Shetty Significance and Innovation

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R-Grants|Significance & Innovation
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WRITE TO EXCITE
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.….. 1.5 pages
Research Strategy
• Significance
WRITE
.…… 0.5 pages
.…… 10 pages
EXCITE
• Innovation
• Approach
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Significance InnovationProblem Solution
• Going to the video store is a pain.
People don't like traveling back and
f h d h
• Innovative video compression and
streaming technology.
TO EXCITE
forth just to rent a movie and they
hate paying late fees even more!
• Impacts over 90 million Americans.
• Dependent on store hours.
• Expense.
• 240 million Americans have
broadband.
• Consumer-Centric Game changer!
• Asynchronous
• ↓ Expense
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• Large carbon footprint.
• Alternate approaches are limited.
• Mailing DVDs
• Kiosks
p
• ↓ Carbon footprint
• Cross-cutting potential.
• Gaming
• Social Media

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Problem Solution
• What is the problem?
• Wh ?
• What advance has happened to make
l i i ll lik l
What’s new and different about
your solution?
NIH Institute
}
TO EXCITE
• Why is it important?
• Whom does it impact?
• Why are current approaches lacking?
• What makes you feel you have a
solution?
your solution potentially likely to
work?
• What new enabling ideas or
technologies does it use?
• What unique resources have you
NIH Institute
Focus}
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• Why is your team qualified to solve
the problem?
• How will your work improve health
through science?
developed or have access to?
• What is the value-add of your
research?
Writing the Significance Section.
“Obesity is a growing problem in the United States, with
much of the population overweight or obese…….
• Level of detail will
extend and validate
TO EXCITE
much of the population overweight or obese…….
And estimates are that the problem will get worse …..
Obesity increases the risk for many problems…….
extend and validate
what was written in the
Specific Aims section.
• Provide a compelling
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In poignant fact, what kills most obese patients is
pneumococcal infection…..
Provide a compelling
narrative for a timely
and important health
problem.
Principal Investigators Association | www.principalinvestigators.org

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Writing the Significance Section.
• Hit significance hard by
describing an approach
In this application we describe an approach that will
overcome the difficult challenges described above…..
TO EXCITE
describing an approach
that will overcome
current challenges.
• Focus on how your work
will cure the illness/
Indeed, preliminary data presented later in this application
are strongly supportive that our approach will be
successful…...
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will cure the illness/
lessen its consequences/
prevent its sequelae.
Principal Investigators Association | www.principalinvestigators.org
Writing the Significance Section.
• Emphasize the Results from this study will be significant not only in
TO EXCITE
significance of the
research in a broader
context.
• Describe the positive
advancing the development of new generations of
treatments for ….. , but also will provide fundamental new
knowledge regarding the nature of …….
Viewed through the prism of the “Research Impact
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impact your research
will have.
Principal Investigators Association | www.principalinvestigators.org
g p p
Framework” (Kuruvilla et al. 2006), our research has the
potential for ……..

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Writing the Innovation Section.
k h
“This work is innovative because it will characterize the
microparticles in plasma of pregnant women in a rigorous
TO EXCITE
Do not make the reviewer
guess where the novelty is,
and do not be afraid to
use the word “innovative.”
way that will lead to new methods to diagnose abnormal
pregnancies.”
“An innovative combination of multi-disciplinary expertise …..
that will lead to new transdisciplinary solutions”.
“The proposed study is distinctive in its ability to test a
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p p y y
singular cohort of individuals after …….. and collect
longitudinal clinical, physiological and biomarker data in a
sample also at risk for the development of …...”
Writing the Innovation Section.
An invention is the creation of something new It’s only when an
TO EXCITE
An invention is the creation of something new. It s only when an
invention becomes valuable or useful to others that it becomes an
innovation. Innovation is all about creating VALUE.
R Robert Buhrke
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Significance + Innovation ≠ Impact
• Significance = importance of a project if every specific aim were
completed successfully
TO EXCITE
completed successfully.
• Impact = What is the likelihood that this project conducted by
these investigators in their environment, with this level of
innovation and the proposed approaches, will have a sustained
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and powerful influence on the field?
(Significance + Innovation + Can they actually do it + Are they the right p
p people to do it?)
IT’S
ALL ABUT
ALL ABOUT IMPACT
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Questions?