The document summarizes the US Global Health Initiative (GHI), which aims to invest $63 billion over six years to strengthen health systems and improve health outcomes in partner countries, with a focus on women, newborns and children. The GHI will work through coordination, integration, country ownership and health systems strengthening. It establishes targets to reduce mortality and prevalence of diseases like HIV/AIDS, tuberculosis, malaria and malnutrition by 2015. The GHI operational plan includes assessing country health plans, focusing US investments, and designating some countries for additional technical and financial support.