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Depression / Bipolar Disorder
Changing Brain Function and
Structure
Dr John Bergman
K
The more meds you take , the worse youll get..... im 57,
never went to dr. Very healty.... The first time I went to
dr. at 50, they wanted to put me on bp med, cholest
med.... I went to a sinus dr. , he wanted to give me
steroids.... I never had high bp till I started going to dr. I
took the med for a while and felt like I was dead... slept
all the time.... they put me on cholest med... my arms
went numb...that made my blood sugar climb.... its
ridiculous....im taking fiber and oatmeal, fish oil, garlic.
vit c and e ,etc. and my cholest and tryg. finally came
down by itself.
Youtube Shout Out
Ancient Greece, disease was thought due to an imbalance in the four
basic bodily fluids, or humors.
Ancient Greek melas, "black", and kholé, "bile", melancholia
Hippocrates:
"fears and despondencies, if they last a long time" as being
symptomatic of the ailment
17th century Robert Burton's book, The Anatomy of Melancholy
melancholy helped by, a healthy diet, sufficient sleep, music, and
"meaningful work", along with talking about the problem with a friend
•1950 depression -chemical imbalance in neurotransmitters in the
brain
•1960s and 70s, manic-depression or bipolar disorder
•1980 Major depressive disorder was added to DSM-III in 1980
History of Depression
The Perfect Storm
•Food
•Elimination
•Movement
•Social &
Mental Health
•Health Care
Organic
Processed/GMO
1 to 3 times a day
½ hour weekly
½ hour daily
Time for self/friends/family
Life out of balance
Work With the Body
Medicate the Body
• Heart conditions- (1 in 3)
•Cancer-------------- (1 in 3)
•Mental Disorders- (1 in 4)
•COPD--(3rd cause of death)
•Joint Disorders----(1 in 3)
•Diabetes------------- (1 in 4)
•High Blood Pres.- (1 in 3)
•Back Problems-- (1 in 4)
•High Cholesterol-- (1 in 6)
•Child Birth-- (C-sec. 30%)
The Rise of "Western" Degenerative Brain Disease
PANDEMIC
Alarming increase in neurological diseases in Western nations:
•Parkinson's
•Alzheimer's
•Dementia
•Attention Deficit Disorder
•Autism-spectrum disorders
•Depression
•Bipolar Disorder
•Fibromyalgia
Causes:
•Trauma
•a sedentary lifestyle
•Artificial sweeteners like aspartame
•Pesticides
•MSG
•Vaccinations
44 yo woman
Jane 52 yo just recovered from
depression
Kay 44 yo 7 Rx’s for Dx of 7 years
Bipolar
Altered structure causes Altered
Function of the Brain
Environment and brain plasticity:
towards an endogenous pharmacotherapy.
Physiol Rev. 2014 Jan
Brain plasticity refers to the remarkable property of cerebral neurons to change
their structure and function in response to experience, a fundamental
theoretical theme in the field of basic research and a major focus for neural
rehabilitation following brain disease.
…the influence exerted by the environment on brain plasticity processes, with
special emphasis on the underlying cellular and molecular mechanisms …
highly relevant work performed in humans.
…how changes at the level of neuronal properties can ultimately affect and
direct key perceptual and behavioral outputs.
…striking ability of environmental enrichment and physical exercise to
empower adult brain plasticity.
Endogenous substances are those that originate from within an organism, tissue, or
cell
Pharmacotherapy is the treatment of disease through the administration of drugs
Hippocampus
Hippocampal interneurons in bipolar disorder.
Arch Gen Psychiatry. 2011; 68(4):340-50 (ISSN: 1538-3636)
(Hippocampus is smaller in people with Bipolar disorder )
hippocampus is part limbic system:
•incoming sensory signals are retransmitted and initiate behavioral
reactions
•Pleasure
•Rage
•Passivity
•excessive sexual drive
•modulation of emotions
•Involved in mood disorders, depression, bipolar disorder
At least three different psychiatric conditions cause the shrinkage (atrophy)
Depression
Post-Traumatic Stress Disorder
Bipolar Disorder
Drug Therapy VS Solution
the available evidence suggests that the hippocampus plays an important role
in the pathophysiology of Bipolar Disorder.
Behav Pharmacol. 2007 Sep;18(5-6):419-30.
The role of hippocampus in the pathophysiology of bipolar disorder.
Unipolar depression to bipolar
depression
*extraordinary boom in bipolar diagnoses, and that is
definitely tied to the widespread use of antidepressants
*kids 25% to 50% kids placed on an antidepressant,
who stay on that antidepressant for five years, will convert
to bipolar illness
*adults 25% of unipolar depression will convert to bipolar.
*Bipolar used to be a fairly rare disorder but now it’s
becoming much more common.
*converting from depression to bipolar, treated with a
cocktail of medications including an antipsychotic
medication
Suicidal Behavior and Severe Neuropsychiatric Disorders
Following Glucocorticoid Therapy in Primary Care
Laurence Fardet, M.D., Ph.D.; Irene Petersen, Ph.D.; Irwin Nazareth, M.D.,
Ph.D.
Am J Psychiatry 2012;
Conclusions: Glucocorticoids increase the risk of suicidal
behavior and neuropsychiatric disorders. Educating patients
and their families about these adverse events and
increasing primary care physicians' awareness about their
occurrence should facilitate early monitoring
Glucocorticoids act on the
hippocampus, amygdala, and frontal lobes
cortisone, hydrocortisone and prednisone
rashes to lupus to asthma
Could Soda and Sugar Be Causing Your Depression?
Fructose malabsorption, a very common condition with surprising correlates.
Published on May 24, 2011 by Emily Deans, M.D in Evolutionary Psychiatry
Turns out that in Central Europe, a large percentage (30-50%) of the
population suffers from certain types of carbohydrate malabsorption
15-20% of Americans may have fructose malabsorption
undigested fructose in the colon, feeding the bacteria there and leading to
bloating, cramping, and diarrhea - basically the symptoms of irritable bowel
syndrome
another study of 3,456 middle-aged civil servants, published
in British Journal of Psychiatry
•a diet which contained a lot of processed foods had a
58% increased risk for depression
•whole foods had a 26% reduced risk for depression.
HIGH BLOOD PRESSURE DRUGS = DEPRESSION
Effects of low Blood Pressure
cause cortisol to be released
Raising Blood Sugar
Blood pressure lowered,
• Less O2 to tissue/ brain
• Dysfunctions = low energy/etc
• depression.
High Blood
Pressure
Diagnosed
Drugs given
MSG and Depression
Researchers have also discovered that most people with
major depressive disease (MDD) have higher levels of the
neurotransmitter glutamate in their spinal fluid (CSF) and
blood plasma.
This is the same glutamate found as a food additive-for
example, MSG (monosodium glutamate), hydrolyzed
proteins, calcium or sodium casienate, soy protein
isolate, vegetable protein concentrate or isolate, etc.
Free glutamate, that is, existing outside the neurons, is very
toxic to brain connections and brain cells themselves --
mainly by a process called excitotoxicity.
Vaccine-related brain injury
Vaccines are made of two components -- the agent you
wish to vaccinate against and an immune adjuvant.
These adjuvants are composed of such things as
aluminum compounds, MSG, lipid compounds and
even mercury.
Studies have shown that these adjuvants, from a single
vaccine, can cause immune overactivation
**No studies show the effects of the hyper-
sensatization of the immune system to yearly flu
shots from 6 months for life
Vaccines, Depression and Neurodegeneration After Age 50:
Another Reason to Avoid the Recommended Vaccines.
By Russell L. Blaylock, M.D., CCN
40 million Americans suffer from major depressive disorder
anxiety disorders, bipolar disorder,
•chronic brain inflammation.
•MSG on your brain and mood
•connections between pesticides and neurological disorders
•vaccinations cause brain inflammation
•impact of an expanding vaccine schedule
Current recommendations by the CDC for adult
vaccinations include a total of 14 separate inoculations with
infectious agents and powerful immune adjuvants.
WARNING: SUICIDALITY AND
ANTIDEPRESSANT DRUGS
Antidepressants increased the risk
compared to placebo of suicidal
thinking and behavior (suicidality)
in children, adolescents, and
young adults in short-term studies
of Major Depressive Disorder
(MDD) and other psychiatric
disorders. Anyone considering the
use of PROZAC or any other
antidepressant in a child,
adolescent, or young adult must
balance this risk with the clinical
need.
Prozac Black Box
Warning Quote Hippocratic oath
“I will use those dietary
regimens which will
benefit my patients
according to my greatest
ability and judgement,
and I will do no harm or
injustice to them.
I will not give a lethal
drug to anyone if I am
asked, nor will I advise
such a plan; and
similarly I will not give a
woman a peccary to
cause an abortion.”
•The hippocampus shrinks in late adulthood
•leading to impaired memory and increased risk for dementia
•Hippocampal and medial temporal lobe volumes are larger in
higher-fit adults
•findings indicate that aerobic exercise training is effective at
reversing hippocampal volume loss in late adulthood…
Exercise training increases size of hippocampus and
improves memory
Researchers at Harvard, Yale, and the M.I.T.
first evidence that meditation can alter the physical
structure of our brains
“Our data suggest that meditation practice can promote cortical plasticity in
adults in areas important for cognitive and emotional processing and well-
being,”
“These findings are consistent with other studies that demonstrated increased
thickness of:
• music areas in the brains of musicians
•visual and motor areas in the brains of jugglers
In other words, the structure of an adult brain can change in response to
repeated practice.”
How Exercise Helps Older Brains
•moderate exercise can reverse normal brain shrinkage by two percent,
effectively reversing age-related hippocampus degeneration by one to two
years
•the people in the control group who didn't exercise saw an average of 1.4
percent decrease in hippocampus size
According to the research team:
"We demonstrate that loss of hippocampal volume in late adulthood is not
inevitable and can be reversed with moderate-intensity exercise."
Other contributing factors to brain …include
•decrease in blood flow to your brain (Blood pressure drugs)
•the accumulation of environmental toxins in your brain (Vaccinations)
Exercise
•increasing blood flow to your brain
•increasing oxygen supply to your brain
•encouraging a more vigorous release of accumulated toxins through better blood
circulation
•Increased blood flow increases nutrients necessary to keep your brain cells
90% of Money Americans spend on food is on
processed foods
 is a neurotransmitter responsible for a variety of mind (mood) and body
functions.
 signals between nerve cells
 Neurotransmitters affect almost ALL of the nearly 40 million brain cells.1
 larger amount of serotonin is manufactured in your intestines in the enteric
nervous system, also called the “gut brain.”
 In fact, 90% of your serotonin supply is found in your digestive tract and
blood platelets.
 Serotonin has a calming effect on your mind (the brain in your head) AND your
body (your gut brain or the enteric nervous system lining your digestive tract).
 Serotonin affects your:
 Mood
 Memory
 Ability to learn
 Appetite
 Arousal
 Aggression
 Impulse control
Serotonin = called the “feel good hormone,”
• Sexual desire
• Sleep
• Some social behaviors
• Heart
• Muscles
• Endocrine system (hormones)
Normal Bipolar Disorder
Depression
The Curve in the Neck is the Arch of Life
Proper nerve supply –
FREE of subluxation
Regular Exercise
Proper Nutrition
Sufficient Rest
Prayer and Meditation
Keep Informed, Stay Healthy:
www.owners-guide.com
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Bergman Family Chiropractic Patient
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Heal your brain from depression

  • 1. Depression / Bipolar Disorder Changing Brain Function and Structure Dr John Bergman
  • 2. K The more meds you take , the worse youll get..... im 57, never went to dr. Very healty.... The first time I went to dr. at 50, they wanted to put me on bp med, cholest med.... I went to a sinus dr. , he wanted to give me steroids.... I never had high bp till I started going to dr. I took the med for a while and felt like I was dead... slept all the time.... they put me on cholest med... my arms went numb...that made my blood sugar climb.... its ridiculous....im taking fiber and oatmeal, fish oil, garlic. vit c and e ,etc. and my cholest and tryg. finally came down by itself. Youtube Shout Out
  • 3. Ancient Greece, disease was thought due to an imbalance in the four basic bodily fluids, or humors. Ancient Greek melas, "black", and kholé, "bile", melancholia Hippocrates: "fears and despondencies, if they last a long time" as being symptomatic of the ailment 17th century Robert Burton's book, The Anatomy of Melancholy melancholy helped by, a healthy diet, sufficient sleep, music, and "meaningful work", along with talking about the problem with a friend •1950 depression -chemical imbalance in neurotransmitters in the brain •1960s and 70s, manic-depression or bipolar disorder •1980 Major depressive disorder was added to DSM-III in 1980 History of Depression
  • 4. The Perfect Storm •Food •Elimination •Movement •Social & Mental Health •Health Care Organic Processed/GMO 1 to 3 times a day ½ hour weekly ½ hour daily Time for self/friends/family Life out of balance Work With the Body Medicate the Body • Heart conditions- (1 in 3) •Cancer-------------- (1 in 3) •Mental Disorders- (1 in 4) •COPD--(3rd cause of death) •Joint Disorders----(1 in 3) •Diabetes------------- (1 in 4) •High Blood Pres.- (1 in 3) •Back Problems-- (1 in 4) •High Cholesterol-- (1 in 6) •Child Birth-- (C-sec. 30%)
  • 5. The Rise of "Western" Degenerative Brain Disease PANDEMIC Alarming increase in neurological diseases in Western nations: •Parkinson's •Alzheimer's •Dementia •Attention Deficit Disorder •Autism-spectrum disorders •Depression •Bipolar Disorder •Fibromyalgia Causes: •Trauma •a sedentary lifestyle •Artificial sweeteners like aspartame •Pesticides •MSG •Vaccinations 44 yo woman
  • 6. Jane 52 yo just recovered from depression Kay 44 yo 7 Rx’s for Dx of 7 years Bipolar Altered structure causes Altered Function of the Brain
  • 7. Environment and brain plasticity: towards an endogenous pharmacotherapy. Physiol Rev. 2014 Jan Brain plasticity refers to the remarkable property of cerebral neurons to change their structure and function in response to experience, a fundamental theoretical theme in the field of basic research and a major focus for neural rehabilitation following brain disease. …the influence exerted by the environment on brain plasticity processes, with special emphasis on the underlying cellular and molecular mechanisms … highly relevant work performed in humans. …how changes at the level of neuronal properties can ultimately affect and direct key perceptual and behavioral outputs. …striking ability of environmental enrichment and physical exercise to empower adult brain plasticity. Endogenous substances are those that originate from within an organism, tissue, or cell Pharmacotherapy is the treatment of disease through the administration of drugs
  • 9. Hippocampal interneurons in bipolar disorder. Arch Gen Psychiatry. 2011; 68(4):340-50 (ISSN: 1538-3636) (Hippocampus is smaller in people with Bipolar disorder ) hippocampus is part limbic system: •incoming sensory signals are retransmitted and initiate behavioral reactions •Pleasure •Rage •Passivity •excessive sexual drive •modulation of emotions •Involved in mood disorders, depression, bipolar disorder At least three different psychiatric conditions cause the shrinkage (atrophy) Depression Post-Traumatic Stress Disorder Bipolar Disorder
  • 10. Drug Therapy VS Solution the available evidence suggests that the hippocampus plays an important role in the pathophysiology of Bipolar Disorder. Behav Pharmacol. 2007 Sep;18(5-6):419-30. The role of hippocampus in the pathophysiology of bipolar disorder.
  • 11.
  • 12. Unipolar depression to bipolar depression *extraordinary boom in bipolar diagnoses, and that is definitely tied to the widespread use of antidepressants *kids 25% to 50% kids placed on an antidepressant, who stay on that antidepressant for five years, will convert to bipolar illness *adults 25% of unipolar depression will convert to bipolar. *Bipolar used to be a fairly rare disorder but now it’s becoming much more common. *converting from depression to bipolar, treated with a cocktail of medications including an antipsychotic medication
  • 13. Suicidal Behavior and Severe Neuropsychiatric Disorders Following Glucocorticoid Therapy in Primary Care Laurence Fardet, M.D., Ph.D.; Irene Petersen, Ph.D.; Irwin Nazareth, M.D., Ph.D. Am J Psychiatry 2012; Conclusions: Glucocorticoids increase the risk of suicidal behavior and neuropsychiatric disorders. Educating patients and their families about these adverse events and increasing primary care physicians' awareness about their occurrence should facilitate early monitoring Glucocorticoids act on the hippocampus, amygdala, and frontal lobes cortisone, hydrocortisone and prednisone rashes to lupus to asthma
  • 14. Could Soda and Sugar Be Causing Your Depression? Fructose malabsorption, a very common condition with surprising correlates. Published on May 24, 2011 by Emily Deans, M.D in Evolutionary Psychiatry Turns out that in Central Europe, a large percentage (30-50%) of the population suffers from certain types of carbohydrate malabsorption 15-20% of Americans may have fructose malabsorption undigested fructose in the colon, feeding the bacteria there and leading to bloating, cramping, and diarrhea - basically the symptoms of irritable bowel syndrome another study of 3,456 middle-aged civil servants, published in British Journal of Psychiatry •a diet which contained a lot of processed foods had a 58% increased risk for depression •whole foods had a 26% reduced risk for depression.
  • 15. HIGH BLOOD PRESSURE DRUGS = DEPRESSION Effects of low Blood Pressure cause cortisol to be released Raising Blood Sugar Blood pressure lowered, • Less O2 to tissue/ brain • Dysfunctions = low energy/etc • depression. High Blood Pressure Diagnosed Drugs given
  • 16. MSG and Depression Researchers have also discovered that most people with major depressive disease (MDD) have higher levels of the neurotransmitter glutamate in their spinal fluid (CSF) and blood plasma. This is the same glutamate found as a food additive-for example, MSG (monosodium glutamate), hydrolyzed proteins, calcium or sodium casienate, soy protein isolate, vegetable protein concentrate or isolate, etc. Free glutamate, that is, existing outside the neurons, is very toxic to brain connections and brain cells themselves -- mainly by a process called excitotoxicity.
  • 17. Vaccine-related brain injury Vaccines are made of two components -- the agent you wish to vaccinate against and an immune adjuvant. These adjuvants are composed of such things as aluminum compounds, MSG, lipid compounds and even mercury. Studies have shown that these adjuvants, from a single vaccine, can cause immune overactivation **No studies show the effects of the hyper- sensatization of the immune system to yearly flu shots from 6 months for life
  • 18. Vaccines, Depression and Neurodegeneration After Age 50: Another Reason to Avoid the Recommended Vaccines. By Russell L. Blaylock, M.D., CCN 40 million Americans suffer from major depressive disorder anxiety disorders, bipolar disorder, •chronic brain inflammation. •MSG on your brain and mood •connections between pesticides and neurological disorders •vaccinations cause brain inflammation •impact of an expanding vaccine schedule Current recommendations by the CDC for adult vaccinations include a total of 14 separate inoculations with infectious agents and powerful immune adjuvants.
  • 19. WARNING: SUICIDALITY AND ANTIDEPRESSANT DRUGS Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of Major Depressive Disorder (MDD) and other psychiatric disorders. Anyone considering the use of PROZAC or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Prozac Black Box Warning Quote Hippocratic oath “I will use those dietary regimens which will benefit my patients according to my greatest ability and judgement, and I will do no harm or injustice to them. I will not give a lethal drug to anyone if I am asked, nor will I advise such a plan; and similarly I will not give a woman a peccary to cause an abortion.”
  • 20. •The hippocampus shrinks in late adulthood •leading to impaired memory and increased risk for dementia •Hippocampal and medial temporal lobe volumes are larger in higher-fit adults •findings indicate that aerobic exercise training is effective at reversing hippocampal volume loss in late adulthood… Exercise training increases size of hippocampus and improves memory
  • 21. Researchers at Harvard, Yale, and the M.I.T. first evidence that meditation can alter the physical structure of our brains “Our data suggest that meditation practice can promote cortical plasticity in adults in areas important for cognitive and emotional processing and well- being,” “These findings are consistent with other studies that demonstrated increased thickness of: • music areas in the brains of musicians •visual and motor areas in the brains of jugglers In other words, the structure of an adult brain can change in response to repeated practice.”
  • 22. How Exercise Helps Older Brains •moderate exercise can reverse normal brain shrinkage by two percent, effectively reversing age-related hippocampus degeneration by one to two years •the people in the control group who didn't exercise saw an average of 1.4 percent decrease in hippocampus size According to the research team: "We demonstrate that loss of hippocampal volume in late adulthood is not inevitable and can be reversed with moderate-intensity exercise." Other contributing factors to brain …include •decrease in blood flow to your brain (Blood pressure drugs) •the accumulation of environmental toxins in your brain (Vaccinations) Exercise •increasing blood flow to your brain •increasing oxygen supply to your brain •encouraging a more vigorous release of accumulated toxins through better blood circulation •Increased blood flow increases nutrients necessary to keep your brain cells
  • 23. 90% of Money Americans spend on food is on processed foods
  • 24.
  • 25.  is a neurotransmitter responsible for a variety of mind (mood) and body functions.  signals between nerve cells  Neurotransmitters affect almost ALL of the nearly 40 million brain cells.1  larger amount of serotonin is manufactured in your intestines in the enteric nervous system, also called the “gut brain.”  In fact, 90% of your serotonin supply is found in your digestive tract and blood platelets.  Serotonin has a calming effect on your mind (the brain in your head) AND your body (your gut brain or the enteric nervous system lining your digestive tract).  Serotonin affects your:  Mood  Memory  Ability to learn  Appetite  Arousal  Aggression  Impulse control Serotonin = called the “feel good hormone,” • Sexual desire • Sleep • Some social behaviors • Heart • Muscles • Endocrine system (hormones)
  • 26. Normal Bipolar Disorder Depression The Curve in the Neck is the Arch of Life
  • 27.
  • 28. Proper nerve supply – FREE of subluxation Regular Exercise Proper Nutrition Sufficient Rest Prayer and Meditation Keep Informed, Stay Healthy:
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