A brief overview of COLLABORATIVE INNOVATION in Health Care and Life Sciences

1. Collaborative Innovation
in Health Care and Life Sciences
Bringing new minds, skills and
collaborations to problems in HC & LS
Jorge Juan FERNÁNDEZ GARCÍA
(@jorgejuan) Berlin, 27 May 2016

2. What is COLLABORATIVE INNOVATION?
COLLABORATIVE INNOVATION:
It’s a different type of innovation,
characterized by:
 Unique partnerships, fostering
innovation through collaboration,
rather than competition
 Involving many agents (not just
bilateral agreements), traditionally
separated
 More concerned about “creating
value” than about “capturing value”
Hospitals Academia Industry Governments IndividualsResearch
institutions

3. CROWDSOURCING CHALLENGES & COMPETITIONS
Kaggle and InnoCentive
https://www.kaggle.com https://www.innocentive.com
 Founded in 2010
 >450.000 data scientists
 202 competitions completed
 12 still active
 Many pertaining to HC&LS
 Formed in 2001 (as pharma companies
begun to struggle with their pipelines)
 Spun out from Eli Lilly
 >375.000 problema solvers
 >2.000 open challenges held

4. HACKATHONS: Hacking Medicine vs Hacking Health
Designed to bring experts from different disciplines face to face
http://hackingmedicine.mit.edu/ http://hackinghealth.ca/
 Founded in 2011
 Headquarters: MIT (Boston, US)
 Our Mission: Hack clever solutions for
healthcare. Break it down, build it up,
make it better around the world.
 Founded in 2012
 Headquarters: Montreal (Canada)
 Our mission:
Foster innovative digital health ecosystems.
Engage and inspire its stakeholders.
Support the development of human-centric solutions.

5. OPEN INNOVATION (through challenges)
UK – Longitude Prize
Longitude Prize is a challenge with a £10 million prize fund to help solve the problem of
global antibiotic resistance. It is being run by Nesta and supported by Innovate UK as
funding partner.
https://longitudeprize.org/

6. OPEN INNOVATION (through challenges)
HBS – Precision Trials Challenge
The Precision Trials Challenge is a pioneering competition to generate ideas on how to
bring diagnostics and therapies to market faster by reinventing the clinical trials process.
www.precisiontrialschallenge.org

7. OPEN INNOVATION (through challenges)
Ideas Challenge – Harvard Medical School
 But in February 2010, Drew Faust, president of
Harvard University, sent an email invitation to
all faculty, staff and students at the university
(more than 40,000 individuals) encouraging
them to participate in an “ideas challenge”
that Harvard Medical School had launched to
generate research topics in Type 1 diabetes.
 Eventually, the challenge was shared with
more than 250,000 invitees, resulting in 150
research ideas and hypotheses.
 These were narrowed down to 12 winners,
and multidisciplinary research teams were
formed to submit proposals on them.
 Today, seven teams of multidisciplinary
researchers are working on the resulting
potential breakthrough ideas.
http://sloanreview.mit.edu/article/experiments-in-open-innovation-at-harvard-medical-school/
https://hms.harvard.edu/news/harvard-medicine/ideation-challenge-diabetes

8. HOSPITALS
Hospitals getting together
http://www.ichom.org/
The International Consortium for Health
Outcomes Measurement (ICHOM) is a
non-profit organization founded by three
esteemed institutions with the purpose to
transform health care systems worldwide
by measuring and reporting patient
outcomes in a standardized way.
Goals of HVHC are to:
 (A) improve care, improve health, and
reduce costs by
 (B) identifying and accelerating widespread
adoption of best-practice care models and
innovative value- based payment model.
http://highvaluehealthcare.org

9. HOSPITALS
100+ children’s hospitals in the US
http://www.solutionsforpatientsafety.org
“The work we do is not
really about collecting
data or creating
processes – it’s about
saving kids’ lives, each
and every day…”.
- Dr. Steve Muething
(Cincinnati Children's
Hospital), SPS co-leader

10. RESEARCH INSTITUTIONS
BIST – Barcelona Institute of Science and Technology
Getting together not to reach scale, but to change scope

11. COMPANIES
Health Transformation Alliance (HTA)
http://www.htahealth.com/
The current health care system is
unsustainable and it costs too much. The
Health Transformation Alliance’s goal is to
improve the way corporations provide health
care benefits in an effort to create better
health care outcomes for their employees. By
coming together to share expertise, 20 of
America’s largest corporations seek to make
the current multilayered supply chain more
efficient. We view it as A Better Way.
Collectively, the 20 companies are
responsible for health care benefits for four
million people and spend more than $14
billion annually on health care for
employees, their dependents and retirees.
1. American Express Company 2. American Water 3. BNSF Railway Company 4. Brunswick Corporation 5. Caterpillar Inc. 6. The Coca-Cola
Company 7. E.I. du Pont de Nemours & Company 8. HCA Inc. 9. The Hartford Financial Services Group Inc. 10. IBM Corporation 11. Ingersoll Rand
12. International Paper Company 13. Lincoln Financial Group 14. Macy’s Inc. 15. Marriott International Inc. 16. NextEra Energy Inc. 17. Pitney
Bowes Inc. 18. Shell Oil Company 19. Verizon Communications Inc. 20. Weyerhaeuser Company

12. REGIONS
Massachusetts Life Sciences Center (MLSC) - Boston (US)
http://www.masslifesciences.com
A 10-year, $1 billion
initiative to invest in the
state’s life sciences sectors,
enacted by the
Massachusetts legislature in
June 2008.
The Initiative is
administered by the
Massachusetts Life Sciences
Center (MLSC), which serves
as the “hub” of the state’s
life sciences community.

13. COUNTRIES
EIT Health (6 Co-Locations Centers)
https://eithealth.eu/
EIT Health has formed six Co-
location Centres across Europe,
with Headquarters based in
Munich:
 London (UK/Ireland)
 Stockholm (Scandinavia)
 Barcelona (Spain)
 Paris (France)
 Heidelberg (Germany)
 Rotterdam (Belgium-Netherlands)
EIT Health furthermore includes
92 associate partners and 6
“InnoStars” regions in Wales,
Portugal, Poland, Hungary,
Slovenia and Croatia.
EIT Health develops talents, drives innovative
business ideas forward and boosts the global
competitiveness of European industry through three
key programs that will offer a vibrant ecosystem for
future entrepreneurs, academics and businesses.

14. CENTERS FOR THERAPEUTIC INNOVATION (CTI) - PFIZER
Launched in 2010, Pfizer’s Centers for Therapeutic
Innovation (CTI) is a unique model for academic-industry
collaboration, designed to bridge the gap between early
scientific discovery and its translation into new medicines.
https://www.pfizercti.com/

15. GLOBAL PHARMACEUTICAL FIRMS + WORLD-LEADING UNIVERSITIES
Apollo Therapeutics
http://www.apollotherapeutics.com/

16. PLATFORMS
Project Data Sphere
https://www.projectdatasphere.org
The Project Data Sphere platform is
available to researchers affiliated with
life science companies, hospitals and
institutions, as well as independent
researchers. Anyone interested in
cancer research can apply to become
an authorized user.
The Project Data Sphere initiative can help the
cancer community unlock the potential of
valuable data by generating new insights and
opening up a new world of research
possibilities.

17. Bio-X
Stanford University (US)
https://biox.stanford.edu/
 Launched in 1998.
 Nearly 700 Bio-X affiliated scholars
who span the campus and come
together at the Clark Center.
Bio-X is Stanford's pioneering
interdisciplinary biosciences
institute, bringing together
biomedical and life science
researchers, clinicians, engineers,
physicists, and computational
scientists to unlock the secrets of
the human body.
MEDICINE + BASIC SCIENCES + ENGINEERING

18. SPARK
Stanford University (US)
http://med.stanford.edu/sparkmed.html
SPARK is a partnership between university and
industry dedicated to:
 Educating faculty, fellows, graduate
students and medical students on the
discovery and development process for
therapeutics and diagnostics.
 Advancing promising research discoveries
to the clinic and commercial sector.
 Innovating efficient and cost-effective
approaches to drug discovery and
development.
Required reading for
any scientists in
academia who plan to
accelerate the
translation of
university-based
discoveries into
clinically relevant
drugs and diagnostics
and into the clinic.

19. BioMedX
Heidelberg (Germany)
http://bio.mx/
The BioMed X Innovation Center is an exciting
new collaboration model at the interface
between academia and industry.
Each team is typically sponsored by a
corporate pharmaceutical or biotech partner
of BioMed X. At the end of a fully funded
project term, successful projects are either
internalized into the development pipeline of
the respective pharmaceutical or biotech
sponsor or spun off into an independent
startup company.
“An OUTCUBATOR: bringing researchers with
varied expertise and skills together in one
physical location can accelerate research”.

20. Biodesign
Stanford University
http://biodesign.stanford.edu/
A systematic approach to needs finding
and the invention and implementation of
new biomedical technologies.
IRELAND STOCKHOLM
BARCELONA AARHUS

21. SYNTHESIS - Policy prescriptions
“Choose wisely when to compete, and when to collaborate”
Soon “collaborative advantage” will win over “competitive advantage”
GOVERNMENTS
COMPANIES
INDIVIDUALS
 Its role has changed:
 BEFORE: spend a good portion of their budgets on the
right priorities
 NOW: involve the private sector with matching funds;
align all the different governmental levels; change the HC
payment system to create the right incentives.
 Everything starts with “talking to the right person at the right
time”
 Choose your “large-scale problem”: safety, cancer, etc.
 Develop new skills (a must for physicians and researchers)
 Engage and create a network of “people with different
backgrounds from yours”

22. Director E-Health
Innovation Department
jfernandez@hsjdbcn.org
@HSJDBCN
Jorge Juan FERNÁNDEZ
@jorgejuan
Director
MOEBIO / d·HEALTH
jjfernandez@biocat.cat
@moebiobarcelona