
real-time automated 3D overlays during X-ray guided
procedures.
Direct Radiology
directradiology.com
JohnArias
MD
Direct Radiology is a physician-owned and operated
teleradiology practice.
Genpharm Inc.
genpharmservices.com
Karim Smaira &
Kamel Ghammachi
Founders & MP
Genpharm provides fast-track Market Access to specialty
pharmaceutical companies looking to expand into the Middle
East and North Africa (MENA) region.
KPMG LLP
home.kpmg.com
Lynne Doughtie
CEO
KPMG is a global network of independent member firms
offering audit, tax, and advisory services.
DISRUPTIVE
MOST
HEALTHCARE SOLUTION PROVIDERS 2018

Company Name Management Brief
LiveProcess
liveprocess.com
TerryZysk
CEO
LiveProcess mobile solutions enable real-time healthcare
coordination and efficient emergency response.
Livio Health Group
liviohealth.com
Mike Nathan
CEO & Founder
Livio delivers the care patients need face to face while
building a relationship to help them get around obstacles that
stand in their way.
Medivizor
Medivizor.com
TalGivoly
CEO
Medivizor aims to improve the lives of people with serious
or chronic medical conditions and of those who care for
them.
NaphCare, Inc.
naphcare.com
JimMcLane
CEO
NaphCare is dedicated to implementing cost-effective,quality
services according to our clients’ needs.
Phronetik
phronetik.com
TaniaMartin-Mercado
President & CEO
Phronetik offers competencies in biotechnology,
bioinformatics, data science, artificial intelligence and
information systems to advance precision medicine and
positively impact scientific research.
Rethink
rethinkfirst.com
Daniel Etra
CEO
Rethink is a global health technology company providing
cloud-based treatment tools, training and clinical supports
for individuals with developmental disabilities and their
caregivers.
Singapore O&G Ltd
sog.com.sg
Ivan Lau
CEO
Singapore O&G Ltd are a leading group of specialist medical
practitioners dedicated to women’s & children’s health and
wellness.
Sunny Days
In-Home Care
sunnydaysinhomecare.com
DavidEllenwood
Founder
Sunny Days In-Home Care provides high quality, client-
centered, and affordable in-home care service.
The TeleDentists
theteledentists.com
Maria Kunstadter &
Michael Sigler, Co-
founders
The TeleDentists has engineered a cutting-edge cloud-based
SaaS service that enables hospitals and urgent care facilities
access to a dental specialist.
Zilico
zilico.co.uk
Sameer Kothari
Chief Executive Director
Zilico is developing the next generation of diagnostic
devices that remove subjectivity, increase accuracy, and
deliver results in real-time.
DISRUPTIVE
MOST

P r o t e i n s a r e
Bet t er B i o m a r k e r s
t h a n G e n e s
he costs of sequencing the order of nucleotide bases
in the DNA strands found in chromosomes have
Tplummeted by a million-fold over the last 25 years.
The entire sequence of 2.9 billion nucleotide base-pairs in a
single human genome can now be determined for less than
$1000. Complete genomes of hundreds of thousands of
people are expected to be sequenced over the next decade.
While the acquisition of such genomic knowledge was
originally forecasted to herald better diagnostics and
therapeutic treatments, the actual deliverables for improved
health care have been disappointing. Excluding cancer, it
has become apparent that only about 10% of the cases of
the most common diseases that afflict our population have a
genetic basis that can be ascribed to hereditary mutations in
the DNA sequences of specific genes.
Over 100 million single nucleotide variants appear to exist
in the human population, and perfectly healthy people
appear to commonly harbour about 100 or so serious
disease-associated mutations without any apparent
manifestations of these particular diseases. Studies, with
over 50,000 genetically identical twins, have shown no
increased risks for the 24 most common diseases amongst
the twins than for a twin with the general population.
Over 95% of the known 21,300 genes carried in the human
genome serve as the blue-prints for the construction of all
of the cellular proteins, known as the proteome. These
proteins function like molecular robots to regulate and carry
out all of the biochemical reactions needed to keep cells
alive. Their programming for specific tasks is partly
hardwired into the structures of these proteins as dictated by
their gene sequences. But, they are also tightly controlled
by reversible modifications after they are initially
manufactured, which are added on by regulatory proteins
that operate within cellular intelligence systems.
While gene sequences can provide some clues as to the
potential functions and interactions of proteins with each
other and other molecules, this information is extremely
limited. Even now, we do not have a real sense of what over
a third of these diverse proteins do, and less than 20% of
these proteins have received any real serious attention in
research labs.
The disconnect between genetic information and the actual
occurrence of disease is due to the high impact of
environmental factors such as diet, life style and exposure
to agents in the environment that can affect the proteome.
Proteomes are immensely complex and dynamic. For
example, blood plasma may contain as many as 40,000
different protein products, and their individual
concentrations can range over a trillion-fold. Consequently,
tracking proteins offers much better insights into the
occurrence of diseases than genetic profiling, and
importantly the opportunity for more rational therapeutic
intervention.
While about 21,300 genes encode proteins in the human
genome, the actual number of distinct protein entities in the
proteome may actually exceed several million, largely due
to the range and degree of added modifications and other
processing. More than 50 types of modifications have been
|November 2018|18

documented in proteins, with phosphorylation as the
predominant reversible regulatory mechanism. Over 85% of
the proteome is known to be phosphorylatable at over
250,000 sites, but the actual number of phosphosites
appears to be closer to a million. The occurrence of these
and other modifications in proteins represent a rich source
of biomarkers that may correlate better with the
development of pathologies.
Most sites of known protein modification were originally
revealed by mass spectrometry (MS). However, apart from
being very expensive, MS requires milligram amount of
biological sample material and is finicky for reliable
detection of desired target proteins. For example, out of
some 3000 phosphosites in proteins that have been well
documented to be functionally important in the scientific
literature, about 22% have not been reported in any MS
studies, whereas another 16% were documented in only one
of thousands of MS analyses that had been performed.
Antibodies have been well proven to be reliable and
effective probes for the detection and quantification of
specific proteins for their present and modification states.
Over a million different antibodies against diverse proteinsare
presently commercially available. Furthermore, the
printing of antibodies as individual microdots on
microscope slide-sized chips with densities exceeding 5000
spots per chip has paved the way for biomarker discovery
that is easily translatable into the development of routine
diagnostic tests. Biomarker antibodies can readily be
re-deployed into other tried and true platforms such as
immunoblotting, ELISA, and immunohistochemistry.
Problems with sample preparation, high background issues,
and low sensitivity of detection initially hampered the wide-
spread adoption of antibody microarrays. However, recent
breakthroughs on all of these fronts have poised antibody
microarrays to become the most versatile, reproducible, and
cost-effective tools in the foreseeable future for biomarker
discovery, using as little as 25 microgram amounts of
protein samples from crude, unfractionated lysates from
cells, tissues, and bio fluids. High content antibody
microarrays can identify the most appropriate and robust
panel of biomarkers. When used to probe lysate microarrays
printed instead with hundreds of patient specimen samples
on each slide, these biomarker antibodies can provide
accurate, comprehensive and economical diagnoses for
diseases and for the monitoring of the effectiveness of
therapeutic treatments.
ABOUT THE AUTHOR
Dr.StevenPelechis theFounder,
President,and ChiefScientific Officer
of KinexusBioinformatics
Corporation, and concurrently a
full professor in the Department of
Medicine at the University of British
Columbia. He was formerly the
founder and president of Kinetek
Pharmaceuticals. He has authored
more than 230 scientific papers
and created the SigNET on-line
Knowledge-bank. Dr. Steven Pelech
Founder, President & Chief Scientific Officer
Exclusive
19 |November2018|

utism Spectrum Disorder (ASD) is a neurological
and developmental disorder that impacts the way a
Aperson socializes, behaves, or interacts with others.
Till date, there is no possible cure for autism. But some
practices can help improve learning, social functioning, and
quality of life for both children and adults with this
condition. Behavioral Health Works (BHW) is a leading
provider of treatment for individuals with autism and
related disorders having offices across the United States.
The company helps individuals with autism and other
developmental disabilities reach their potential by working
collaboratively with families, schools, and relevant
professionals. By focusing on ways in which people
respond to their environment (behavior), it provides
opportunities to learn in specific and observable ways,
leading to a positive outcome (health). BHW renders
superior personalized care and service delivery, maintaining
a personal connection with each family and committing to
the advancement of each and every client. It operates from
a CARES philosophy with the focus on Compassion,
Accountability, Research-based treatments, Effective and
Efficient changes, and is consolidated with a family unit
Systems-approach.
The Philanthropist’s Story
Dr. Rob Douk is the Founder, Chairman, and CEO of
BHW. Fleeing death and seeking hope, Rob’s family
escaped a Cambodian labor camp and migrated to America
in the early 1980’s. Building their life from nothing, his
parents taught him how to love hard and work hard through
any situation. Today, these circumstances best define him.
Regarded as a thought leader in the behavioral health
industry, Rob is a clinician turned social entrepreneur,
executive coach, and ForbesBooks Featured Author. He isa
RestoringHope for FamiliesFacing Autism
withPremium Service Delivery
Westrivetobringlightintodark
placesofthisworldbydelivering
premiumcareandservices
”
”Dr.RobDouk
Founder,Chairman,&CEO
|November 2018|20

serial entrepreneur, having built multiple successful
enterprises, incorporating an emphasis on making
measurable societal changes in each venture.
Rob married his college mate, Ami, and together theybuilt
the Hope Out Loud Foundation, an international nonprofit
that helps communities around the world. Rob is known to
coach from a principle of having “faith over fear” and he
believes that “character” is the most important to hire for.
BHW’s Prudent Approach
BHW’s approach to treatment is naturalistic, using
everyday family routines to foster generalization of skills
and to promote independence right from the start. This
approach is rooted in Applied Behavior Analysis (ABA)
with emphasis on individualized programs, focusing on
each person’s strengths and challenges. Its programs focus
on increasing each client’s motivation to learn, making each
session both fun and functional. It also considers all
scientifically proven methods when tailoring each program
to fit the unique needs of each client. The company’s
treatment approach in each of BHW’s programs shares the
common goal of teaching individuals the tools necessary to
obtain a better quality of life and to lead a more
independent life.
Patients’ Journey with BHW
When with BHW, patients get more than a clinical team at
their front door. They also get an administrative team to
support them, behind the scenes, every step of the way.
BHW has a friendly and smart team at the back office,
along with a caring and knowledgeable clinical team to
work with patients using the best and the latest in clinical
research. To keep everything together, the company has a
user-friendly and robust proprietary technology platform
that captures every BHW program to make what it does
simply a cut above the rest. It has been servicing across
multiple regions with one united team with a consolidated
approach and one voice.
Services and Accomplishments
BHW is a one-stop shop for premium autism service
delivery. It offers ABA therapy for the entire life span,
diagnostic clinics, speech and occupational therapy as well
as social skills groups and counseling. The company
provides a holistic customized program suited for every
individual.
From certifying its therapists with RBT credentials to
responding to the patients’referrals in less than 2 hours and
retaining more than 99% of the clients, BHW strongly
believes in delivering premium services. This is its biggest
achievement and a testament to all its employees that
deliver on this commitment, day in and day out. The
company has graduated over 70% of its clients within two
years and has a 0% client relapse rate.
Continuously Improving with TQM
Total Quality Management (TQM) is a philosophy and set
of guiding principles that BHW adopts to focus on
continuously improving the organization, its procedures,
and the services that it provides the clients. TQM focuses
on the needs of the client and on improving the quality of
work and providing a finished product. It promotes
continuous monitoring and improvement of company
procedures in order to reduce inefficient or wasteful
practices. It also involves the entire organization in the
improvement of quality and also empowers employees at all
levels.
The Three C’s of Work Environment
Collaboration: BHW prides itself on maintaining a fun,
open-door working environment where collaboration is the
cornerstone of its success.
Cause-driven: BHW and its employees embrace thatthere
is more to a career than a title. What they do actually
matters to them.
Celebration: Members of BHW, aka “BHWers”, support
one another through celebrating their clients’ successes.
The employees are encouraged to stop by the main office to
enjoy the staff lounge, take a break, and indulge in posting
on or reading the client success board.
Speaking about the future, Rob asserts, “We would like to
serve as many families in need as we are able to, while
maintaining high quality service delivery for each family.”
DISRUPTIVE
MOST
21|November 2018|

Clearsense
s there anything in common between finance and
healthcare? Not much, but both of them are being
Ipositively disrupted by the technology. Disruptive
innovation is leading the new era of advancement, and it is
much needed. One of the major factors contributing to this
innovation in healthcare is the use of data science. Withthe
rise in the number of clinical documents produced every
day and the sensitive nature of medical data, it is necessary
to find a way to collect, organize, and process the huge
amount of data for a more informed, better healthcare. One
of the companies leading this revolution is Clearsense.
Based in Jacksonville, Florida, Clearsense is a technology-
based company that provides a platform to solve the
fundamental problem of data in healthcare. The company is
an offshoot of Optimum Healthcare IT that has been around
since 2012. Started as an analytics company, Clearsense,
today, has become a technology driven organization that is
re-imagining and simplifying data analytics to help
healthcare organizations realize measurable value from
their data.
The Novel Leader
Charles Boicey is the Co-founder and Chief Innovation
Officer at Clearsense who has expertise and experience in a
variety of areas. In the medical field, he specializes in
Trauma Critical Care Nursing. Charles ran the trauma unit
at LA County USC medical center for about 15 years and
then made a transition into Biomedical Information
Systems as well as Biomedical Engineering. After that, he
earned the degrees in Computer Science and Technology
Management from Stevens Institute of Technology in
Driving Innovations to Bringan End to the
Eraof Disconnected Data
Weareheretoorganizethechaos
inhealthcare
”
”CharlesBoicey
Co-founder&CIO
|November 2018|22

Hoboken New Jersey and then brought that training back
into healthcare. During his time at the University of
California Irvine, he was the user of various social media
platforms like Facebook, Twitter, and LinkedIn. He was
very fascinated with their technologies and was set to
implement the same kind of ease in data management for
healthcare. Working on this, he has innovated his way to the
top and led Clearsense to its success today.
Tracing Back the Roadmap to Success
Clearsense started small; they had just a couple of clients
who were Charles’ partners at the University of California
Irvine and Meharry Medical College. For Meharry Medical
College, the company built a data science institute, and for
the University of California Irvine, it developed a system
for real-time monitoring of patients in high acuity area.
With this, Clearsense brought all the patients’ data together,
which includes data from a clinical environment, laboratory
systems, etc. in real time. This helped make the clinicians
aware of the patients whose health would be slightly
deteriorating so that there can be intervention before
reaching any adverse conditions.
Additionally, the company has also brought in the legacy
data systems and made it available for folks in health
information systems. Another thing the company did create
and provide a platform for its clients involved in mergers
and acquisitions. It takes the data from the segment being
acquired and brings it into Clearsense and sends it to the
system doing the acquiring after adequate transformation of
that data. Clearsense does this in a very short period of
time, comparatively.
So, started with a few initial clients and have reached miles
already, it plans to expand further.
What sets itApart?
The technologies used by Clearsense have just started to
creep in the healthcare market. Although the company has a
couple of competitors that have started to bring these
technologies in, Clearsense started long back and had
already adapted to these technologies. Alongside, it has a
holistic team, which includes clinical professionals, data
scientists, developers, etc. This has proved to be a great
benefit for the company. Another one of its key
differentiators is that the company has not just learned the
technologies, but has helped develop them. This brings a
huge advantage to the business as well as its clients.
Clearsense provides a full-blown data ecosystem and has
made use of big data. This has helped it automate the large
part of work processes for its clients. Also, the company
allows the integration and synchronization of data in the
database within days and not weeks, saving a lot of time
and at affordable costa. It also has different governance
around the data and provides adequate security.
Life at Clearsense
The company fosters a free work environment. At
Clearsense, every individual is accountable and has the
freedom to be innovative and creative. The company
encourages its employees to ask questions and seek help.
“It is very important in a tech company and it kind of goes
back to you know, my clinical time when somebody new
enters the clinical environment, the most important thing
they could say is ‘I don’t know, I can’t figure this out,’and
we come in and help them,” says Charles. The company
also has a provision for the employees to work remotely.
There is also a culture of celebration in the organization.
What’sAhead?
“We are very much in a growth trajectory. We are signing
up more and more healthcare clients as we go,” says the
CIO. This will allow its clients to collaborate with each
other. The company has already started to get involved
with Academia and wants to expand in it further. It isalso
getting inquiries from outside of healthcare. So, it will be
potentially moving outside of healthcare as well, keeping
healthcare at its nexus.
DISRUPTIVE
MOST
23 |November2018|

obile phones, especially smartphones, are doing
Mmore than what they were intended to do.
Thanks to all the apps that developers around
the world are busy making to simplify the lives. These
mobile apps come in all shapes and sizes and do a myriad
of things for smartphone users. While gaming, social media,
and retail apps continue to rule the charts, health apps are
surely catching up. With people becoming more health
conscious than ever, these apps are also making their mark.
Good health is attributed to many factors. One needs to
have a proper diet, exercise, routine checkups, and the likes.
What most people tend to neglect intentionally or
unintentionally is the medication routine. Medicines, be it a
lifesaving drug or just a vitamin pill, is also essential for
good health. Unfortunately, most people tend to forget
taking their pills on time. Some blame it on their schedule,
some don’t ﬁnd the time, some are too busy to remember,
and some, like the elderly, just forget to take it.According
Dose:Medication Apps
Never
a
ScienceScoop
to a report published in Annals of Internal Medicine,
September 2012, America loses $100 – $289 billion in a
year due to medication non-adherence. The situation is
graver in case of chronic illnesses. Treatment of such
disease requires long-term use of medicines. But patients
are seen not adhering to it due to various reasons. A study
from Mayo Clinic states “approximately 50% of patients do
not take their medications as prescribed.” This amounts to
not only monetary loss but also health issues. Some patients
end up in emergency rooms because they did take
medicines on time. Even small issues turn into serious ones
if not treated properly. Doctors have long been advising
people to take their medicines as prescribed. But the results
just don’t match up.
Keeping a digital eye on health
Mobile apps are now being used to ﬁght this underrated
health concern. A huge population of these patients uses
smartphones. Mobile apps are now being recommended by
|November 2018|24

doctors and other patients alike to tackle this menace. These
apps are easy to use, mostly free, and are designed to
perform a lot of things for the patients. These apps have a
number of features to assist patients with drug adherence.
The process is simple and starts with the patient uploading
their prescription or filling in the drugs that they are on.
They can then customize alarms, set up emergency
numbers, put a tracker, and other such features. Some apps
even use games to help patients understand the importance
of taking medication on time.
Apps full of features
Different apps offerdifferent features and sometimes
address only a particular concern. Some apps are free of
cost while some are premium and offermuch-advanced
features. But most apps do the following:
Set up reminders -- Easiest way to get your dose on time is
to set up alarms. The apps set offalarms at a definitive time
and some even light up the screen with particular colors to
remind the patients of their pending dose. Some even auto-
adjust to the time zones, so that the patients do not mess up
their dosage when traveling to different parts of the world.
Send messages to caregiver -- Some apps send messages to
the patient’s caregiver (mostly family member) and doctor
when they miss a dose. They can then remind the patient to
take their medicine.
Manage family health -- Some apps can help patients deal
with multiple profiles. This allows one member track the
medicine habits of the entire family.
Drug Interaction – Few apps have the feature to let patients
know about drug interactions i.e. if any two or more of
one’s medicines can react and cause issues to his/her
wellbeing. This feature can really help if one takes over-the-
counter drugs with prescribed medicine.
Medical Jargons – Mobile apps can let patients understand
medical terms too. Terms like CR (Controlled Release)
printed on the medicine can often be confusing for patients.
These apps help them crack such codes.
Refill reminders – These mobile apps remind patients in
advance when they are about to run out of their prescribed
medicines.
Contacting Pharmacy -- A few apps let patients upload their
prescription with the pharmacy and get their medicines
door-step delivered when they need it. They even allow the
pharmacy to cross-check with the patient’s doctor to make
sure that the prescribed medicines need to be continued.
Generic Report – Some medicine mobile apps also let
patients record their blood pressure, sugar levels and send
them to their doctors at a fixed time interval (say once in a
month).
These mobile apps are really proving to be a boon
especially for the elderly and those suffering from chronic
illnesses or illnesses like Parkinson where the patient
genuinely forgets to take the pills. Timely reminders,
interactive interface, easy-to-use and manage features,
sounds and lights, all make them suitable for patients across
the world. Some paid and advanced apps even let patients
take a video consultation with their doctors. The world is
getting smarter and better. The world of medicine apps is
slowly recognizing the opportunity and the what this market
can be in the future. Such apps are surely going to make
this world a healthier place! - Sneha Sinha
|November 2018|26

Genpharm
enpharm is a leading regional pharmaceutical
market access and marketing company focused
Gmainly on niche therapeutics and diagnostics for
rare genetic diseases. The company has partnered with
multinational companies that have evidence-based and
innovative drugs looking to expand into the Middle East
and North Africa (MENA) region. The company operates
through an experienced and dedicated team of medical
science liaisons and key account managers. Thecompany’s
partnerships are based on long-term regional commercial
agreements or in-licensing deals under the Genpharm
brand.
Genpharm was established by the two influential Founders
& Managing Partners, Karim Smaira and Kamel
Ghammachi, whose leadership has been a consistent
presence in the MENA pharmaceutical sector for over forty
years. They both have successfully occupied several
industry roles and managed large multinational
pharmaceutical organizations in both regional and
international functions.
Outshining with its Diverse Services
Genpharm offers its expertise to achieve fast market access
for companies looking to expand into the Middle East
region. Being the exclusive partner for pharmaceutical
organizations, it offers every required service to its clients
at the highest standards which include regulatory, medical
and pharmacovigilance support, quality and logistics,
market access (pricing and reimbursement). It also
dedicates field staff for them to work closely with the key
stakeholders on disease awareness, patient support
programs, CME events, scientific meetings, advisory boards
and expert panels.
A Foremost Pharmaceutical Organization Offering
Tailor-made and Comprehensive Solutions
Ourmissionistoprovidehealthcare
organizationswithinnovative
therapeuticsolutionsinnicheand
raregeneticdiseaseareas,market
accessstrategiesandsustainable
commercialsolutions
”
”KamelGhammachi
Founder&MP
KarimSmaira
Founder&MP
|November 2018|28

Genpharm also offers consultancy services on market entry
strategies for companies interested to set up a regional
office or that simply want to understand the commercial
potential of their portfolio and the best strategies to
approach the Middle East market with.
Prominent Landmarks in Genpharm’s Journey
Genpharm was a simple entrepreneurial idea and a vision
shared by the two founders that saw the light in 2012.
Seeing a significant gap in the rare disease space in the
Middle East, possessing the regional pharmaceutical
expertise and a wide global network, they decided to turn
this into an opportunity. With every new initiative, there are
risks and many “nay-sayers”. This has been a constant
motivation to set ambitious objectives and surpass them.
Genpharm was born out of the idea to become a market
access provider for small pharmaceutical as well as biotech
organizations with innovative products. The industry
reputation of its experienced management, the strong brand
identity acquired and the high quality of the work
performed, attracted large leading corporations such as
GSK, Sanofi and Novartis which embodied a validation for
its business model and standards as well.
Genpharm’s work has been recognized by working
references from its partners and also through several
business and industry awards such as the “Best
Pharmaceutical Market Access Company” and the “Best
Pharmaceutical Marketing and Consultancy Company” in
2016 and 2017 by the MEA business awards.
Creating Eminence with its Core Values and Vivid
Visualization
Genpharm believes that its core values have been its real
driving force.
 Patient Care: It is focused on rare diseases, caring for
the patient and their families are central to what we do.
This is a key motivator that is used in our
communication and our recruitment. We are usually the
only hope that these patients have for a better life. This
is the overarching motivation and the drive behind what
Genpharm stands for.
 Innovation: Although, the product innovationcomes
from its partners, Genpharm innovates in the market
solutions that it offers, particularly in the areas of market
access, disease awareness, and diagnosis.
 Accountability: The company wishes its employees to
be responsible and accountable for their actions. It
believes that the organizational culture of ownership and
entrepreneurial spirit is extremely difficult to maintain if
employees don’t feel accountable.
 Integrity: Ethical standards and honesty are core values.
Genpharm stays transparent internally and with its
external stakeholders.
 Teamwork: Joining experiences, skills and sharing
information helps them achieve more together as a
group than lone individual.
Elevating Environment at Genpharm
Being a start-up business, Genpharm is fully focused on
maintaining an interactive work environment and offers its
employees learning on the job through hands-on
experience. Moreover, it tends to look internally for
promotions which are very motivating. Today, its mid-level
management is composed exclusively of internal talents.
Genpharm maintains a very open environment for
discussion and feedback with management practicing an
open-door policy. The Management team likes to
emphasize the fact that, “If you want to lead people, lead
them from behind”. This has led to several internal
promotions, particularly for those that believe that
“leadership is what you do when your manager is not
around”.
Future Potential
Genpharm is all set to continue its growth trajectory with
several new collaborations, capitalizing on its expertise and
recent track record. The company believes that the current
research and technological breakthroughs will certainly lead
to new advancements in disease management and even to
curative therapies creating opportunities for its business
development appetite.
“We are growing organically at an average of 23% per
year. We see no reason why we cannot continue this
aggressive growth and complete our current expansion
plans. We believe we have an unlimited potential for
profitable growth”, asserts the duo confidently.
DISRUPTIVE
MOST
29 |November2018|

Phronetik
easoning, the power to question and search
answers makes human beings different from other
Rmammals. As a race, we have always been
autodidacts and found solace in learning, growing and
teaching. Why and how has it always been important and
has invoked us to find answers to the unknown? The reason
for this inquisitiveness ranges from personal to social, but
what is important is the fact that the journey to the truth has
mostly ended in benefitting the society.
It was with this curiosity and a quest for answers to
unanswered questions that Phronetik was founded. What
triggered the quest was a simple question, “How and why
does one get a disease without any genetic predisposition,
no family history or adverse lifestyle behaviors?” Phronetik
was started to try and find answer these and other questions.
The company’s name is an amalgamation of two Greek
words: phronesis (wisdom) and kinetic (to move) which
justifies its quest to leverage technology and innovation to
improve health care, as they move forward with wisdom.
A biotechnology company, Phronetik advances precision
medicine by leveraging OMICS data, artificial intelligence
and informatics to improve diagnosis, treatment, and
monitoring. It also supports translational research with
particular interest in studies that encompass precision
medicine. Over years the company has been trying to
answer the questions with the science behind genetic
predisposition followed by epigenetic studies and
population health research. The diagnosis and interpretation
of data and calculation to determine the diseases has
become the central focus of the company.
Never say Never
Quitting is unacceptable for Tania Martin-Mercado,
President & CEO, Phronetik, and the idea reverberates
Unmasking Genetics to Improve Health
Weaimtoprovideanswerswhere
therewerepreviouslynone
”
”TaniaM
President&CEO
|November 2018|30

throughout the company, its employees and its workings.
She started the company in 2013 with modest beginnings,
no outside venture capital or influx of seed money and has
toiled hard to bring it where it stands today. When asked
what keeps her going, she answered, “I have questioned my
sanity from time to time. Then I remember why I’m doing
this. Maybe, though the efforts of the Phronetik team, its
University partners and industry collaborators, we help a
family predict and prevent the onset of disease.” She
continues to voice her thoughts, “We prevent a death. We
improve quality of care at a practice and quality of life for a
patient. We provide answers where there were previously
none. I believe in what we are doing wholeheartedly.”
Spearheaded by its leader and aptly supported by its staff,
Phronetik has been designing and re-designing its offerings
and focus, starting with clinical trial services and support
and broadening to sequencing and genetic services. It now
partners with a number of CAP/CLIA accredited
laboratories where it offers the services of genomic testing
such as diagnostic testing, predictive genetic tests,
pharmacogenomics, and carrier testing. This OMICS data is
then processed to offernext-generation sequencing services
and data analysis. It also offers technical support to the
solutions. These professional services include strategic
planning, technology roadmaps, HIPAA risk, security
assessments and more. Its managed services,
SupportDR™, is an IT offering perfect for providing
technical support for clinical trials, private practices and
other health care organizations. Specific SupportDR™
services include public portals, asset and inventory
management, system monitoring and maintenance,
24x7x365 support, remote end-user support and more.
The company is committed to its mission to provide
sustainable, innovative, transformative and disruptive
technologies and services to support clinical trials,
translational research, and patient-driven outcomes. It offersa
holistic approach to translational and clinical research.
The company being anti-silo believes in informational
transparency and necessary (compliant) data exchange to
achieve its goals of advanced scientific discovery,
reproducible studies with data to back them up and
accurate, accessible data for clinicians to improve
healthcare delivery. Phronetik credits its power to remain
flexible and adaptable to the needs of the clients as the key
to its towering stature over competitors. It helps in offeringa
wide array of services to support the client’s initiatives.
Phronetik’s effort, as it strides along the path to realizing its
values of “Good science, good data, excellence in
innovation, and integrity in all we do”, has received
recognition and accolades in many leading magazines.
Phronetik serves the government, life science, hospitals,
ambulatory/private practices, pharmaceutical, non-profit,
and community-based organizations.
The company values its employees like its customers and
doesn’t hesitate in going that extra mile to keep them
motivated, innovative and in love with their work. With the
exception of lab work, employees are allowed to work from
home, providing Phronetik access to the best talent in data
science and biotech regardless of geographical location.
Employee development is highly encouraged and they are
given an environment where they have the freedom to be
creative and think outside the box.
Preparing Today,for a Brighter Tomorrow
The healthcare and biotechnology landscape is constantly
changing, and Phronetik’s journey continues. It opines this
journey as an opportunity and is the passion that the
company thrives on. It entails the discovery of ways it can
be a part of improving health care while contributing to the
larger body of scientific knowledge. It keeps an eye on the
other developments happening worldwide, from new
vaccines to new human cell structures. Innovations which
help population and individual patients induce a sense of
pride and self-worth in them for being a part of this
industry. The management and employees keep up with
trends by reading publications like Science Daily and Gene,
Engineering & Biotechnology News. The Phronetik team
also stays in touch with groups and organizations in the life
science and biotechnology space news coming from
individual practices, hospitals, ambulatory centers, and
mental health practices to spark ideas to work upon.
Phronetik aims at having its own CAP/CLIA accredited
biotechnology laboratory in the near future. That is a very
important goal. Releasing an artificial intelligence engine
for point-of-care diagnostics is also on the charts. The
company strives to learn from failure and move ahead with
double the zeal. Phronetik will continue to grow and adapt
to the ever-changing science, technology, and healthcare
space.
DISRUPTIVE
MOST
31|November 2018|

HIV research has come a long way since the disease was discovered in the 1980's.
Antiretroviral therapy was a major milestone that has changed the lives of millions, but
the goal now is to nd an HIV cure before 2020. Over the past several decades,
researchers have learned a lot about the human immunode ciency virus (HIV) and the
disease itcauses, acquired immunode ciency syndrome (AIDS).
HIVSTILL AN IMPENDING THREAT TO MANKIND
HIV Awareness Month
|November 2018|34

01
02
STOPPING THE REPLICATION OF HIV
Lastyear in a clinical trialscientists showed thatthis
approach has the potential tobecome a functional
cure for HIV. The key to its potential is that it can
target the reservoir of HIV viruses that “hide”
inactive within our cells. Current therapies
suppress the virus in circulation by inhibiting the
formation of new viruses, but they don't touch the
reservoir. Once you stop, the virus comes back in
10-14 days. ABX464 is the rst drug candidate
ever shown to reduce the HIV reservoir. The drug,
called ABX464, binds to a speci c sequence in the
RNA of thevirus, inhibiting itsreplication.
SHOCK AND KILL
Another approach that is becoming popular in the ght
against HIV also goes after the hidden HIV reservoir. The
“shock and kill” or “kick and kill” approach uses latency-
reversing agents (LRAs) that activate or “kick” the latent
HIV reservoir, making it possible for standard
antiretroviral therapy to “kill” these viruses. In 2016, a
group of UK universities reported promising results from
one patient treated with this approach. A similar strategy
using vaccine is currently being tested. One stimulates
the production of antibodies that block the replication of
HIV,while the other attacks the reservoir.
35 |November2018|

It is estimated that about 1% of the people in the world
are naturally immune to HIV. The reason is a genetic
mutation on the gene that encodes CCR5, a protein on
the surface of immune cells that the HIV virus uses to
enter and infect them. People with this mutation are
missing part of the CCR5 protein, making it impossible
for HIV to bind to it. Using gene therapy, it would, in
theory, be possible to edit our DNA and introduce this
mutation to stop HIV. In the future, gene therapy for HIV
could be done with CRISPR, a gene editing tool that is
much easier and faster to make. Its potential in HIV has
already been shown in vitro, and soon HIV could
become of the rstdiseases tobe cured withCRISPR.
GENE THERAPY
What makes HIV so dangerous is that it attacks the
immune system, leaving people unprotected
against infections. Butwhat ifwecould supercharge
immune cells to ght back? That's the reasoning
behind immunotherapies. Researchers reported
last year that thanks to an immunotherapy that
primes the immune system against the virus, 7 out
of 15 patients were cured. Their approach
combines a drug to activate the hidden HIV
reservoir with a vaccine that can induce an immune
response thousands of timesstronger than usual.
IMMUNOTHERAPY
03
04
WHEN WILL WE HAVE AN HIV CURE?
Although there are several approaches that could eventually bring a functional HIV cure, there are still
some challenges ahead. One of the biggest concerns around any HIV treatments is the virus’ ability to
quickly mutate and develop resistance, and for many of these new approaches there is still no data on
whether the virus will be able to become resistant.
So far, none of these functional cures have reached late-stage clinical testing, meaning it doesn’t seem
likely that we will meet the goal of having an HIV cure by 2020.
- Sayali Rane
|November 2018|36

Sunny Days In-Home Care
Originated from the founder’s desire toprovide
quality care for people, Sunny Days In-Home
Care is committed to providing high quality,
client-centric, and affordable in-home care services to its
clients. It assists them in leading dignified and
independent lives in the comfort and safety of theirown
homes. The company sees that its clients’individual
needs are carefully assessed, understood, and met
through the selective assignment of qualified,
trustworthy, and a compassionate personnel.
Sunny Days began in a small in-home office with the
Founder, David Ellenwood, controlling all operations.
Shortly after, David met with clients, developed care
plans, and hired caregivers, while his wife helped assist
with building the business structure. Later, a field
manager was hired to manage care and client shift
coverage. After about one year into the business, a new
office space was rented, office staff was hired, and
additional field management was brought to the team.
Today, Sunny Days is headquartered at Canonsburg, PA,
and operated by an office staff of about ten along with
ten Regional Field Managers.
The company desires to provide the individuals, with
disabilities and seniors, an atmosphere in their homes
that is respectful, caring, and compassionate, so that they
can live their lives to the fullest.
The Benevolent Kingpin
David has worked as a sales professional most of hislife.
His experience has been in marketing for several home
healthcare agencies. Addressing the same, he asserts, “I
witnessed first-hand companies providing sub-par at-
home care, who were in the business just to make a
Re-shaping the Healthcare Landscape
withIn-Home Care
Wearecommittedtoprovide
enrichedandcompassionate
in-homecareservices
”
”DavidEllenwood
Founder
|November 2018|38

buck.” For David, this became increasingly frustrating
because he believed people deserved good care first.This
led to the doors of Sunny Days In-Home Care openingin
February 2011.
David himself was the very first caregiver. He worked
around the clock caring for clients while learning their
needs. During this time he worked at keeping all other
functions of the new business running smoothly. He was,
essentially, a one-man band for the first few months.
Later, his wife, Evelyn, quit her full-time job and joined
him. Together they continue to make a great team while
providing elite healthcare solutions for patrons seeking
home care services.
Distinctive Products and Services
Sunny Days provides professional, affordable, and caringin-
home living assistance for seniors in the Pittsburgh area
and surrounding regions. Its Pittsburgh home care offers
companionship, light housekeeping, medication
reminders, personal care, transfers, and a lot more. The
company aspires to provide the highest level of care in
every home by making the seniors the most important
part of what it does. At Sunny Days, local fieldmanagers
develop relationships with the clients and caregivers and
strategic training is provided with an aim to equip
caregivers as much as possible.
The company currently cares for 234 clients, in about
10,000 care hours, weekly across western Pennsylvania.
Clients are locally managed by Field Managers, who
meet with the client, develop a care plan, and
strategically match them with a caregiver to make sure
that their needs are met. Client care is monitored
monthly by a monthly client visit by the Field Manager
and care is regularly assessed through an online portalto
make sure tasks are completed at each visit.
NoteworthyAccomplishments
Sunny Days In-Home Care has been an Inc. 5000
recipient for two years, 2017 and 2018. This list
represents some of the fastest growing companies in the
nation, and the company was honored to be included.
Additionally, Sunny Days is recognized by the BBB. In
2016, David and Evelyn Ellenwood were nominatedfor
EY Entrepreneur of the Year. Sunny Days has also
received local recognition for participation in local
events and assisting with the community.
The Values Abided
 Client care is the top priority
 Sunny Days is always accessible and available
 Commitment to the godly principles that SunnyDays
was founded upon
 To create a caring and respectful environment in the
homes of the clients
 To foster an atmosphere of trust and safety between
the clients and employees
 To create a positive work environment for the
employees in its clients’ homes
 To conduct business with the highest level of integrity
Staying at Pace with Advancements in theIndustry
Since the healthcare industry is ever-evolving, the
company continuously tries to stay compliant and up-to-
date on the newest methods and information on quality
care and for those with disabilities. In Pennsylvania,
Medicaid recipients of in-home care recently were made
to fall under the control of Managed Care Organizations.
At Sunny Days, new methods, technology, and
procedures are now in place to make sure all clients are
served appropriately. The agency has “adapted with the
times” to ensure needs are met and protocols are being
followed.
Future Plans
Sunny Days plans to continue to grow within the region.
“The growth and service opportunities are limitless!”
asserts David. The company also plans on adding
different certifications to diversify the types of care that
it can provide to its clients.
DISRUPTIVE
MOST
39 |November2018|

n the UK, the NHS is the backbone of our healthcare
system - a place we know care will be provided
Iindependent of wealth. When health information enters
the equation, the IT systems that have been put in place are
focussed on the system rather than what patients and health
professionals need - relevant information at the point of
care to improve care outcomes and make informed
healthcare decisions.
Today we are more than familiar with IT systems being
there to help keep us informed - the parcel that arrives from
online shopping, the carrier knows exactly where it is, and
shares that information with us. In healthcare, it’s still a
very different story – our doctors are reliant on letters sent
through the post to keep information and we can wait weeks
to know our results. The medicines we take and the notes
about our health are stored in multiple systems that often
mean we must tell our healthcare professionals what’s
wrong rather than them already knowing. It’s estimated that
in 2000, 70% of errors in hospitals are caused by not having
record at the point of care, and this hasn’t really changed.
Centralised standards rather than person-centred
standards have failed repeatedly
The National Programme for IT “NpfIT” started in 2002
with a budget of £6.5bn. By 2012 it was estimated that up
to £40bn was spent and the programme is now seen as the
biggest IT project failure ever. The objective of the project
was to build software under the direction of the NHS with 5
IT integrators. There was a published ambition to stop using
IT solutions from the open market. The NHS IT market has
still not recovered, and investment markets are now wary
about investing in IT if the NHS is the customer.
The NHS is not one organisation. It is thousands of differentlegal
entities. Each organisation including every GP practice is
responsible independently for its own information
governance. Even if there was a central plan that could
work it is highly unlikely that every Trust in the NHS
would decide to adopt it. Unless people are asked
explicitly under GDPR for permission to share their data it
is not possible to do it. If however people had copies of
their health records stored and ready to share they could
offerimmediate permission themselves.
People powered health - IT systems should place the
person at the heart of design
Whilst it has been clear that the national IT programmes
over the years did not listen to the clinical users it is even
more clear that they did not deliver what the people they
serve want. Over the last 20 years many successful
commercial IT initiatives were driven by serving the
suppliers of services even if the NHS failed in this way.
This is why when we compare the IT we use to shop online
with receiving letters from the NHS though the post we are
frustrated and disappointed.
Newer ways of working which have delivered companies
like Airbnb focus not on the supplier of the service buttheir
customer. They have a ruthless desire to deliver what we all
want from their services. This allows completely new ways
of working to be adopted and improves our lives. I would
argue the NHS needs to think this way.
If we were to improve the booking of trains by focussing on
the ticket office we would increase the number of staff and
give them better computers. The Trainline app means we
don’t need a ticket office to book a train. Apply this to the
NHS and we could see a world where there are no server
rooms and everything is cloud based. Without this drive
there will always be a need for the organisation to buy
better computers and employ more staff.
What needs to change?
The latest NHS IT policy states that projects should be
focussed on the user need, so it seems that lessons are
starting to be learned. I believe we also need to consider the
following:
Why isit important for healthcare providers to
move towards patient-personalised services?
Expert’s View
|November 2018|40

each country in the UK. We also get private care and we
now record information ourselves from steps and weight to
blood pressure.
The NHS is only one provider of health data. We all want
all our health data to be available and we want to take this
anywhere to be treated in England or not, private or not.
This, together with the fact that not all NHS organisations
have the permission to share data with each other shows
that the only real way we can have a complete record is if
we have a record owned and controlled by us. By doing this
we can also solve the problem that the NHS has not yet got
a single record for us and take information each time we
use an NHS service instead. By moving towards a more
personalised approach when it comes to owning and sharing
health records, more accurate, up to date information will
help improve care outcomes for people.
Stephen Critchlow isthe Founder and CEO
of Evergreen Group – compromisingof
three brands – EvergreenLife, a personal
health record app used by over half a
million people inthe UK;Evergreen
Energy, helping individualsand
businessestake control of their energy
supply, and EvergreenSmartPower–
an innovative energy business
designed to load balance domestic
energy.
Critchlow initially founded healthcare
software company Ascribein1989, with
a visionto ensure all health decisions
were informed at the point of care. This
businessserved more than 75%of UK
hospitals aswellas hospitals
overseas.Critchlow grew the businessby
acquiring 9other companies, employing
270staffand waseventually listed on the
AIM market. In2013Ascribe wasacquired by
fellowhealthcare software provider EMISGroup
ina saleworth an initial £57.5m.After the sale,
Critchlow then went on to setup ASC Renewables,
a pioneer for renewable energy which he isnow inthe
process of scaling asthe Evergreen Group.
Critchlow has also invested inother sustainablebusinessesand ventures
that align withhisvisionand providesongoing mentorshipto, including
SuperCarers,Open Bionicsand Switchee.Critchlow wasawarded Icon of the
Year – North Region inthe Barclays Entrepreneur Awards 2018.
About the Author
Stephen Critchlow
Founder&CEO
1.Stop all hand-written health records within two years
including notes and any personal information
2. Make all health data, as it is created, available via a
standard interface to any organisation the patient wishes
to share it with and oﬀer a copy for their personal health
record so that they can share it as and when needed
3. Halt the delivery of the NHS App (technology which is
already available and proven) and instead provide an
integration layer for all app providers
Health information should be owned and controlled by
us
Most people don't get care just from the NHS; social
services provide care and often use diﬀerent systems, and
most of us travel and receive private healthcare at some
point in our life. IT systems are managed separately for
41 |November2018|

s technology advances at exponential
levels, innovative technologies are hitting
Athe market at a break-neck speed. Over the
last decade, the healthcare domain has witnessed
gigantic transformation by embracing trending
technologies, improvising patient amenities,
exploring new dimensions in medical research to
name a few. The medical fraternity has unearthed
new opportunities that continue to streamline and
minimize the challenges faced by the patients as
well as the doctors.
With the abundance of healthcare providers in the
industry, players are now concentrating on
developing new delivery models that help to
improve medical care facilities. Among thevarious
trending business models that are shaping the
current healthcare industry, ‘Telemedicine’ stands
tall among making a lasting impression and
bringing about a break-through change. It comes
with a promise of eradicating healthcare’s last mile
issue. Although it has been in the industry forquite
a while, it has seen a remarkable growth in the past
two decades.
An interesting analysis by experts reveals that the
‘doctor-patient’ ratio in India is around 1:921. If
compared over the last few decades, this data is
|November 2018|44

actually impressive. However, as a populous nation, several
patients living in tier II and III towns along with the people
living in rural areas still don’t have the access to quality
medical facilities. Inspite of all the advancement in the
medical sector, a majority of the people cannot utilize the
benefits or fall short of the best medical solutions. This
blockade is primarily due to the physical distance from a
city along with the unawareness among the rural and
underserved population.
This is where telemedicine technology evolves as a boon
for the patients living in far-off areas. This technology is the
amalgamation of state-of-the-art electronics, ICT, and
associated applications that assist in providing education to
healthcare professionals. By connecting the doctors
together with the patients, telemedicine is changing the
dynamics of the sector at a rapid pace. Simplifying the
interaction, this technology bridges the existing gaps and
diminishes the obstacle to avail optimum medical facilities
– even while staying at any remotest corner of the country!
Right from having a medical consultation, complex
ailments, medication reminders, tracking health
parameters, transmission of medical records – telemedicine
does it all! In general, there are three versions of this
technology that can be used as per requirement:
 Collaborative medicine: real-timecommunication
with physicians
 Store & Forward: sharing patient information
 Remote Monitoring: done through mobile
monitoring devices
Along with the private players, the Government is
providing assistance in the form of initiatives, reforms,
unified platform and reliefs. Since 2000, the Government of
India has taken various measures to implement this
technology at the remote ground levels. This technology is
gaining momentum as there is a huge surge in the Indian
tech industry. Many hospitals already have and majorities
are in the process of setting-up the state-of-art infrastructure
A Revolutionary Step in Healthcare
Telemedicine
to offer the best medical services at a PAN India-level. By
investing in interactive video conferences, aligning the
software and hardware components and seamless high-
speed connectivity, the medical giants are successful in
penetrating into the remotest geographies of the country.
Making a Difference!
Before anything, the ease of accessibility is the foremost
reason for this technology to witness a positive trajectory of
growth in the last few years. The high volumes of elderly
and specially-abled patients are also a major factor fuelling
the rise of telemedicine services in the sub-continent.
Offering the most viable health care services to the
inaccessible corners of the country has made it the ultimate
choice for the providers. Knowledge sharing and educating
the medical services available at the rural areas enables
them to build their own resources and facilitates complex
emergency and intensive care services.
To a huge extent, telemedicine reduces the financial burdens
on the families by minimizing the hospital stays, traveling
charges, and by cutting offother expenses. This technology
is one of the best in its kind, as a patient gets access to
premium healthcare, irrespective of the time and location.
Additionally, it plays a pivotal role in doing
epidemiological surveillance for creating the healthcare
database of a particular region.
The Journey Ahead
The country has taken big strides forward in adopting
technology and delivering innovative healthcare solutions.
However, this is just the beginning and a lot needs to be
done. Countries like India and other developing countries
can act as the pioneers to innovative medical solutions and
match the medical superiority of the western world.
Knitting the country with this technology is surely a
progressive step to eradicate the stigma of the unavailability
of quality medical services across the nation.
Editor’s Insight
- Devasish Kanojiya
45 |November2018|

The TeleDentists
avities, worn tooth enamel or fillings, gum
disease, fractured teeth, or exposed roots are
Csome of the most common dental problems that
have been prevalent since ages. According toa
prominent research, more than six million people
annually experience an urgent dental problem but many
find it challenging to find a right doctor on immediate
basis.
Moreover, Hospital Emergency Departments (ED) are
not fully equipped with the state-of-art infrastructurethat
is needed to provide efficient dental solutions to patients.
This ultimately results in no dental treatment and
ultimately bears a high treatment cost to the patient. To
solve this prevalent problem, a U.S. based company-
The TeleDentists entered into the market.
Founded by notable dentists with decades of vital
experience in healthcare, this company is seen as a tele-
health pioneer in healthcare industry. This company
offers an innovative model that saves patients’ time and
money, reduces unnecessary Emergency Department
visits and provides health payers and employers a more
cost-effective option.
The TeleDentists has engineered a cutting-edge cloud-
based SaaS service that enables hospitals and urgentcare
facilities access to a specialist who can treat oral care
level one problems at a fraction of the cost that would be
incurred if treated by the ER doctor. With its leading-
edge solution, this company is transforming the way
people treat urgent oral and dental problems. Its solution
is one of the first in the market that offers an improved
way to access care, providing essential dental services
24/7/365, wherever a dentist is needed.
Delivering Top-notch DentistryServicesat
YourDoorstep ina Cost-effective Way
Ourinnovativemodelsaves
patients'time,money,and
reducesunnecessaryEmergency
Departmentvisitsaswell
”
”Drs.MariaKunstadter
Co-founder
MichaelSigler
Co-founder
|November 2018|46

Brief Journey
The company has done a lot of research and customer
surveys to craft a platform that can alter the face of
dentistry treatment in the U.S. region. The company
began its research and development in 2014 and
launched its platform in 2016. In the subsequent year,
The TeleDentists had launched the next 2.0 version of its
trademarked solution after receiving immense praiseand
acceptance from people all across the U.S.
The company’s vision is to expand the horizon of dental
services into the far deeper pockets of U.S., such that
everyone who encounters a dental problem can use its
platform to connect with the dentist in quick time. Its
platform also integrates oral health into total healthcare
and provides much greater financial benefits to the
patients in terms of total healthcare cost reduction.
Studies show a 12% reduction in overall healthcarecosts
by integrating oral health so the healthcare system
benefits and patients benefit by being healthier.
The TeleDentists provides a virtual dentist at the desired
time by adding virtual dentists in emergency rooms,
urgent care centers, walk–in clinics, senior living
centers, primary care clinics, and as an additionalservice
to current tele-health companies.
Its dentists provide patients/providers with consultations
to assess the problem and make recommendations
regarding the best patient outcome. If an antibiotic is
needed, the dentist sends an e-script to the patient’s
pharmacy of choice. Non-narcotic pain meds can also be
prescribed. In some instances, if a follow-up visit with
an actual dentist is needed, their platform assists the
patient to arrange an appointment too.
Services and Its Uniqueness
The company offers dental emergencies, provides
answers to the vital questions concerning oral health
through its cutting-edge platform. It also addresses the
huge urgent care market as well as provides an oral
health maintenance program for primary care,workplace
wellness centers, and FQHCs.
The TeleDentists has a robust network of 35,000
specialist dentists who are spread across 48 states inthe
U.S. territory and available on demand whenever
required in quick time. “Since the rollout of the 2.0
version of our platform, we have acquired several
strategic partners, started our Series A fundraising
round, secured contracts to provide our services and are
land-grabbing the healthcare industry as the Dental
Specialist,” stated the company.
About the Ingenious Leadership
Drs. Maria Kunstadter and Michael Sigler are the
Co-founders of The TeleDentists. They are bothdentists
and have delivered dental care for years. In 2012, Dr.
Kunstadter was appointed the Dental Director of the
PAINS Alliance of Kansas City, a group dedicated to
help with the chronic pain crisis inAmerica.
While recounting the challenges of healthcare industry
especially of dentistry, Dr. Kunstadter revealed many
interesting facts. “There are no dentists in emergency
rooms. Something had to change. When $1.7B is being
spent in ERs, where no treatment or remedy is provided,
we had to come up with a better solution. That’s when
telemedicine came to mind. A virtual dentist can be in
all the places people go to seek help with their dental
needs,” Dr. Kunstadter asserts.
Road Ahead
The company aspires to become a dental specialist in
coming years as its tele-dentistry platform has the
potential to provide an easy access to oral health
specialist at the touch of the finger. “We are going
internationally as well. Since dental disease is the most
prevalent disease in the world, we have an unlimited
marketplace,” concluded Dr. Kunstadter.
DISRUPTIVE
MOST
47 |November2018|

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