Overview presentation of the best Radiation Therapy technique available in the world. Anyone having a tumor resected should know about IOERT.

1. IntraOp Medical Corporation Saving Lives

3. IntraOp Medical Corporation IntraOp Medical Corporation Self-Shielded, Mobile Device that Delivers Intraoperative Electron Beam Radiation Therapy (IOERT) to Cancer Patients During Tumor Removal Surgery

4. IntraOp Medical Corporation Overview

10. IntraOp Medical Corporation Conventional IOERT IOERT Overall Recurrence by Disease IOERT – Definitive Clinical Evidence Overall 5 Year Survival by Disease * Conventional Treatment = Surgery, external beam, and chemotherapy to current standards * Except Inoperable Pancreatic – 3 Year Overall Survival with radiation sensitizer

11. IntraOp Medical Corporation * Includes time required for actual patient transport ** T4 for advanced cancers, T3 for breast boost, T1 for single dose *** Some cosmetic side effects involved with Xray The Mobetron vs. Other Treatment Modalities Treatment specifics Mobetron IOERT Brachytherapy (Mammosite) Low Energy X-ray EBRT Xoft Intrabeam Single Dose Breast         IORT Boost Breast         Dermatology       Advanced Cancers      At time of Surgery      Treatment Time 2 Min 5 Days 5 Days 30 Min 5 Days+ Max Tumor Size T4 ** T1 T1 T1 T4 Oncoplasty Option     ***  OR Based       Mobile & Self Shielded         Uniform Dose         

12. IntraOp Medical Corporation Breast Cancer

15. IntraOp Medical Corporation Surgery IOERT Boost Reconstruction Time Saving and Resource Efficient Conventional Start Treatment Surgery Radiation 1 – 2 weeks 1 day 6 – 8 weeks Reconstruction Recovery 1 day 2 – 4 weeks Mobetron w/ Boost Start Treatment Recovery Radiation Recovery 1 – 2 weeks 1 day 2 – 4 weeks 3 – 5 weeks 2 – 4 weeks Total Time 7 – 14 weeks Total Time 14 – 40+ weeks Mobetron Single Fraction Start Treatment Surgery IOERT Boost Reconstruction Recovery 1 – 2 weeks 1 day 2 – 4 weeks Total Time 3 – 6 weeks Recovery 2 – 6 weeks Recovery 2 – 20 weeks

17. IntraOp Medical Corporation Poland (2): Jagiellonian University, Krakow, Wielkopolskie Centrum Onkologii Cancer Center, Poznan Spain: San Jaime Hospital, Torrevieja Belgium: St. Augustinus Hospital, Antwerp Japan(2): Nagoya University Hospital, Nagoya Gunma Prefectural Hospital China (2): Beijing, Beijing Tumor Hospital Beijing General Hospital Holland: MCH Westeinde, Den Haag Germany (2): CDT Strahleninstitut, Koln University Hospital Giessen and Marburg GmbH - Marburg Latin America : Instituto Nacional de Cancerologia, Bogota, Colombia Worldwide Presence Florida : Robert A. Gardner, M.D. Foundation , West Palm Beach Southwest Florida Dermrad LLC , Fort Myers, Italy (5): Ospedale Borgo Trento, Verona Centro di Riferimento Oncologico, Aviano Ospedale Maggiore della Carita, U. of Novara, Novara Ospedali Riuniti, Trieste, Italy Azienda Ospedaliera S. Croce e Carle, Cuneo Indiana: Methodist Hospitals of Indianapolis St. Vincent's Hospital – Indianapolis North Carolina : University of North Carolina, Chapel Hill California: University of California at San Francisco Stanford Hospital and Clinics, Palo Alto St. Joseph Hospital, Orange Ohio : The Ohio State University, Columbus University Hospital of Cleveland – Case Western Kentucky : University of Louisville Arizona : Mayo Clinic, Scottsdale North America (12)